Standout Papers
Citation Impact
Citing Papers
Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death
2015
Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome
2013
Nonshivering thermogenesis and its adequate measurement in metabolic studies
2010
ER Tubules Mark Sites of Mitochondrial Division
2011 StandoutScience
Cold-Activated Brown Adipose Tissue in Healthy Men
2009 Standout
Energy Expenditure and Adaptive Responses to an Acute Hypercaloric Fat Load in Humans with Lipodystrophy
2005
BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis
2017
Sirtuins as regulators of metabolism and healthspan
2012 Standout
EBF2 Determines and Maintains Brown Adipocyte Identity
2013
SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling
2014
The TGR5 gene is expressed in human subcutaneous adipose tissue and is associated with obesity, weight loss and resting metabolic rate
2013
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
2015
Further Support to the Uncoupling-to-Survive Theory: The Genetic Variation of Human UCP Genes Is Associated with Longevity
2011
An Expanded View of Complex Traits: From Polygenic to Omnigenic
2017 Standout
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
2022
Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs
2013
Mitochondrial uncoupling and lifespan
2010
Brown and Beige Fat: Physiological Roles beyond Heat Generation
2015
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Recruited brown adipose tissue as an antiobesity agent in humans
2013
Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis
2014
Adipose tissue browning and metabolic health
2013
A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans
2013
Human Skeletal Muscle Mitochondrial Uncoupling Is Associated with Cold Induced Adaptive Thermogenesis
2008
Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat
2015
MicroRNA networks regulate development of brown adipocytes
2013
Brown and beige fat: development, function and therapeutic potential
2013 Standout
Loss of the RNA polymerase III repressor MAF1 confers obesity resistance
2015
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
Interventions for Human Frailty: Physical Activity as a Model
2016
Chronic inflammation in the etiology of disease across the life span
2019 Standout
Human Uncoupling Protein‐3 and Obesity: An Update
2003
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Pharmacological and nutritional agents promoting browning of white adipose tissue
2012
Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes
2015
Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
2016
Evidence for two types of brown adipose tissue in humans
2013
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
2013 Nature
Is mitochondrial dysfunction a cause of insulin resistance?
2008
Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis
2020
Hallmarks of aging: An expanding universe
2023 Standout
Opposite effects of pioglitazone and rosiglitazone on mitochondrial respiration in skeletal muscle of patients with type 2 diabetes
2010
Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
2013
System-wide Benefits of Intermeal Fasting by Autophagy
2017
Treatment of Obesity with Celastrol
2015 Standout
The Human Transcription Factors
2018 Standout
Uncoupling protein-1 is not leaky
2010
Sarcopenic obesity: Time to meet the challenge
2018
Axis of ageing: telomeres, p53 and mitochondria
2012
Random Point Mutations with Major Effects on Protein-Coding Genes Are the Driving Force behind Premature Aging in mtDNA Mutator Mice
2009
Medium‐Chain Fatty Acids Attenuate Agonist‐Stimulated Lipolysis, Mimicking the Effects of Starvation
2004
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
Mild Cold Exposure Modulates Fibroblast Growth Factor 21 (FGF21) Diurnal Rhythm in Humans: Relationship between FGF21 Levels, Lipolysis, and Cold-Induced Thermogenesis
2012
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues
2016
Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart
2008
The mitochondrial uncoupling-protein homologues
2005
Mechanisms of NAFLD development and therapeutic strategies
2018 Standout
High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria
2008
Metazoan MicroRNAs
2018 Standout
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Tracking adipogenesis during white adipose tissue development, expansion and regeneration
2013
Control of brown and beige fat development
2016
The different shades of fat
2014 Nature
MyomiR-133 regulates brown fat differentiation through Prdm16
2012
Chronic cold exposure results in subcutaneous adipose tissue browning and altered global metabolism in Qinghai-Tibetan plateau pika (Ochotona curzoniae)
2018 StandoutNobel
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
2018 StandoutNobel
Sarcopenia
2019 Standout
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
2017
Key proteins and pathways that regulate lifespan
2017
Mitochondrial dysfunction in COPD patients with low body mass index
2006
Frailty: implications for clinical practice and public health
2019 Standout
Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity
2013
The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice
2015
PPARγ signaling and metabolism: the good, the bad and the future
2013 Standout
Functional mapping and annotation of genetic associations with FUMA
2017 Standout
Understanding the brown adipocyte as a contributor to energy homeostasis
2013
Mechanisms of insulin resistance related to white, beige, and brown adipocytes
2020
Adaptive thermogenesis in adipocytes: Is beige the new brown?
2013
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
The role of mitochondria in health and disease
2009
Accumulation of succinate controls activation of adipose tissue thermogenesis
2018 Nature
Mechanisms of fatty acid-induced inhibition of glucose uptake.
1994 Standout
Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak
2012
Myogenin Regulates Exercise Capacity and Skeletal Muscle Metabolism in the Adult Mouse
2010
What We Talk About When We Talk About Fat
2014 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
UCP1 deficiency increases susceptibility to diet‐induced obesity with age
2005
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
2016 Standout
Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells
2012
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
2013
Effects of chronic activation of peroxisome proliferator-activated receptor-α or high-fat feeding in a rat infarct model of heart failure
2005
Adiponectin Regulation and Function
2018
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Caloric restriction mimetics: towards a molecular definition
2014
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
2012
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
The Hallmarks of Aging
2013 Standout
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
The PI3K Pathway in Human Disease
2017 Standout
IRF4 Is a Key Thermogenic Transcriptional Partner of PGC-1α
2014
Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet
2019
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
2015
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance
2012
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
2016 StandoutNobel
Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins
2019
Bi-directional interconversion of brite and white adipocytes
2013
miR-133a Regulates Adipocyte Browning In Vivo
2013
Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats
2010
Mitochondrial Uncoupling Proteins: Subtle Regulators of Cellular Redox SignalingReviewing Editors: Jerzy Beltowski, Joseph Burgoyne, Gabor Csanyi, Sergey Dikalov, Frank Krause, Anibal Vercesi, and Jeremy Ward
2018
Mitochondrial Dynamics in Diabetes
2010
Pathogenesis of Insulin Resistance in Skeletal Muscle
2010
Brown Adipose Tissue in Adult Humans: A Metabolic Renaissance
2013
Brown Adipose Tissue Growth and Development
2013
Individual Thermogenic Responses to Mild Cold and Overfeeding Are Closely Related
2007
Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+
1995 Standout
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria
2012
Myocardial Fatty Acid Metabolism in Health and Disease
2010 Standout
Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure
2014
SUMO-1 Regulates Body Weight and Adipogenesis via PPARγ in Male and Female Mice
2012
Importance of Assessing Cardiorespiratory Fitness in Clinical Practice: A Case for Fitness as a Clinical Vital Sign: A Scientific Statement From the American Heart Association
2016 Standout
Brown and Beige Fat: Molecular Parts of a Thermogenic Machine
2015
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
2014 Standout
Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
2017
Fiber Types in Mammalian Skeletal Muscles
2011 Standout
Pathophysiology of Type 2 Diabetes Mellitus
2020 Standout
Anatomical Locations of Human Brown Adipose Tissue
2013
Spermidine in health and disease
2018 StandoutScience
Uncoupling proteins and the control of mitochondrial reactive oxygen species production
2011
Organ-Specific Physiological Responses to Acute Physical Exercise and Long-Term Training in Humans
2014
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
2021 Science
Alterations in Glutathione Redox Metabolism, Oxidative Stress, and Mitochondrial Function in the Left Ventricle of Elderly Zucker Diabetic Fatty Rat Heart
2012
Thyroid Hormone Regulation of Metabolism
2014 Standout
Mitochondria-Targeted Drugs
2018
Mitochondrial Energetics in the Heart in Obesity-Related Diabetes
2007
Brown Fat Activation Mediates Cold-Induced Thermogenesis in Adult Humans in Response to a Mild Decrease in Ambient Temperature
2013
Mechanisms of Diabetic Complications
2013 Standout
An endocrine role for brown adipose tissue?
2013
Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle
2011
Plasma Free Fatty Acids and Peroxisome Proliferator–Activated Receptor α in the Control of Myocardial Uncoupling Protein Levels
2005
Implications of nonshivering thermogenesis for energy balance regulation in humans
2011
On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury
2016 StandoutNobel
Mitochondrial and metabolic dysfunction in ageing and age-related diseases
2022
AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity
2012
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
PPARγ activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1α and D2
2012
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Mitochondrial dysfunction and insulin resistance: an update
2014
Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues
2017
Fat cells directly sense temperature to activate thermogenesis
2013
Exploring the therapeutic space around NAD+
2012
Uncoupling proteins: Martin Klingenberg's contributions for 40 years
2018
Works of Joris Hoeks being referenced
High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance
2012
UCP1 and Defense against Oxidative Stress
2006
Effect of β1- and β2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans
2003
Adaptations in Mitochondrial Function Parallel, but Fail to Rescue, the Transition to Severe Hyperglycemia and Hyperinsulinemia: A Study in Zucker Diabetic Fatty Rats
2009
Mitochondrial function, content and ROS production in rat skeletal muscle: Effect of high‐fat feeding
2008
Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice
2012
Increase in Brown Adipose Tissue Activity after Weight Loss in Morbidly Obese Subjects
2012
Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue
2017
Putative function and physiological relevance of the mitochondrial uncoupling protein-3: Involvement in fatty acid metabolism?
2005
Short-term increase of plasma free fatty acids does not interfere with intrinsic mitochondrial function in healthy young men
2011
Glucose uptake in human brown adipose tissue is impaired upon fasting-induced insulin resistance
2014
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
2012 Standout
Mitochondrial dysfunction and lipotoxicity
2009
Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
2015
The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice
2008
Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism
2007
Significance of uncoupling protein 3 in mitochondrial function upon mid- and long-term dietary high-fat exposure
2011
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
2011
Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice
2011
Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids
2006
Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function
2021
Differential response of UCP3 to medium versus long chain triacylglycerols; manifestation of a functional adaptation
2003
Cold tolerance of UCP1-ablated mice: A skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects
2010
Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans
2020
Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
2013
Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease
2016
Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance
2010
Increased Oxygen Consumption in Human Adipose Tissue From the “Brown Adipose Tissue” Region
2013
High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII
2014
Uncoupling protein 3 as a mitochondrial fatty acid anion exporter
2003
Lower Intrinsic ADP-Stimulated Mitochondrial Respiration Underlies In Vivo Mitochondrial Dysfunction in Muscle of Male Type 2 Diabetic Patients
2008