Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor
2000 StandoutScience
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Proteasome Involvement in Agonist-induced Down-regulation of μ and δ Opioid Receptors
2001
Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways
2003 StandoutNobel
Cell adhesion molecules and their subgroups in the nervous system
1991
Molecular pharmacology of the opioid receptors
1995
DAMGO recognizes four residues in the third extracellular loop to discriminate between μ- and κ-opioid receptors
1998
Functional interaction of β-catenin with the transcription factor LEF-1
1996 StandoutNature
Go-protein α-Subunits Activate Mitogen-activated Protein Kinase via a Novel Protein Kinase C-dependent Mechanism
1996 StandoutNobel
cDNA cloning and regional distribution of a novel member of the opioid receptor family
1994
OPIOID RECEPTOR SIGNALLING MECHANISMS
1999
A Mutation in the Second Transmembrane Region of the CB1 Receptor Selectively Disrupts G Protein Signaling and Prevents Receptor Internalization
1999
The Role of a Conserved Inter-Transmembrane Domain Interface in Regulating α2a-Adrenergic Receptor Conformational Stability and Cell-Surface Turnover
2001
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
μ and δ Opioid Receptors Are Differentially Desensitized by the Coexpression of β-Adrenergic Receptor Kinase 2 and β-Arrestin 2 in Xenopus Oocytes
1997
ORL1, a novel member of the opioid receptor family
1994
Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain
1992
Determination of the Amino Acid Residue Involved in [3H]β-Funaltrexamine Covalent Binding in the Cloned Rat µ Opioid Receptor
1996
Related Contribution of Specific Helix 2 and 7 Residues to Conformational Activation of the Serotonin 5-HT2A Receptor
1995
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
Tolerance to μ‐opioid agonists in human neuroblastoma SH‐SY5Y cells as determined by changes in guanosine‐5′‐O‐(3‐[35S]‐thio)triphosphate binding
1997
Opioids: first lessons from knockout mice
1999
Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type
1994
Vertebrate Smoothened functions at the primary cilium
2005 StandoutNature
Creating a Functional Opioid Alkaloid Binding Site in the Orphanin FQ Receptor through Site-Directed Mutagenesis
1998
Selective targeting of somatostatin receptor 3 to neuronal cilia
1999
Dissociation of Functional Roles of Dynamin in Receptor-mediated Endocytosis and Mitogenic Signal Transduction
1999
Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
1991
Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization
2002
Retention of Supraspinal Delta-like Analgesia and Loss of Morphine Tolerance in δ Opioid Receptor Knockout Mice
1999
Plasmon Resonance Studies of Agonist/Antagonist Binding to theHuman δ-Opioid Receptor: New Structural Insights into Receptor-Ligand Interactions
2000
New players in the 5-HT receptor field: genes and knockouts
1995
G Protein-coupled Receptors
1998 StandoutNobel
Transmembrane molecular assemblies regulated by the greater cadherin family
1991
Wnt/β-Catenin Signaling and Disease
2012 Standout
G Protein-Coupled Receptor Heteromerization: A Role in Allosteric Modulation of Ligand Binding
2011
Differential effects of NaCl concentration on the constitutive activity of the thyrotropin and the luteinizing hormone/chorionic gonadotropin receptors
1996
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
cDNA Cloning of an orphan opiate receptor gene family member and its splice variant
1994
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Activation of the Luteinizing Hormone Receptor Following Substitution of Ser-277 with Selective Hydrophobic Residues in the Ectodomain Hinge Region
2000 StandoutNobel
Preprodynorphin-, preproenkephalin-, preprotachykinin A- and preprotachykinin B-immunoreactive neurons in the accumbens nucleus and olfactory tubercle: double-immunofluorescence analysis
2002
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Morphine Activates Opioid Receptors without Causing Their Rapid Internalization
1996
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Receptors and G proteins as primary components of transmembrane signal transduction
1995
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously
1995 StandoutNobel
Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family
1994
Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor
1995 StandoutNature
Sequential Binding of Agonists to the β2 Adrenoceptor
2003 StandoutNobel
The transmembrane 7-alpha-bundle of rhodopsin: distance geometry calculations with hydrogen bonding constraints
1997
Adenylylcyclase Supersensitization in μ-Opioid Receptor-transfected Chinese Hamster Ovary Cells Following Chronic Opioid Treatment
1995
Octreotide in the Management of Hormone-Refractory Prostate Cancer
2001
A Light‐Activated β‐Turn Scaffold within a Somatostatin Analog: NMR Structure and Biological Activity
2006
Transmembrane Regions V and VI of the Human Luteinizing Hormone Receptor Are Required for Constitutive Activation by a Mutation in the Third Intracellular Loop
1996 StandoutNobel
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27
1995 StandoutScience
Protocadherins: a large family of cadherin-related molecules in central nervous system.
1993 Standout
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
1994 StandoutNobel
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia
1997
Memory--a Century of Consolidation
2000 StandoutScience
Activity of the δ-Opioid Receptor Is Partially Reduced, Whereas Activity of the κ-Receptor Is Maintained in Mice Lacking the μ-Receptor
1998
Desmocollins form a distinct subset of the cadherin family of cell adhesion molecules.
1991
Inactivation of a Serotonin-Gated Ion Channel by a Polypeptide Toxin from Marine Snails
1998 StandoutScienceNobel
Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic receptor sensitivity to allosteric modulation by monovalent cations and fully effective receptor/G-protein coupling.
1994
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Controlling signaling with a specifically designed G i -coupled receptor
1998
Synthesis of an Eight-Membered Cyclic Pseudo-Dipeptide Using Ring Closing Metathesis
2001
Cadherin-mediated cell interactions are necessary for the activation of MyoD in Xenopus mesoderm.
1994 StandoutNobel
A Homolog of the armadillo Protein in Drosophila (Plakoglobin) Associated with E-Cadherin
1991 Science
Substitution of a mutant α 2a -adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
1997
Agonist-induced conformational changes in the G-protein-coupling domain of the β 2 adrenergic receptor
2001 StandoutNobel
Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity
2000 StandoutNobel
The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated.
1993 StandoutNobel
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome
1991
Tandem Catalysis: The Sequential Mediation of Olefin Metathesis, Hydrogenation, and Hydrogen Transfer with Single-Component Ru Complexes
2001 StandoutNobel
Drug Abuse: Hedonic Homeostatic Dysregulation
1997 StandoutScience
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma
1992 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Investigation of the Selectivity of Oxymorphone- and Naltrexone-Derived Ligands via Site-Directed Mutagenesis of Opioid Receptors: Exploring the ‘Address' Recognition Locus
2001
The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.
1992 StandoutNobel
Catalytic Asymmetric Conjugate Addition and Allylic Alkylation with Grignard Reagents
2008 StandoutNobel
The D2 dopamine receptor isoforms signal through distinct Gi alpha proteins to inhibit adenylyl cyclase. A study with site-directed mutant Gi alpha proteins.
1994
Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
1995 StandoutScience
Allosteric activation of the CaR by l -amino acids
2000 StandoutNobel
Significance analysis of microarrays applied to the ionizing radiation response
2001 Standout
Regio- and Stereoselective Synthesis of (E)-Alkene trans-Xaa-Pro Dipeptide Mimetics Utilizing Organocopper-Mediated Anti-SN2‘ Reactions
2002
A Range of Research-Based Pharmacotherapies for Addiction
1997 Science
Emerging Targets in Photopharmacology
2016 StandoutNobel
Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors.
1991
Human kappa opiate receptor second extracellular loop elevates dynorphin's affinity for human mu/kappa chimeras
1994
Novel “Restoration of Function” Mutagenesis Strategy to Identify Amino Acids of the δ-Opioid Receptor Involved in Ligand Binding
1997
A Solid-Phase Approach to Mouse Melanocortin Receptor Agonists Derived from a Novel Thioether Cyclized Peptidomimetic Scaffold
2002 StandoutNobel
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
Identification of a Potent Heterocyclic Ligand To Somatostatin Receptor Subtype 5 by the Synthesis and Screening of β-Turn Mimetic Libraries
1999
cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript.
1992
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness
1998
Works of K Raynor being referenced
Analogs of somatostatin selectively label distinct subtypes of somatostatin receptors in rat brain.
1989
Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.
1994
Splice variant of the somatostatin receptor 2 subtype, somatostatin receptor 2B, couples to adenylyl cyclase.
1993
Characterization of cloned human somatostatin receptor SSTR5.
1994
Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules
1990
A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.
1993
Subtypes of somatostatin receptors are expressed in the anterior pituitary cell line GH3.
1993
Molecular mechanisms of agonist-induced desensitization of the cloned mouse kappa opioid receptor.
1994
Agonists and antagonists bind to different domains of the cloned kappa opioid receptor.
1994
Cloning and functional comparison of kappa and delta opioid receptors from mouse brain.
1993
Approaches to peptidomimetics which serve as surrogates for the cis amide bond: novel disulfide-constrained bicyclic hexapeptide analogs of somatostatic.
1993
Molecular Biology of Opioid Receptors
1996
Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.
1993
Differential distribution of somatostatin receptor subtypes in rat brain revealed by newly developed somatostatin analogs
1991