Citation Impact
Citing Papers
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
2013 Science
ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1
2005
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Rationally engineered Cas9 nucleases with improved specificity
2015 StandoutScience
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination
2014
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
2005
Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
2012
Evolution of the Immunoglobulin Heavy Chain Class Switch Recombination Mechanism
2007
Hallmarks of Cancer: The Next Generation
2011 Standout
Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to, but distinct from, cellular DSB repair
2008
RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
2013
PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
2017
CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity
2014
The DNA-damage response in human biology and disease
2009 StandoutNature
DNA damage checkpoints: from initiation to recovery or adaptation
2007
Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA
2009
"ATR activation in response to ionizing radiation: still ATM territory"
2006
Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks
2009
The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition
2010 Standout
Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes
2009
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
2009
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints
2010
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Catalytic and Noncatalytic Roles of the CtIP Endonuclease in Double-Strand Break End Resection
2014
Regulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex
2010
MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals
2006
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
2009
The SIOD disorder protein SMARCAL1 is an RPA-interacting protein involved in replication fork restart
2009
When Checkpoints Fail
1997 StandoutNobel
ATR: an essential regulator of genome integrity
2008
Origin of Chromosomal Translocations in Lymphoid Cancer
2010
Cell Cycle-dependent Complex Formation of BRCA1·CtIP·MRN Is Important for DNA Double-strand Break Repair
2008
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
2010
Mechanisms of FUS mutations in familial amyotrophic lateral sclerosis
2016
The FANCM/FAAP24 Complex Is Required for the DNA Interstrand Crosslink-Induced Checkpoint Response
2010
Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes
2009
DNA repair in terminally differentiated cells
2002
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
2006
Decoding ALS: from genes to mechanism
2016 StandoutNature
Repair of Strand Breaks by Homologous Recombination
2013
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
2009
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
2009 Nature
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
2008
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break
2008 StandoutNobel
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Multiple functions of MRN in end-joining pathways during isotype class switching
2009
Suppressor mutations in Mecp2 -null mice implicate the DNA damage response in Rett syndrome pathology
2020
Checkpoint control and cancer
2011
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Tip60: Connecting chromatin to DNA damage signaling
2010
BRCA1 and its toolbox for the maintenance of genome integrity
2009
Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation
2008
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
2010
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
2006
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination
2009
Deoxyribonucleoside triphosphate levels: A critical factor in the maintenance of genetic stability
1994
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Repairs DNA Damage Induced by Topoisomerases I and II and Base Alkylation in Vertebrate Cells
2012
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Common pitfalls in preclinical cancer target validation
2017 StandoutNobel
Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends
2008
MERIT40 controls BRCA1–Rap80 complex integrity and recruitment to DNA double-strand breaks
2009
Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
2008 Nature
Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus Egg Extracts Requires Binding of ATRIP to ATR but Not the Stable DNA-binding or Coiled-coil Domains of ATRIP
2005
The DNA damage response and cancer therapy
2012 Nature
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
2006
Spartan deficiency causes genomic instability and progeroid phenotypes
2014
Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends
2008
BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair
2011 StandoutNobel
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
2013
Synthetic lethality: the road to novel therapies for breast cancer
2016
Ubiquitin signalling in DNA replication and repair
2010
The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
2008
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Crosstalk between histone modifications during the DNA damage response
2009
Involvement of novel autophosphorylation sites in ATM activation
2006
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Targeting DNA topoisomerase II in cancer chemotherapy
2009 Standout
Quantitative Proteomic Analysis of Cellular Protein Modulation upon Inhibition of the NEDD8-Activating Enzyme by MLN4924
2011
The Hallmarks of Aging
2013 Standout
The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
2007 Nature
Mechanisms of Dealing with DNA Damage-Induced Replication Problems
2008
Biotinylation by antibody recognition—a method for proximity labeling
2017
RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
2007
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
TopBP1 Activates the ATR-ATRIP Complex
2006
Identification of Domains of Ataxia-telangiectasia Mutated Required for Nuclear Localization and Chromatin Association
2005
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
2010 Nature
DNA damage response at functional and dysfunctional telomeres
2008
Chapter 2 DNA-PK
2008
Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth
2008
Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex
2006
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Mre11–Rad50–Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
2008
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Multiple roles of ATM in monitoring and maintaining DNA integrity
2010
DNA helicases Sgs1 and BLM promote DNA double-strand break resection
2008
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
2010
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
2008
A Novel Tel1/ATM N-Terminal Motif, TAN, Is Essential for Telomere Length Maintenance and a DNA Damage Response
2008 StandoutNobel
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage–modified chromatin
2008
Following the Path of the Virus: The Exploitation of Host DNA Repair Mechanisms by Retroviruses
2006
Function of a Conserved Checkpoint Recruitment Domain in ATRIP Proteins
2007
The ubiquitin landscape at DNA double-strand breaks
2009
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
2006
Processing of Damaged DNA Ends for Double-Strand Break Repair in Mammalian Cells
2012
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection
2013 Science
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
End-resection at DNA double-strand breaks in the three domains of life
2013
Kinase-Independent Functions of TEL1 in Telomere Maintenance
2009 StandoutNobel
Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin
2008
Double-Strand Break End Resection and Repair Pathway Choice
2011
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
The DNA-damage response: new molecular insights and new approaches to cancer therapy
2009
Long-term XPC Silencing Reduces DNA Double-Strand Break Repair
2007
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
Surviving the Breakup: The DNA Damage Checkpoint
2006
Cdc13 Telomere Capping Decreases Mec1 Association but Does Not Affect Tel1 Association with DNA Ends
2007
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
The ATM-mediated DNA-damage response: taking shape
2006
Dissociation of in vitro DNA deamination activity and physiological functions of AID mutants
2008 StandoutNobel
Mechanism and Regulation of Class Switch Recombination
2008
Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation
2005
53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination
2010
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
2013
DNA Damage Responses: Mechanisms and Roles in Human Disease
2008
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
2010 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Posttranslational regulation of the mammalian circadian clock by cryptochrome and protein phosphatase 5
2006 StandoutNobel
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Evidence for Cardiomyocyte Renewal in Humans
2009 StandoutScience
Recruitment of DNA Damage Checkpoint Proteins to Damage in Transcribed and Nontranscribed Sequences
2005 StandoutNobel
Works of Julia Coates being referenced
Replication stress induces 53BP1-containing OPT domains in G1 cells
2011
PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
2015 Science
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
2013
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
2005 Nature
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
2009 Nature
New patterns of bulk DNA repair in ultraviolet irradiated mouse embryo carcinoma cells following differentiation
1993
Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells
2016
p53 Prevents the Accumulation of Double-Strand DNA Breaks at Stalled-Replication Forks Induced by UV in Human Cells
2004
Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining
2010
Human CtIP promotes DNA end resection
2007 Nature
CDK targeting of NBS1 promotes DNA‐end resection, replication restart and homologous recombination
2012
Murine radiation myeloid leukaemogenesis: Relationship between interstitial telomere‐like sequences and chromosome 2 fragile sites
1993