Standout Papers
Citation Impact
Citing Papers
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
The WD 40 domain of ATG 16L1 is required for its non‐canonical role in lipidation of LC 3 at single membranes
2018
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
The ATG conjugation systems are important for degradation of the inner autophagosomal membrane
2016 Science
Mechanisms of Autophagy Initiation
2017
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
TOR Signaling in Growth and Metabolism
2006 Standout
Dedicated SNARE s and specialized TRIM cargo receptors mediate secretory autophagy
2016
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens
2017
ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
2009
The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy
2015 StandoutNobel
Pleiotropic Coupling of G Protein-coupled Receptors to the Mitogen-activated Protein Kinase Cascade
1999 StandoutNobel
The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
1998
Receptor protein tyrosine phosphatase α activates Src-family kinases and controls integrin-mediated responses in fibroblasts
1999
Targeting autophagy in obesity: from pathophysiology to management
2018
The Sensation and Regulation of Interactions with the Extracellular Environment: The Cell Biology of Lymphocyte Adhesion Receptors
1990
Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains
1992
Integrin-Mediated Signal Transduction in Human Endothelial Cells: Analysis of Tyrosine Phosphorylation Events
1994
The role of the Atg1/ULK1 complex in autophagy regulation
2010 Standout
Nuclear Functions of Actin
2010
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
2013 Standout
Architecture of the Atg17 Complex as a Scaffold for Autophagosome Biogenesis
2012
Autophagosomes form at ER–mitochondria contact sites
2013 StandoutNature
DAP1, a Novel Substrate of mTOR, Negatively Regulates Autophagy
2010
mTOR Signaling in Growth Control and Disease
2012 Standout
Protein tyrosine phosphatase 1B negatively regulates integrin signaling
1998
Stimulation of tyrosine‐ and serine‐phosphorylation of focal adhesion kinase in mouse 3T3 cells by fibronectin and fibroblast growth factor
1994
Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily
1995
Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src
1997
Integrins in cancer: biological implications and therapeutic opportunities
2009 Standout
Mechanism and medical implications of mammalian autophagy
2018 Standout
Autophagy and the Integrated Stress Response
2010 Standout
Derailed endocytosis: an emerging feature of cancer
2008
Phosphorylation of Tyrosine 397 in Focal Adhesion Kinase Is Required for Binding Phosphatidylinositol 3-Kinase
1996
Calcium's Role in Mechanotransduction during Muscle Development
2014 Standout
Structural basis of starvation-induced assembly of the autophagy initiation complex
2014 StandoutNobel
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Regulated expression and binding of three VLA (β1) integrin receptors on T cells
1990 Nature
Autophagy in mammalian development and differentiation
2010 Standout
Control of Cell Cycle Progression by Fibronectin Matrix Architecture
1998
A Calcium-dependent Tyrosine Kinase Splice Variant in Human Monocytes
1998
The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death
2008
Hallmarks of aging: An expanding universe
2023 Standout
Integrin signaling and cell growth control
1998
Vesicular trafficking and autophagosome formation
2009
Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
2010
Adhesion molecules in cancer: the role of integrins
1993
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
1994 Nature
Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes
1992
The machinery of macroautophagy
2013 Standout
Genetic Analyses of Integrin Signaling
2010
Signal transduction through integrins: A central role for focal adhesion kinase?
1995
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
2013 Standout
Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II
1994
Control of motile and invasive cell phenotypes by focal adhesion kinase
2004
Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane
2011
Autophagy mediates the mitotic senescence transition
2009
Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways
1997
Phorbol ester-induced differentiation of U937 cells enhances attachment to fibronectin and distinctly modulates the α5β1 and α4β1 fibronectin receptors
1991
Autophagy-Independent Functions of the Autophagy Machinery
2019
Cooperation between soluble factors and integrin‐mediated cell anchorage in the control of cell growth and differentiation
1996
Autophagy: Renovation of Cells and Tissues
2011 Standout
mTOR at the nexus of nutrition, growth, ageing and disease
2020 Standout
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
2017
A Novel Link between Integrins, Transmembrane-4 Superfamily Proteins (CD63 and CD81), and Phosphatidylinositol 4-Kinase
1997
alpha vbeta 3 integrin associates with activated insulin and PDGFbeta receptors and potentiates the biological activity of PDGF
1997
Recent insights into the function of autophagy in cancer
2016
TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis
2016
Autophagy maintains the metabolism and function of young and old stem cells
2017 Nature
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα
1999 StandoutNobel
The β2 Integrin Mac-1 Induces Protective LC3-Associated Phagocytosis of Listeria monocytogenes
2018
Cytosolic lipolysis and lipophagy: two sides of the same coin
2017
Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491]
1992
A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein
1998
Chemical modulators of autophagy as biological probes and potential therapeutics
2010
Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP‐kinase and focal adhesion kinase in cultured Swiss 3T3 cells
1993
Biochemical signals and biological responses elicited by the focal adhesion kinase
2001
Selective autophagy mediated by autophagic adapter proteins
2011 Standout
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins
2010
Autophagy and Tumor Metabolism
2017
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Autophagy, Immunity, and Microbial Adaptations
2009
Integrin signalling and tyrosine phosphorylation: just the FAKs?
1998
Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes
2011 StandoutNobel
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
2008 Nature
Perspectives series: cell adhesion in vascular biology. Integrin signaling in vascular biology.
1997
Regulation of Fibroblast Motility by the Protein Tyrosine Phosphatase PTP-PEST
1999
Autophagy genes in immunity
2009
Integrin cytoplasmic interactions and bidirectional transmembrane signalling
1996
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
1997
ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle
2020
CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis
2017
Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling
1993
Delivery of Cytosolic Components by Autophagic Adaptor Protein p62 Endows Autophagosomes with Unique Antimicrobial Properties
2010
Force-induced focal adhesion translocation: effects of force amplitude and frequency
2004
Cell Migration: A Physically Integrated Molecular Process
1996 Standout
Proteins associated with with cytoplasmic surface of adhesion molecules
1993
Adhesion receptors of the immune system
1990 StandoutNature
Methods in Mammalian Autophagy Research
2010 Standout
Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes
2014
Autophagy modulation as a potential therapeutic target for diverse diseases
2012 Standout
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production
2013
ATM functions at the peroxisome to induce pexophagy in response to ROS
2015
p53 status determines the role of autophagy in pancreatic tumour development
2013 Nature
Fibulin-5/DANCE is essential for elastogenesis in vivo
2002 StandoutNatureNobel
Chapter 12 Monitoring Autophagic Degradation of p62/SQSTM1
2009
The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression
1996
Autophagy and Aging
2011 Standout
Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion
1991
Congenital disorders of autophagy: an emerging novel class of inborn errors of neuro-metabolism
2015
Autophagy as a target for anticancer therapy
2011
Characterization of the Atg17–Atg29–Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae
2009 StandoutNobel
Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast
1998
Differential Effects of the Integrins α9β1, αvβ3, and αvβ6 on Cell Proliferative Responses to Tenascin
1996
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Adhesive signaling in platelets
1994
Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information
1992
LC3-Associated Phagocytosis and Inflammation
2017
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
1991 StandoutNatureNobel
Degradation of the Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) by the Ubiquitin-Proteasome Pathway
2000 StandoutNobel
Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells
1997
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
2011 Standout
Ubiquitin signaling and autophagy
2017
The autophagic network and cancer
2018
Focal adhesion kinase and associated proteins
1994
Overexpression of Atg5 in mice activates autophagy and extends lifespan
2013
Dynamics and diversity in autophagy mechanisms: lessons from yeast
2009 StandoutNobel
Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs
1994 StandoutNatureNobel
Atg17 recruits Atg9 to organize the pre‐autophagosomal structure
2009 StandoutNobel
Regulation of growth factor signaling and cell cycle progression by cell adhesion and adhesion-dependent changes in cellular tension
2005
Autophagy-related Protein 32 Acts as Autophagic Degron and Directly Initiates Mitophagy
2012 StandoutNobel
Signaling through focal adhesion kinase
1997
Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake
2017
Autophagy in the liver: functions in health and disease
2017
Paxillin: A cytoskeletal target for tyrosine kinases
1994
Integrin-dependent Activation of the p70 Ribosomal S6 Kinase Signaling Pathway
1996
Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity
2014
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Autophagy in immunity and inflammation
2011 StandoutNature
The long journey of actin and actin-associated proteins from genes to polysomes
2009
Actin-related proteins in the nucleus: life beyond chromatin remodelers
2010
Differentiation of C2C12myoblasts is critically regulated by FAK signaling
2005
The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy
2014
Integrin-mediated Activation of MEK and Mitogen-activated Protein Kinase Is Independent of Ras
1996
Innate Immunity to Intracellular Pathogens: Balancing Microbial Elimination and Inflammation
2017
Dissection of Pathways Implicated in Integrin-mediated Actin Cytoskeleton Assembly
1997
Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins
2002
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein
1990 StandoutNatureNobel
Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival
1998
2014
Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis
2015
Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.
1993
The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes.
1994
Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras.
1994
Focal adhesion kinase (p125FAK) and paxillin are substrates for sphingomyelinase-induced tyrosine phosphorylation in Swiss 3T3 fibroblasts
1996
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation.
1996
Stimulation of tyrosine phosphorylation and accumulation of GTP-bound p21ras upon antibody-mediated alpha 2 beta 1 integrin activation in T-lymphoblastic cells.
1993
Autophagy requires endoplasmic reticulum targeting of the PI3-kinase complex via Atg14L
2010
The cytoplasmic domain of the integrin lymphocyte function-associated antigen 1 beta subunit: sites required for binding to intercellular adhesion molecule 1 and the phorbol ester-stimulated phosphorylation site.
1991
Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
2017
Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.
1994
mTOR's role in ageing: protein synthesis or autophagy?
2009
Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.
1995
Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase.
1994
Integrins, Oncogenes, and Anchorage Independence
1997
Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy
2015
Mechanisms and context underlying the role of autophagy in cancer metastasis
2018
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.
1996
Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly.
1994
Regulation of Adhesion to ICAM-1 by the Cytoplasmic Domain of LFA-1 Integrin β Subunit
1991 Science
An Atg1/Atg13 Complex with Multiple Roles in TOR-mediated Autophagy Regulation
2009
A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretion.
1990
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.
1995
Integrating with integrins.
1994
Specialized functional properties of the integrin alpha 4 cytoplasmic domain.
1995
Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.
1994
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING
1996 Standout
Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.
1995
Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTEN
1998 Science
Signal transduction from the extracellular matrix.
1993
p37mos-associated serine/threonine protein kinase activity correlates with the cellular transformation function of v-mos
1986
CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells
1997
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
2010
pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.
1992
Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events
1998
Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.
1994
Tyrosine phosphorylation of pp125FAK by the aggregation of high affinity immunoglobulin E receptors requires cell adherence.
1993
Translocation of interleukin-1β into a vesicle intermediate in autophagy-mediated secretion
2015 Nobel
Lymphocyte interactions with extracellular matrix
1991
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
Structural requirements of a membrane-spanning domain for protein anchoring and cell surface transport
1985
Embryonic mesodermal defects in α5 integrin-deficient mice
1993
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region
1987 StandoutNatureNobel
Integrin α1β1 Mediates a Unique Collagen-dependent Proliferation Pathway In Vivo
1998
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
2011 Science
The RhoA-dependent assembly of focal adhesions in Swiss 3T3 cells is associated with increased tyrosine phosphorylation and the recruitment of both pp125FAK and protein kinase C-δ to focal adhesions
1994
Biogenesis and Cargo Selectivity of Autophagosomes
2011
Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases
1998
The extracellular matrix as a cell survival factor.
1993
Inhibition of pp125FAK in cultured fibroblasts results in apoptosis.
1996
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins
2017
Integrins in point contacts mediate cell spreading: factors that regulate integrin accumulation in point contacts vs. focal contacts.
1993
Integrin-mediated cell adhesion activates mitogen-activated protein kinases.
1994
Regulation Mechanisms and Signaling Pathways of Autophagy
2009 Standout
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function
1995 Science
A role for autophagy in long‐term spatial memory formation in male rodents
2017
Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells.
1992
Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.
1993
Multiple Mechanisms of Protein Insertion into and Across Membranes
1985 Science
FIP200 regulates targeting of Atg16L1 to the isolation membrane
2013
Retrograde signaling from autophagy modulates stress responses
2017
Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.
1993
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.
1992
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions.
1996
Beta 2-integrin LFA-1 signaling through phospholipase C-gamma 1 activation.
1993
ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction
2018
Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth.
1994
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
Autonomous Expression of a Noncatalytic Domain of the Focal Adhesion-Associated Protein Tyrosine Kinase pp125FAK
1993
Integrin Signaling
1999 StandoutScience
Autophagy in metabolism and quality control: opposing, complementary or interlinked functions?
2021
Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten
1999
Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.
1992
Induction of p130cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases
1996
Synthetic peptides as nuclear localization signals
1986 StandoutNatureNobel
Autophagy in stem cells: repair, remodelling and metabolic reprogramming
2018
Rac Regulates Integrin-Mediated Spreading and Increased Adhesion of T Lymphocytes
1998
The synergistic activity of αvβ3 integrin and pdgf receptor increases cell migration
1998
Cytoplasmic and transmembrane domains of integrin beta 1 and beta 3 subunits are functionally interchangeable.
1991
Deletion in Cysteine-Rich Region of LDL Receptor Impedes Transport to Cell Surface in WHHL Rabbit
1986 ScienceNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
2008
Two integrin-binding peptides abrogate T cell-mediated immune responses in vivo.
1991
Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association
1992
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
Analysis of progressive deletions of the transmembrane and cytoplasmic domains of influenza hemagglutinin.
1986
Adhesive recognition sequences
1991
Stimulation of phosphatidylinositol 3'-kinase association with foca adhesion kinase by platelet-derived growth factor.
1994
Autophagy, a key mechanism of oncogenesis and resistance in leukemia
2016
Autophosphorylation of the Focal Adhesion Kinase, ppl25FAK, Directs SH2-Dependent Binding of pp60src
1994
Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells.
1994
Drosophila myoblast city Encodes a Conserved Protein That Is Essential for Myoblast Fusion, Dorsal Closure, and Cytoskeletal Organization
1997
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
2009 Standout
Focal adhesion kinase: at the crossroads of signal transduction
1997
Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.
1992
Platelet-derived growth factor modulation of focal adhesion kinase (p125FAK) and paxillin tyrosine phosphorylation in Swiss 3T3 cells. Bell-shaped dose response and cross-talk with bombesin.
1994
Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130cas, and Nck Adaptor Proteins
1997
Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases
1995
Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
2010
Impaired Integrin-mediated Adhesion and Signaling in Fibroblasts Expressing a Dominant-negative Mutant PTP1B
1998
Autophagy balances inflammation in innate immunity
2017
Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation
2013
Induction of tyrosine phosphorylation during ICAM-3 and LFA-1-mediated intercellular adhesion, and its regulation by the CD45 tyrosine phosphatase.
1994
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
2013
Phosphatidylinositol 3-Kinase Is Required for Integrin-Stimulated AKT and Raf-1/Mitogen-Activated Protein Kinase Pathway Activation
1997
Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle
1999
Regulation of innate immune responses by autophagy-related proteins
2010
Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK
1999
Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.
1995 StandoutNobel
The SH3 Domain Directs Acto-Myosin-Dependent Targeting of v-Src to Focal Adhesions via Phosphatidylinositol 3-Kinase
2000
Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels
1993
Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts
1997
Nuclear Role of WASp in the Pathogenesis of Dysregulated T H 1 Immunity in Human Wiskott-Aldrich Syndrome
2010
Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectin.
1993
Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos.
1991
Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex.
1995
Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.
1994
A charged amino acid substitution within the transmembrane anchor of the Rous sarcoma virus envelope glycoprotein affects surface expression but not intracellular transport.
1987
Disruption of integrin function and induction of tyrosine phosphorylation by the autonomously expressed beta 1 integrin cytoplasmic domain
1994
An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure
2008
Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion
1994
Regulation of development and differentiation by the extracellular matrix
1993
Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.
1994
RNA splicing regulates agrin-mediated acetylcholine receptor clustering activity on cultured myotubes
1992
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Integrin-dependent induction of early growth response genes in capillary endothelial cells
1996
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease
2016 Science
Plasticity of cell migration: a multiscale tuning model
2009
Kinase-Inactivated ULK Proteins Inhibit Autophagy via Their Conserved C-Terminal Domains Using an Atg13-Independent Mechanism
2008
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance
2011
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
2022
Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.
1993
Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin
1992 StandoutScienceNobel
Coordination of cell polarization and migration by the Rho family GTPases requires Src tyrosine kinase activity
2001
Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.
1994
Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction.
1994
Ubiquitination of exposed glycoproteins by SCF FBXO27 directs damaged lysosomes for autophagy
2017
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Minireview: Autophagy in Pancreatic β-Cells and Its Implication in Diabetes
2015
Quantitative Changes in Integrin and Focal Adhesion Signaling Regulate Myoblast Cell Cycle Withdrawal
1999
Receptor functions for the integrin VLA-3: fibronectin, collagen, and laminin binding are differentially influenced by Arg-Gly-Asp peptide and by divalent cations.
1991
Tyrosine phosphorylation of paxillin and focal adhesion kinase by activation of muscarinic m3 receptors is dependent on integrin engagement by the extracellular matrix
1998
Tor Directly Controls the Atg1 Kinase Complex To Regulate Autophagy
2009 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton.
1992
Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.
1992
Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering
1992
Acetylation in the regulation of autophagy
2022
IL-32 Promotes Angiogenesis
2013
Identification of a tetrapeptide recognition sequence for the alpha 2 beta 1 integrin in collagen.
1991
pp125FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk
1995
Induction of HoxB Transcription by Retinoic Acid Requires Actin Polymerization
2009
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex
2009
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.
1993
Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak- binding region
1994
The Role of Atg Proteins in Autophagosome Formation
2011 StandoutNobel
An artificial anchor domain: hydrophobicity suffices to stop transfer
1985
Four molecular pathways of T cell adhesion to endothelial cells: roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions.
1991
Works of Jun‐Lin Guan being referenced
Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling
2016
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin
2013
Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents
2011
Regulation of Focal Adhesion Kinase by a Novel Protein Inhibitor FIP200
2002
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
2009 Standout
Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells
2009
Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control
2005
Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model
2016
Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin
1995
Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation
1992 Nature
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
2011
Role of Grb7 Targeting to Focal Contacts and Its Phosphorylation by Focal Adhesion Kinase in Regulation of Cell Migration
2000
p62/SQSTM1 synergizes with autophagy for tumor growth in vivo
2014
Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration
1999
An autophagy-independent role for LC3 in equine arteritis virus replication
2012
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1
1990
FAK-Mediated Src Phosphorylation of Endophilin A2 Inhibits Endocytosis of MT1-MMP and Promotes ECM Degradation
2005
Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis
1997
Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)
1998
FIP200, a key signaling node to coordinately regulate various cellular processes
2007
Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners
2006
A Novel Role of the Actin-nucleating Arp2/3 Complex in the Regulation of RNA Polymerase II-dependent Transcription
2007
FIP200 is required for maintenance and differentiation of postnatal neural stem cells
2013
Focal Adhesion Kinase Regulation of N-WASP Subcellular Localization and Function
2004
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain
2001
Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration
2009
Pro-tumorigenic function of autophagy in mammary oncogenesis
2012
Role of focal adhesion kinase in integrin signaling
1997
The Association of Focal Adhesion Kinase with a 200‐kDa Protein that is Tyrosine Phosphorylated in Response to Platelet‐Derived Growth Factor
1996
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer
2011
Association of Focal Adhesion Kinase with Grb7 and Its Role in Cell Migration
1999
Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation
2016
Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways
2006
Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction
2003
FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells
2010
Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.
1990
Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.
1994
Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
2005
Autophagy gene FIP200 in neural progenitors non–cell autonomously controls differentiation by regulating microglia
2017
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.
1994
Pyk2 and FAK differentially regulate progression of the cell cycle
2000
The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway
2017
Conversion of a secretory protein into a transmembrane protein results in its transport to the golgi complex but not to the cell surface
1984
Focal adhesion kinase: protein interactions and cellular functions.
2002
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
2008
Mechanism of Cell Cycle Regulation by FIP200 in Human Breast Cancer Cells
2005
Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration
1998
Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide
2016
Autophagy Deficiency by Hepatic FIP200 Deletion Uncouples Steatosis From Liver Injury in NAFLD
2013
Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn
1996
Biochemistry and Biomechanics of Cell Motility
2005
The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response againstSalmonella
2011
Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.
1991
Identification of Transcription Factor KLF8 as a Downstream Target of Focal Adhesion Kinase in Its Regulation of Cyclin D1 and Cell Cycle Progression
2003
Impaired autophagy in macrophages promotes inflammatory eye disease
2016
Retroviral expression of alternatively spliced forms of rat fibronectin.
1990
Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction
2021
Transcriptional Activation of Cyclin D1 Promoter by FAK Contributes to Cell Cycle Progression
2001
Suppression of Pyk2 Kinase and Cellular Activities by Fip200
2000
Regulation of the Cell Cycle by Focal Adhesion Kinase
1998
The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells
2002