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Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Effects of HuIFN-α2 and HuIFN-α (Namalwa) on Breast Cancer Cells Grown in Culture and as Xenografts in the Nude Mouse
1982
Novel Growth and Death Related Interferon-Stimulated Genes (ISGs) in Melanoma: Greater Potency of IFN- β Compared with IFN- α 2
2003
Exogenous and Endogenous IL-10 Regulate IFN-α Production by Peripheral Blood Mononuclear Cells in Response to Viral Stimulation
1998
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Different Relative Activities of Human Cell-Derived Interferon-α Subtypes: IFN-α8 Has Very High Antiviral Potency
1996
Toll-like Receptor-dependent and -independent Viperin Gene Expression and Counter-regulation by PRDI-binding Factor-1/BLIMP1
2006
Identification and sequence of an accessory factor required for activation of the human interferon γ receptor
1994
Structural Basis for Cytokine Hormone-Receptor Recognition and Receptor Activation
1998
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
2009 StandoutNature
Reconstitution of a High Affinity Binding Site for Type I Interferons
1995
mRNA Is an Endogenous Ligand for Toll-like Receptor 3
2004 StandoutNobel
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
GART, SON, IFNAR, and CRF2-4 genes cluster on human Chromosome 21 and mouse Chromosome 16
1993
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
1996 Standout
Oncogenic kinase signalling
2001 StandoutNature
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Identification and functional characterization of a second chain of the interleukin-10 receptor complex
1997
The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the Nucleus
1999
Prognostic significance of autoimmunity during treatment of melanoma with interferon
2011
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
The role of gamma interferon in antimicrobial immunity
2001
Genetic transfer of a functional human interferon α receptor into mouse cells: Cloning and expression of its c-DNA
1990
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
Human T cells elicit IFN-α secretion from dendritic cells following cell to cell interactions
2000
Inducible Gene Targeting in Mice
1995 StandoutScience
Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia
1999
Antitumour actions of interferons: implications for cancer therapy
2016
Role of the cytoplasmic domains of the type I interferon receptor subunits in signaling
2000
The Short Form of the Interferon α/β Receptor Chain 2 Acts as a Dominant Negative for Type I Interferon Action
1997
Classification of tyrosine kinases from Dictyostelium discoideum with two distinct, complete or incomplete catalytic domains
1996
Characterization of β-R1, a Gene That Is Selectively Induced by Interferon β (IFN-β) Compared with IFN-α
1996
The Evolution of the Type I Interferons1
1998
IFNs activate toll-like receptor gene expression in viral infections
2001
Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein
1988 StandoutNatureNobel
A family of cytokine-inducible inhibitors of signalling
1997 StandoutNature
The Interferon Genes
1986
Transcription factors induced by interferons α and γ
1990
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
1994 StandoutScience
Cytokine gene polymorphism in human disease: on-line databases
1999
Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene
2003
Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons
2011
Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling
1999
Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons
1997
Tyrosine Phosphorylation of Jak2 in the JH2 Domain Inhibits Cytokine Signaling
2004
Cancer immunotherapy comes of age
2011 StandoutNature
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ
1996
CRF2-4: isolation of cDNA clones encoding the human and mouse proteins
1997
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
2001
Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon α Transmembrane Signaling
1995
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
The Human Type I Interferon Receptor
1996
The Biologic Activity and Molecular Characterization of a Novel Synthetic Interferon-Alpha Species, Consensus Interferon
1996
Role of interferons in the regulation of cell proliferation, differentiation, and development
1994
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
2005 StandoutNature
Pathogen Recognition and Innate Immunity
2006 Standout
Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity
1995
Differences in Interferon α and β Signaling
1996
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
2006 StandoutNature
Interleukin-1 polymorphisms associated with increased risk of gastric cancer
2000 StandoutNature
Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain
2000
A receptor for interleukin 10 is related to interferon receptors.
1993
Exogenous and endogenous IL-10 regulate IFN-alpha production by peripheral blood mononuclear cells in response to viral stimulation.
1998
Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
2000
Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C
2004
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Interleukin -10and Related Cytokines and Receptors
2004
Functional Subdomains of STAT2 Required for Preassociation with the Alpha Interferon Receptor and for Signaling
1997
Tumor Necrosis Factor (TNF)
1985 StandoutScience
Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains
2000
The Orphan Receptor CRF2-4 Is an Essential Subunit of the Interleukin 10 Receptor
1998
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.
1992 StandoutNobel
Ligand-Induced Association of the Type I Interferon Receptor Components
1995
Activation of Jak2 Catalytic Activity Requires Phosphorylation of Y1007 in the Kinase Activation Loop
1997
Mutation in the Jak Kinase JH2 Domain Hyperactivates Drosophila and Mammalian Jak-Stat Pathways
1997
Cachectin and tumour necrosis factor as two sides of the same biological coin
1986 StandoutNatureNobel
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Sendai Virus Blocks Alpha Interferon Signaling to Signal Transducers and Activators of Transcription
2000
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
STATs and Gene Regulation
1997 StandoutScience
Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.
1996
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.
1996
Comparisons of several biological and physicochemical properties of human leukocyte interferons produced by human leukocytes and by E. coli
1980
Elimination of size and charge heterogeneities of human leukocyte interferons by chemical cleavage
1977
JAKS AND STATS: Biological Implications
1998 Standout
Protein Tyrosine Kinase Structure and Function
2000
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors
1995
Functional Role of Type I and Type II Interferons in Antiviral Defense
1994 StandoutScience
Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA
1999
Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor
1996
Recombinant Human IFN-α Inhibits Cerebral Malaria and Reduces Parasite Burden in Mice
2007
Activation of Different Stat5 Isoforms Contributes to Cell-Type-Restricted Signaling in Response to Interferons
1996
A family of structural genes for human lymphoblastoid (leukocyte-type) interferon
1980 Nature
Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
2011 StandoutNobel
Antiviral Actions of Interferons
2001 Standout
Regulation of cell proliferation and differentiation by interferons
1985
Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency
1996
Autoinhibition of Jak2 Tyrosine Kinase Is Dependent on Specific Regions in Its Pseudokinase Domain
2003
Novel Proteinaceous Infectious Particles Cause Scrapie
1982 StandoutScienceNobel
Existence of distinct sodium channel messenger RNAs in rat brain
1986 StandoutNature
Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity
1997
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
1998 Standout
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997
Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells.
1985
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
Interferon production in glia and glioma cell lines
1978
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Expression of Hepatitis C Virus Proteins Inhibits Signal Transduction through the Jak-STAT Pathway
1999
Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.
1989
Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro
1985 StandoutScience
The Herpes Simplex Virus ICP0 RING Finger Domain Inhibits IRF3- and IRF7-Mediated Activation of Interferon-Stimulated Genes
2004
RNA Scanning of a Molecular Machine with a Built-in Ruler
2016 StandoutNobel
Sensitivity of the Epstein-Barr Virus Transformed Human Lymphoid Cell Lines to Interferon
1975
Effect of Interferon-α1 from E. coli on Some Cell Functions
1980 StandoutScienceNobel
Differential Responses to IFN-α Subtypes in Human T Cells and Dendritic Cells
2003
The structure of eight distinct cloned human leukocyte interferon cDNAs
1981 Nature
Negative Regulation of Cytokine Signaling Pathways
2000 Standout
Positive self regulation of cytotoxicity in human natural killer cells by production of interferon upon exposure to influenza and herpes viruses.
1982
Interferon-responsive regulatory elements in the promoter of the human 2',5'-oligo(A) synthetase gene.
1987
Regulation of STAT‐dependent pathways by growth factors and cytokines
1996
A protein tyrosine kinase in the interferon αβ signaling pathway
1992
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.
1996
Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection.
1976
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes
1993 StandoutScience
Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
2015
Heterogeneity of purified mouse interferons
1975
Single amino acid changes that render human IFN-alpha 2 biologically active on mouse cells.
1987
Biosynthesis of mouse interferon by translation of its messenger RNA in a cell-free system.
1975 StandoutNobel
Inhibition of Alpha Interferon but Not Gamma Interferon Signal Transduction by Phorbol Esters Is Mediated by a Tyrosine Phosphatase
1996
A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.
1995
Works of K. E. Mogensen being referenced
Assignment of the Human Interferon-α Receptor Gene to Chromosome 21q22.1 by In Situ Hybridization
1990
The Type I Interferon Receptor: Structure, Function, and Evolution of a Family Business
1999
Differences in Activity between α and β Type I Interferons Explored by Mutational Analysis
1998
Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: The class II cytokine receptors and their ligands in mammals and fish
2003
Interferon-α-dependent Activation of Tyk2 Requires Phosphorylation of Positive Regulatory Tyrosines by Another Kinase
1996
Receptor dynamics of closely related ligands: ‘fast’ and ‘slow’ interferons.
1985
STABILITY OF HUMAN LEUKOCYTE INTERFERON TOWARDS HEAT
1973
HindIII RFLP at the human IFNAR locus
1990
Specific antiviral activities of the human α interferons are determined at the level of receptor (IFNAR) structure
1992
Shared receptor components but distinct complexes for α and β interferons 1 1Edited by M. Yaniv
1998
The cellular receptor of the alpha-beta interferons
1989
Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-α/β and for Signal Transduction
1995
Electrostatic interactions in the cellular dynamics of the interferon‐receptor complex
1988
Hydrophobie cluster analysis reveals duplication in the external structure of human α‐interferon receptor and homology with γ‐interferon receptor external domain
1990
Interferon removes its own receptors as it blocks the division of Daudi cells
1988
α and α Interferons and Their Receptor and Their Friends and Relations
1995
Domains of Interaction between Alpha Interferon and its Receptor Components
1994
Loss of Specific Antigenicity on Carboxymethylation of Mercaptoethanol-Reduced Interferon of Human Leukocyte Origin
1973
Human Leukocyte Interferon: a Role for Disulphide Bonds
1974
Isolation of Daudi Cells with Reduced Sensitivity to Interferon. II. On The Mechanisms of Resistance
1983
Biological Activities and Receptor Binding of Two Human Recombinant Interferons and their Hybrids
1986
RAISING ANTIBODIES TO HUMAN LEUKOCYTE INTERFERON
1975
Production of Human Lymphoblastoid Interferon
1975
Behavior of a cloned murine interferon alpha/beta receptor expressed in homospecific or heterospecific background.
1992
[37] Radioiodination of human alpha interferons by the chloramine T method
1986
NO EVIDENCE FOR A CARBOHYDRATE MOIETY AFFECTING THE CLEARANCE OF CIRCULATING HUMAN LEUKOCYTE INTERFERON IN RABBITS
1974
Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.
1995
Interferon receptors.
1983
Binding of 125I‐labelled human αinterferon to human lymphoid cells
1981
Affinity Chromatography of Human Leukocyte and Diploid Cell Interferons on Sepharose-Bound Antibodies
1975
Isolated interferonα‐receptor complexes stabilized in vitro
1983
Kinetic Evidence for an Activation Step Following Binding of Human Interferonα2 to the Membrane Receptors of Daudi Cells
1983