Standout Papers
- The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect (2010)
- The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo (2012)
Citation Impact
Citing Papers
High-throughput characterization of protein–protein interactions by reprogramming yeast mating
2017 StandoutNobel
Generation of ordered protein assemblies using rigid three-body fusion
2021 StandoutNobel
Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment
2008
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green
2018 StandoutNobel
Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs
2010 Science
Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose
2016
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Rational Design of Molecular Fluorophores for Biological Imaging in the NIR‐II Window
2017
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Immunotargeted Nanoshells for Integrated Cancer Imaging and Therapy
2005
Photoactivatable CO release from engineered protein crystals to modulate NF-κB activation
2016 StandoutNobel
Complexation and release of doxorubicin from its complexes with pluronic P85-b-poly(acrylic acid) block copolymers
2007
Photosensitiser delivery for photodynamic therapy. Part 2: systemic carrier platforms
2008
Reversal of multidrug resistance by co-delivery of tariquidar (XR9576) and paclitaxel using long-circulating liposomes
2011
Stimuli responsive polymers for biomedical applications
2005
Gold nanorods: Their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions
2011
Does a targeting ligand influence nanoparticle tumor localization or uptake?
2008
Oxidative stress, inflammation, and cancer: How are they linked?
2010 Standout
Cancer nanomedicine: progress, challenges and opportunities
2016 Standout
Mesoporous silica nanoparticles in biomedical applications
2012 StandoutNobel
Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
2013 Standout
Multifunctional dendritic polymers in nanomedicine: opportunities and challenges
2011
Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor
2012
Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel
2011
Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: Analogy between angina pectoris and solid tumors and enhancement of the EPR effect
2010
Principles of nanoparticle design for overcoming biological barriers to drug delivery
2015 Standout
Targeted polymeric therapeutic nanoparticles: design, development and clinical translation
2012
Nanocaged platforms: modification, drug delivery and nanotoxicity. Opening synthetic cages to release the tiger
2016
Delivery of nanomedicines to extracellular and intracellular compartments of a solid tumor
2011
Anticancer nanomedicine and tumor vascular permeability; Where is the missing link?
2012
Targeting gold nanocages to cancer cells for photothermal destruction and drug delivery
2010
Perspectives and opportunities for nanomedicine in the management of atherosclerosis
2011
Recent advances in stealth coating of nanoparticle drug delivery systems
2012
MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome
2011
Polymeric anticancer drugs with pH-controlled activation
2004
Lipid-based systemic delivery of siRNA
2009
Two-photon-induced photoluminescence imaging of tumors using near-infrared excited gold nanoshells
2008
Increased Tumor Homing and Tissue Penetration of the Filamentous Plant Viral Nanoparticle Potato virus X
2012
Novel Conjugation of Tumor‐Necrosis‐Factor‐Related Apoptosis‐Inducing Ligand (TRAIL) with Monomethyl Auristatin E for Efficient Antitumor Drug Delivery
2013
Vitamin E down-modulates iNOS and NADPH oxidase in c-Myc/TGF-α transgenic mouse model of liver cancer
2004
Tumor Hypoxia and Malignant Progression
2004
Modulating Pharmacokinetics, Tumor Uptake and Biodistribution by Engineered Nanoparticles
2011
Polymer conjugates as anticancer nanomedicines
2006 Standout
Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines
2007
Stimuli-responsive nanocarriers for delivery of bone therapeutics – Barriers and progresses
2018
Plasmonic photothermal therapy (PPTT) using gold nanoparticles
2007 Standout
Polymer Therapeutics: Concepts and Applications
2006
The golden age: gold nanoparticles for biomedicine
2011 Standout
Bioengineered protein-based nanocage for drug delivery
2016
Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
2004
Dual roles of Nrf2 in cancer
2008
The enhanced permeability retention effect: a new paradigm for drug targeting in infection
2012
Ligand-targeted particulate nanomedicines undergoing clinical evaluation: Current status
2013
Frontiers in cancer nanomedicine: directing mass transport through biological barriers
2010
Near-infrared narrow-band imaging of gold/silica nanoshells in tumors
2009
Gold Nanocage-Photosensitizer Conjugates for Dual-Modal Image-Guided Enhanced Photodynamic Therapy
2014
PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
2010
Beating cancer in multiple ways using nanogold
2011
Photodynamic therapy of cancer: An update
2011 Standout
Paclitaxel poliglumex (XYOTAX™, CT-2103): A macromolecular taxane
2005
Iron oxide nanoparticle encapsulated diatoms for magnetic delivery of small molecules to tumors
2013
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
2004
Transporting and Shielding Photosensitisers by Using Water‐Soluble Organometallic Cages: A New Strategy in Drug Delivery and Photodynamic Therapy
2013
Elevated copper and oxidative stress in cancer cells as a target for cancer treatment
2008
CT-2103: A Novel Macromolecular Taxane with Potential Advantages Compared with Conventional Taxanes
2004
Photothermal therapy in a murine colon cancer model using near-infrared absorbing gold nanorods
2010
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Gold Nanorods: From Synthesis and Properties to Biological and Biomedical Applications
2009 Standout
Nanoshell-Enabled Photothermal Cancer Therapy: Impending Clinical Impact
2008
State-of-the-art materials for ultrasound-triggered drug delivery
2014
Reactive oxygen species: Current knowledge and applications in cancer research and therapeutic
2008
Intra‐organ biodistribution of gold nanoparticles using intrinsic two‐photon‐induced photoluminescence
2010
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Heme oxygenase-1 protects tumor cells against photodynamic therapy-mediated cytotoxicity
2006
Engineered Nanoparticles for Drug Delivery in Cancer Therapy
2014 Standout
Imaging macrophages with nanoparticles
2014
Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures
2013 Standout
Albumin-bound paclitaxel: a next-generation taxane
2006
Heme Oxygenase-1 in Tumors: Is It a False Friend?
2007
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
ExCage
2014 StandoutNobel
Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy
2008
Targeting of drugs and nanoparticles to tumors
2010
Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature
2015
Use of Size and a Copolymer Design Feature To Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model
2011
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
2023 StandoutNobel
Macromolecular therapeutics in cancer treatment: The EPR effect and beyond
2012
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
2018 StandoutNobel
Mimicking the Cell: Bio-Inspired Functions of Supramolecular Assemblies
2015
Supramolecular Double-Helix Formation by Diastereoisomeric Conformations of Configurationally Enantiomeric Macrocycles
2016 StandoutNobel
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer
2005 Standout
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
2005 StandoutScience
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
2011 StandoutNobel
Designed Ankyrin Repeat Proteins (DARPins): Binding Proteins for Research, Diagnostics, and Therapy
2011
Compact Cysteine-Coated CdSe(ZnCdS) Quantum Dots for in Vivo Applications
2007 StandoutNobel
Advanced Thermoelectric Design: From Materials and Structures to Devices
2020 Standout
Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation
2014
Design of biomaterials for intracellular delivery of carbon monoxide
2015
Delivery and Efficacy of a Cancer Drug as a Function of the Bond to the Gold Nanoparticle Surface
2009
Effect of molecular size of pegylated peptide on the pharmacokinetics and tumor targeting in lymphoma-bearing mice.
2003
Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
2021 StandoutNobel
Role of Glutathione in Cancer Progression and Chemoresistance
2013
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology
2013
Proteolysis: A Biological Process Adapted in Drug Delivery, Therapy, and Imaging
2009
Markedly Enhanced Permeability and Retention Effects Induced by Photo-immunotherapy of Tumors
2012
Colloidal Aggregation Affects the Efficacy of Anticancer Drugs in Cell Culture
2012
Nanoparticles with targeting, triggered release, and imaging functionality for cancer applications
2010
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
2012 StandoutNobel
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide
2005
Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates
2011
Influence of Constitution and Charge on Radical Pairing Interactions in Tris-radical Tricationic Complexes
2016 StandoutNobel
Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and Doxorubicin
2011
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Mediating Tumor Targeting Efficiency of Nanoparticles Through Design
2009
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Polymere Therapeutika: Konzepte und Anwendungen
2006
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
2015
Absorption by water increases fluorescence image contrast of biological tissue in the shortwave infrared
2018 StandoutNobel
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Organic nanoscale drug carriers coupled with ligands for targeted drug delivery in cancer
2009
Inorganic Nanoparticles for MRI Contrast Agents
2009 Standout
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Works of Jun Fang being referenced
Nanostructured SnSe integrated with Se quantum dots with ultrahigh power factor and thermoelectric performance from magnetic field-assisted hydrothermal synthesis
2019
Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application
2009
HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases
2015
Carbon monoxide, generated by heme oxygenase‐1, mediates the enhanced permeability and retention effect in solid tumors
2011
Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour
2003
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin
2003
Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications
2003
Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles
2011
Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease
2014
Therapeutic Potential of Pegylated Hemin for Reactive Oxygen Species-Related Diseases via Induction of Heme Oxygenase-1: Results from a Rat Hepatic Ischemia/Reperfusion Injury Model
2011
SMA–copolymer conjugate of AHPP: A polymeric inhibitor of xanthine oxidase with potential antihypertensive effect
2009
SMA–doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours
2004
The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
2010 Standout
Tumor-targeted induction of oxystress for cancer therapy
2007
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
2012 Standout
High-loading nanosized micelles of copoly(styrene–maleic acid)–zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor
2006
Therapeutic strategies by modulating oxygen stress in cancer and inflammation
2009
Polymeric micelles of zinc protoporphyrin for tumor targeted delivery based on EPR effect and singlet oxygen generation
2007
Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer
2017
Exploiting the enhanced permeability and retention effect for tumor targeting
2006
Factors and Mechanism of “EPR” Effect and the Enhanced Antitumor Effects of Macromolecular Drugs Including SMANCS
2005
Macromolecular Therapeutics
2003
A Retrospective 30 Years After Discovery of the Enhanced Permeability and Retention Effect of Solid Tumors: Next‐Generation Chemotherapeutics and Photodynamic Therapy—Problems, Solutions, and Prospects
2015
Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide.
2002
In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor.
2003
Pegylated Zinc Protoporphyrin: A Water-Soluble Heme Oxygenase Inhibitor with Tumor-Targeting Capacity
2002
Protective Role ofd -Amino Acid Oxidase against Staphylococcus aureus Infection
2012
Synthesis and therapeutic effect of styrene–maleic acid copolymer‐conjugated pirarubicin
2014