Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
Agonist-dependent phosphorylation of human muscarinic receptors in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases.
1995
Rhodopsin and Phototransduction
1993
Arrestin Interactions with G Protein-coupled Receptors
1995
Inhibition of Rhodopsin Kinase by Recoverin
1995
Regulation of the G Protein-coupled Receptor Kinase GRK5 by Protein Kinase C
1997
Serpentine cAMP receptors may act through a G protein-independent pathway to induce postaggregative development in dictyostelium
1995
Projection structure of rhodopsin
1993 StandoutNatureNobel
Molecular mechanism of vectorial proton translocation by bacteriorhodopsin
2000 StandoutNatureNobel
Identification of a Short Sequence Highly Divergent Between β‐Adrenergic‐Receptor Kinases 1 and 2 that Determines the Affinity of Binding to βγ Subunits of Heterotrimeric Guanine‐Nucleotide‐Binding Regulatory Proteins
1997
Regulation of G Protein-Coupled Receptors by Receptor Kinases and Arrestins
1995
The GRK4 Subfamily of G Protein-coupled Receptor Kinases
1999 StandoutNobel
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Rhodopsin Kinase Autophosphorylation
1995
Control of Rhodopsin Multiple Phosphorylation
1994
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
The β-Adrenergic Receptor Kinase (GRK2) Is Regulated by Phospholipids
1995
G Protein-coupled Receptor Kinase Specificity for Phosphorylation and Desensitization of α2-Adrenergic Receptor Subtypes
1996
Targeting G protein-coupled receptor kinases to their receptor substrates
1997 StandoutNobel
Agonist-dependent Phosphorylation and Desensitization of the Rat A3 Adenosine Receptor
1995
Rhodopsin Mutants Discriminate Sites Important for the Activation of Rhodopsin Kinase and G
1995
Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2.
1995
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor
1995 StandoutNobel
G Protein-coupled Receptor Kinase 6A Phosphorylates the Na+/H+ Exchanger Regulatory Factor via a PDZ Domain-mediated Interaction
1999 StandoutNobel
Structure and functions of arrestins
1994
G Protein-coupled Receptor Kinase 2/Gαq/11 Interaction
2003
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Rhodopsin Phosphorylation and Dephosphorylation in Vivo
1995
G Protein-coupled Receptor Kinase GRK2 Is a Phospholipid-dependent Enzyme That Can Be Conditionally Activated by G Protein βγ Subunits
1996
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Functional consequences of A1 adenosine-receptor phosphorylation by the β-adrenergic receptor kinase
1993
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Seven Helix Chemoattractant Receptors Transiently Stimulate Mitogen-activated Protein Kinase in Dictyostelium
1996
Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor
1995
Sequential phosphorylation of rhodopsin at multiple sites
1993
Phosphorylation of muscarinic receptors: regulation by G proteins
1993
Molecular mechanisms of membrane receptor desensitization
1993
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin
1998 StandoutNobel
Characterization of the G Protein-coupled Receptor Kinase GRK4
1996 StandoutNobel
The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator
1994
Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations
1989
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
1992 StandoutNatureNobel
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
Phosphorylation and Desensitization of Human Endothelin A and B Receptors
1997 StandoutNobel
Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms
1995
Identification of the G Protein-coupled Receptor Kinase Phosphorylation Sites in the Human β2-Adrenergic Receptor
1996 StandoutNobel
The phospho‐opsin Phosphatase from Bovine Rod Outer Segments
1994
Activation of a GTP‐Binding Protein and a GTP‐Binding‐Protein‐Coupled Receptor Kinase (β‐Adrenergic‐Receptor Kinase‐1) by a Muscarinic Receptor m2 Mutant Lacking Phosphorylation Sites
1994
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
The presence of a calcium‐sensitive p26‐containing complex in bovine retina rod cells
1993
Rhodopsin kinase: Studies on the sequence of and the recognition motif for multiphosphorylations
1994
Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2
1999 Nobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
1998 StandoutNatureNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
G Protein-coupled Receptors
1998 StandoutNobel
Identification of the Major Phosphorylation Sites in Human C5a Anaphylatoxin Receptor in Vivo
1995
The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction
1992
High Affinity Binding of β-Adrenergic Receptor Kinase to Microsomal Membranes
1996
Ca2+-dependent Interaction of Recoverin with Rhodopsin Kinase
1995 StandoutNobel
Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES
1996 StandoutNobel
Interplay of phosphorylation and dephosphorylation in vision: protein phosphatases of bovine rod outer segments
1989
Phosphorylation sites in bovine rhodopsin
1993
Location of agonist‐dependent‐phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype)
1994
Mutational Analysis of Gβγ and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2
2000
Binding and Phosphorylation of Tubulin by G Protein-coupled Receptor Kinases
1998
Synergies and Coincidence Requirements between NO, cGMP, and Ca2+ in the Induction of Cerebellar Long-Term Depression
1997 StandoutNobel
Regulation of G protein-coupled Receptor Kinase 5 (GRK5) by Actin
1998 StandoutNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Arresting developments in heptahelical receptor signaling and regulation
2002 StandoutNobel
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases
1996 StandoutNobel
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
1998
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.
1993
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK6.
1994
Identification of additional members of human G-protein-coupled receptor kinase multigene family.
1993
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.
1995 StandoutNobel
Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase
1993
Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs),
2001
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
In Vivo Assessment of Local Phosphodiesterase Activity Using Tailored Cyclic Nucleotide–Gated Channels as Camp Sensors
2001
G Protein–Coupled Receptor Rhodopsin
2006
A splice variant of arrestin. Molecular cloning and localization in bovine retina.
1994
Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.
1994
MOLECULAR MECHANISM OF PHOTOSIGNALING BY ARCHAEAL SENSORY RHODOPSINS
1997
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.
1996
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Visual arrestin binding to rhodopsin. Intramolecular interaction between the basic N terminus and acidic C terminus of arrestin may regulate binding selectivity.
1994
Isolation of Drosophila genes encoding G protein-coupled receptor kinases.
1991
Palmitoylation Increases the Kinase Activity of the G Protein-Coupled Receptor Kinase, GRK6
1998 StandoutNobel
Mechanisms of Rhodopsin Inactivation in Vivo as Revealed by a COOH-Terminal Truncation Mutant
1995 Science
Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.
1994
Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.
1994
Myocardial overexpression of GRK3 in transgenic mice: evidence for in vivo selectivity of GRKs
1998
Visual excitation and recovery
1991
Structure of the human gene encoding the beta-adrenergic receptor kinase.
1994
Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation.
1993
Transduction mechanisms of vertebrate and invertebrate photoreceptors.
1994
Phosphorylation of the N-Formyl Peptide Receptor Carboxyl Terminus by the G Protein-coupled Receptor Kinase, GRK2
1995
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family
1991 StandoutNobel
Mechanism of beta-adrenergic receptor kinase activation by G proteins
1993
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL
2006
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
G-protein-coupled receptor kinases
1991
Rhodopsin is the major in situ substrate of protein kinase C in rod outer segments of photoreceptors.
1993
The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.
1991 StandoutNobel
Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase.
1993
Seven-helix receptors
1991
Synergistic activation of a G protein-coupled receptor kinase by G protein beta gamma subunits and mastoparan or related peptides.
1994
Heptahelical Receptor Signaling: Beyond the G Protein Paradigm
1999 StandoutNobel
Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.
1994 StandoutNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
1992 StandoutScienceNobel
Identification of the autophosphorylation sites in rhodopsin kinase.
1992
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Phosphorylation-Independent Desensitization of G Protein-Coupled Receptors?
2002
Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin
1996 Science
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
1990 StandoutScienceNobel
Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.
1992 StandoutNobel
Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.
1993
A G protein-coupled receptor at work: the rhodopsin model
2009
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Rat G Protein-Coupled Receptor Kinase GRK4: Identification, Functional Expression, and Differential Tissue Distribution of Two Splice Variants*
1998
Light activation of one rhodopsin molecule causes the phosphorylation of hundreds of others. A reaction observed in electropermeabilized frog rod outer segments exposed to dim illumination.
1990
Regulation of Rhodopsin Dephosphorylation by Arrestin
1989
Structure and mechanism of the G protein-coupled receptor kinases.
1993 StandoutNobel
Works of K. Palczewski being referenced
Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase
1991 StandoutNobel
Characterization of a truncated form of arrestin isolated from bovine rod outer segments
1994
Turned on by Ca2+! The physiology and pathology of Ca2+-binding proteins in the retina
1996
The catalytic subunit of phosphatase 2A dephosphorylates phosphoopsin
1989
Mechanism of rhodopsin kinase activation
1991
Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin.
1993
Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods.
1994
Regulation of rhodopsin kinase by autophosphorylation.
1991
G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin.
2001
Purification and characterization of rhodopsin kinase.
1988
Interaction between photoactivated rhodopsin and its kinase: Stability and kinetics of complex formation
1993