Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
2001 StandoutScience
Mismatch Repair-dependent Iterative Excision at Irreparable O6-Methylguanine Lesions in Human Nuclear Extracts
2006 StandoutNobel
Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition
2006 StandoutNobel
Mechanisms in Eukaryotic Mismatch Repair
2006 StandoutNobel
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Assay for 2-oxoglutarate decarboxylating enzymes based on the determination of [1-14C]succinate: Application to prolyl 4-hydroxylase
1990
Base-excision repair of oxidative DNA damage
2007 StandoutNature
Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases
2004 StandoutNobel
Pancreatic cancer
2004 Standout
Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
2016 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Prolyl 4-hydroxylase, a target enzyme for drug development
1991
Selective inhibition of hepatic collagen accumulation in experimental liver fibrosis in rats by a new prolyl 4-hydroxylase inhibitor
1998
Physician assessment of family cancer history and referral for genetic evaluation in colorectal cancer patients
2004
Inhibition of 2-oxoglutarate dependent oxygenases
2011
Incidence of Hereditary Nonpolyposis Colorectal Cancer and the Feasibility of Molecular Screening for the Disease
1998
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
Guidelines for colorectal cancer screening and surveillance in moderate and high risk groups (update from 2002)
2010
Genetic instabilities in human cancers
1998 StandoutNature
Genetics of hereditary colorectal cancer
2005
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
Exome sequencing reveals three novel candidate predisposition genes for diffuse gastric cancer
2015
Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates
2006
Hydrolytic function of Exo1 in mammalian mismatch repair
2014 StandoutNobel
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Cancer risk in mutation carriers of DNA-mismatch-repair genes
1999
Inhibition of prolyl 4-hydroxylase in vitro and in vivo by members of a novel series of phenanthrolinones
2001
Novel aspects of macromolecular repair and relationship to human disease
2004
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
How oxygen makes its presence felt: Figure 1.
2002 StandoutNobel
Hypoxia and the extracellular matrix: drivers of tumour metastasis
2014 StandoutNobel
Structure of the Human MutSα DNA Lesion Recognition Complex
2007 StandoutNobel
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia
2012
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Ulcerative colitis
2012 Standout
Mutations Predisposing to Hereditary Nonpolyposis Colorectal Cancer
1997
U1 snRNP regulates cancer cell migration and invasion in vitro
2020 Standout
Prolyl 4-hydroxylases and their protein disulfide isomerase subunit
1998
Hereditary Colorectal Cancer
2003 Standout
Physiological and pathological roles for microRNAs in the immune system
2010 Nobel
MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ
2010 StandoutNobel
Gastric cancer
2020 Standout
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors
2012 StandoutNobel
Controlled 15-year trial on screening for colorectal cancer in families with hereditary nonpolyposis colorectal cancer
2000
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC☆
1999 Standout
DNA mismatch repair and cancer
2001
Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland
2000 Standout
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting Highlights and Bethesda Guidelines
1997
p53-dependent non-coding RNA networks in chronic lymphocytic leukemia
2015
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Hereditary nonpolyposis colorectal cancer (Lynch syndrome): An updated review
1996
Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation
2001 StandoutNobel
The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis
2000
Pancreatic cancer
2011 Standout
Cancer of the Ovary
2004 Standout
Collagen Hydroxylases and the Protein Disulfide Isomerase Subunit of Prolyl 4‐Hydroxylases
1998
Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer
2003
Lynch Syndrome Genes
2005
Characterizing variants of unknown significance in rhodopsin: A functional genomics approach
2019
Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans
2000
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
1p36 Tumor Suppression—A Matter of Dosage?
2012
PROLINE HYDROXYLATION AND GENE EXPRESSION
2005 StandoutNobel
Inherited Susceptibility to Colorectal Cancer
2005
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
2003 Standout
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
1998 Standout
URINARY TRACT CANCER AND HEREDITARY NONPOLYPOSIS COLORECTAL CANCER: RISKS AND SCREENING OPTIONS
1998
Activation of C−H Bonds by Metal Complexes
1997 Standout
Protein hydroxylation: prolyl 4‐hydroxylase, an enzyme with four cosubstrates and a multifunctional subunit
1989
Genetic susceptibility to non-polyposis colorectal cancer
1999
The Hereditary Nonpolyposis Colorectal Cancer Syndrome: Genetics and Clinical Implications
2003
CpG island methylator phenotype in colorectal cancer
1999 Standout
Syncatalytic inactivation of prolyl 4-hydroxylase by anthracyclines
1988
Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues
1994
Recommendations for the care of individuals with an inherited predisposition to Lynch syndrome: a systematic review.
2006
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Cosubstrate binding site of Pseudomonas sp. AK1 gamma-butyrobetaine hydroxylase. Interactions with structural analogs of alpha-ketoglutarate
1991
Works of Julia Mohr being referenced
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis (vol 110, pg 1020, 1996)
1996
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis
1996
Panel-based next generation sequencing as a reliable and efficient technique to detect mutations in unselected patients with retinal dystrophies
2013
Time-dependent inactivation of chick-embryo prolyl 4-hydroxylase by coumalic acid. Evidence for a syncatalytic mechanism
1987
Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial
2009
miR-34a as part of the resistance network in chronic lymphocytic leukemia
2008
Inhibition of prolyl hydroxylation and procollagen processing in chick-embryo calvaria by a derivative of pyridine-2,4-dicarboxylate. Characterization of the diethyl ester as a proinhibitor
1991