Citation Impact
Citing Papers
Computational protein design enables a novel one-carbon assimilation pathway
2015 StandoutNobel
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
A synthetic pathway for the fixation of carbon dioxide in vitro
2016 Science
Developmental refinement of hair cell synapses tightens the coupling of Ca 2 + influx to exocytosis
2014 StandoutNobel
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway
2015 StandoutNobel
A cell-free platform for the prenylation of natural products and application to cannabinoid production
2019 StandoutNobel
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
2013 Standout
Thiamin diphosphate in biological chemistry: exploitation of diverse thiamin diphosphate‐dependent enzymes for asymmetric chemoenzymatic synthesis
2009
The re-emergence of natural products for drug discovery in the genomics era
2015 Standout
Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
2013 StandoutNobel
C C bond formation using ThDP-dependent lyases
2013
Enzyme immobilisation in biocatalysis: why, what and how
2013 Standout
Computational Enzyme Design
2013 StandoutNobel
Direct Visualization of Asymmetric Adenine Nucleotide-Induced Conformational Changes in MutLα
2008 StandoutNobel
Otoferlin: a multi-C2 domain protein essential for hearing
2012
Current mechanistic understanding of thiamin diphosphate-dependent enzymatic reactions
2003
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Activity-Based Metabolomic Profiling of Enzymatic Function: Identification of Rv1248c as a Mycobacterial 2-Hydroxy-3-oxoadipate Synthase
2010
Electrostatic Origin of the Catalytic Power of Enzymes and the Role of Preorganized Active Sites
1998 StandoutNobel
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Umpolung by N‐Heterocyclic Carbenes: Generation and Reactivity of the Elusive 2,2‐Diamino Enols (Breslow Intermediates)
2012
Folding membrane proteins in vitro: A table and some comments
2014
Catalysis with N‐Heterocyclic Carbenes under Oxidative Conditions
2013
X‐ray Crystallography in Open‐Framework Materials
2015
α,β‐Unsaturated Acyl Azoliums from N‐Heterocyclic Carbene Catalyzed Reactions: Observation and Mechanistic Investigation
2011
Metabolomics: the apogee of the omics trilogy
2012 Standout
Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate
2014
Enantioselective Enzymes by Computational Design and In Silico Screening
2015 StandoutNobel
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Benzaldehyde is a precursor of phenylpropylamino alkaloids as revealed by targeted metabolic profiling and comparative biochemical analyses in Ephedra spp.
2012
Molecular Daisy Chains: Synthesis and Aggregation Studies of an Amphiphilic Molecular Rod
2013 StandoutNobel
Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
2022 Standout
Electrostatic Basis for Bioenergetics
2004 StandoutNobel
Kinetic Resolution and Stereoselective Synthesis of 3‐Substituted Aspartic Acids by Using Engineered Methylaspartate Ammonia Lyases
2013 StandoutNobel
Enzymatic asymmetric synthesis by decarboxylases
2000
An overview of N-heterocyclic carbenes
2014 StandoutNature
Functional diversity of organic molecule enzyme cofactors
2013
Molecular Basis for G Protein Control of the Prokaryotic ATP Sulfurylase
2006 StandoutNobel
Asymmetric catalysis with N-heterocyclic carbenes as non-covalent chiral templates
2014
Engineering the third wave of biocatalysis
2012 StandoutNature
Mapping‐Out Catalytic Processes in a Metal–Organic Framework with Single‐Crystal X‐ray Crystallography
2017 StandoutNobel
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Snapshot of a Reaction Intermediate: Analysis of Benzoylformate Decarboxylase in Complex with a Benzoylphosphonate Inhibitor
2009
Channeling of Substrates and Intermediates in Enzyme-Catalyzed Reactions
2001
Optimization of Enzyme Mechanism along the Evolutionary Trajectory of a Computationally Designed (Retro-)Aldolase
2017
Directed Evolution: Bringing New Chemistry to Life
2017 StandoutNobel
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Hybridization of MOFs and polymers
2017 StandoutNobel
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase
2018 StandoutNobel
Organocatalysis by N-Heterocyclic Carbenes
2007 Standout
Catalytic Effects of Mutations of Distant Protein Residues in Human DNA Polymerase β: Theory and Experiment
2012 StandoutNobel
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
Observation of an Acryloyl−Thiamin Diphosphate Adduct in the First Step of Clavulanic Acid Biosynthesis
2007
A Proficient Enzyme Revisited: The Predicted Mechanism for Orotidine Monophosphate Decarboxylase
1997 Science
Discovery and Protein Engineering of Biocatalysts for Organic Synthesis
2011
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
C−C Bond-Forming Lyases in Organic Synthesis
2011
Directed Evolution of Protein Catalysts
2018
On Catalytic Preorganization in Oxyanion Holes: Highlighting the Problems with the Gas-Phase Modeling of Oxyanion Holes and Illustrating the Need for Complete Enzyme Models
2010 StandoutNobel
Synthetic potential of thiamin diphosphate-dependent enzymes
1999
Enantioselective synthesis of hydroxy ketones through cleavage and formation of acyloin linkage. Enzymatic kinetic resolution via C–C bond cleavage
2001
Organocatalytic Reactions Enabled by N-Heterocyclic Carbenes
2015 Standout
Catalytic Cyclophanes. Part XI. A flavo‐thiazolio‐cyclophane as a biomimetic catalyst for the preparative‐scale electro‐oxidation of aromatic aldehydes to methyl esters
1997
Röntgenkristallographie an Materialien mit offenen Gerüsten
2015
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Computer simulations of enzyme catalysis: Finding out what has been optimized by evolution
1998 StandoutNobel
Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II
2018
Functional Anthology of Intrinsic Disorder. 3. Ligands, Post-Translational Modifications, and Diseases Associated with Intrinsically Disordered Proteins
2007
Remarkable Stabilization of Zwitterionic Intermediates May Account for a Billion-fold Rate Acceleration by Thiamin Diphosphate-Dependent Decarboxylases
1999
On the Organocatalytic Activity of N-Heterocyclic Carbenes: Role of Sulfur in Thiamine
2012
Origin of the Catalytic Power of Acetylcholinesterase: Computer Simulation Studies
1998 StandoutNobel
Metals and Their Scaffolds To Promote Difficult Enzymatic Reactions
2006
Engineering stereoselectivity of ThDP-dependent enzymes
2013
Radical Enzymes in Anaerobes
2006
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
2018 StandoutNobel
A key role for transketolase-like 1 in tumor metabolic reprogramming
2016
Pyruvate Ferredoxin Oxidoreductase and Its Radical Intermediate
2003
Artificial concurrent catalytic processes involving enzymes
2014
Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism
2008
Aryl−Aryl Bond Formation One Century after the Discovery of the Ullmann Reaction
2002 Standout
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Gold(I)-Catalyzed Activation of Alkynes for the Construction of Molecular Complexity
2015 Standout
Works of Kai Tittmann being referenced
Radical Phosphate Transfer Mechanism for the Thiamin Diphosphate- and FAD-Dependent Pyruvate Oxidase from Lactobacillus plantarum . Kinetic Coupling of Intercofactor Electron Transfer with Phosphate Transfer to Acetyl-thiamin Diphosphate via a Transient FAD Semiquinone/Hydroxyethyl-ThDP Radical Pair
2005
New function of the amino group of thiamine diphosphate in thiamine catalysis
2009
Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes
2008
A lysine–cysteine redox switch with an NOS bridge regulates enzyme function
2021 Nature
Observation of a stable carbene at the active site of a thiamin enzyme
2013
Glutamate 636 of the Escherichia coli Pyruvate Dehydrogenase-E1 Participates in Active Center Communication and Behaves as an Engineered Acetolactate Synthase with Unusual Stereoselectivity
2005
Mechanisms of acetohydroxyacid synthases
2005
Examination of Donor Substrate Conversion in Yeast Transketolase
2001
The Crystal Structure of the C2A Domain of Otoferlin Reveals an Unconventional Top Loop Region
2011
Reaction mechanisms of thiamin diphosphate enzymes: redox reactions
2009
A Δ38 Deletion Variant of Human Transketolase as a Model of Transketolase-Like Protein 1 Exhibits No Enzymatic Activity
2012
Sweet siblings with different faces: The mechanisms of FBP and F6P aldolase, transaldolase, transketolase and phosphoketolase revisited in light of recent structural data
2014
The Crystal Structure of Human Transketolase and New Insights into Its Mode of Action
2010
The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography
2006
Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy
2005
Activation of thiamine diphosphate in pyruvate decarboxylase from Zymomonas mobilis
1998
Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate
2013
Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate–thiamin diphosphate adduct in AHAS I
2012
ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space
2015
Activation of thiamin diphosphate in enzymes
1998
New evidence for cofactor’s amino group function in thiamin catalysis by transketolase
2007
NMR Analysis of Covalent Intermediates in Thiamin Diphosphate Enzymes
2003
Direct Kinetic Evidence for Half-Of-The-Sites Reactivity in the E1 Component of the Human Pyruvate Dehydrogenase Multienzyme Complex through Alternating Sites Cofactor Activation
2006
Binding and Activation of Thiamin Diphosphate in Acetohydroxyacid Synthase
2001
DFT and MP2 studies on the C2 C2α bond cleavage in thiamin catalysis
2009
Significant Catalytic Roles for Glu47 and Gln 110 in All Four of the C−C Bond-Making and -Breaking Steps of the Reactions of Acetohydroxyacid Synthase II
2011
Recombinant Expression, in Vitro Refolding, and Biophysical Characterization of the Human Glucagon-like Peptide-1 Receptor
2010
Strain and Near Attack Conformers in Enzymic Thiamin Catalysis: X-ray Crystallographic Snapshots of Bacterial Transketolase in Covalent Complex with Donor Ketoses Xylulose 5-phosphate and Fructose 6-phosphate, and in Noncovalent Complex with Acceptor Aldose Ribose 5-phosphate
2007
Cyclohexane-1,2-dione hydrolase: A new tool to degrade alicyclic compounds
2009
Double Duty for a Conserved Glutamate in Pyruvate Decarboxylase: Evidence of the Participation in Stereoelectronically Controlled Decarboxylation and in Protonation of the Nascent Carbanion/Enamine Intermediate,
2010
Steric and electronic properties of the cofactor's amino group control the lifetime of the central carbanion/enamine intermediate in transketolase
2009
Structural and Kinetic Studies on Native Intermediates and an Intermediate Analogue in Benzoylformate Decarboxylase Reveal a Least Motion Mechanism with an Unprecedented Short-Lived Predecarboxylation Intermediate
2009
Conversion of Pyruvate Decarboxylase into an Enantioselective Carboligase with Biosynthetic Potential
2011
How Thiamine Diphosphate Is Activated in Enzymes
1997 Science
Valine 375 and Phenylalanine 109 Confer Affinity and Specificity for Pyruvate as Donor Substrate in Acetohydroxy Acid Synthase Isozyme II from Escherichia coli
2010
Catalytic Acid−Base Groups in Yeast Pyruvate Decarboxylase. 1. Site-Directed Mutagenesis and Steady-State Kinetic Studies on the Enzyme with the D28A, H114F, H115F, and E477Q Substitutions
2001
Investigation of the carboligase activity of thiamine diphosphate-dependent enzymes using kinetic modeling and NMR spectroscopy
2009
Consequences of a Modified Putative Substrate-Activation Site on Catalysis by Yeast Pyruvate Decarboxylase
2001
Thiamin Diphosphate Catalysis: Enzymic and Nonenzymic Covalent Intermediates
2008
X-ray crystallographic snapshots of reaction intermediates in pyruvate oxidase and transketolase illustrate common themes in thiamin catalysis
2009
Converting Transaldolase into Aldolase through Swapping of the Multifunctional Acid–Base Catalyst: Common and Divergent Catalytic Principles in F6P Aldolase and Transaldolase
2015
Intermediates and Transition States in Thiamin Diphosphate-Dependent Decarboxylases. A Kinetic and NMR Study on Wild-Type Indolepyruvate Decarboxylase and Variants Using Indolepyruvate, Benzoylformate, and Pyruvate as Substrates
2005