K J Hoffmann

Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

Polymorphism of human cytochrome P450 enzymes and its clinical impact

Interaction of citrus juices with felodipine and nifedipine

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs

Drug glucuronidation in humans

Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls

Determination of the R,R- and S,S-enantiomers of vamicamide in human serum and urine by high-performance liquid chromatography on a Chiral-AGP column

Phase II Multi-Institutional Trial of the Histone Deacetylase Inhibitor Romidepsin As Monotherapy for Patients With Cutaneous T-Cell Lymphoma

Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells

Prediction of Drug Absorption Using Multivariate Statistics

Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore

Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes

Polymeric drugs by direct copolymerization: Polymer of β‐adrenergic antagonist alprenolol and its binding to receptors and antibodies

Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease

Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters.

Omeprazole

Pharmacogenetic testing among patients with mood and anxiety disorders is associated with decreased utilization and cost: A propensity-score matched study

The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

Felodipine kinetics in healthy men

The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer

Human Jejunal Effective Permeability and Its Correlation with Preclinical Drug Absorption Models

Application of Stable Isotope-Labeled Compounds in Metabolism and in Metabolism-Mediated Toxicity Studies

Mechanism of Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

Prescribed drugs containing nitrogen heterocycles: an overview

Identification of the main urinary metabolites of omeprazole after an oral dose to rats and dogs.

Comparative metabolic disposition of oral doses of omeprazole in the dog, rat, and mouse.

The metabolic disposition of the selective beta 1-adrenoceptor agonist prenalterol in mice, rats, dogs, and humans.

Identification of two main urinary metabolites of [14C]omeprazole in humans.

Compound mixtures in Caco-2 cell permeability screens as a means to increase screening capacity.

Identification of Urinary and Biliary Metabolites of Alprenolol in the Rat

Presystemic elimination of the beta-blocker pafenolol in the rat after oral and intraperitoneal administration and identification of a main metabolite in both rats and humans.

Urinary metabolites of felodipine, a new vasodilator drug, in man, dog, rat and mouse

Stereoselective disposition of RS-tocainide in man

Absorption, Distribution and Elimination of Felodipine in Man

Identification of felodipine metabolites in rat urine

Metabolism of Metoprolol in the Ratin vitroandin vivo