Citation Impact
Citing Papers
Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction
2008
The Mechanism of Endogenous Receptor Activation Functionally Distinguishes Prototype Canonical and Noncanonical Wnts
2005
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Bone Density Ligand, Sclerostin, Directly Interacts With LRP5 but Not LRP5G171V to Modulate Wnt Activity
2006
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
2007
Requirement of Prorenin Receptor and Vacuolar H + -ATPase–Mediated Acidification for Wnt Signaling
2010 Science
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
2010 StandoutNobel
Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone
2008
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
2009
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
2005
Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer
2005 StandoutScience
Dual Positive and Negative Regulation of Wingless Signaling by Adenomatous Polyposis Coli
2008 Science
Wnt Stabilization of β-Catenin Reveals Principles for Morphogen Receptor-Scaffold Assemblies
2013 Science
RanBP3 enhances nuclear export of active β-catenin independently of CRM1
2005
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of β-catenin
2008
Small-Molecule Inhibitors of Phosphatidylinositol 3-Kinase/Akt Signaling Inhibit Wnt/β-Catenin Pathway Cross-Talk and Suppress Medulloblastoma Growth
2009
High-Content Screening Assay for Activators of the Wnt/Fzd Pathway in Primary Human Cells
2005
Comprehensive genomic characterization of head and neck squamous cell carcinomas
2015 StandoutNature
Skeletal defects inringelschwanzmutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis
2004
Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity
2012
Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6
2008
Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled
2016
Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
2013
DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation
2008
The Gli code: an information nexus regulating cell fate, stemness and cancer
2007
Dynamic recruitment of axin by Dishevelled protein assemblies
2007
Rethinking WNT signaling
2004 Nobel
Shifting paradigms in Hedgehog signaling
2007
β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells
2010
The wnt-frizzled cascade in cardiovascular disease
2002
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
2005 Nature
A family with osteoporosis pseudoglioma syndrome due to compound heterozygosity of two novel mutations in the LRP5 gene
2006
Hedgehog: functions and mechanisms
2008 Standout
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Caught up in a Wnt storm: Wnt signaling in cancer
2003
Novel mutations affecting LRP5 splicing in patients with osteoporosis-pseudoglioma syndrome (OPPG)
2011
Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it
2011
Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
1999
The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal–mesenchymal interaction
2011
Structural basis of the Axin–adenomatous polyposis coli interaction
2000
Can we safely target the WNT pathway?
2014
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
2014
Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor
2013 Nature
Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling
2003
TBL1–TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
2008
Control of osteoblast function and regulation of bone mass
2003 Nature
Role of wnts in prostate cancer bone metastases
2005
Direct Inhibition of GSK3β by the Phosphorylated Cytoplasmic Domain of LRP6 in Wnt/β-Catenin Signaling
2008
Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation
2013
WNT1 Mutations in Families Affected by Moderately Severe and Progressive Recessive Osteogenesis Imperfecta
2013
Genetic regulation of bone mass and susceptibility to osteoporosis
2006
Caveolin Is Necessary for Wnt-3a-Dependent Internalization of LRP6 and Accumulation of β-Catenin
2006
Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats
2006
Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
2012 Standout
Autosomal Recessive Familial Exudative Vitreoretinopathy Is Associated with Mutations in LRP5
2004
β-Catenin destruction complex-independent regulation of Hippo–YAP signaling by APC in intestinal tumorigenesis
2015
Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass
2005
Wnt/β-catenin signaling: new (and old) players and new insights
2008
A receptor for phosphatidylserine-specific clearance of apoptotic cells
2000 Nature
The Cell Surface Membrane Proteins Cdo and Boc Are Components and Targets of the Hedgehog Signaling Pathway and Feedback Network in Mice
2006
Regulation of GSK-3
2001
Targeting the Wnt/β-Catenin Pathway to Regulate Bone Formation in the Adult Skeleton
2007
Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases
2015
Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer
2004
Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
2003
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
2002 Standout
Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism
2008
The Drosophila Circadian Network Is a Seasonal Timer
2007 StandoutNobel
Roles of Axin in the Wnt Signalling Pathway
1999
Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by β-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT
2005
WNT and β-catenin signalling: diseases and therapies
2004 Standout
GSK-3β Controls Osteogenesis through Regulating Runx2 Activity
2007
The Hedgehog's tale: developing strategies for targeting cancer
2011
Secreted and Transmembrane Wnt Inhibitors and Activators
2012
Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade
2015
Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP
2007
Six Novel Missense Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene in Different Conditions with an Increased Bone Density
2003
Regulation of β-Catenin Signaling in the Wnt Pathway
2000
The many roles of PTK7: A versatile regulator of cell–cell communication
2012
Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo
2009
Osteocytes, mechanosensing and Wnt signaling
2008
A Nuclear Function for Armadillo/β-Catenin
2004 Nobel
β-Catenin destruction complex: insights and questions from a structural perspective
2006
The hedgehog signaling network
2003
Canonical and Noncanonical Hedgehog/GLI Signaling in Hematological Malignancies
2012
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
2009 Nature
Lymphoid Enhancer Factor-1 and -Catenin Inhibit Runx2-dependent Transcriptional Activation of the Osteocalcin Promoter
2003
Oncogenic K-ras Stimulates Wnt Signaling in Colon Cancer Through Inhibition of GSK-3β
2005
Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
2005
Mining the Wnt pathway for cancer therapeutics
2006
Synergistic Activation of the Wnt Signaling Pathway by Dvl and Casein Kinase Iε
2001
A Mechanism for Wnt Coreceptor Activation
2004
New aspects of Wnt signaling pathways in higher vertebrates
2001
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
2012
Wnt/β-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis
2005
A Rate-Limiting Role for Dickkopf-1 in Bone Formation and the Remediation of Bone Loss in Mouse and Primate Models of Postmenopausal Osteoporosis by an Experimental Therapeutic Antibody
2011
Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein α and Peroxisome Proliferator-activated Receptor γ
2007
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
2005
SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor
2005
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Inhibition of GSK3 Phosphorylation of β-Catenin via Phosphorylated PPPSPXS Motifs of Wnt Coreceptor LRP6
2009
Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity
2012
Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms
2007
Roles of Wnt proteins in neural development and maintenance
2000 StandoutNobel
Skeletal remodeling in health and disease
2007 Standout
Large-Scale Analysis of Association Between <emph type="ital">LRP5</emph> and <emph type="ital">LRP6</emph> Variants and Osteoporosis
2008
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
2015
Protein phosphatase 1 regulates assembly and function of the β‐catenin degradation complex
2007
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Hedgehog Signaling in Development and Homeostasis of the Gastrointestinal Tract
2007
G Protein-coupled Receptor Kinase 2/Gαq/11 Interaction
2003
Wnt Signaling from Development to Disease: Insights from Model Systems
2009
Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling
2008
Direct Binding of the PDZ Domain of Dishevelled to a Conserved Internal Sequence in the C-Terminal Region of Frizzled
2003
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
The subcellular destinations of apc proteins
2002
Integration of BMP, Wnt, and notch signaling pathways in osteoblast differentiation
2011
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
2010
Mechanism of Intracellular cAMP Sensor Epac2 Activation
2011
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
2011
Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum
2008
Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3β-mediated phosphorylation of β-catenin
2007
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling
2001
Differential Regulation of Glycogen Synthase Kinase 3β by Insulin and Wnt Signaling
2000
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
2009
You Wnt some, you lose some: oncogenes in the Wnt signaling pathway
2003
Identification of the cell lineage at the origin of basal cell carcinoma
2010
Oxidative Stress Antagonizes Wnt Signaling in Osteoblast Precursors by Diverting β-Catenin from T Cell Factor- to Forkhead Box O-mediated Transcription
2007
The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment
2006
Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling
2008
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis
2000
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
Wnt11 Promotes Osteoblast Maturation and Mineralization through R-spondin 2
2009
YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response
2014
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb
2008
An Integrated Phosphoproteomics Work Flow Reveals Extensive Network Regulation in Early Lysophosphatidic Acid Signaling
2010
The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma
2003
Canonical Wnt/β-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes
2005
The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
2010
Building strong bones: molecular regulation of the osteoblast lineage
2011
A Second Canon
2003
Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation
2010
The many ways of Wnt in cancer
2007
Inhibition of Wnt signaling by Dishevelled PDZ peptides
2009
A model for familial exudative vitreoretinopathy caused by LPR5 mutations
2008 StandoutNobel
The Low Density Lipoprotein Receptor-related Protein 6 Interacts with Glycogen Synthase Kinase 3 and Attenuates Activity
2005
Clinical and Molecular Findings in Osteoporosis-Pseudoglioma Syndrome
2005
Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled‐related protein‐1
2006
LRP5 Mutations Linked to High Bone Mass Diseases Cause Reduced LRP5 Binding and Inhibition by SOST
2006
Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42
2003
Mutations in LRP5 or FZD4 Underlie the Common Familial Exudative Vitreoretinopathy Locus on Chromosome 11q
2004
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
2003
Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone
2006
Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
2005
The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations
2008
Regulation of bone mass by Wnt signaling
2006
Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo
2011
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
2006
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression
2006
Hedgehog beyond medulloblastoma and basal cell carcinoma
2010
Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
2011
An LRP5 Receptor with Internal Deletion in Hyperparathyroid Tumors with Implications for Deregulated WNT/β-Catenin Signaling
2007
Wnt-independent activation of β-catenin mediated by a Dkk1-Fz5 fusion protein
2005
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
2010
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
The opposing roles of laminin-binding integrins in cancer
2016
Parathyroid hormone signaling through low-density lipoprotein-related protein 6
2008
Mechanisms and functions of Hedgehog signalling across the metazoa
2011
Modulation of Wnt signaling influences fracture repair
2010
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling
2006
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015 StandoutNature
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in theLRP5and/orFZD4genes
2005
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
2006
Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway
2005
Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression
2003
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Osteoporosis-pseudoglioma syndrome: Description of 9 new cases and beneficial response to bisphosphonates
2008
Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation
2007
Rapid, Wnt-Induced Changes in GSK3β Associations that Regulate β-Catenin Stabilization Are Mediated by Gα Proteins
2005
Genetics of osteoporosis: accelerating pace in gene identification and validation
2009
Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo
2008
Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin
2004
Identification of the first deletion in the LRP5 gene in a patient with Autosomal Dominant Osteopetrosis type I
2011
Wnt signalling in stem cells and cancer
2005 StandoutNature
Hedgehog Signaling in Development and Cancer
2008 Standout
Growth factors regulate β-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing
2003
Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways
2010
Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity
2003 Nobel
Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2
2010
R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and β-Catenin Signaling
2007
Update on Wnt signaling in bone cell biology and bone disease
2011
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction
2005 Nature
Essential Role of β-Catenin in Postnatal Bone Acquisition
2005
A Role of Dishevelled in Relocating Axin to the Plasma Membrane during Wingless Signaling
2003
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
A Photocontrolled β‐Hairpin Peptide
2005
Distinct Domains of Mouse Dishevelled Are Responsible for the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activation and the Axis Formation in Vertebrates
1999
2014
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
HIF-1α is required for development of the sympathetic nervous system
2019 StandoutNobel
The role of Dickkopf-1 in bone development, homeostasis, and disease
2008
Wntless functions in mature osteoblasts to regulate bone mass
2012
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled
2012
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
1999
Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin
2004
Canonical and noncanonical Hedgehog pathway in the pathogenesis of multiple myeloma
2012
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
High Bone Mass in Mice Expressing a Mutant LRP5 Gene
2003
Heterozygous Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene Are Associated With Primary Osteoporosis in Children
2005
In Vivo Analysis of Wnt Signaling in Bone
2007
Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
2007 Science
Identification of a Specific Inhibitor of the Dishevelled PDZ Domain
2005
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor
2002
Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation
2007
Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation
2008
Wnt/β-Catenin Pathway
2005
Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
2004
Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling
2005
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd
2001
Lrp6 Hypomorphic Mutation Affects Bone Mass Through Bone Resorption in Mice and Impairs Interaction With Mesd
2008 StandoutNobel
Analysis of Endogenous LRP6 Function Reveals a Novel Feedback Mechanism by Which Wnt Negatively Regulates Its Receptor
2007
Wnt signaling and cancer
2000 Standout
Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
2009
Sclerostin: A gem from the genome leads to bone-building antibodies
2010
DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability
1999
Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
2002
Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2
2016
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
2009
N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/β-Catenin Signaling, Osteoblast Function, and Bone Formation
2008
Gli Proteins in Development and Disease
2011
Regulation of osteoblastogenesis and bone mass by Wnt10b
2005
Overexpression of secreted frizzled-related protein 1 inhibits bone formation and attenuates parathyroid hormone bone anabolic effects
2009
Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
2008
Judging a Protein by More Than Its Name: GSK-3
2001
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
2006
Sequential roles of Hedgehog and Wnt signaling in osteoblast development
2004
Constitutive activation of smoothened (SMO) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation and ductal dysplasia
2007
The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
2004
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
2004
β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins
2001 StandoutNobel
Functional Studies of Shaggy/Glycogen Synthase Kinase 3 Phosphorylation Sites in Drosophila melanogaster
2004
Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation
2008 Science
A Wnt- and β-catenin-dependent pathway for mammalian cardiac myogenesis
2003
Targeted Disruption of the Wnt Regulator Kremen Induces Limb Defects and High Bone Density
2008
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
2005
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6
2007
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Wise, a context-dependent activator and inhibitor of Wnt signalling
2003
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Targeting Hedgehog — a Cancer Stem Cell Pathway
2010
Distinct roles for Hedgehog and canonical Wnt signaling in specification,differentiation and maintenance of osteoblast progenitors
2006
Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification
2000
Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation
2015 StandoutNobel
The Genetics of Low-Density Lipoprotein Receptor-Related Protein 5 in Bone: A Story of Extremes
2007
The Wnt Antagonist Secreted Frizzled-Related Protein-1 Is a Negative Regulator of Trabecular Bone Formation in Adult Mice
2004
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells
2015 StandoutNobel
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis
2010
GSK-3: tricks of the trade for a multi-tasking kinase
2003 Standout
Regulation of nuclear factor κB activation by G-protein-coupled receptors
2001
Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
2012
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
2005
Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6
2004
Inhibition of the Wnt Signaling Pathway by Idax, a Novel Dvl-Binding Protein
2001
Frizzled signalling and cell polarisation inDrosophilaand vertebrates
2003
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Dishevelled Regulates the Metabolism of Amyloid Precursor Protein via Protein Kinase C/Mitogen-Activated Protein Kinase and c-Jun Terminal Kinase
2001
Two-signal requirement for growth-promoting function of Yap in hepatocytes
2015
Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass
2006
Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
2014
Axin2 controls bone remodeling through the β-catenin–BMP signaling pathway in adult mice
2009
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro
2006
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
Oropharyngeal Skeletal Disease Accompanying High Bone Mass and Novel LRP5 Mutation
2005
TOPGAL Mice Show That the Canonical Wnt Signaling Pathway Is Active During Bone Development and Growth and Is Activated by Mechanical Loading In Vitro
2005
Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization
1999
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Orally Bioavailable GSK-3α/β Dual Inhibitor Increases Markers of Cellular Differentiation In Vitro and Bone Mass In Vivo
2006
Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction
2000
Wnt signaling function in Alzheimer’s disease
2000
The Orphan Receptor Tyrosine Kinase Ror2 Promotes Osteoblast Differentiation and Enhances ex Vivo Bone Formation
2006
Works of Junhao Mao being referenced
A Novel Somatic Mouse Model to Survey Tumorigenic Potential Applied to the Hedgehog Pathway
2006
Regulation of Gli1 Transcriptional Activity in the Nucleus by Dyrk1
2002
The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila
2014
Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma
2008
Low-Density Lipoprotein Receptor-Related Protein-5 Binds to Axin and Regulates the Canonical Wnt Signaling Pathway
2001
Fgf-Dependent Etv4/5 Activity Is Required for Posterior Restriction of Sonic hedgehog and Promoting Outgrowth of the Vertebrate Limb
2009
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.
2000
Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors
1998
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
2004
TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function
2013
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
2002
A laminin 511 matrix is regulated by TAZ and functions as the ligand for the α6Bβ1 integrin to sustain breast cancer stem cells
2015
Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled
2002
Dishevelled Proteins Lead to Two Signaling Pathways
1999
Tec/Bmx non-receptor tyrosine kinases are involved in regulation of Rho and serum response factor by Galpha 12/13
1998
Hedgehog Signaling Is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis
2009
Suppression of Glycogen Synthase Kinase Activity Is Not Sufficient for Leukemia Enhancer Factor-1 Activation
1999
Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract
2010
Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells.
1999
Guanine nucleotide exchange factor GEF115 specifically mediates activation of Rho and serum response factor by the G protein α subunit Gα13
1998
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
2012
The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd
2004