Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
MYC Drives Pten/Trp53 -Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
2015
Phthalimide conjugation as a strategy for in vivo target protein degradation
2015 Science
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
beditor : A Computational Workflow for Designing Libraries of Guide RNAs for CRISPR-Mediated Base Editing
2019
RNA modifications modulate gene expression during development
2018 Science
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
2020 Science
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Multiplex nucleotide editing by high-fidelity Cas9 variants with improved efficiency in rice
2019
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
2016
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Engineering of high-precision base editors for site-specific single nucleotide replacement
2019
Acute B lymphoblastic leukaemia‐propagating cells are present at high frequency in diverse lymphoblast populations
2012
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
How chemokines organize the tumour microenvironment
2023
RNAi screening comes of age: improved techniques and complementary approaches
2014
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
2020 StandoutNobel
A view on drug resistance in cancer
2019 StandoutNature
Predicting the mutations generated by repair of Cas9-induced double-strand breaks
2018
Adenine base editing in an adult mouse model of tyrosinaemia
2019
A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes
2019
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
BE-FLARE: a fluorescent reporter of base editing activity reveals editing characteristics of APOBEC3A and APOBEC3B
2018
Methods and Applications of CRISPR-Mediated Base Editing in Eukaryotic Genomes
2017
Prediction of the sequence-specific cleavage activity of Cas9 variants
2020
CRISPR/Cas-Mediated Base Editing: Technical Considerations and Practical Applications
2019
Continuous evolution of base editors with expanded target compatibility and improved activity
2019
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
2016
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
2016
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Enabling functional genomics with genome engineering
2015
Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9
2016
An Optimized microRNA Backbone for Effective Single-Copy RNAi
2013
Identification of Druggable Cancer Driver Genes Amplified across TCGA Datasets
2014
An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries
2017
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Delivery technologies for cancer immunotherapy
2019 Standout
Base editing: precision chemistry on the genome and transcriptome of living cells
2018
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
2019
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
High-Throughput Approaches to Pinpoint Function within the Noncoding Genome
2017
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy
2015
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Search-and-replace genome editing without double-strand breaks or donor DNA
2019 StandoutNature
Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
2019
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
2019 Standout
CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
2015
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
2019 Nature
BET domain co-regulators in obesity, inflammation and cancer
2012
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
2012
Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors
2020
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
2012
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
Reading, writing and erasing mRNA methylation
2019 Standout
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
The PI3K Pathway in Human Disease
2017 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects
2020
High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells
2020
Development and Application of Base Editors
2019
CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
2015
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
2014 Science
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
2014
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
2017
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Improved base editor for efficient editing in GC contexts in rabbits with an optimized AID‐Cas9 fusion
2019
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
2012
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
2013
Analysis and minimization of cellular RNA editing by DNA adenine base editors
2019
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers
2014
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
2019
Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6
2017
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Genetics and biology of pancreatic ductal adenocarcinoma
2016
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics
2018
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Junwei Shi being referenced
Genome-Editing Technologies in Adoptive T Cell Immunotherapy for Cancer
2017
The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
2022
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
Optimized base editors enable efficient editing in cells, organoids and mice
2018
The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition
2014
The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;NrasG12D acute myeloid leukemia
2012
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
2015
Rapid generation of drug-resistance alleles at endogenous loci using CRISPR-Cas9 indel mutagenesis
2017
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
2017 Nature
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
2011
Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)
2012
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
2018 Science