Citation Impact
Citing Papers
Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis
2005 Science
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma.
1994
Hereditary desmoid disease due to a frameshift mutation at codon 1924 of the APC gene.
1996
Hallmarks of Cancer: The Next Generation
2011 Standout
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer
1994
The tor pathway: a target for cancer therapy
2004 Standout
Tumor-suppressor gene products in cell contacts: the cad herin-APC-armadillo connection
1994
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
2004
Tumor Suppressing Pathways
1998
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
1995
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
2014
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
1998 StandoutNobel
APC mutations occur early during colorectal tumorigenesis
1992 StandoutNature
Mining the Wnt pathway for cancer therapeutics
2006
The Hallmarks of Cancer
2000 Standout
Lessons from Hereditary Colorectal Cancer
1996 Standout
Eukaryotic initiation factor-4E in superficial and muscle invasive bladder cancer and its correlation with vascular endothelial growth factor expression and tumour progression
2000
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Molecular Analysis of Surgical Margins in Head and Neck Squamous Cell Carcinoma Patients
2002
The APC Protein and E-cadherin Form Similar but Independent Complexes with α-Catenin, β-Catenin, and Plakoglobin
1995
Cancer genes and the pathways they control
2004 Standout
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Endogenous mutagens and the causes of aging and cancer
1991
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Amplification of a gene encoding a p53-associated protein in human sarcomas
1992 StandoutNature
Quantitation and prognostic value of breast cancer angiogenesis: Comparison of microvessel density, Chalkley count, and computer image analysis
1995
The ABC of APC
2001
Familial infiltrative fibromatosis (desmoid tumours) (MIM135290) caused by a recurrent 3' APC gene mutation
1996
Vascular endothelial growth factor is of high prognostic value in node-negative breast carcinoma.
1998
Antisense RNA to eIF4E Suppresses Oncogenic Properties of a Head and Neck Squamous Cell Carcinoma Cell Line
2000
Mutations of theAPC adenomatous polyposis coli) gene
1993
Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis
1995
Tumor angiogenesis in node-negative breast carcinomas ? relationship with epidermal growth factor receptor, estrogen receptor, and survival
1994
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Hereditary Gastrointestinal Polyposis and Nonpolyposis Syndromes
1994
Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
2011
Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix
1994 StandoutNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Apc Tumor Suppressor Gene Is the “Zonation-Keeper” of Mouse Liver
2006
Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging
1998
Mismatch Repair Deficiency in Phenotypically Normal Human Cells
1995 StandoutScienceNobel
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
1995
Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin
2004
eIF4E expression in tumors: its possible role in progression of malignancies
1999
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
The gastrointestinal tract stem cell niche
2006
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
2005
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Attenuated familial adenomatous polyposis due to a mutation in the 3′ part of the APC gene. A clue for understanding the function of the APC protein
1996
Life with Oxygen
2007 StandoutScienceNobel
Mbd4 inactivation increases C→T transition mutations and promotes gastrointestinal tumor formation
2002
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation
1999 Standout
Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.
1995
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Correlation of Vascular Endothelial Growth Factor Content With Recurrences, Survival, and First Relapse Site in Primary Node-Positive Breast Carcinoma After Adjuvant Treatment
2000
Genetic instability and darwinian selection in tumours
1999
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
2011
Characterisation of tumour‐derived microvesicles in cancer patients' blood and correlation with clinical outcome
2017
Cancer Cell Cycles
1996 StandoutScience
Bridging of β-catenin and glycogen synthase kinase-3β by Axin and inhibition of β-catenin-mediated transcription
1998
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Expression of the translation initiation factor eIF4E in the polyp-cancer sequence in the colon.
2001
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis
1997
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
2001 StandoutNobel
Deletion of an Amino-Terminal Sequence Stabilizes β-Catenin In Vivo and Promotes Hyperphosphorylation of the Adenomatous Polyposis Coli Tumor Suppressor Protein
1996
Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.
1992
Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance.
1994 StandoutNobel
Binding of APC to the Human Homolog of the Drosophila Discs Large Tumor Suppressor Protein
1996 Science
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
The ins and outs of APC and β‐catenin nuclear transport
2002
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.
1993
Clonal ordering of 17p and 5q allelic losses in Barrett dysplasia and adenocarcinoma.
1993
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.
1992
Cancer Genome Landscapes
2013 StandoutScience
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma
2001 StandoutNobel
Correlation of intratumoral endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation in breast carcinoma.
1994
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
1997 StandoutScience
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
APC binds to the novel protein EB1.
1995
Chromosome Aberrations and Cancer
1991 Science
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system
1994
Angiogenesis in Endocrine Tumors
2003
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Association of the APC Gene Product with β-Catenin
1993 Science
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein
1997
Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene
1992 Science
Dimer formation by an N-terminal coiled coil in the APC protein.
1993
Surface molecular recognition
2001 StandoutNobel
Apoptosis and APC in colorectal tumorigenesis.
1996
Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly
1996 Science
Works of K Smith being referenced
Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer
1999
Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer
1992
Differential expression of vascular endothelial growth factor mRNA vs protein isoform expression in human breast cancer and relationship to eIF-4E
1998
The APC gene product in normal and tumor cells.
1993
Association between wild type and mutant APC gene products.
1993
Molecular determinants of dysplasia in colorectal lesions.
1994
Inactivation of both APC alleles in human and mouse tumors.
1994
Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers
1991 Science