Standout Papers
Citation Impact
Citing Papers
p53: puzzle and paradigm.
1996 Standout
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
Cellular Inclusion Bodies of Mutant Huntingtin Exon 1 Obscure Small Fibrillar Aggregate Species
2012 StandoutNobel
Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain
1997 Standout
p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53
1999
Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
1999
Inflammation and cancer
2002 StandoutNature
A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway
1997
Regulation of p53 stability by Mdm2
1997 StandoutNature
The Shc adaptor protein is highly phosphorylated at conserved, twin tyrosine residues (Y239/240) that mediate protein–protein interactions
1996
WAF1, a potential mediator of p53 tumor suppression
1993 Standout
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
p53 in growth control and neoplasia
1996
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
2001
DNA damage activates p53 through a phosphorylation–acetylation cascade
1998
Tumor spectrum analysis in p53-mutant mice
1994 Standout
Structure and ligand recognition of the phosphotyrosine binding domain of Shc
1995 Nature
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
1997 Standout
Specificity of the PTB Domain of Shc for β Turn-forming Pentapeptide Motifs Amino-terminal to Phosphotyrosine
1995
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides
1995
p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat
1995
Tumor surveillance via the ARF–p53 pathway
1998
What the papers say: The p53‐mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?
1993
Proteolytic Cleavage of the mdm2 Oncoprotein during Apoptosis
1997
Synergistic activation of transcription by CBP and p53
1997 Nature
When Checkpoints Fail
1997 StandoutNobel
p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades
2001
Identification of an Evolutionarily Conserved Heterotrimeric Protein Complex Involved in Protein Targeting
1998
Structural basis for IL-4 receptor phosphopeptide recognition by thelRS-1 PTB domain
1996
The Hallmarks of Cancer
2000 Standout
Recognition and specificity in protein tyrosine kinase-mediated signalling
1995
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
COMMENTARY: p53 Tumor suppressor gene: from the basic research laboratory to the clinic—an abridged historical perspective
1996
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
SAG/ROC2/RBX2 is a HIF-1 target gene that promotes HIF-1α ubiquitination and degradation
2007 StandoutNobel
p300/MDM2 Complexes Participate in MDM2-Mediated p53 Degradation
1998
Proteasome inhibitors induce mitochondria‐independent apoptosis in human glioma cells
1999 StandoutNobel
Inhibiting the p53–MDM2 interaction: an important target for cancer therapy
2003
The p53–Mdm2 module and the ubiquitin system
2002
Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis
1997
Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases
1995
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2
1998
The MDM2 gene amplification database
1998
Protein modules and signalling networks
1995 StandoutNature
E1A signaling to p53 involves the p19ARFtumor suppressor
1998
ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
1998
Live or let die: the cell's response to p53
2002 Standout
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Modular peptide binding: From a comparison of natural binders to designed armadillo repeat proteins
2013
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Transcriptional activation by p53 correlates with suppression of growth but not transformation
1994
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals
1997 StandoutNobel
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
A functionally inactive p53 protein interatocarcinoma cells is activated by either DNA damage or cellular differentiation
1996
Role of IRS-2 in insulin and cytokine signalling
1995 Nature
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1995 Nature
p53 regulation by post-translational modification and nuclear retention in response to diverse stresses
1999
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain
1998 StandoutNobel
The Gut-enriched Krüppel-like Factor (Krüppel-like Factor 4) Mediates the Transactivating Effect of p53 on the p21 Promoter
2000
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
1997
p53 in signaling checkpoint arrest or apoptosis
1996
Cancer-related inflammation
2008 StandoutNature
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain
1997
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
1995 Standout
Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution
1994 Nature
Candidate Adaptor Protein CED-6 Promotes the Engulfment of Apoptotic Cells in C. elegans
1998
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
1996 StandoutNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant.
1996
A Genetic Approach to Mapping the p53 Binding Site in the MDM2 Protein
1997
The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.
1995
The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein
1996
Regulation of Mdm2-Directed Degradation by the C Terminus of p53
1998
A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity
1999
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.
1995
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
2000 StandoutNobel
Regulation of p53 Function
2001
Human TAFII31 protein is a transcriptional coactivator of the p53 protein.
1995
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
The mdm-2 gene is induced in response to UV light in a p53-dependent manner.
1993
High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif
1997
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
1999 Nobel
Absence of WAF1 mutations in a variety of human malignancies
1994
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Induction of apoptosis in HeLa cells by trans-activation-deficient p53.
1995
Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.
1994
MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING
1997
Analysis of the degradation function of Mdm2.
1999
Cyclin G is a transcriptional target of the p53 tumor suppressor protein.
1994
p53 Inhibits DNA Replication In Vitro in a DNA-Binding-Dependent Manner
1995
Signaling Through Scaffold, Anchoring, and Adaptor Proteins
1997 StandoutScience
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
p53 and E2F-1 cooperate to mediate apoptosis.
1994
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein.
1994
Activation and activities of the p53 tumour suppressor protein
2001
mdm-2 Inhibits the G1 Arrest and Apoptosis Functions of the p53 Tumor Suppressor Protein
1996
MDM2 Suppresses p73 Function without Promoting p73 Degradation
1999 StandoutNobel
Mdm-2: “big brother” of p53
1997
Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis
2001
Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene
1995
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1998
The potential tumor suppressor p73 differentially regulates cellular p53 target genes.
1998
Anti-apoptotic activity of low levels of wild-type p53.
1996
Essential role for p53-mediated transcription in E1A-induced apoptosis.
1995
Kinetics of p53 Binding to Promoter Sites In Vivo
2001
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
1997
p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells
1998
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
1997 Standout
p53 oligomerization and DNA looping are linked with transcriptional activation.
1994
Two Domains of p53 Interact with the TATA-Binding Protein, and the Adenovirus 13S E1A Protein Disrupts the Association, Relieving p53-Mediated Transcriptional Repression
1995
Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6
1998
A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy
1999 Science
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
p53 domains: identification and characterization of two autonomous DNA-binding regions.
1993
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Identification of a p53 binding site in the human retinoblastoma susceptibility gene promoter.
1994
Cell type-specific inhibition of p53-mediated apoptosis by mdm2.
1996
Non-p53 p53RE binding protein, a human transcription factor functionally analogous to P53
1998
SAG/ROC2/Rbx2 Is a Novel Activator Protein-1 Target that Promotes c-Jun Degradation and Inhibits 12-O-Tetradecanoylphorbol-13-Acetate–Induced Neoplastic Transformation
2007
Vitamin B 2 -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals
1998 StandoutNobel
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.
1995
Human DNA Repair Genes
2001 StandoutScienceNobel
Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway.
1994
The N-Terminal Domain of p73 Interacts with the CH1 Domain of p300/CREB Binding Protein and Mediates Transcriptional Activation and Apoptosis
2000
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.
1996
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential.
1994
A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
2001
Mapping of the p53 and mdm-2 interaction domains.
1993
Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain
1995
The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2
1996
Gas1-Induced Growth Suppression Requires a Transactivation-Independent p53 Function
1995
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1998
Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage
1998
Cyclin E Restores p53 Activity in Contact-Inhibited Cells
1995
Works of Jun Wu being referenced
Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity
2005
The p53-mdm-2 autoregulatory feedback loop.
1993 Standout
Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk.
1992
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.
1994