Citation Impact
Citing Papers
CRISPR–Cas9 Structures and Mechanisms
2017 StandoutNobel
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
A genomic region associated with protection against severe COVID-19 is inherited from Neandertals
2021 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Systematic mapping of functional enhancer–promoter connections with CRISPR interference
2016 Science
VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data
2020 StandoutNobel
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage
2022 StandoutNobel
CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing
2017 StandoutNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
2020
Reading the glyco-code: New approaches to studying protein–carbohydrate interactions
2022 StandoutNobel
Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals
2016
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
An Expanded View of Complex Traits: From Polygenic to Omnigenic
2017 Standout
Siglec-mediated regulation of immune cell function in disease
2014
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level
2017
Untangling Genetic Risk for Alzheimer’s Disease
2017
A view on drug resistance in cancer
2019 StandoutNature
Genetic effects on gene expression across human tissues
2017 StandoutNature
Neuropathological correlates and genetic architecture of microglial activation in elderly human brain
2019
Different molecular complexes that mediate transcriptional induction and repression by FoxP3
2017
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Associations of genetic polymorphisms of Siglecs with human diseases
2014
DNA recognition by an RNA-guided bacterial Argonaute
2017 StandoutNobel
Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits
2017
Hallmarks of aging: An expanding universe
2023 Standout
Germinal Center and Extrafollicular B Cell Responses in Vaccination, Immunity, and Autoimmunity
2020
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
2016
CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions
2018 StandoutNobel
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
Diverse partial reprogramming strategies restore youthful gene expression and transiently suppress cell identity
2022
Natural selection and infectious disease in human populations
2014
The role of regulatory variation in complex traits and disease
2015
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
2016
Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
2018
Confirmation of five novel susceptibility loci for Systemic Lupus Erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci
2017
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Dendritic cells in cancer immunology
2021
Drug delivery systems for RNA therapeutics
2022
CRISPR/Cas9-Based Engineering of the Epigenome
2017
Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting
2017
Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches
2015
A transcriptomic atlas of aged human microglia
2018
Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity
2018
Genome-wide analysis reveals specificities of Cpf1 endonucleases in human cells
2016
The major genetic risk factor for severe COVID-19 is inherited from Neanderthals
2020 StandoutNatureNobel
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
2018 Standout
Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy
2018 StandoutNobel
Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity
2024 StandoutNobel
A new era in functional genomics screens
2021
Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing
2017
Genetics of Alzheimer’s Disease
2014
Synthetic lethality and cancer
2017
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
The Current State and Future of CRISPR-Cas9 gRNA Design Tools
2018
Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases
2020 StandoutNobel
Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response
2018
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease
2019
Mapping the multiscale structure of biological systems
2021
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
2017 Standout
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
2019 StandoutNobel
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
2020 StandoutNobel
Siglecs as Immune Cell Checkpoints in Disease
2020
Regulatory T Cells and Human Disease
2020 StandoutNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226
2015
Inflammation as a central mechanism in Alzheimer's disease
2018 Standout
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Genetic and epigenetic variation in the lineage specification of regulatory T cells
2015
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function
2016 StandoutNobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
2022 Standout
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Religious Orders Study and Rush Memory and Aging Project
2018 Standout
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Epigenetic Reprogramming in Naive CD4+ T Cells Favoring T Cell Activation and Non‐Th1 Effector T Cell Immune Response as an Early Event in Lupus Flares
2016
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Alzheimer's disease‐associated TREM2 variants exhibit either decreased or increased ligand‐dependent activation
2016
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape
2017
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
2016
Works of Joseph M. Replogle being referenced
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
2019 Science
Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing
2020
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
2015
Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection
2013
CD33 modulates TREM2: convergence of Alzheimer loci
2015
Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing
2021
CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility
2013
Interindividual variation in human T regulatory cells
2014
A TREM 1 variant alters the accumulation of Alzheimer‐related amyloid pathology
2014
Trans -pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci
2016
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
2016
A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants
2017