K. Grime

Drugs as CYP3A Probes, Inducers, and Inhibitors

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

A robust cell culture system supporting the complete life cycle of hepatitis B virus

Structure and function of the blood–brain barrier

Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor

PROTAC targeted protein degraders: the past is prologue

Applications of machine learning in drug discovery and development

Long-term hepatitis B infection in a scalable hepatic co-culture system

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation

The impact of cytokines on the expression of drug transporters, cytochrome P450 enzymes and chemokine receptors in human PBMC

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Interspecies scaling and prediction of human clearance: comparison of small- and macro-molecule drugs

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations

The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

Sorghum β-Amylase Production: Relationship With Grain Cultivar, Steep Regime, Steep Liquor Composition and Kilning Temperature

Oxadiazoles in Medicinal Chemistry

Novel food and non-food uses for sorghum and millets

In Silico Prediction of Volume of Distribution in Human Using Linear and Nonlinear Models on a 669 Compound Data Set

Isoniazid clearance is impaired among human immunodeficiency virus/tuberculosis patients with high levels of immune activation

Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents

Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

Pharmacokinetic consequences of time-dependent inhibition using the isolated perfused rat liver model

The Impact of In Vitro Binding on In Vitro - In Vivo Extrapolations, Projections of Metabolic Clearance and Clinical Drug-Drug Interactions

Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods

Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG

Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5

Application of In Silico, In Vitro and Preclinical Pharmacokinetic Data for the Effective and Efficient Prediction of Human Pharmacokinetics

THE RELEASE OF BOUND β-AMYLASE BY MACROMOLECULES