Citation Impact
Citing Papers
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
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Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Sleep Drives Metabolite Clearance from the Adult Brain
2013 StandoutScience
β-Amyloid Activates the O⨪2 Forming NADPH Oxidase in Microglia, Monocytes, and Neutrophils
1999
The DNA-damage response in human biology and disease
2009 StandoutNature
Molecular mediators of hepatic steatosis and liver injury
2004 Standout
Amyloid-β: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-β
2003
Spermine reverses lipopolysaccharide-induced memory deficit in mice
2015
The Antioxidant Vitamin E Modulates Amyloid β-Peptide-Induced Creatine Kinase Activity Inhibition and Increased Protein Oxidation: Implications for the Free Radical Hypothesis of Alzheimer's Disease
1999
Inflammatory processes in Alzheimer's disease
2007
Apoptosis in the nervous system
2000 StandoutNature
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
Molecular identification of a renal urate–anion exchanger that regulates blood urate levels
2002 StandoutNature
On the mechanism of the inhibition of glutamine synthetase and creatine phosphokinase by methionine sulfoxide
1996
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
2002 StandoutNature
Neuronal and glial calcium signaling in Alzheimer’s disease
2003
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
2000 StandoutNature
Oxidative stress, inflammation, and cancer: How are they linked?
2010 Standout
4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes
1997
A detailed analysis of hydrogen peroxide-induced cell death in primary neuronal culture
1995
Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium
1995
Mechanisms of Neuronal Degeneration in Alzheimer's Disease
1996
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
2000 StandoutNature
Oxidative Damage Is the Earliest Event in Alzheimer Disease
2001 Standout
Salen- Manganese Complexes: Combined Superoxide Dismutase/Catalase Mimics with Broad Pharmacological Efficacy
1996
Mitochondrial dysfunction, apoptotic cell death, and Alzheimer’s disease
2003
Accelerated evolution of the electron transport chain in anthropoid primates
2004
Copper, iron and zinc in Alzheimer's disease senile plaques
1998 Standout
The Nonfibrillar Amyloid β‐Peptide Induces Apoptotic Neuronal Cell Death
1999
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
2003
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
2006
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease
2006
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
2021 Standout
H2o2 and 4-hydroxynonenal mediate amyloid β-induced neuronal apoptosis by activating jnks and p38mapk
2003
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
2002 StandoutNature
Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex
2010
β‐Site APP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways
2005
Zinc takes the center stage: its paradoxical role in Alzheimer’s disease
2003
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
2002 StandoutNature
Role of hydrogen peroxide and oxidative stress in healing responses
2002
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
Prion Protein Peptides Induce .alpha.-Helix to .beta.-Sheet Conformational Transitions
1995
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
2012 StandoutNature
Decoding ALS: from genes to mechanism
2016 StandoutNature
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
[48] Amyloid β-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease
1999
Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures
2001
Life in extreme environments
2001 StandoutNature
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
2002
BCL-2 expression or antioxidants prevent hyperglycemia-induced formation of intracellular advanced glycation endproducts in bovine endothelial cells.
1996
Neurovascular regulation in the normal brain and in Alzheimer's disease
2004 Standout
Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease
1997
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
2004 StandoutNobel
Alzheimer's Disease
2010 Standout
Oxidation of Cytosolic Proteins and Expression of Creatine Kinase BB in Frontal Lobe in Different Neurodegenerative Disorders
1999
Alzheimer's disease and Aβ toxicity: from top to bottom
2001
Reactive oxygen species and Alzheimer's disease
1997
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Inhibition of Aβ fibril formation and Aβ-induced cytotoxicity by senile plaque-associated proteins
2000
Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease
2006
Genetic analysis of ageing: role of oxidative damage and environmental stresses
1996
Biochemistry and molecular cell biology of diabetic complications
2001 StandoutNature
SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein
1999
β‐Amyloid inhibits integrated mitochondrial respiration
and key enzyme activities
2001
Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes
1995
Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis
2004
Neurodegenerative diseases and oxidative stress
2004 Standout
Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders
2003
Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium
2006
Mitochondrial DNA damage and repair in neurodegenerative disorders
2008
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
2002 StandoutNobel
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Oxidative stress and neurodegenerative disorders
1998
Activation of microglial cells by β-amyloid protein and interferon-γ
1995 Nature
Lipid oxidation and improving the oxidative stability
2010 Standout
Vitamin E and Alzheimer disease: the basis for additional clinical trials
2000
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease
2000
Brain metabolism and brain disease: Is metabolic deficiency the proximate cause of Alzheimer dementia?
2001
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
2001
Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons
1995
The p66shc adaptor protein controls oxidative stress response and life span in mammals
1999 StandoutNature
Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons
1999
Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.
1999
Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia
1996
Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation
1997
Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.
1995
The Free Radical Theory of Aging Matures
1998 Standout
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
1997 Nature
Oxidative stress, cell cycle, and neurodegeneration
2003
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
1995 StandoutNobel
Cytochemical Demonstration of Oxidative Damage in Alzheimer Disease by Immunochemical Enhancement of the Carbonyl Reaction with 2,4-Dinitrophenylhydrazine
1998
Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction
1998
Calcium and neuronal injury in Alzheimer's disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise.
1994
Fresh and nonfibrillar amyloid β protein(1–40) induces rapid cellular degeneration in aged human fibroblasts: evidence for AβP‐channel‐mediated cellular toxicity
2000
Iron: A Pathological Mediator of Alzheimer Disease?
2002
Spermidine in health and disease
2018 StandoutScience
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Mitochondrial Diseases in Man and Mouse
1999 StandoutScience
Calcium and Neuronal Injury in Alzheimer's Disease
1994
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Endogenous generation of reactive oxidants and electrophiles and their reactions with DNA and protein
2003
The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer’s and Parkinson’s diseases1,2 11Guest Editors: Mark A. Smith and George Perry 22This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.
2002
Aβ-peptides enhance vasoconstriction in cerebral circulation
2001
Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis
2002
Ischemic Cell Death in Brain Neurons
1999 Standout
Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction
1997
Alzheimer Disease: from Molecular Biology to Therapy
1997
Converging Pathogenic Mechanisms in Vascular and Neurodegenerative Dementia
2003
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
A dendrimer-based platform for simultaneous dual fluorescence imaging of hydrogen peroxide and pH gradients produced in living cells
2011
Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity
1999
Rapid metabolic evolution in human prefrontal cortex
2011 StandoutNobel
Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1
2002
Coupled prediction of protein secondary and tertiary structure
2003 StandoutNobel
Molecular mediators of hepatic steatosis and liver injury
2004 Standout
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
1996 StandoutNature
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
2004
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase
1998
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
1986 StandoutNobel
Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis
2003 StandoutScience
Oxidative and Inflammatory Events in Prion Diseases: Can They Be Therapeutic Targets?
2019
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
2003 StandoutScience
Recombinant scrapie-like prion protein of 106 amino acids is soluble
1996 StandoutNobel
Creatine and Creatinine Metabolism
2000 Standout
Works of K. Hensley being referenced
Region‐selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain
2002
Oxidative stress in brain agingImplications for therapeutics of neurodegenerative diseases
2002
Glutamine Synthetase‐Induced Enhancement of β‐Amyloid Peptide Aβ(1–40) Neurotoxicity Accompanied by Abrogation of Fibril Formation and Aβ Fragmentation
1996
β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease
1994
Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease‐Associated Amyloid Beta Peptidea
1996
Oxidative biochemical markers; clues to understanding aging in long-lived species
2001
Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria
2000
Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure
1994
Message and protein-level elevation of tumor necrosis factor α (TNFα) and TNFα-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis
2003
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.
1994
A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of "molecular shrapnel" for Alzheimer's disease.
1995
Enhancement of β‐Amyloid Peptide Aβ(1–40)‐Mediated Neurotoxicity by Glutamine Synthetase
1995
Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death
1995