Citation Impact
Citing Papers
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
2010 StandoutScience
Vaccine-delivered HIV envelope inhibits CD4+ T-cell activation, a mechanism for poor HIV vaccine responses
2006 StandoutNobel
The N-terminal Domain of Drosophila Gram-negative Binding Protein 3 (GNBP3) Defines a Novel Family of Fungal Pattern Recognition Receptors
2009 StandoutNobel
β-Arrestin-dependent Constitutive Internalization of the Human Chemokine Decoy Receptor D6
2004 StandoutNobel
Regulation of Human Chemokine Receptors CXCR4
1997
Detection and Delineation of CXCR-4 (Fusin) as an Entry and Fusion Cofactor for T Cell-Tropic HIV-1 by Three Different Monoclonal Antibodies
1998
Two murine homologues of the human chemokine receptor CXCR4 mediating stromal cell‐derived factor 1α activation of Gi2 are differentially expressed in vivo
1997
The Role of the CD4 Receptor versus HIV Coreceptors in Envelope-Mediated Apoptosis in Peripheral Blood Mononuclear Cells
2002
X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells
2010 StandoutNobel
Determinants of HIV-1 Coreceptor Function on CC Chemokine Receptor 3
1997
Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
1998
Chemokines and leukocyte traffic
1998 StandoutNature
DC-SIGN-Mediated Internalization of HIV Is Required for Trans-Enhancement of T Cell Infection
2002
Chemokines — Chemotactic Cytokines That Mediate Inflammation
1998 Standout
Chemokines and HIV–1 second receptors
1996
Host factors and the pathogenesis of HIV-induced disease
1996 Nature
Role of the Amino-Terminal Extracellular Domain of CXCR-4 in Human Immunodeficiency Virus Type 1 Entry
1997
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Unwelcomed Guests with Master Keys: How HIV Uses Chemokine Receptors for Cellular Entry
1997
HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor
1997
Atomic structure of the ectodomain from HIV-1 gp41
1997 StandoutNature
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
1998 StandoutNature
Dimeric association and segmental variability in the structure of human CD4
1997 Nature
Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: Implications for HIV primary infection
1997
Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function
1999
SNAREpins: Minimal Machinery for Membrane Fusion
1998 StandoutNobel
Chemokine Receptor Regulation and HIV Type 1 Tropism in Monocyte-Macrophages
1998
Core Structure of gp41 from the HIV Envelope Glycoprotein
1997 Standout
A CXCR4/CD4 Pseudotype Rhabdovirus That Selectively Infects HIV-1 Envelope Protein-Expressing Cells
1997
A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less
1997 Standout
Construction of a Novel Virus That Targets HIV-1-Infected Cells and Controls HIV-1 Infection
1997
Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
1998 StandoutNature
HIV-1 envelope gp41 is a potent inhibitor of chemoattractant receptor expression and function in monocytes.
1998
Dimerization of chemokine receptors in living cells: key to receptor function and novel targets for therapy
2008
N-Formyl Peptide Receptors Internalize but Do Not Recycle in the Absence of Arrestins
2003 StandoutNobel
Trafficking of the HIV Coreceptor CXCR4
1999
HIV-1 Integration in the Human Genome Favors Active Genes and Local Hotspots
2002 Standout
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
2000 Standout
CXCR4 Sequences Involved in Coreceptor Determination of Human Immunodeficiency Virus Type-1 Tropism
1998
Bias in cross-validated freeRfactors: mitigation of the effects of non-crystallographic symmetry
2006
Host Genes and HIV: The Role of the Chemokine Receptor Gene CCR5 and Its Allele (∆32 CCR5)
1997
CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs
1999 Standout
Exploiting dendritic cells to improve vaccine efficacy
2002 StandoutNobel
Asthma
2001 Standout
A Membrane-proximal Basic Domain and Cysteine Cluster in the C-terminal Tail of CCR5 Constitute a Bipartite Motif Critical for Cell Surface Expression
2001 StandoutNobel
HIV-1 Coreceptor Activity of CCR5 and Its Inhibition by Chemokines: Independence from G Protein Signaling and Importance of Coreceptor Downmodulation
1997
Dissociation of ligand-induced internalization of CXCR-4 from its co-receptor activity for HIV-1 Env-mediated membrane fusion
1998
Co-receptors for HIV-1 entry
1997
How Do Viruses Enter Cells? The HIV Coreceptors Teach Us a Lesson of Complexity
1997
Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor
1997
Reduced Cell Surface Expression of CCR5 in CCR5Δ32 Heterozygotes Is Mediated by Gene Dosage, Rather Than by Receptor Sequestration
2002 StandoutNobel
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
1997 StandoutNatureNobel
Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure
2005
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
2007 Standout
Modulation of chemokine receptor activity through dimerization and crosstalk
2008
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
1998
CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons
1997
CD4-Independent Infection by HIV-2 (ROD/B): Use of the 7-Transmembrane Receptors CXCR-4, CCR-3, and V28 for Entry
1997
HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors
2003
The Many Roles of Chemokines and Chemokine Receptors in Inflammation
2006 Standout
Identification and Characterization of the CXCR4 Chemokine Receptor in Human T Cell Lines: Ligand Binding, Biological Activity, and HIV-1 Infectivity
1998
The structure of LepA, the ribosomal back translocase
2008 StandoutNobel
DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
2003 StandoutNobel
CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4+T Cells: Role of signal transduction
1998
Exploiting dendritic cells to improve vaccine efficacy
2002 StandoutNobel
gp120 envelope glycoproteins of human immunodeficiency viruses competitively antagonize signaling by coreceptors CXCR4 and CCR5
1998
Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5
1997
Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses
1997
A monoclonal antibody (12G5) directed against CXCR-4 inhibits infection with the dual-tropic human immunodeficiency virus type 1 isolate HIV-1(89.6) but not the T-tropic isolate HIV-1(HxB)
1997
CD4-Independent Binding of SIV gp120 to Rhesus CCR5
1997 Science
Exploiting dendritic cells to improve vaccine efficacy
2002 StandoutNobel
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
1999 StandoutNobel
Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4
1997
Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein
1999
Chemokines
1997 Standout
Two Orphan Seven-Transmembrane Segment Receptors Which Are Expressed in CD4-positive Cells Support Simian Immunodeficiency Virus Infection
1997
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen
2003 StandoutNobel
APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection
2006 StandoutNobel
Human Immunodeficiency Virus (HIV) Envelope Binds to CXCR4 Independently of CD4, and Binding Can Be Enhanced by Interaction with Soluble CD4 or by HIV Envelope Deglycosylation
1998
In Vitro Behavior of Hematopoietic Progenitor Cells Under the Influence of Chemoattractants: Stromal Cell–Derived Factor-1, Steel Factor, and the Bone Marrow Environment
1998
Molecular uncoupling of C-C chemokine receptor 5-induced chemotaxis and signal transduction from HIV-1 coreceptor activity
1997
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Effect of Mutations in the Second Extracellular Loop of CXCR4 on Its Utilization by Human and Feline Immunodeficiency Viruses
1999
Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1
1997
Detection and delineation of CXCR-4 (fusin) as an entry and fusion cofactor for T-tropic [correction of T cell-tropic] HIV-1 by three different monoclonal antibodies.
1998
Human immunodeficiency virus strains differ in their ability to infect CD4+ cells expressing the rat homolog of CXCR-4 (fusin)
1997
Membrane Fusion and Exocytosis
1999 StandoutNobel
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
2000 Standout
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
2002 StandoutNobel
Use of Murine CXCR-4 as a Second Receptor by Some T-Cell-Tropic Human Immunodeficiency Viruses
1998
Cytokine Regulation of Human Immunodeficiency Virus Type 1 Entry and Replication in Human Monocytes/Macrophages through Modulation of CCR5 Expression
1998
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
1998 StandoutNobel
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance
2002 StandoutNobel
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
1999 StandoutScience
CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease
1999 Standout
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein
1997
An overview of the determinants of CCR5 and CXCR4 co-receptor function
2001
Rapid Infection of Oral Mucosal-Associated Lymphoid Tissue with Simian Immunodeficiency Virus
1999 StandoutScienceNobel
CD4-independent infection by human immunodeficiency virus type 2 strain ROD/B: the role of the N-terminal domain of CXCR-4 in fusion and entry
1997
HIV Coreceptor Downregulation as Antiviral Principle: SDF-1α–dependent Internalization of the Chemokine Receptor CXCR4 Contributes to Inhibition of HIV Replication
1997
The leukotriene B4receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells
1998
Interaction of Chemokine Receptor CCR5 with its Ligands: Multiple Domains for HIV-1 gp120 Binding and a Single Domain for Chemokine Binding
1997
Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
1998
The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens
1998 StandoutScience
Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity
1997
Tandem Native Mass-Spectrometry on Antibody–Drug Conjugates and Submillion Da Antibody–Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector
2015
Multiple extracellular domains of CCR-5 contribute to human immunodeficiency virus type 1 entry and fusion
1997
Relationships between CD4 Independence, Neutralization Sensitivity, and Exposure of a CD4-Induced Epitope in a Human Immunodeficiency Virus Type 1 Envelope Protein
2001
Multiple Residues Contribute to the Inability of Murine CCR-5 To Function as a Coreceptor for Macrophage-Tropic Human Immunodeficiency Virus Type 1 Isolates
1998
HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation
2004 StandoutNobel
Envelope glycoproteins from human immunodeficiency virus types 1 and 2 and simian immunodeficiency virus can use human CCR5 as a coreceptor for viral entry and make direct CD4-dependent interactions with this chemokine receptor
1997
Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains
1997
Chemokines
1997
Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions
1999
Plasma elevation of stromal cell–derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells
2001 StandoutNobel
Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody
1997
Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains
1997
TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex
2002
Chemokine receptors and human immunodeficiency virus infection
1998
Works of Jun Ouyang being referenced
Reproductible production of a PEGylated dual-acting peptide for diabetes
2007
High‐pressure refolding of bikunin: Efficacy and thermodynamics
2004
Structure of Aspartate-β-semialdehyde Dehydrogenase from Escherichia coli, a Key Enzyme in the Aspartate Family of Amino Acid Biosynthesis
1999
Increased Association of Glycoprotein 120-CD4 with HIV Type 1 Coreceptors in the Presence of Complex-Enhanced Anti-CD4 Monoclonal Antibodies
1999
Profiling Antibody Drug Conjugate Positional Isomers: A System-of-Equations Approach
2012
Evidence for Cell-Surface Association Between Fusin and the CD4-gp120 Complex in Human Cell Lines
1996 Science