Standout Papers
- Helminth parasites – masters of regulation (2004)
- Tissue-resident macrophages (2013)
- Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection (2005)
- Alternative Activation Is an Innate Response to Injury That Requires CD4+ T Cells to be Sustained during Chronic Infection (2007)
Citation Impact
Citing Papers
Species Interactions in a Parasite Community Drive Infection Risk in a Wildlife Population
2010 StandoutScience
Ecological rules governing helminth–microparasite coinfection
2008
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
2012 StandoutScience
Rapid Host Defense against Aspergillus fumigatus Involves Alveolar Macrophages with a Predominance of Alternatively Activated Phenotype
2011
IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation
2009
Macrophages in Allergic Asthma: Fine-Tuning Their Pro- and Anti-Inflammatory Actions for Disease Resolution
2011
Differential Roles of Macrophages in Diverse Phases of Skin Repair
2010 Standout
Macrophages as APC and the Dendritic Cell Myth
2008
Francisella tularensis Live Vaccine Strain Induces Macrophage Alternative Activation as a Survival Mechanism
2008
The co-distribution of Plasmodium falciparum and hookworm among African schoolchildren
2006
Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation
2012
Hallmarks of Cancer: The Next Generation
2011 Standout
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
How chemokines organize the tumour microenvironment
2023
Susceptibility to Trypanosoma cruzi is modified by a previous non‐related infection
1999
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARγ−/−, PPARδ−/−, PPARγδ−/−, or LXRαβ−/− bone marrow
2008
An Acquired and Endogenous Glycocalyx Forms a Bidirectional “Don’t Eat” and “Don’t Eat Me” Barrier to Phagocytosis
2020 StandoutNobel
The IL-21 receptor augments Th2 effector function and alternative macrophage activation
2006
Th2 Cytokine-Induced Alterations in Intestinal Smooth Muscle Function Depend on Alternatively Activated Macrophages
2008
Parasite interactions in natural populations: insights from longitudinal data
2008
Concomitant infections, parasites and immune responses
2001
Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages
2012
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting
2004
The role of macrophages in skin homeostasis
2017
Animal models of chronic obstructive pulmonary disease
2008
Microglial brain region−dependent diversity and selective regional sensitivities to aging
2016
Homing to suppress: address codes for Treg migration
2005
Pulmonary fibrosis: pathogenesis, etiology and regulation
2009 Standout
Towards a recombinant antigen vaccine against Onchocerca volvulus
2002
Immunopathogenesis of schistosomiasis
2004
CD301b+ Macrophages Are Essential for Effective Skin Wound Healing
2016
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Regulatory T Cells Induced by Parasites and the Modulation of Allergic Responses
2005
Macrophages: Master Regulators of Inflammation and Fibrosis
2010 Standout
Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites
2006
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1
2006
Structure in parasite component communities in wild rodents: predictability, stability, associations and interactions .... or pure randomness?
2008
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor α1 chain
2007
Mechanism of splenic cell death and host mortality in a Plasmodium yoelii malaria model
2017
Black, White, and Gray: Macrophages in Skin Repair and Disease
2017
Macrophages in atherosclerosis: a dynamic balance
2013 Standout
Vaccination against helminth parasites ‐ the ultimate challenge for vaccinologists?
1999
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
2010 Standout
Malaria and helminth interactions in humans: an epidemiological viewpoint
2006
IL-4 Receptor Signaling Is Required for Mannose Receptor Expression by Macrophages Recruited to Granulomata but not Resident Cells in Mice Infected with Schistosoma mansoni
2003
The chemokine system in diverse forms of macrophage activation and polarization
2004 Standout
The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
2023
Macrophages in Tissue Repair, Regeneration, and Fibrosis
2016 Standout
Choreographing Immunity in the Skin Epithelial Barrier
2019
Synergistic associations between hookworm and other helminth species in a rural community in Brazil
2006
FIZZ1 and Ym as Tools to Discriminate between Differentially Activated Macrophages
2002
Hookworm vaccines: past, present, and future
2006
Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore–induced allergic airway disease
2010
Alternatively activated macrophages in helminth infections
2007
How much would the safety of blood transfusion be improved by including p24 antigen in the battery of tests?
1995
The development and maintenance of resident macrophages
2015
Retnla (Relmα/Fizz1) Suppresses Helminth-Induced Th2-Type Immunity
2009
Expression of chitinase‐like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice
2006
Could control of soil-transmitted helminthic infection influence the HIV/AIDS pandemic
2003
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
2010 Standout
Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis
2009
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
2012 Standout
Alternative Activation of Macrophages: Mechanism and Functions
2010 Standout
Mitochondria in the Regulation of Innate and Adaptive Immunity
2015
The role of residential location in apparent helminth and malaria associations
2006
Origin and physiological roles of inflammation
2008 StandoutNature
Host Defense Pathways: Role of Redundancy and Compensation in Infectious Disease Phenotypes
2011
Macrophage plasticity and polarization: in vivo veritas
2012 Standout
A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation
2011
Alternatively activated macrophages during parasite infections
2004
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
2011
Protective and pathogenic functions of macrophage subsets
2011 Standout
Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
2016
Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold
2008
Towards improvements in molecular tools for diagnosis and management of HIV infections
1999 StandoutNobel
Neutrophils in cancer: neutral no more
2016 Standout
Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis
2006
Alternative Macrophage Activation Is Essential for Survival during Schistosomiasis and Downmodulates T Helper 1 Responses and Immunopathology
2004
Delineation of Diverse Macrophage Activation Programs in Response to Intracellular Parasites and Cytokines
2010
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Chronic helminth infections modulate allergen‐specific immune responses: Protection against development of allergic disorders?
2007
Alternatively activated macrophages in protozoan infections
2007
Two ways to survive infection: what resistance and tolerance can teach us about treating infectious diseases
2008
Cationic Amino Acid Transporter-2 Regulates Immunity by Modulating Arginase Activity
2008
Helminth infections: the great neglected tropical diseases
2008 Standout
SHIP Represses the Generation of Alternatively Activated Macrophages
2005
INTERACTIONS BETWEEN MACROPARASITES AND MICROPARASITES DRIVE INFECTION PATTERNS IN FREE-RANGING AFRICAN BUFFALO
2008
Exploring the full spectrum of macrophage activation
2008 Standout
Cancer-related inflammation: Common themes and therapeutic opportunities
2011
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
2006 Standout
Alternative activation of macrophages
2003 Standout
Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease
2001
Adipose tissue macrophages
2007
Microglial Corpse Clearance: Lessons From Macrophages
2020
Metchnikoff's policemen: macrophages in development, homeostasis and regeneration
2011
Leishmaniasis
1999 Standout
Control of adaptive immunity by the innate immune system
2015 Standout
Imaging macrophages with nanoparticles
2014
Nrf2, the Master Regulator of Anti-Oxidative Responses
2017
Toll-Like Receptor 7 Mediates Early Innate Immune Responses to Malaria
2013
Type I IL-4Rs Selectively Activate IRS-2 to Induce Target Gene Expression in Macrophages
2008
Control of Macrophage Activation and Function by PPARs
2010
Recombination in theompAGene but Not theomcBGene ofChlamydiaContributes to Serovar-Specific Differences in Tissue Tropism, Immune Surveillance, and Persistence of the Organism
2001
IL-31–IL-31R interactions negatively regulate type 2 inflammation in the lung
2007
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Modulation of host immune responses by nematode cystatins
2003
Novel Effector Molecules in Type 2 Inflammation: Lessons Drawn from Helminth Infection and Allergy
2006
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Biochemical and functional characterization of three activated macrophage populations
2006
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
T reg cells limit IFN-γ production to control macrophage accrual and phenotype during skeletal muscle regeneration
2018
B7x in the Periphery Abrogates Pancreas-Specific Damage Mediated by Self-reactive CD8 T Cells
2012 StandoutNobel
Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences
2005
Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting
2014
Eotaxin Is Specifically Cleaved by Hookworm Metalloproteases Preventing Its Action In Vitro and In Vivo
2000
IL-4 suppresses osteoclast development and mature osteoclast function by a STAT6-dependent mechanism: irreversible inhibition of the differentiation program activated by RANKL
2003
Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages
2002
Obstacles and opportunities for understanding macrophage polarization
2011
Reactive Oxygen Species and 12/15-Lipoxygenase Contribute to the Antiproliferative Capacity of Alternatively Activated Myeloid Cells Elicited during Helminth Infection
2005
Alternatively activated macrophage-derived RELM-α is a negative regulator of type 2 inflammation in the lung
2009
Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor
2013 StandoutNobel
Epidemiology of Plasmodium-Helminth Co-Infection in Africa: Populations at Risk, Potential Impact on Anemia, and Prospects for Combining Control
2007
Immunopathology of schistosomiasis
2006
Innate Immune Responses to Lung-Stage Helminth Infection Induce Alternatively Activated Alveolar Macrophages
2006
CD4+regulatory cells as a potential immunotherapy
2005 StandoutNobel
Alternative Activation of Macrophages: An Immunologic Functional Perspective
2008 Standout
Single-nanometer iron oxide nanoparticles as tissue-permeable MRI contrast agents
2021 StandoutNobel
Disease Tolerance as a Defense Strategy
2012 StandoutScience
Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway
2005
Plenary Perspective: The complexity of constitutive and inducible gene expression in mononuclear phagocytes
2012
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion
2009
Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1β System by IL-13
2005
Wound Healing: A Cellular Perspective
2018 Standout
Of Mice and Not Men: Differences between Mouse and Human Immunology
2004 Standout
Chronic Helminth Infection Induces Alternatively Activated Macrophages Expressing High Levels of CCR5 with Low Interleukin-12 Production and Th2-Biasing Ability
2002
Arginase and polyamine synthesis are key factors in the regulation of experimental leishmaniasis in vivo
2005
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Decomposing health: tolerance and resistance to parasites in animals
2008
Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase
2015 StandoutNobel
A Secreted Protein from the Human Hookworm Necator americanus Binds Selectively to NK Cells and Induces IFN-γ Production
2004
On the conservative nature of intragenic recombination
2005 StandoutNobel
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
Repositioning of an existing drug for the neglected tropical disease Onchocerciasis
2010
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
Host-Pathogen Interactions: Redefining the Basic Concepts of Virulence and Pathogenicity
1999
Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages
2011
Alternatively activated macrophages derived from THP‐1 cells promote the fibrogenic activities of human dermal fibroblasts
2017
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Host Cytokine Production, Lymphoproliferation, and Antibody Responses during the Course of Ancylostoma ceylanicum Infection in the Golden Syrian Hamster
2005
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
2009
Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis
2015
Alternative Macrophage Activation and Metabolism
2011
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Judith E. Allen being referenced
Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of T H 2 Inflammation
2011 Science
Chitinase and Fizz Family Members Are a Generalized Feature of Nematode Infection with Selective Upregulation of Ym1 and Fizz1 by Antigen-Presenting Cells
2004
Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection
2005 StandoutNobel
Removal of Regulatory T Cell Activity Reverses Hyporesponsiveness and Leads to Filarial Parasite Clearance In Vivo
2005
Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function
2011
Alternative Activation Is an Innate Response to Injury That Requires CD4+ T Cells to be Sustained during Chronic Infection
2007 StandoutNobel
IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype
2002
Interferon γ suppresses glucocorticoid augmentation of macrophage clearance of apoptotic cells
2004
Macrophages in chronic type 2 inflammation have a novel phenotype characterized by the abundant expression of Ym1 and Fizz1 that can be partly replicated in vitro
2003
Divergent roles for macrophages in lymphatic filariasis
2001
APC from mice harbouring the filarial nematode, Brugia malayi, prevent cellular proliferation but not cytokine production
1996
Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage
2014
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths
2013
Evolution of Th2 Immunity: A Rapid Repair Response to Tissue Destructive Pathogens
2011
Malaria‐Filaria Coinfection in Mice Makes Malarial Disease More Severe unless Filarial Infection Achieves Patency
2005
Of Mice, Cattle, and Humans: The Immunology and Treatment of River Blindness
2008
Tissue-resident macrophages
2013 Standout
Chitinases and chitinase‐like proteins: potential therapeutic targets for the treatment of T‐helper type 2 allergies
2009
Blockade of TNF receptor 1 reduces disease severity but increases parasite transmission during Plasmodium chabaudi chabaudi infection
2007
Early recruitment of natural CD4+Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection
2008
Th1-Th2: Reliable paradigm or dangerous dogma?
1997
Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation
2013
Helminth parasites – masters of regulation
2004 Standout
Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell-to-cell contact
2000
Transmission of Human Immunodeficiency Virus (HIV) by Blood Transfusions Screened as Negative for HIV Antibody
1988
Tissue-specific contribution of macrophages to wound healing
2016
Co‐infected C57BL/6 mice mount appropriately polarized and compartmentalized cytokine responses to Litomosoides sigmodontis and Leishmania major but disease progression is altered
2005
Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair
2015
Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin
2014
Profound suppression of cellular proliferation mediated by the secretions of nematodes
1998
Immunology of Human Helminth Infection
1996
Suppressive Antigen-Presenting Cells in Helminth Infection
1999
Antigen‐presenting cells recruited by Brugia malayi induce Th2 differentiation of naïve CD4 + T cells
2000
Both Free-Living and Parasitic Nematodes Induce a Characteristic Th2 Response That Is Dependent on the Presence of Intact Glycans
2003
A single peptide from the major outer membrane protein of Chlamydia trachomatis elicits T cell help for the production of antibodies to protective determinants
1991
Analysis of Genes Expressed at the Infective Larval Stage Validates Utility of Litomosoides sigmodontis as a Murine Model for Filarial Vaccine Development
2000
Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct
2014
Similarity and Diversity in Macrophage Activation by Nematodes, Trematodes, and Cestodes
2010
F4/80+ Alternatively Activated Macrophages Control CD4+ T Cell Hyporesponsiveness at Sites Peripheral to Filarial Infection
2006
Evolutionary Causes and Consequences of Immunopathology
2005
The Abundant Larval Transcript-1 and -2 Genes ofBrugia malayiEncode Stage-Specific Candidate Vaccine Antigens for Filariasis
2000
Murine gammaherpesvirus-induced fibrosis is associated with the development of alternatively activated macrophages
2008
Infection of IL-4-deficient mice with the parasitic nematode Brugia malayi demonstrates that host resistance is not dependent on a T helper 2-dominated immune response.
1995
Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells
2006
Immune specificity of murine T-cell lines to the major outer membrane protein of Chlamydia trachomatis
1992
IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1
2013
ABrugia malayiHomolog of Macrophage Migration Inhibitory Factor Reveals an Important Link Between Macrophages and Eosinophil Recruitment During Nematode Infection
2001
Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing
2009
Requirement for In Vivo Production of IL-4, But Not IL-10, in the Induction of Proliferative Suppression by Filarial Parasites
1998
Identification by sequence analysis of two-site posttranslational processing of the cysteine-rich outer membrane protein 2 of Chlamydia trachomatis serovar L2
1989
Alternatively activated dendritic cells regulate CD4+T-cell polarization in vitro and in vivo
2012