Citation Impact
Citing Papers
The role of gene dosage and genetic transpositions in carcinogenesis
1981 Nature
Human papillomavirus type 16 E7 binds to the conserved carboxy-terminal region of the TATA box binding protein and this contributes to E7 transforming activity.
1997
Effects of an Rb mutation in the mouse
1992 StandoutNature
Regulation of p53 stability by Mdm2
1997 StandoutNature
The human papillomavirus E7 protein as a transforming and transactivating factor
1993
Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
2000 Standout
Loss of Net as Repressor Leads to Constitutive Increased c-fos Transcription in Cervical Cancer Cells
2004 StandoutNobel
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
A genetic model for colorectal tumorigenesis
1990 Standout
Expression of RB and p53 proteins in HPV‐positive and HPV‐negative cervical carcinoma cell lines
1991
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
1990 Standout
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
1991 StandoutNature
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome
1990 StandoutNature
Isolation, Characterization, and Partial Purification of a Novel Ubiquitin-Protein Ligase, E3
1996 StandoutNobel
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
The p53 tumour suppressor gene
1991 StandoutNature
Amplification of a gene encoding a p53-associated protein in human sarcomas
1992 StandoutNature
Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene
1989
Human papillomavirus immortalization and transformation functions
2002
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
1992 StandoutNature
Anti-sense phosphorothioate oligonucleotides have both specific and non-specific effects on cells containing human papillomavirus type 16
1991
Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix
1994 StandoutNobel
Human papillomavirus type 16 and 18 gene expression in cervical neoplasias
1992
The Tumor Suppressor Protein p16 and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System
2004 StandoutNobel
The E7 oncoprotein associates with Mi2 and histone deacetylase activity to promote cell growth
1999
Epidemiologic Classification of Human Papillomavirus Types Associated with Cervical Cancer
2003 Standout
Defects in the Ubiquitin Pathway Induce Caspase-independent Apoptosis Blocked by Bcl-2
1998 StandoutNobel
The location of nucleosomes in chromatin: specific or statistical?
1981 StandoutNatureNobel
p53 Mutations in Human Cancers
1991 StandoutScience
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development.
1994
Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype.
1991
Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27
1995 StandoutScience
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
1983 StandoutNature
Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus
1984 StandoutNatureNobel
Transforming growth factors beta 1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells
1990
Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations
1994 StandoutScience
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
1991
Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.
1989
A region of the polyoma virus genome between the replication origin and late protein coding sequences is required in cis for both early gene expression and viral DNA replication
1981
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA
1983 StandoutNobel
The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
1991
Activation of the c-myc gene by translocation: a model for translational control.
1983 StandoutNobel
Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes
1992
Activation of the c-fos gene by the HPV16 oncoproteins depends upon the cAMP-response element at -60
1994
Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.
1992
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.
1989 Standout
The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein
1993
Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.
1992
Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7
1989
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes
1989 Standout
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
The arrangement of nucleosomes in nucleoprotein complexes from polyoma virus and SV40
1977
Expression of the mouse p53 cellular tumor antigen in monkey cells.
1984
Activation of a translocated c-myc gene: role of structural alterations in the upstream region.
1984 StandoutNobel
Viruses in Human Cancers
1991 StandoutScienceNobel
Effect of human papillomavirus type 16 oncogenes on MAP kinase activity
1995
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation
1984 Nature
Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.
1983 StandoutNobel
Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters
1990
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma
1989
Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells.
1991 StandoutNobel
Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein.
1990
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2
1994 StandoutNobel
Progesterone and glucocorticoid response elements occur in the long control regions of several human papillomaviruses involved in anogenital neoplasia
1989
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
1990 StandoutScience
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
1989 StandoutScience
The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product
1989 StandoutScience
Specific interaction between the p53 cellular tumour antigen and major heat shock proteins
1986 Nature
Ha-ras oncogene-induced transcription of human papillomavirus type 18 E6 and E7 oncogenes.
1997
Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture
1985 StandoutNatureNobel
Works of K. Osborn being referenced
Mutations of the human papillomavirus type 16 E7 gene that affect transformation, transactivation and phosphorylation by the E7 protein
1990
Transformation of primary human fibroblast cells with human papillomavirus type 16 DNA and Ej‐ras
1988
Co-transformation by Human Papillomavirus Types 6 and 11
1990
Comparison of the in vitro transforming activities of human papillomavirus types.
1988
Characterization of the Complex between SV40 Large T Antigen and the 53K Host Protein in Transformed Mouse Cells
1980
Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells.
1988
Polyoma DNA Replication: Location of the Origin in Different Virus Strains
1974