Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
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Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
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Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
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Premature Aging in Mice Deficient in DNA Repair and Transcription
2002 Science
Hallmarks of Cancer: The Next Generation
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The impact of rare and low-frequency genetic variants in common disease
2017
Engineered receptors for soluble cellular communication and disease sensing
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Redistribution of Silencing Proteins from Telomeres to the Nucleolus Is Associated with Extension of Life Span in S. cerevisiae
1997
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor
2004
Apoptosis in the nervous system
2000 StandoutNature
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MicroRNAs
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Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells
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Presenilin/γ-Secretase Activity Is Located in Acidic Compartments of Live Neurons
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Skeletal and CNS Defects in Presenilin-1-Deficient Mice
1997 Nobel
Variant Alzheimer Disease With Spastic paraparesis: Neuropathological phenotype
2001
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
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Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells
1997
Mechanisms of Neuronal Degeneration in Alzheimer's Disease
1996
Do Changes in Chromosomes Cause Aging?
1996
Oxidative Stress Hypothesis in Alzheimer's Disease
1997 Standout
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
2004
The presenilins and Alzheimer's disease
1997
Genetic instability syndromes with progeroid features
2007
Identification and Expression of the TREX1 and TREX2 cDNA Sequences Encoding Mammalian 3′→5′ Exonucleases
1999
Alzheimer's disease
2011 Standout
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue
1997
Problems and Solutions in the Genetic Analysis of Late-Onset Alzheimer’s Disease
2004
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Hallmarks of aging: An expanding universe
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest
1997
Molecular Dissection of Domains in Mutant Presenilin 2 That Mediate Overproduction of Amyloidogenic Forms of Amyloid β Peptides
1998
An Alzheimer's Disease-Linked PS1 Variant Rescues the Developmental Abnormalities of PS1-Deficient Embryos
1998
Epigenetic gene silencing in cancer: the DNA hypermethylome
2007
Telomere states and cell fates
2000 StandoutNatureNobel
Mutator pathways unleashed by epigenetic silencing in human cancer
2007
The Transmembrane Aspartates in Presenilin 1 and 2 Are Obligatory for γ-Secretase Activity and Amyloid β-Protein Generation
2000
Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ42(43)
1996
A novel nuclease-ATPase (Nar71) from archaea is part of a proposed thermophilic DNA repair system
2004
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Protein Oxidation in Aging, Disease, and Oxidative Stress
1997 Standout
Subcellular Distribution and Turnover of Presenilins in Transfected Cells
1998
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
1997 StandoutNature
Human Exonuclease I Is Required for 5′ and 3′ Mismatch Repair
2002 StandoutNobel
The case described by Alois Alzheimer in 1911
1998
DNA Damage, Aging, and Cancer
2009 Standout
Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators
2002
Identification of a Novel PSD-95/Dlg/ZO-1 (PDZ)-like Protein Interacting with the C Terminus of Presenilin-1
1999
Progeria: A Paradigm for Translational Medicine
2014
Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
2008
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
1998
Rapid accumulation of genome rearrangements in liver but not in brain of old mice
1997
Structure and Expression of the TREX1 and TREX2 3′→5′ Exonuclease Genes
2001
Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors
1997
Transgenic mouse models of Alzheimer’s disease
2000
Apolipoprotein E genotype in patients with alzheimer's disease: Implications for the risk of dementia among relatives
1995
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
The biology of replicative senescence
1997
Mechanisms of cellular senescence
1997
Alzheimer's disease
2006 Standout
Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin
1997
Extrachromosomal rDNA Circles— A Cause of Aging in Yeast
1997
A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
1998
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
2003
Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP
1998
Genetic analysis of ageing: role of oxidative damage and environmental stresses
1996
Increased Aβ42(43) from cell lines expressing presenilin 1 mutations
1998
Myc influences global chromatin structure
2006
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
2018 Standout
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
1996 Nature
Somatic mutagenesis and antimutagenesis in aging research
1996
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
1997
Amyloid β-Protein Fibrillogenesis
1997
Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein
2003
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
1995
A phylogenomic study of DNA repair genes, proteins, and processes
1999
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
A Loss of Function Mutation of Presenilin-2 Interferes with Amyloid β-Peptide Production and Notch Signaling
1999
Molecular mechanisms of yeast aging
1998
The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex
1998
Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm
1997 Nature
Transcriptional regulation and transformation by Myc proteins
2005
A pdf Neuropeptide Gene Mutation and Ablation of PDF Neurons Each Cause Severe Abnormalities of Behavioral Circadian Rhythms in Drosophila
1999 StandoutNobel
DNA helicases in inherited human disorders
1997
Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms
2008
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein
1999
Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression
1998
A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease
1997
Solution structures of micelle-bound amyloid β-(1-40) and β-(1-42) peptides of Alzheimer’s disease 1 1Edited by P. E. Wright
1999
Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein
1997
9 Quelling in Neurospora crassa
2002
Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo
1996
Amyloid, the presenilins and Alzheimer's disease
1997
Excision of 3′ Termini by the Trex1 and TREX2 3′→5′ Exonucleases
2001
Nucleases: diversity of structure, function and mechanism
2010
Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1
1999
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
1996
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Characterization of Drosophila Presenilin and its colocalization with Notch during development
1998
Expression of Alzheimer’s Disease-associated Presenilin-1 Is Controlled by Proteolytic Degradation and Complex Formation
1998
Cellular senescence: hot or what?
2009
The molecular pathology of Alzheimer's disease
1991 Standout
Molecular Biology of Aging
1999
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
Tau is a candidate gene for chromosome 17 frontotemporal dementia
1998
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain
1997
The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)
1996 Science
Assessment of normal and mutant human presenilin function in Caenorhabditis elegans
1996
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease
1997 Standout
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies
2004
The Free Radical Theory of Aging Matures
1998 Standout
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
Molecular Pathology of Laminopathies
2021
Quality Control by DNA Repair
1999 StandoutScienceNobel
Contrasting Role of Presenilin-1 and Presenilin-2 in Neuronal DifferentiationIn Vitro
1999
Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation
1996 Science
A Century of Alzheimer's Disease
2006 StandoutScience
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
1998
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.
1996
Genetics of Aging
1997 Science
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel- 12 and hop- 1 in Notch-pathway signaling
1999
Aging and Genome Maintenance: Lessons from the Mouse?
2003 Science
The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue
1997
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
1999
The Genetics of Aging
2001 StandoutNobel
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP
2001 Science
SIRT6, a Mammalian Deacylase with Multitasking Abilities
2019
Apparent mtDNA heteroplasmy in Alzheimer’s disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes
1997
Aging, life span, and senescence
1998 StandoutNobel
Toxic Proteins in Neurodegenerative Disease
2002 Science
Alzheimer's Disease--Genotypes, Phenotype, and Treatments
1997 Science
Premature aging in mice activates a systemic metabolic response involving autophagy induction
2008
NOTCH AND PRESENILIN : Regulated Intramembrane Proteolysis Links Development and Degeneration
2003
Molecular and Behavioral Analysis of Four period Mutants in Drosophila melanogaster Encompassing Extreme Short, Novel Long, and Unorthodox Arrhythmic Types
1998 StandoutNobel
Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants
1997 Science
Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix
1999
Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons
1999
LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes
2022
Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4.
1996
ALZHEIMER'S DISEASE: Genetic Studies and Transgenic Models
1998
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
1997
Human DNA Repair Genes
2001 StandoutScienceNobel
Membrane Topology of the C. elegans SEL-12 Presenilin
1996
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Gene Expression Profile of Aging and Its Retardation by Caloric Restriction
1999 Science
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Surface Enhanced Raman Spectroscopy of Individual Rhodamine 6G Molecules on Large Ag Nanocrystals
1999 StandoutNobel
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
The Alzheimer family of diseases: Many etiologies, one pathogenesis?
1997
Forebrain degeneration and ventricle enlargement caused by double knockout of Alzheimer's presenilin-1 and presenilin-2
2004
Longevity, Genes, and Aging
1996 Science
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations
1999
Works of Junko Oshima being referenced
The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis
2008
Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference
2005
Werner Helicase Is Localized to Transcriptionally Active Nucleoli of Cycling Cells
1998
The Werner syndrome protein is a DNA helicase
1997
Werner Syndrome Protein
1998
Homozygous and compound heterozygous mutations at the Werner syndrome locus
1996
Genomic Structure and Expression of STM2, the Chromosome 1 Familial Alzheimer Disease Gene
1996
A YAC, P1, and Cosmid Contig and 17 New Polymorphic Markers for the Werner Syndrome Region at 8p12–p21
1996
Regulation of c‐fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors
1995
Lessons from human progeroid syndromes
2000 Nature
Coronary artery disease in a Werner syndrome‐like form of progeria characterized by low levels of progerin, a splice variant of lamin A
2011
Characterization of Werner syndrome protein DNA helicase activity: Directionality, substrate dependence and stimulation by replication protein A
1998
Association of a polymorphic variant of the Werner helicase gene with myocardial infarction in a Japanese population
1997
Werner syndrome protein limits MYC-induced cellular senescence
2003
Comparative aspects of the Werner syndrome gene.
2000
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group.
1997
Linkage disequilibrium and haplotype studies of chromosome 8p 11.1-21.1 markers and Werner syndrome.
1994
LMNA mutations in atypical Werner's syndrome
2003
Polymorphisms at the Werner locus: I. Newly identified polymorphisms, ethnic variability of 1367Cy/Arg, and its stability in a population of Finnish centenarians
1999
Accelerated epigenetic aging in Werner syndrome
2017
DNA methylation signatures in Blood DNA of Hutchinson–Gilford Progeria syndrome
2022
Werner Syndrome
2002
Positional Cloning of the Werner's Syndrome Gene
1996 Science
Mismatch repair in extracts of Werner syndrome cell lines.
1997
Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus
1995 StandoutScience
WRN's Tenth Anniversary
2006
Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strains
2001
Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers.
1996