Citation Impact
Citing Papers
Twist Transcriptionally Up-regulates AKT2 in Breast Cancer Cells Leading to Increased Migration, Invasion, and Resistance to Paclitaxel
2007
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
2007 StandoutScience
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
2004 Standout
Inhibition of the Phosphatidylinositol 3-Kinase/Akt Pathway by Inositol Pentakisphosphate Results in Antiangiogenic and Antitumor Effects
2005
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
2003 Standout
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt
2004
TOR Signaling in Growth and Metabolism
2006 Standout
PKB/AKT: functional insights from genetic models
2001
Activation of Akt-1 (PKB-α) Can Accelerate ErbB-2-Mediated Mammary Tumorigenesis but Suppresses Tumor Invasion
2004
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Herceptin-induced inhibition of phosphatidylinositol-3 kinase and Akt Is required for antibody-mediated effects on p27, cyclin D1, and antitumor action.
2002
Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities
2008
Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution
2024 StandoutNobel
LinkedOmics: analyzing multi-omics data within and across 32 cancer types
2017 Standout
EGFR Antagonists in Cancer Treatment
2008 Standout
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
1995 Standout
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
2011
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Inhibition of Aurora-A suppresses epithelial–mesenchymal transition and invasion by downregulating MAPK in nasopharyngeal carcinoma cells
2008
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Ovarian cancer
2014 Standout
Akt-regulated pathways in prostate cancer
2005
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
2008 Standout
Immunohistochemical localization of pulmonary surfactant apoproteins in various lung tumors: Special reference to nonmucus producing lung adenocarcinomas
1988 StandoutNobel
Activation of AKT Kinases in Cancer: Implications for Therapeutic Targeting
2005
Ubiquitin ligases: cell-cycle control and cancer
2006
Effects of extracellular matrix viscoelasticity on cellular behaviour
2020 StandoutNature
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
2005 StandoutNobel
Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium
2014
Autocrine Signalling Through erbB Receptors Promotes Constitutive Activation of Protein Kinase B/Akt in Breast Cancer Cell Lines
2003
Aurora-A — A guardian of poles
2005
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
2010 Standout
Actinin-4 gene amplification in ovarian cancer: a candidate oncogene associated with poor patient prognosis and tumor chemoresistance
2009
Upstream and downstream of mTOR
2004 Standout
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
Apoptosis-based therapies
2002
Perturbations of the AKT signaling pathway in human cancer
2005
Phase II trial of the mTOR inhibitor, temsirolimus and evaluation of circulating tumor cells and tumor biomarkers in persistent and recurrent epithelial ovarian and primary peritoneal malignancies: A Gynecologic Oncology Group study
2011
On the Dependency of Cellular Protein Levels on mRNA Abundance
2016 Standout
Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase
2003
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
2003
A molecular cell atlas of the human lung from single-cell RNA sequencing
2020 Nature
Aurora Kinases and Their Inhibitors: More Than One Target and One Drug
2007
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Honokiol, a Small Molecular Weight Natural Product, Inhibits Angiogenesis in Vitro and Tumor Growth in Vivo
2003 Standout
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
2004
AKT/PKB Signaling: Navigating the Network
2017 Standout
Olaparib Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer
2012 Standout
The PI3K Pathway in Human Disease
2017 Standout
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
2009 Standout
Mosaic Disorders of the PI3K/PTEN/AKT/TSC/mTORC1 Signaling Pathway
2016
Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27Kip1 by PKB/Akt-mediated phosphorylation in breast cancer
2002
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
2008 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Oncogenic herpes viruses
1975
Hierarchical Assembly of Model Cell Surfaces: Synthesis of Mucin Mimetic Polymers and Their Display on Supported Bilayers
2007 StandoutNobel
Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes
2005 StandoutNobel
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
2003 StandoutNobel
Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance
2003 Standout
Lymphoproliferative disease in a cotton‐top marmoset after inoculation with infectious mononucleosis‐derived Epstein‐Barr virus
1975 StandoutNobel
Phenotypic consequences of lung-specific inducible expression of FGF-3
2001 StandoutNobel
PTEN Activity Is Modulated During Ischemia and Reperfusion
2005 StandoutNobel
Apoptosis: A Review of Programmed Cell Death
2007 Standout
Genetic element from human surfactant protein SP-C gene confers bronchiolar-alveolar cell specificity in transgenic mice
1991
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: The MPAKT model
2003
Persisting oncogenic herpesvirus induced by the tumour promoter TPA
1978 StandoutNatureNobel
An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells
1985 Standout
Inositol Polyphosphate Multikinase Inhibits Angiogenesis via Inositol Pentakisphosphate-Induced HIF-1α Degradation
2017 StandoutNobel
AKT plays a central role in tumorigenesis
2001
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
Viruses in Human Cancers
1991 StandoutScienceNobel
Rapid Actions of Steroid Receptors in Cellular Signaling Pathways
2002
Failure to protect the myocardium against ischemia/reperfusion injury after chronic atorvastatin treatment is recaptured by acute atorvastatin treatment
2005
Immortalization of monkey epithelial cells by specific fragments of Epstein–Barr virus DNA
1984 Nature
DNA sequence and expression of the B95-8 Epstein—Barr virus genome
1984 StandoutNature
The Acute Respiratory Distress Syndrome
1996 Standout
Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein.
1986
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2005 StandoutScience
Spatiotemporal Analysis of Differential Akt Regulation in Plasma Membrane Microdomains
2008
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
The role of intraalveolar fibrosis in the process of pulmonary structural remodeling in patients with diffuse alveolar damage.
1987
Lymphoma in cotton-top marmosets after inoculation with Epstein-Barr virus: tumor incidence, histologic spectrum antibody responses, demonstration of viral DNA, and characterization of viruses.
1977
Nonnuclear Actions of Estrogen
2002
Segregation of the EBV‐determined nuclear antigen (EBNA) in somatic cell hybrids derived from the fusion of a mouse fibroblast and a human burkitt lymphoma line
1974 StandoutNobel
Works of June E. Paciga being referenced
Distribution and subcellular localization of surfactant-associated glycoproteins in human lung.
1985
AKT1/PKBα Kinase Is Frequently Elevated in Human Cancers and Its Constitutive Activation Is Required for Oncogenic Transformation in NIH3T3 Cells
2001
Epstein‐barr virus: Transformation of non‐human primate lymphocytes in vitro
1974
Ultrastructural and immunohistochemical studies of bronchiolo-alveolar carcinoma
1984
Surfactant “apoproteins” in human amniotic fluid: An enzyme-linked immunosorbent assay for the prenatal assessment of lung maturity
1982
Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K.
2001
Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer.
2003