Citation Impact
Citing Papers
CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies
2012
Navitoclax Enhances the Efficacy of Taxanes in Non–Small Cell Lung Cancer Models
2011
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
2008 Standout
Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers
2014
Role of Survivin in EGFR Inhibitor–Induced Apoptosis in Non–Small Cell Lung Cancers Positive for EGFR Mutations
2010
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification
2012
Overcoming Acquired Resistance to AZD9291, A Third-Generation EGFR Inhibitor, through Modulation of MEK/ERK-Dependent Bim and Mcl-1 Degradation
2017
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
2009
Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
NOX3, a Superoxide-generating NADPH Oxidase of the Inner Ear
2004
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
Cancer Invasion and the Microenvironment: Plasticity and Reciprocity
2011 Standout
Vascular NADPH oxidases: molecular mechanisms of activation
2004
Nuclear landscape of HIV-1 infection and integration
2016
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors
2012
Inflammation and metabolic disorders
2006 StandoutNature
Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo
2001
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
2012
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M
2009 StandoutNature
The superoxide-generating NADPH oxidase: structural aspects and activation mechanism
2002
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
2011 StandoutNobel
Increased oxidative stress in obesity and its impact on metabolic syndrome
2004 Standout
Alternative splicing of Bim and Erk-mediated BimEL phosphorylation are dispensable for hematopoietic homeostasis in vivo
2012
Differential upregulation of Nox homologues of NADPH oxidase by tumor necrosis factor‐α in human aortic smooth muscle and embryonic kidney cells
2006
Structural and functional characterization of the two human ThOX/Duox genes and their 5′-flanking regions
2004
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment
2011
NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells
2003
Bcl-2 inhibitors: small molecules with a big impact on cancer therapy
2008
Identification of Early Replicating Fragile Sites that Contribute to Genome Instability
2013
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
2008
Uric Acid and Cardiovascular Risk
2008 Standout
Transcriptional regulation of the NADPH oxidase isoform, Nox1, in colon epithelial cells: Role of GATA-binding factor(s)
2005
Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
2013 Standout
NOX enzymes and the biology of reactive oxygen
2004 Standout
Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia
2005
EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer
2008
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells
2006
BCL-2 family antagonists for cancer therapy
2008
Drug resistance analysis of gefitinib-targeted therapy in non-small cell lung cancer
2016
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
BIM Mediates EGFR Tyrosine Kinase Inhibitor-Induced Apoptosis in Lung Cancers with Oncogenic EGFR Mutations
2007
Mechanism of Ca2+ Activation of the NADPH Oxidase 5 (NOX5)
2004
Point Mutations in the Proline-rich Region of p22 Are Dominant Inhibitors of Nox1- and Nox2-dependent Reactive Oxygen Generation
2005
Multisite Phosphorylation Regulates Bim Stability and Apoptotic Activity
2008
Mitochondria, Oxidants, and Aging
2005 Standout
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases
2011
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment
2003
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells
2003
Cancer invasion and resistance: interconnected processes of disease progression and therapy failure
2011
Targeting apoptosis in cancer therapy
2020 Standout
The Nox Family of NAD(P)H Oxidases: Host Defense and Beyond
2004
Increased Nox2 expression in human cardiomyocytes after acute myocardial infarction
2003
Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology
2003
H2O2 activates Nox4 through PLA2‐dependent arachidonic acid production in adult cardiac fibroblasts
2005
Targeting the IL-6/JAK/STAT3 signalling axis in cancer
2018 Standout
ROS Generation by Nonphagocytic NADPH Oxidase
2003
Clinical Implications of the BIM Deletion Polymorphism in Advanced Lung Adenocarcinoma Treated With Gefitinib
2018
Novel Human Homologues of p47 and p67 Participate in Activation of Superoxide-producing NADPH Oxidases
2003
Cell Death
2009
The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network
2009
Nox proteins in signal transduction
2009
Free radical formation from sonolysis of water in the presence of different gases
2011
The NADPH oxidase of professional phagocytes—prototype of the NOX electron transport chain systems
2004
Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1
2003
The superoxide‐producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells
2005
Molecular composition and regulation of the Nox family NAD(P)H oxidases
2005
Bisphosphonates in cancer therapy
2007
Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development
2010
Dual Oxidase-2 Has an Intrinsic Ca2+-dependent H2O2-generating Activity
2005
Free radicals and antioxidants in normal physiological functions and human disease
2006 Standout
A Role for NOX NADPH Oxidases in Alzheimer's Disease and Other Types of Dementia?
2003
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
NADPH oxidase in human lung fibroblasts
2004
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase
2004
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
EGF blocks NADPH oxidase activation by TGF‐β in fetal rat hepatocytes, impairing oxidative stress, and cell death
2005
Survey of the year 2003 commercial optical biosensor literature
2004
The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle
2004
Phosphine-Catalyzed α-P-Addition on Activated Alkynes: A New Route to P−C−P Backbones
2006
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Aiding and abetting roles of NOX oxidases in cellular transformation
2012
Flying under the radar: the new wave of BCR–ABL inhibitors
2007
A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes
2001
Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases
2005
The Bcl-2 apoptotic switch in cancer development and therapy
2007 Standout
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
Survey of the year 2005 commercial optical biosensor literature
2006
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
2009
Targeting polo-like kinase 1 for cancer therapy
2006
Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells
2005
PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells
2009
Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim
2010
Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5
2001
A Noninvasive System for Monitoring Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors with Plasma DNA
2011
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4
2005
BH3 mimetic ABT-737 neutralizes resistance to FLT3 inhibitor treatment mediated by FLT3-independent expression of BCL2 in primary AML blasts
2007
Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
2010
Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
2009
Expression of Nox4 in osteoclasts
2004
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Analysis of mRNA Transcripts from the NAD(P)H Oxidase 1 (Nox1) Gene
2004
NADPH Oxidases in Cardiovascular Health and Disease
2006
NADPH Oxidase-Mediated Oxidative Stress: Genetic Studies of the p22 phox Gene in Hypertension
2005
First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
2010
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
2016 Standout
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Nox4 NAD(P)H Oxidase Mediates Hypertrophy and Fibronectin Expression in the Diabetic Kidney
2005
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells
2004
Comparison of imatinib mesylate, dasatinib (BMS-354825), and nilotinib (AMN107) in an N-ethyl-N-nitrosourea (ENU)–based mutagenesis screen: high efficacy of drug combinations
2006
The NADPH Oxidase NOX4 Drives Cardiac Differentiation: Role in Regulating Cardiac Transcription Factors and MAP Kinase Activation
2006
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
H 2 O 2 , a Necessary Evil for Cell Signaling
2006 StandoutScience
NADPH oxidase promotes NF-κB activation and proliferation in human airway smooth muscle
2002
Plasma proteomics identifies a ‘chemokine storm’ in idiopathic multicentric Castleman disease
2018
Cytochromeb558–Dependent NAD(P)H Oxidase–Phox Units in Smooth Muscle and Macrophages of Atherosclerotic Lesions
2002
Role of components of the phagocytic NADPH oxidase in oxygen sensing
2002
Role of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 1 in Oxidative Burst Response to Toll-Like Receptor 5 Signaling in Large Intestinal Epithelial Cells
2004
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells
2003
ERBB3 knockdown induces cell cycle arrest and activation of Bak and Bax-dependent apoptosis in colon cancer cells
2014
Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB
2004
Phosphine Organocatalysis
2018 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
Clinical features of Bim deletion polymorphism and its relation with crizotinib primary resistance in Chinese patients with ALK/ROS1 fusion‐positive non–small cell lung cancer
2017
Expression of gp91phox/Nox2 in COS-7 cells: cellular localization of the protein and the detection of outward proton currents
2005
Cytokine Storm
2020 Standout
Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells
2004
Functional π-Gelators and Their Applications
2014 Standout
Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields
2014 Standout
Versatile Small-Molecule Motifs for Self-Assembly in Water and the Formation of Biofunctional Supramolecular Hydrogels
2010
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Redox Paradox
2005
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Metabolic Regulation of Potassium Channels
2004
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Superoxide Ion: Generation and Chemical Implications
2016 Standout
An NAD(P)H oxidase regulates growth and transcription in melanoma cells
2002
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges
2012
Contrasting Roles of NADPH Oxidase Isoforms in Pressure-Overload Versus Angiotensin II–Induced Cardiac Hypertrophy
2003
Overview of Castleman disease
2020
MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) Shows Differential Antitumor Effects in Non-small Cell Lung Cancer According to MET Alterations
2011
Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells
2007
Multiple Myeloma
2011 Standout
Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim
2010
Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase
2004
Proteins Homologous to p47 and p67 Support Superoxide Production by NAD(P)H Oxidase 1 in Colon Epithelial Cells
2003
Mcl-1 Down-regulation Potentiates ABT-737 Lethality by Cooperatively Inducing Bak Activation and Bax Translocation
2007
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
2013 Standout
NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91phox in the Regulated Production of Superoxide by Phagocytes
2003
Myeloperoxidase: friend and foe
2005 Standout
Works of Junya Kuroda being referenced
A Novel Superoxide-producing NAD(P)H Oxidase in Kidney
2001
Apoptosis-based dual molecular targeting by INNO-406, a second-generation Bcr-Abl inhibitor, and ABT-737, an inhibitor of antiapoptotic Bcl-2 proteins, against Bcr-Abl-positive leukemia
2007
Phase 1 study in Japan of siltuximab, an anti-IL-6 monoclonal antibody, in relapsed/refractory multiple myeloma
2015
Intravesical administration of small interfering RNA targeting PLK-1 successfully prevents the growth of bladder cancer
2005
Identification of IGHCδ–BACH2 fusion transcripts resulting from cryptic chromosomal rearrangements of 14q32 with 6q15 in aggressive B‐cell lymphoma/leukemia
2011
The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate
2003
Cytotoxic effects of γδ T cells expanded ex vivo by a third generation bisphosphonate for cancer immunotherapy
2005
ABT‐737 is a useful component of combinatory chemotherapies for chronic myeloid leukaemias with diverse drug‐resistance mechanisms
2007
Involvement of BH3-only proteins in hematologic malignancies
2008
Fully automated and super-rapid system for the detection of JAK2V617F mutation
2008
Bcl-2 is a better therapeutic target than c-Myc, but attacking both could be a more effective treatment strategy for B-cell lymphoma with concurrent Bcl-2 and c-Myc overexpression
2011
Antiproliferative Efficacy of the Third-Generation Bisphosphonate, Zoledronic Acid, Combined with Other Anticancer Drugs in Leukemic Cell Lines
2004
Rapid quantitation of immunoglobulin G antibodies specific for blood group antigens A and B by surface plasmon resonance
2004
Zoledronate synergises with imatinib mesylate to inhibit Ph+ primary leukaemic cell growth
2005
Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2
2018
p53‐independent anti‐tumor effects of the nitrogen‐containing bisphosphonate zoledronic acid
2004
Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics
2007
Efficacy of the third-generation bisphosphonate, zoledronic acid alone and combined with anti-cancer agents against small cell lung cancer cell lines
2004
A third-generation bisphosphonate, minodronic acid (YM529), augments the interferon alpha/beta-mediated inhibition of renal cell cancer cell growth both in vitro and in vivo.
2005
Thalidomide for tocilizumab‐resistant ascites with TAFRO syndrome
2015
A Third-Generation Bisphosphonate, Minodronic Acid (YM529), Augments the Interferon α/β-Mediated Inhibition of Renal Cell Cancer Cell Growth Both In vitro and In vivo
2005
Bim and Bad mediate imatinib-induced killing of Bcr/Abl + leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
2006
INNO-406, a novel BCR-ABL/Lyn dual tyrosine kinase inhibitor, suppresses the growth of Ph+ leukemia cells in the central nervous system, and cyclosporine A augments its in vivo activity
2006
Early Ultrasonographic Diagnosis and Clinical Follow-up of Hepatic Veno-Occlusive Disease after Allogeneic Bone Marrow Transplantation in a Patient with Acute Lymphoblastic Leukemia
2009
Is TAFRO syndrome a subtype of idiopathic multicentric Castleman disease?
2019
NS-187, a potent and selective dual Bcr-Abl/Lyn tyrosine kinase inhibitor, is a novel agent for imatinib-resistant leukemia
2005