Standout Papers
Citation Impact
Citing Papers
Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila
1995 Science
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
2002 StandoutScience
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
2002 StandoutScience
The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughterless/achaete-scute protein complexes
1991
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain
1996
The Bearded box, a novel 3′ UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression
1997
Specificity of embryonic lethal mutations in Drosophila analyzed in germ line clones
1986 StandoutNobel
MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex
1997
Correlative changes in homoeotic and segmentation gene expression in Krüppel mutant embryos of Drosophila
1986
Parkin Facilitates the Elimination of Expanded Polyglutamine Proteins and Leads to Preservation of Proteasome Function
2003
A model for extradenticle function as a switch that changes HOX proteins from repressors to activators
1997
Structure of a DNA-bound Ultrabithorax–Extradenticle homeodomain complex
1999 Nature
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
A Model for the Cooperative Binding of Eukaryotic Regulatory Proteins to Nucleosomal Target Sites
1996
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
1984 StandoutNobel
T1/ST2 Signaling Establishes It as a Member of an Expanding Interleukin-1 Receptor Family
1996
Homeodomain Proteins: Cooperating to be different
1995
The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences.
1993
Hox proteins meet more partners
1998
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
The UCH-L1 Gene Encodes Two Opposing Enzymatic Activities that Affect α-Synuclein Degradation and Parkinson's Disease Susceptibility
2002
RSC, an Essential, Abundant Chromatin-Remodeling Complex
1996 StandoutNobel
Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm.
1995
Community effects and related phenomena in development
1993 StandoutNobel
Pbx1-Hox Heterodimers Bind DNA on Inseparable Half-Sites That Permit Intrinsic DNA Binding Specificity of the Hox Partner at Nucleotides 3' to a TAAT Motif
1996
SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein
2001
Proteasome inhibition by paired helical filament‐tau in brains of patients with Alzheimer's disease
2003
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
1999 Nature
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Homeobox genes: Their function in Drosophila segmentation and pattern formation
1994
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
1984 StandoutNobel
Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
2001 StandoutNobel
The specificity of homeotic gene function
1995
brahma: A regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2SWI2
1992
Molecular genetics of Drosophila immunity
1994
Molecular and Genetic Organization of The Antennapedia Gene Complex of Drosophila melanogaster
1990
Nuclear Translocation of Extradenticle Requires , which Encodes an Extradenticle-Related Homeodomain Protein
1997
Transcriptional activation and repression by Ultrabithorax proteins in cultured Drosophila cells
1989
Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA
1999
PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
Drosophila innate immunity: an evolutionary perspective
2002 StandoutNobel
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3
1995 StandoutNatureNobel
The immune response of Drosophila
2003 StandoutNatureNobel
A homeotic gene cluster patterns the anteroposterior body axis of C. elegans
1993
The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity
1998
Independent evolution of Toll and related genes in insects and mammals
2000
Induction and regulation of antimicrobial peptides in Drosophila
1999
Toll receptors in innate immunity
2001 StandoutNobel
Patterning C. elegans: homeotic cluster genes, cell fates and cell migrations
1994
Structural and functional diversity in the leucine-rich repeat family of proteins
1996
Intranuclear ataxin1 inclusions contain both fast- and slow-exchanging components
2002
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
1995 StandoutNobel
The Antimicrobial Host Defense of Drosophila
2000 StandoutNobel
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner
1988 StandoutNobel
C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia
1994 StandoutNobel
Homeodomain-DNA recognition
1994 StandoutNobel
The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense
1997
A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
1989 StandoutNobel
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Functional dissection of ultrabithorax proteins in D. melanogaster
1990
Cellular Defenses against Unfolded Proteins
2001
The Toll-receptor family and control of innate immunity
1999
Tissue and stage-specific expression of the Tolls in Drosophila embryos
2002 StandoutNobel
A gradient of bicoid protein in Drosophila embryos
1988 StandoutNobel
Transcriptional abnormalities in Huntington disease
2003
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation
1999
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
Functional differences between HOX proteins conferred by two residues in the homeodomain N-terminal arm.
1994
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Drosophila immunity
1997
Functional similarity in appendage specification by the Ultrabithorax and abdominal-A Drosophila HOX genes.
1996
Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity
1993
Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex
1999
Extradenticle protein is a selective cofactor for the Drosophila homeotics: role of the homeodomain and YPWM amino acid motif in the interaction.
1995
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Of Flies and Fishes
1994 StandoutScienceNobel
The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling
1998
Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
2002
Extra specificity from extradenticle: the partnership between HOX and PBX/EXD homeodomain proteins
1996
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia
2001
Cloning and Characterization of Two Toll/Interleukin-1 Receptor–Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans
1998
Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila
2010 StandoutNobel
Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins
2000
Organization of anterior pattern in the Drosophila embryo by the maternal gene bicoid
1986 StandoutNatureNobel
Plasticity of the Differentiated State
1985 Science
Differentiation requires continuous regulation.
1991 Nobel
The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins.
1994
Coordinate regulation of downstream genes by extradenticle and the homeotic selector proteins.
1994 StandoutNobel
Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity
1997
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
abdA expression in Drosophila embryos.
1990
extradenticle determines segmental identities throughout Drosophila development
1995 StandoutNobel
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube
1998
Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product
1985 StandoutNobel
The abdominal region of the bithorax complex
1985
Determination of Anteroposterior Polarity in Drosophila
1987 StandoutScienceNobel
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins.
1995
A family of human receptors structurally related to Drosophila Toll
1998 Standout
Deformed protein binding sites and cofactor binding sites are required for the function of a small segment-specific regulatory element in Drosophila embryos.
1994
Body-Wall Muscle Formation in Caenorhabditis elegans Embryos that Lack the MyoD Homolog hlh-1
1992 StandoutScienceNobel
The large upstream control region of the Drosophila homeotic gene Ultrabithorax
1991
dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS
1998
Requirements for autosomal gene activity during precellular stages of Drosophila melanogaster
1988 StandoutNobel
Overlapping roles of two Hox genes and theexdorthologceh-20in diversification of theC. eleganspostembryonic mesoderm
2000 StandoutNobel
Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm
1994
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Expression of Abdominal-B homeoproteins in Drosophila embryos
1990
Parasegments and compartments in the Drosophila embryo
1985 Nature
Nematode homeobox cluster
1991 StandoutNatureNobel
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.
1991
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Control of Drosophila adult pattern by extradenticle
1995
Impairment of the Ubiquitin-Proteasome System by Protein Aggregation
2001 StandoutScience
Works of Juan Botas being referenced
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
Genetic interactions between the Polycomb locus and the Antennapedia and Bithorax complexes of Drosophila
1986
Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis
1994
Control of morphogenesis and differentiation by HOM/Hox genes
1993
Identification of genes that modify ataxin-1-induced neurodegeneration
2000 Nature
Chromosomal binding sites of Ultrabithorax homeotic proteins
1996
Mouse and fly models of neurodegeneration
2002
The DNA binding specificity of ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
1994
Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less
1992
The reinforcement-extinction process of selector gene activity: a positive feed-back loop and cell-cell interactions in Ultrabithorax patterning
1988
Distribution of Ultrabithorax proteins in mutants of Drosophila bithorax complex and its transregulatory genes
1985 Nature
Negative autoregulation by Ultrabithorax controls the level and pattern of its expression
1993
Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth
1998
The effect of aneuploidy on embryonic development in Drosophila melanogaster
1983
Gene-dose titration analysis in the search of trans-regulatory genes in Drosophila.
1982
Homeotic transformations of the abdominal segments ofDrosophilacaused by breaking or deleting a central portion of the bithorax complex
1983
The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll
1994