Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
MYC Drives Pten/Trp53 -Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
2015
Phthalimide conjugation as a strategy for in vivo target protein degradation
2015 Science
Identification and characterization of essential genes in the human genome
2015 Science
Acquired Resistance to BET-PROTACs (Proteolysis-Targeting Chimeras) Caused by Genomic Alterations in Core Components of E3 Ligase Complexes
2019
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
2019
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)
2020
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
2014 Standout
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Degradation of proteins by PROTACs and other strategies
2019
Advances in targeted degradation of endogenous proteins
2019
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
2017 StandoutNature
Major advances in targeted protein degradation: PROTACs, LYTACs, and MADTACs
2021
Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
2020
Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer
2016
Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
2020
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Prey for the Proteasome: Targeted Protein Degradation—A Medicinal Chemist's Perspective
2020
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
2014 Nature
RNAi screening comes of age: improved techniques and complementary approaches
2014
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
A view on drug resistance in cancer
2019 StandoutNature
The PROTACtable genome
2021
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Exploring Targeted Degradation Strategy for Oncogenic KRASG12C
2019
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
2017
Targeting Epigenetic Readers in Cancer
2012
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
The Human Transcription Factors
2018 Standout
The changing landscape of atherosclerosis
2021 StandoutNature
Regulatory Enhancer–Core-Promoter Communication via Transcription Factors and Cofactors
2016
An Optimized microRNA Backbone for Effective Single-Copy RNAi
2013
PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics
2020
The multifaceted functions of sirtuins in cancer
2015
PROTACs: An Emerging Therapeutic Modality in Precision Medicine
2020
Proteasomal and lysosomal degradation for specific and durable suppression of immunotherapeutic targets
2020
LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation
2021 StandoutNobel
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Targeted Degradation of SLC Transporters Reveals Amenability of Multi-Pass Transmembrane Proteins to Ligand-Induced Proteolysis
2020
Metazoan MicroRNAs
2018 Standout
A Phase Separation Model for Transcriptional Control
2017
Structural basis of PROTAC cooperative recognition for selective protein degradation
2017
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy
2015
Phenotypic screening with target identification and validation in the discovery and development of E3 ligase modulators
2021
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery
2020
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Targeted protein degradation: expanding the toolbox
2019
CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
2015
EMT: 2016
2016 Standout
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
PROTAC targeted protein degraders: the past is prologue
2022 Standout
BET domain co-regulators in obesity, inflammation and cancer
2012
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs
2019
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
TGF-β Tumor Suppression through a Lethal EMT
2016
Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?
2018
Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia
2014
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
2012
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery
2020
The PI3K Pathway in Human Disease
2017 Standout
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Harnessing the Power of Proteolysis for Targeted Protein Inactivation
2020
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Expanding the arsenal of E3 ubiquitin ligases for proximity-induced protein degradation
2021
Plasticity in binding confers selectivity in ligand-induced protein degradation
2018
Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations
2019
Cancer therapies based on targeted protein degradation — lessons learned with lenalidomide
2021
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
2019
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
A UTX-MLL4-p300 Transcriptional Regulatory Network Coordinately Shapes Active Enhancer Landscapes for Eliciting Transcription
2017
Induced protein degradation: an emerging drug discovery paradigm
2016
Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting
2013
Transforming targeted cancer therapy with PROTACs: A forward-looking perspective
2021
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing
2017 Nature
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
2019
Emerging role of nanog in tumorigenesis and cancer stem cells
2013
Targeted Protein Degradation Tools: Overview and Future Perspectives
2020
Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells
2014
JAK2 activation by growth hormone and other cytokines
2015
Acute Myeloid Leukemia
2015 Standout
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
2014 Science
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
2014
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
2013
Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
2013
Unifying Catalysis Framework to Dissect Proteasomal Degradation Paradigms
2021
Epigenetic plasticity: A central regulator of epithelial-to-mesenchymal transition in cancer
2014
The von Hippel-Lindau Tumor Suppressor Gene
2020
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
2015
Investigating DNA supercoiling in eukaryotic genomes
2017
Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes
2015
Metabolic reprogramming and cancer progression
2020 StandoutScience
Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers
2014
Bruton tyrosine kinase degradation as a therapeutic strategy for cancer
2018
Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1
2021
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia
2021 StandoutNobel
Genetics and biology of pancreatic ductal adenocarcinoma
2016
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Impact of Overweight and Obesity on US Papillary Thyroid Cancer Incidence Trends (1995–2015)
2019
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics
2018 StandoutNobel
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Works of Jun Qi being referenced
RapidCaP, a Novel GEM Model for Metastatic Prostate Cancer Analysis and Therapy, Reveals Myc as a Driver of Pten -Mutant Metastasis
2014
Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non–Small Cell Lung Cancer
2013
Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition
2013
Small-Molecule Inhibition of BRDT for Male Contraception
2012
Development and preclinical validation of a novel covalent ubiquitin receptor Rpn13 degrader in multiple myeloma
2019
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
2015
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models
2015
Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
2013
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands
2018
BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
2013
Implication of expression of Nanog in prostate cancer cells and their stem cells
2012
Metformin and JQ1 synergistically inhibit obesity-activated thyroid cancer
2018
The dTAG system for immediate and target-specific protein degradation
2018
HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase
2017 StandoutNobel
Genome-wide determination of drug localization
2013
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
2012
Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms
2014
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
2018