Citation Impact
Citing Papers
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Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
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Unequal impact of age, percentage body fat, and serum testosterone concentrations on the somatotrophic, IGF-I, and IGF-binding protein responses to a three-day intravenous growth hormone-releasing hormone pulsatile infusion in men
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Acromegaly
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Differential effects of in vivo estrogen administration on hypothalamic growth hormone releasing hormone and somatostatin gene expression
1992
Nutritional Regulation of the Insulin-Like Growth Factors*
1994
Anatomy and regulation of the central melanocortin system
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Insulin-Like Growth Factors I and II. Peptide, Messenger Ribonucleic Acid and Gene Structures, Serum, and Tissue Concentrations*
1989 Standout
Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans
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Biodegradable nanoparticles for drug and gene delivery to cells and tissue
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Physiological Significance of the Rhythmic Secretion of Hypothalamic and Pituitary Hormones
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Age and Relative Adiposity Are Specific Negative Determinants of the Frequency and Amplitude of Growth Hormone (GH) Secretory Bursts and the Half-Life of Endogenous GH in Healthy Men*
1991
Metabolic Effects and Pharmacokinetics of a Growth Hormone Pulse in Healthy Adults: Relation to Age, Sex, and Body Composition
1997
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
2007 Standout
Sexually Dimorphic Expression of the Growth Hormone-Releasing Hormone Gene Is Not Mediated by Circulating Gonadal Hormones in the Adult Rat*
1991
Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver Disease
2010
Nature of Altered Growth Hormone Secretion in Hyperthyroidism*
1991
Combined deficits in the somatotropic and gonadotropic axes in healthy aging men: An appraisal of neuroendocrine mechanisms by deconvolution analysis
1994
Trends in GPCR drug discovery: new agents, targets and indications
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Premature mortality due to cardiovascular disease in hypopituitarism
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Alterations in the Pulsatile Mode of Growth Hormone Release in Men and Women with Insulin-Dependent Diabetes Mellitus*
1989
Hormonal Regulation of Growth Hormone Secretion and Messenger Ribonucleic Acid Accumulation in Cultured Bovine Pituitary Cells*
1988
The adolescent brain and age-related behavioral manifestations
2000 Standout
Selective Expression of Estrogen Receptor α and β Isoforms in Human Pituitary Tumors1
1998
Effect of chronic metabolic acidosis on the growth hormone/IGF-1 endocrine axis: New cause of growth hormone insensitivity in humans
1997
The Impact of Gonadal Steroid Hormone Action on Growth Hormone Secretion During Childhood and Adolescence*
1992
Altered endogenous growth hormone secretory kinetics and diurnal GH‐binding protein profiles in adults with chronic liver disease
1995
Growth Hormone (GH) Response to GH-Releasing Hormone by Perifused Pituitary Cells from Male, Female, and Testicular Feminized Rats*
1989
Masculinization of growth hormone (GH) secretory pattern by dihydrotestosterone is associated with augmentation of hypothalamic somatostatin and GH-releasing hormone mRNA levels in ovariectomized adult rats
1992
Physiological role of somatostatin on growth hormone regulation in humans
1990
Alterations in the Pulsatile Properties of Circulating Growth Hormone Concentrations during Puberty in Boys*
1989
Metabolic clearance of recombinant human growth hormone in health and chronic renal failure.
1994
Abdominal Visceral Fat and Fasting Insulin Are Important Predictors of 24-Hour GH Release Independent of Age, Gender, and Other Physiological Factors
2001
Insulin and insulin-like growth factor signalling in neoplasia
2008 Standout
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Growth Hormone‐Releasing Hormone and Growth Hormone‐Releasing Peptide as Potential Therapeutic Modalities
1990
The Somatotropic Axis in Critical Illness: Effect of Continuous Growth Hormone (GH)-Releasing Hormone and GH-Releasing Peptide-2 Infusion1
1997
Neuroendocrine control of pulsatile growth hormone release in the human: relationship with gender
1998
BASIC COUNTERPOINT: Mechanisms and Pathways of Gonadal Steroid Modulation of Growth Hormone Secretion*
1992
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
2004 Standout
A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans.
1993
Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics, Strength, and Adiposity1
1998
Ghrelin induces adiposity in rodents
2000 StandoutNature
Growth Hormone-Releasing Hormone Messenger Ribonucleic Acid in the Hypothalamus of the Adult Male Rat Is Increased by Testosterone*
1990
Maturation of the Regulation of Growth Hormone Secretion in Young Males with Hypogonadotropic Hypogonadism Pharmacologically Exposed to Progressive Increments in Serum Testosterone1
1997
Effect of Restricted Feeding on the Relationship Between Hypophysial Portal Concentrations of Growth Hormone (GH)-Releasing Factor and Somatostatin, and Jugular Concentrations of GH in Ovariectomized Ewes*
1991
The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency
1989 Standout
Growth Hormone Status during Long-Term Hexarelin Therapy
1998
Contrasting Effects of Oral and Transdermal Routes of Estrogen Replacement Therapy on 24-Hour Growth Hormone (GH) Secretion, Insulin-Like Growth Factor I, and GH-Binding Protein in Postmenopausal Women*
1991
Defective Hypothalamic Growth Hormone (GH)-Releasing Hormone Activity May Contribute to Declining GH Secretion with Age in Man1
1997
Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion
2002
Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: Lessons from transgenic animal models
1993
Pyridostigmine treatment selectively amplifies the mass of GH secreted per burst without altering GH burst frequency, half-life, basal GH secretion or the orderliness of GH release
1997
Evaluation of pulsatile patterns of growth hormone release in humans: A brief review
1993
Effects of Gonadal Steroids on Clearance of Growth Hormone at Steady State in the Rat*
1991
THE ENDOCRINOLOGY OF OBESITY
1996
Suppression of growth hormone (GH) secretion by a selective GH-releasing hormone (GHRH) antagonist. Direct evidence for involvement of endogenous GHRH in the generation of GH pulses.
1993
Temporal Profiles and Clinical Significance of Pulsatile Insulin Secretion
1998
Growth Hormone in the Brain: Characteristics of Specific Brain Targets for the Hormone and Their Functional Significance
2000
Effects of Human Growth Hormone in Men over 60 Years Old
1990
Testosterone and Oxandrolone, a Nonaromatizable Androgen, Specifically Amplify the Mass and Rate of Growth Hormone (GH) Secreted per Burst without Altering GH Secretory Burst Duration or Frequency or the GH Half-Life*
1990
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
1998 StandoutNature
Endocytosis and Degradation of the Growth Hormone Receptor Are Proteasome-dependent
2000
Estrogen Action on Growth Hormone in Pituitary Cell Cultures from Adult and Juvenile Macaques*
1991
Pulsatile growth hormone release in normal women during the menstrual cycle
1992
Negative feedback regulation of pulsatile growth hormone secretion by insulin-like growth factor I. Involvement of hypothalamic somatostatin.
1994
Revised Equations for Estimated GFR From Serum Creatinine in Japan
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Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease
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Self-organized segmentation of time series: separating growth hormone secretion in acromegaly from normal controls
1996
Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans
1997
Thirty-Second Sampling of Plasma Growth Hormone in Man: Correlation with Sleep Stages*
1991
Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay.
1995
Effect of naloxone on the growth hormone response to clonidine in normal women during the mid-luteal phase
1989
Ghrelin: Structure and Function
2005 Standout
Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep.
1991
Plasma Insulin-Like Growth Factor-I/Somatomedin-C in Acromegaly: Correlation With the Degree of Growth Hormone Hypersecretion*
1988
5α-Reductase Isozymes in the Central Nervous System
1998
Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice
1999 StandoutNobel
Dual Defects in Pulsatile Growth Hormone Secretion and Clearance Subserve the Hyposomatotropism of Obesity in Man*
1991
Protein therapeutics: a summary and pharmacological classification
2007 Standout
Physiology, Signaling, and Pharmacology of Galanin Peptides and Receptors: Three Decades of Emerging Diversity
2014
Levels of GH binding activity, IGFBP‐1, insulin, blood glucose and cortisol in intensive care patients
1991
Ghrelin immunoreactivity in human plasma is suppressed by somatostatin
2002
Neuroendocrine Alterations in the Somatotropic Axis in Chronic Renal Failure
1991
Growth hormone responses to growth hormone-releasing hormone and hexarelin in fed and fasted dogs: effect of somatostatin infusion or pretreatment with pirenzepine
1998
Adipose Tissue as an Endocrine Organ
2004 Standout
Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men.
1997
Somatostatin Inhibition of Growth Hormone Secretion by Somatotropes from Male, Female, and Androgen Receptor-Deficient Rats: Evidence for Differing Sensitivities*
1989
Neonatal ureteral obstruction stimulates recruitment of renin-secreting renal cortical cells
1994
Alterations in Growth and Body Composition During Puberty: III. Influence of Maturation, Gender, Body Composition, Fat Distribution, Aerobic Fitness, and Energy Expenditure on Nocturnal Growth Hormone Release1
1998
Leptin participates in the regulation of glucocorticoid and growth hormone axes
1998
A Short Isoform of the Human Growth Hormone Receptor Functions as a Dominant Negative Inhibitor of the Full-Length Receptor and Generates Large Amounts of Binding Protein
1997
Nutritional predictors of insulin-like growth factor I and their relationships to cancer in men.
2003
Pathophysiology of Human Visceral Obesity: An Update
2013 Standout
Recovery of Growth Hormone Release from Suppression by Exogenous Insulin-Like Growth Factor I (IGF-I): Evidence for a Suppressive Action of Free Rather Than Bound IGF-I1
1998
Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human*
1998 Standout
Cell Biology of the Glomerular Podocyte
2003 Standout
Distinctive Inhibitory Mechanisms of Age and Relative Visceral Adiposity on Growth Hormone Secretion in Pre- and Postmenopausal Women Studied under a Hypogonadal Clamp
2005
Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender.
1994
JAK2 activation by growth hormone and other cytokines
2015
Pituitary sex steroid receptors: Localization and function
1997
Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two-day fast in normal men
1992
A highly sensitive growth hormone (GH) enzyme-linked immunosorbent assay uncovers increased contribution of a tonic mode of GH secretion in adults with organic GH deficiency.
1996
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Physiological time-series analysis using approximate entropy and sample entropy
2000 Standout
Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr
2000 Standout
MK-677, an Orally Active Growth Hormone Secretagogue, Reverses Diet-Induced Catabolism1
1998
Increased Pulsatile, But Not Basal, Growth Hormone Secretion Rates and Plasma Insulin-Like Growth Factor I Levels during the Periovulatory Interval in Normal Women
1998
Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release.
1994
Differential orderliness of the GH release process in castrate male and female rats
1998
Growth hormone secretion after the administration of GHRP‐6 or GHRH combined with GHRP‐6 does not decline in late adulthood
1995
Shared Risk Factors for Falls, Incontinence, and Functional Dependence
1995 Standout
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
1999 Standout
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Recombinant human growth hormone poly(lactic-co-glycolic acid) microsphere formulation development1This manuscript is dedicated to the memory of Dr. Michael J. Cronin. Dr. Cronin was a brilliant endocrine scientist with an incredible ability to objectively evaluate any problem, no matter how complex. His spirit and knowledge contributed to the success of the work described herein and his wisdom continues to guide those of us fortunate enough to have known him.1
1997
Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study
1998 StandoutScience
Signals for Sorting of Transmembrane Proteins to Endosomes and Lysosomes
2003 Standout
Tamoxifen attenuates pulsatile growth hormone secretion: mediation in part by somatostatin.
1992
Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans
2001
Short-term adult exposure to estradiol feminizes the male pattern of spontaneous and growth hormone-releasing factor-stimulated growth hormone secretion in the rat.
1992
Random Secretion of Growth Hormone in Humans
1996
Osteoporosis in Men
2008
Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization.
1993
Fasting as a metabolic stress paradigm selectively amplifies cortisol secretory burst mass and delays the time of maximal nyctohemeral cortisol concentrations in healthy men.
1996
Quantitative Insulin Sensitivity Check Index: A Simple, Accurate Method for Assessing Insulin Sensitivity In Humans
2000 Standout
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
2011 Standout
Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice
2000
Birth and Death of Bone Cells: Basic Regulatory Mechanisms and Implications for the Pathogenesis and Treatment of Osteoporosis*
2000 Standout
Effects of recombinant human growth hormone on metabolic indices, body composition, and bone turnover in healthy elderly women.
1994
Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency.
1995
Appendicular skeletal muscle mass: effects of age, gender, and ethnicity
1997
Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome
2000 Standout
Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses
2012 Standout
About Sleep's Role in Memory
2013 Standout
A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day.
1992
Prolactin: Structure, Function, and Regulation of Secretion
2000 Standout
Pituitary adenylate cyclase activating polypeptide, growth hormone (GH)-releasing peptide and GH-releasing hormone stimulate GH release through distinct pituitary receptors.
1992
Fractal dynamics in physiology: Alterations with disease and aging
2002 Standout
Effects of Antagonists of Growth Hormone-Releasing Hormone (GHRH) on GH and Insulin-Like Growth Factor I Levels in Transgenic Mice Overexpressing the Human GHRH Gene, an Animal Model of Acromegaly*
1997 Nobel
Androgen receptor blockade with flutamide enhances growth hormone secretion in late pubertal males: evidence for independent actions of estrogen and androgen.
1993
Growth hormone secretion in recently operated acromegalic patients.
1994
Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males
1996
Growth Factors and Cancer
1991 StandoutScience
Developmental regulation of pituitary growth hormone-releasing hormone receptor gene expression in the rat.
1996
Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence.
1994
Oral administration of growth hormone (GH)-releasing peptide stimulates GH secretion in normal men.
1992
Sexual Dimorphism of Somatostatin and Growth Hormone-Releasing Factor Signaling in the Control of Pulsatile Growth Hormone Secretion in the Rat*
1991
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.
1996
Sex differences in growth hormone response to growth hormone-releasing hormone
1991
Effect of Aging on the Sensitivity of Growth Hormone Secretion to Insulin-Like Growth Factor-I Negative Feedback*
1997
Endurance training amplifies the pulsatile release of growth hormone: effects of training intensity
1992
Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects.
1995
Acute growth hormone (GH) response to GH-releasing hexapeptide in humans is independent of endogenous GH-releasing hormone.
1992
Females secrete growth hormone with more process irregularity than males in both humans and rats
1996
The Diagnosis of Cushing's Syndrome: An Endocrine Society Clinical Practice Guideline
2008 Standout
Chronic estrogen treatment in male rats reveals mammosomatotropes and allows inhibition of prolactin secretion by somatostatin.
1996
Loss of 'Complexity' and Aging
1992
Divergent effects of short term glucocorticoid excess on the gonadotropic and somatotropic axes in normal men.
1992
Neuroendocrine Control of Growth Hormone Secretion
1999
Twenty-four-hour growth hormone (GH)-releasing peptide (GHRP) infusion enhances pulsatile GH secretion and specifically attenuates the response to a subsequent GHRP bolus.
1993
Works of K. Ho being referenced
THE PHARMACOKINETICS, SAFETY AND ENDOCRINE EFFECTS OF AUTHENTIC BIOSYNTHETIC HUMAN GROWTH HORMONE IN NORMAL SUBJECTS
1989
Therapeutic Efficacy of the Somatostatin Analog SMS 201-995 (Octreotide) in Acromegaly
1990
QUANTIFICATION OF URINARY GROWTH HORMONE (GH) EXCRETION BY CENTRIFUGAL ULTRAFILTRATION AND RADIOIMMUNOASSAY: APPRAISAL OF THE RELATIONSHIP BETWEEN 24 H URINARY GH AND MEAN 24 H SERUM GH LEVELS IN NORMAL AND ABNORMAL STATES OF GH SECRETION
1989
Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.
1988
Effects of Gonadal Steroids on Somatotroph Function in the Rat: Analysis by the Reverse Hemolytic Plaque Assay*
1988
Impact of intensive venous sampling on characterization of pulsatile GH release
1987
Sex-related differences in GH secretion in rat using reverse hemolytic plaque assay
1986
Effects of Sex and Age on the 24-Hour Profile of Growth Hormone Secretion in Man: Importance of Endogenous Estradiol Concentrations*
1987
Control of growth hormone (GH) binding protein release from human hepatoma cells expressing full-length GH receptor.
1995
Potent effects of human galanin in man: growth hormone secretion and vagal blockade.
1993