Standout Papers
Citation Impact
Citing Papers
Role of Sec61p in the ER-associated degradation of short-lived transmembrane proteins
2008 StandoutNobel
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
TROSY-NMR reveals interaction between ERp57 and the tip of the calreticulin P-domain
2002 StandoutNobel
Fusion of Cells by Flipped SNAREs
2003 StandoutScienceNobel
Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System
2007
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001 StandoutNature
Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system
2000
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
2002 StandoutNature
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Endoproteolytic Cleavage and Proteasomal Degradation of Presenilin 2 in Transfected Cells
1997
Endoplasmic Reticulum (ER)-associated Degradation of Misfolded N-Linked Glycoproteins Is Suppressed upon Inhibition of ER Mannosidase I
2000
ER protein quality control and proteasome-mediated protein degradation
1999
The nature of the MHC class I peptide loading complex
1999
Distinct Machinery Is Required in Saccharomyces cerevisiae for the Endoplasmic Reticulum-associated Degradation of a Multispanning Membrane Protein and a Soluble Luminal Protein
2004
Endoplasmic Reticulum Degradation of a Mutated ATP-binding Cassette Transporter Pdr5 Proceeds in a Concerted Action of Sec61 and the Proteasome
1998
Molecular Mechanism of Membrane Protein Integration into the Endoplasmic Reticulum
1997
Architecture of the Protein-Conducting Channel Associated with the Translating 80S Ribosome
2001 StandoutNobel
Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants
1998 Nobel
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
The Degradation of Apolipoprotein B100 Is Mediated by the Ubiquitin-proteasome Pathway and Involves Heat Shock Protein 70
1997 StandoutNobel
Proteasome inhibitors and antigen presentation
1997
The Engagement of Sec61p in the ER Dislocation Process
1999 StandoutNobel
Protein Unfolding Is Not a Prerequisite for Endoplasmic Reticulum-to-Cytosol Dislocation
2003
HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C
1998 StandoutNature
Active Site-directed Inhibitors of Rhodococcus 20 S Proteasome
1997
Cytosolic Degradation of T-cell Receptor α Chains by the Proteasome
1997
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
2001 Nature
Autoubiquitination of the Hrd1 Ligase Triggers Protein Retrotranslocation in ERAD
2016
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Retrotranslocation of a Misfolded Luminal ER Protein by the Ubiquitin-Ligase Hrd1p
2010
Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
1997
Endoplasmic reticulum-associated protein degradation
2000
The α Chain of the T Cell Antigen Receptor Is Degraded in the Cytosol
1997
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
2002 StandoutNature
Peroxisomal protein import and ERAD: variations on a common theme
2010
Molecular architecture of the ER translocase probed by chemical crosslinking of Sss1p to complementary fragments of Sec61p
1997
The class I MHC homologue of human cytomegalovirus inhibits attack by natural killer cells
1997 Nature
Folding of Secretory and Membrane Proteins
1998
Structure of the E. coli protein-conducting channel bound to a translating ribosome
2005 StandoutNatureNobel
Caspase Functions in Cell Death and Disease
2013 Standout
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48
2002
Exogenous antigens are processed through the endoplasmic reticulum-associated degradation (ERAD) in cross-presentation by dendritic cells
2004
Polyubiquitin Serves as a Recognition Signal, Rather than a Ratcheting Molecule, during Retrotranslocation of Proteins across the Endoplasmic Reticulum Membrane
2003
ER Quality Control: The Cytoplasmic Connection
1997
A Role for the Endoplasmic Reticulum Protein Retrotranslocation Machinery during Crosspresentation by Dendritic Cells
2006
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Protein dislocation from the ER
2010
Cleaning up in the endoplasmic reticulum: ubiquitin in charge
2014
Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: β2‐microglobulin inactivation in MSI‐positive tumors and LMP7/TAP2 downregulation in MSI‐negative tumors
2003
The protein translocation channel binds proteasomes to the endoplasmic reticulum membrane
2005
The Mechanism Underlying Cystic Fibrosis Transmembrane Conductance Regulator Transport from the Endoplasmic Reticulum to the Proteasome Includes Sec61β and a Cytosolic, Deglycosylated Intermediary
1998
Retrograde protein translocation: ERADication of secretory proteins in health and disease
1999
Cross‐presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
2004
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
Protein degradation: The ins and outs of the matter
1997
A membrane protein required for dislocation of misfolded proteins from the ER
2004 Nature
ERAD: the long road to destruction
2005
Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation
2000 Standout
The Aqueous Pore through the Translocon Has a Diameter of 40–60 Å during Cotranslational Protein Translocation at the ER Membrane
1997
ER-associated degradation in protein quality control and cellular regulation
2002
Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation
1997 Nature
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
A genetically humanized mouse model for hepatitis C virus infection
2011 StandoutNatureNobel
Regulated Co-translational Ubiquitination of Apolipoprotein B100
1998
Role of the proteasome in membrane extraction of a short-lived ER-transmembrane protein
1998
Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin
2001
Global quantification of mammalian gene expression control
2011 StandoutNature
The ubiquitin system
1997
Oligosaccharide Modification in the Early Secretory Pathway Directs the Selection of a Misfolded Glycoprotein for Degradation by the Proteasome
1999
Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor
1999
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
2008 StandoutNature
Protein Translocation: Tunnel Vision
1998
Regulating protein degradation by ubiquitination
1997
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Ubiquitination Is Required for the Retro-translocation of a Short-lived Luminal Endoplasmic Reticulum Glycoprotein to the Cytosol for Degradation by the Proteasome
1998
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
2009 StandoutNature
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
2004 Nature
A regulatory link between ER-associated protein degradation and the unfolded-protein response.
2000
Aggresomes: A Cellular Response to Misfolded Proteins
1998 Standout
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
The Class I Antigen-processing Pathway for the Membrane Protein Tyrosinase Involves Translation in the Endoplasmic Reticulum and Processing in the Cytosol
1998
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 + T cells in a spectrum of human MHC I haplotypes
2007 StandoutNobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells
1997
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
Probing the SecYEG translocation pore size with preproteins conjugated with sizable rigid spherical molecules
2011 StandoutNobel
ER-associated and proteasomemediated protein degradation: how two topologically restricted events came together
1997
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane
2005
The Pathway of Us11-Dependent Degradation of Mhc Class I Heavy Chains Involves a Ubiquitin-Conjugated Intermediate
1999
Setting the Standards: Quality Control in the Secretory Pathway
1999 Science
Endoplasmic reticulum degradation: reverse protein flow of no return
1997
Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors
1997
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Novel Aspects of Degradation of T Cell Receptor Subunits from the Endoplasmic Reticulum (ER) in T Cells: Importance of Oligosaccharide Processing, Ubiquitination, and Proteasome-dependent Removal from ER Membranes
1998 StandoutNobel
The Conserved Npl4 Protein Complex Mediates Proteasome-dependent Membrane-bound Transcription Factor Activation
2001
Intracellular Functions of N-Linked Glycans
2001 StandoutScience
Cholera Toxin Is Exported from Microsomes by the Sec61p Complex
2000
The Translocon: A Dynamic Gateway at the ER Membrane
1999
Processing of Human Cytomegalovirus UL37 Mutant Glycoproteins in the Endoplasmic Reticulum Lumen prior to Mitochondrial Importation
2006
UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS
1998
The ubiquitin-proteasome pathway: on protein death and cell life
1998 StandoutNobel
Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation
2005
Der3p/Hrd1p Is Required for Endoplasmic Reticulum-associated Degradation of Misfolded Lumenal and Integral Membrane Proteins
1998
Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence
1998
Hepatitis C Virus Envelope Glycoprotein E1 Originates in the Endoplasmic Reticulum and Requires Cytoplasmic Processing for Presentation by Class I MHC Molecules
1999 StandoutNobel
Neoantigens in cancer immunotherapy
2015 StandoutScience
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
1998
Alignment of Conduits for the Nascent Polypeptide Chain in the Ribosome-Sec61 Complex
1997 StandoutScienceNobel
Dendritic cell targeted HIV gag protein vaccine provides help to a DNA vaccine including mobilization of protective CD8 + T cells
2010 StandoutNobel
Sec61p Serves Multiple Roles in Secretory Precursor Binding and Translocation into the Endoplasmic Reticulum Membrane
1998 StandoutNobel
Introduction of a Glycosylation Site into a Secreted Protein Provides Evidence for an Alternative Antigen Processing Pathway: Transport of Precursors of Major Histocompatability Complex Class I–Restricted Peptides from the Endoplasmic Reticulum to the Cytosol
1997
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Noncytolytic Control of Viral Infections by the Innate and Adaptive ImmuneResponse
2001
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
Biosynthesis and Degradation of CFTR
1999
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Works of Joyce E. Yu being referenced
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
1996 StandoutNature
Neonatal-Onset Multisystem Inflammatory Disease Responsive to Interleukin-1β Inhibition
2007