Standout Papers
- Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis (2010)
- The thioredoxin antioxidant system (2013)
- A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? (2005)
- Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch (2006)
- Solution Structure of the Vam7p PX Domain, (2002)
- Solution Structure of the RIM1α PDZ Domain in Complex with an ELKS1b C-terminal Peptide (2005)
Citation Impact
Citing Papers
Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion
2009 StandoutScienceNobel
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
2007
CAPS drives trans -SNARE complex formation and membrane fusion through syntaxin interactions
2009
Structural bases for F plasmid conjugation and F pilus biogenesis in Escherichia coli
2019
In vitro system capable of differentiating fast Ca 2+ -triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release
2011 Nobel
Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion
2009 StandoutScienceNobel
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
2012 StandoutScienceNobel
SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open
2012 StandoutScienceNobel
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
Binding to Rab3A-interacting Molecule RIM Regulates the Presynaptic Recruitment of Munc13-1 and ubMunc13-2
2006
Munc18-1 binds directly to the neuronal SNARE complex
2007 StandoutNobel
Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release
2012 Science
From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective
2019
Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7
2010 StandoutNobel
Direct alkenylation of non-aromatic enamides via palladium-catalyzed oxidative coupling: Synthetic developments and applications
2013
RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels
2007
Biomimetic Aerobic CH Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5‐Trisubstituted Benzenes
2014
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
Copper‐Mediated Direct Cross‐Coupling of 1,3,4‐Oxadiazoles and Oxazoles with Terminal Alkynes
2010
RhIII‐Catalyzed Oxidative Olefination of Vinylic CH Bonds: Efficient and Selective Access to Di‐unsaturated α‐Amino Acid Derivatives and Other Linear 1,3‐Butadienes
2011
Aerobic Double Dehydrogenative Cross Coupling between Cyclic Saturated Ketones and Simple Arenes
2014
The Presynaptic Dense Projection of theCaenorhabiditis elegansCholinergic Neuromuscular Junction Localizes Synaptic Vesicles at the Active Zone through SYD-2/Liprin and UNC-10/RIM-Dependent Interactions
2011
Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release
2006
Short-term forms of presynaptic plasticity
2011
Palladium(II)‐Catalyzed Oxidative CH/CH Cross‐Coupling between Two Structurally Similar Azoles
2012
Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking
2013 StandoutNobel
Concentration dependent antioxidant/pro-oxidant activity of curcumin
2008
The Agrobacterium VirB/VirD4 T4SS: Mechanism and Architecture Defined Through In Vivo Mutagenesis and Chimeric Systems
2018
Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density
2008
RIM1α and RIM1β Are Synthesized from Distinct Promoters of theRIM1Gene to Mediate Differential But Overlapping Synaptic Functions
2008 StandoutNobel
UNC-13 and UNC-10/Rim Localize Synaptic Vesicles to Specific Membrane Domains
2006
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
Antagonistic Regulation of Synaptic Vesicle Priming by Tomosyn and UNC-13
2006
ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses
2009 StandoutNobel
The Presynaptic Active Zone
2012 StandoutNobel
Structure and function of SNARE and SNARE-interacting proteins
2005
Pushing synaptic vesicles over the RIM
2011
The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors
2011
Ruthenium- and rhodium-catalyzed cross-coupling reaction of acrylamides with alkenes: efficient access to (Z,E)-dienamides
2012
Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans
2006
Synaptic vesicle fusion
2008
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Accessory Proteins Stabilize the Acceptor Complex for Synaptobrevin, the 1:1 Syntaxin/SNAP-25 Complex
2008 Nobel
Relaxation time prediction for a light switchable peptide by molecular dynamics
2010
The N-terminal Domains of Syntaxin 7 and vti1b Form Three-helix Bundles That Differ in Their Ability to Regulate SNARE Complex Assembly
2002
SNAREs — engines for membrane fusion
2006 Standout
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Molecular machines governing exocytosis of synaptic vesicles
2012 Nature
Differential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1
2010
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
2011 Standout
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Munc13-1 Is Required for Presynaptic Long-Term Potentiation
2011
Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins
2003
Molecular organization of the presynaptic active zone
2006
Regulation of Membrane Fusion in Synaptic Excitation-Secretion Coupling: Speed and Accuracy Matter
2007
Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex
2011
Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release
2006 StandoutNobel
RIM proteins and their role in synapse function
2010
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion
2007 StandoutNobel
Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions
2011 Standout
RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone
2011 StandoutNobel
RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13
2011 StandoutNobel
Synthesis of Conjugated Dienes via a Biomimetic Aerobic Oxidative Coupling of Two CvinylH Bonds
2013
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)
2007
Palladium‐Catalyzed Cross‐Coupling of Internal Alkenes with Terminal Alkenes to Functionalized 1,3‐Butadienes Using CH Bond Activation: Efficient Synthesis of Bicyclic Pyridones
2010
Multiple Roles of Calcium Ions in the Regulation of Neurotransmitter Release
2008 Nobel
Munc13 Homology Domain-1 in CAPS/UNC31 Mediates SNARE Binding Required for Priming Vesicle Exocytosis
2011
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
2007 StandoutNobel
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
2006 StandoutNobel
Redox Control of Protein Conformation in Flavoproteins
2009
Clues from cell metabolism
2010 StandoutNatureNobel
Single-Molecule Studies of the Neuronal SNARE Fusion Machinery
2009 Nobel
Reluctance to membrane binding enables accessibility of the synaptobrevin SNARE motif for SNARE complex formation
2011
Binding of the Munc13-1 MUN Domain to Membrane-Anchored SNARE Complexes
2008
Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations
2015 Standout
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion
2010 StandoutNobel
Imaging single membrane fusion events mediated by SNARE proteins
2004 StandoutNobel
Palladium-catalyzed direct cross-coupling reaction between indenes and electron-deficient alkenes
2010
Type IV secretion systems: Advances in structure, function, and activation
2020
RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
2011 StandoutScienceNobel
RIM function in short- and long-term synaptic plasticity
2005 StandoutNobel
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
Development and Applications of Disulfonimides in Enantioselective Organocatalysis
2015 StandoutNobel
Stereo- and Chemoselective Cross-Coupling between Two Electron-Deficient Acrylates: An Efficient Route to (Z,E)-Muconate Derivatives
2015
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
2009 StandoutNobel
Synthesis and characterization of a cyclic vinylpalladium(ii) complex: vinylpalladium species as the possible intermediate in the catalytic direct olefination reaction of enamide
2011
Reaction mechanism of Drosophila cryptochrome
2010 StandoutNobel
Plasmid Transfer by Conjugation in Gram-Negative Bacteria: From the Cellular to the Community Level
2020
Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds
2011 Standout
Crystal Structure of the RIM1α C2B Domain at 1.7 Å Resolution,
2007 StandoutNobel
Role of Glutathione in Cancer Progression and Chemoresistance
2013
Ester‐Directed Selective Olefination of Acrylates by Rhodium Catalysis
2014
CAPS-1 and CAPS-2 Are Essential Synaptic Vesicle Priming Proteins
2007
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
E-Syts, a family of membranous Ca 2+ -sensor proteins with multiple C 2 domains
2007 StandoutNobel
RIM genes differentially contribute to organizing presynaptic release sites
2012 StandoutNobel
Palladium(ii)-catalyzed cross-coupling of simple alkenes with acrylates: a direct approach to 1,3-dienes through C–H activation
2013
Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle
2010
Palladium-Catalyzed Direct Cross-Coupling Reaction of Glycals with Activated Alkenes
2011
Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development
2012 StandoutNobel
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Halloysite Clay Nanotubes for Loading and Sustained Release of Functional Compounds
2015 Standout
Palladium(II)-Catalyzed Direct Alkenylation of Nonaromatic Enamides
2012
Towards an integrated model of bacterial conjugation
2014
Catalytic Enantioselective Allylation of Carbonyl Compounds and Imines
2011
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
2010 StandoutNobel
Direct C‐2 Alkylation of Quinoline N‐Oxides with Ethers via Palladium‐Catalyzed Dehydrogenative Cross‐Coupling Reaction
2013
Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography
2010
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Palladium(II)-Catalyzed Dehydrogenative Alkenylation of Cyclic Enaminones via the Fujiwara–Moritani Reaction
2011
SNARE Protein Structure and Function
2003
Pd(II)-Catalyzed Dehydrogenative Olefination of Vinylic C–H Bonds with Allylic Esters: General and Selective Access to Linear 1,3-Butadienes
2012
Palladium-Catalyzed Bisolefination of C−C Triple Bonds: A Facile Method for the Synthesis of Naphthalene Derivatives
2010
RIM function in short- and long-term synaptic plasticity
2005 StandoutNobel
Works of Jun Lu being referenced
Disruption of the mitochondrial thioredoxin system as a cell death mechanism of cationic triphenylmethanes
2011
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
2010 StandoutNobel
Synthesis and characterization of Δlac-acetogenins that potently inhibit mitochondrial complex I
2008
High-resolution structures of oxidized and reduced thioredoxin reductase fromHelicobacter pylori
2007
Structural Basis for a Munc13–1 Homodimer to Munc13–1/RIM Heterodimer Switch
2006 StandoutNobel
Analysis and characterization of the IncFV plasmid pED208 transfer region
2002
Mechanistic Basis of Plasmid-Specific DNA Binding of the F Plasmid Regulatory Protein, TraM
2014
Inhibition of the Human Thioredoxin System
2008
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
2005 StandoutNobel
Structural basis of specific TraD–TraM recognition during F plasmid‐mediated bacterial conjugation
2008
A minimal domain responsible for Munc13 activity
2005
Enantioselective allylation of aldehydes catalyzed by chiral indium(iii) complexes immobilized in ionic liquids
2005
Solution Structure of the RIM1α PDZ Domain in Complex with an ELKS1b C-terminal Peptide
2005 StandoutNobel
NMR analysis of the closed conformation of syntaxin-1
2008
Thioredoxin Reductase Is Irreversibly Modified by Curcumin
2005
Relaxosome function and conjugation regulation in F‐like plasmids – a structural biology perspective
2012
Structural basis of cooperative DNA recognition by the plasmid conjugation factor, TraM
2011
The role of H‐NS in silencing F transfer gene expression during entry into stationary phase
2004
Inhibition of Mammalian Thioredoxin Reductase by Some Flavonoids: Implications for Myricetin and Quercetin Anticancer Activity
2006
Mutations in the C-Terminal Region of TraM Provide Evidence for In Vivo TraM-TraD Interactions during F-Plasmid Conjugation
2005
Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
2007
Agrobacterium tumefaciens VirC2 enhances T-DNA transfer and virulence through its C-terminal ribbon–helix–helix DNA-binding fold
2009
Direct Cross-Coupling Reaction of Simple Alkenes with Acrylates Catalyzed by Palladium Catalyst
2009
Calothrixins, a New Class of Human DNA Topoisomerase I Poisons
2009
Solution Structure of the Vam7p PX Domain,
2002 StandoutNobel