Standout Papers
Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production
2009
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis
2002 Science
Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells
2005 StandoutNobel
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
Copper-free click chemistry in living animals
2010 StandoutNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
2011 Standout
rC5a Directs the In Vitro Migration of Human Memory and Naive Tonsillar B Lymphocytes: Implications for B Cell Trafficking in Secondary Lymphoid Tissues
1999
Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease
2009
Naturally Occurring Lung CD4+CD25+ T Cell Regulation of Airway Allergic Responses Depends on IL-10 Induction of TGF-β
2007
Chimeric antigen receptor -T cell therapy: Applications and challenges in treatment of allergy and asthma
2019
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis
2018 StandoutNobel
Therapeutic potential of complement modulation
2009
Tumour escape from immune surveillance through dendritic cell inactivation
2002
Manipulation of cell surface macromolecules by flaviviruses
2003
Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study
2020 Standout
The Role of Complement in Inflammatory Diseases From Behind the Scenes into the Spotlight
2007
Delayed graft function in kidney transplantation
2004 Standout
The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction
2009
Complement and its role in innate and adaptive immune responses
2009 Standout
The SKG model of spondyloarthritis
2017
Modulation of the SDF-1–CXCR4 axis by the third complement component (C3)—Implications for trafficking of CXCR4+ stem cells
2006
Therapeutically effective antibodies against amyloid-β peptide target amyloid-β residues 4–10 and inhibit cytotoxicity and fibrillogenesis
2002
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
2013
Synovial Tissue Inflammation Mediated by Autoimmune T Cells
2019 StandoutNobel
Essential role for the second extracellular loop in C5a receptor activation
2005
Prostaglandin E2 Regulates the Complement Inhibitor CD55/Decay-accelerating Factor in Colorectal Cancer
2004
C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
2007 Nature
Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment
2011 StandoutNobel
SKG arthritis as a model for evaluating therapies in rheumatoid arthritis with special focus on bone changes
2012 StandoutNobel
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
Complement-Mediated Ischemia-Reperfusion Injury
2009
Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection
2002
Neutrophils in development of multiple organ failure in sepsis
2006
Neutrophils in a mouse model of autoantibody‐mediated arthritis: Critical producers of Fc receptor γ, the receptor for C5a, and lymphocyte function−associated antigen 1
2010
Complement: coming full circle
2009
Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome
2003 Standout
Purinergic regulation of the immune system
2016
Complexity of complement activation in sepsis
2008
Complement evasion by human pathogens
2008
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
2009 StandoutNature
The Complement Anaphylatoxin C5a Induces Apoptosis in Adrenomedullary Cells during Experimental Sepsis
2008
Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
2017 Standout
Immunodesign of experimental sepsis by cecal ligation and puncture
2008 Standout
Complement: a key system for immune surveillance and homeostasis
2010 Standout
Cytotoxic T lymphocyte antigen‐4‐dependent down‐modulation of costimulatory molecules on dendritic cells in CD4+ CD25+ regulatory T‐cell‐mediated suppression
2006
An Anti-inflammatory Function for the Complement Anaphylatoxin C5a-binding Protein, C5L2
2005
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Mast Cell Chemotaxis – Chemoattractants and Signaling Pathways
2012
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Functions of C5a receptors
2009
Antisense oligonucleotides: towards clinical trials
1996
Complex-trait genetics: emergence of multivariate strategies
2002
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Arthritis Critically Dependent on Innate Immune System Players
2002
Immunity, Inflammation, and Cancer
2010 Standout
Complement regulators and inhibitory proteins
2009
How regulatory T cells work
2008 Standout
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Adipokines and the Immune System: An Adipocentric View
2008
Inflammation and Bone Destruction in Arthritis: Synergistic Activity of Immune and Mesenchymal Cells in Joints
2012
The PD‐1 pathway in tolerance and autoimmunity
2010 Standout
Liver inflammation and regeneration: Two distinct biological phenomena or parallel pathophysiologic processes?
2005
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Host innate immune responses to sepsis
2013
Complement and coagulation: strangers or partners in crime?
2007
Role of C5a???C5aR Interaction in Sepsis
2003
FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis
2010
Origin and physiological roles of inflammation
2008 StandoutNature
The Role of the N-terminal Domain of the Complement Fragment Receptor C5L2 in Ligand Binding
2006
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Cell-derived anaphylatoxins as key mediators of antibody-dependent type II autoimmunity in mice
2006
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
2019 Standout
Harmful molecular mechanisms in sepsis
2008
Anaphylatoxins
2007
Cancer-related inflammation
2008 StandoutNature
Crosstalk pathways between Toll-like receptors and the complement system
2010
The mouse as a model for human biology: a resource guide for complex trait analysis
2006
Contribution of the innate immune system to autoimmune myocarditis: a role for complement
2001
A crucial role for macrophages in the pathology of K/B × N serum‐induced arthritis
2005
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
2005
A full complement of receptors in immune complex diseases
2002
The spectrum of complement alternative pathway‐mediated diseases
2008
Mechanisms of effects of complement inhibition in murine collagen‐induced arthritis
2002
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
The dark side of C5a in sepsis
2004
Complement-targeted therapeutics
2007
β‐glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice
2012
Alternative Complement Pathway in Schizophrenia
2010
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
2016 Standout
Complement fragments C3a and C5a: The salt and pepper of the immune response
2010
Nrf2 activation improves experimental rheumatoid arthritis
2023 StandoutNobel
Modulation of the antitumor immune response by complement
2008
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Allosteric inhibition of complement function by a staphylococcal immune evasion protein
2010
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
2016 Standout
T‐cell receptor signaling and the pathogenesis of autoimmune arthritis: insights from mouse and man
2012 StandoutNobel
Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host
2009
Single nucleotide polymorphisms of complement component 5 and periodontitis
2009
Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation
2003
"Complementing" Toll Signaling
2010
Complement-Induced Impairment of Innate Immunity During Sepsis
2002
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation
2019 StandoutNobel
Drusen complement components C3a and C5a promote choroidal neovascularization
2006
Role of C5a in Multiorgan Failure During Sepsis
2001
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
2005 StandoutNobel
Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice
2016 StandoutNobel
Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion
2011 StandoutScience
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Lipopolysaccharides fromLegionellaandRhizobiumstimulate mouse bone marrow granulocytes via Toll-like receptor 2
2002
The SKG Mutation in ZAP ‐70 also Confers Arthritis Susceptibility in C57 Black Mouse Strains
2016
Essential Role of Neutrophils in the Initiation and Progression of a Murine Model of Rheumatoid Arthritis
2001
Absence of the Complement Anaphylatoxin C3a Receptor Suppresses Th2 Effector Functions in a Murine Model of Pulmonary Allergy
2002
Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans
2005
Modulation of three key innate immune pathways for the most common retinal degenerative diseases
2018
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
The carbon tetrachloride model in mice
2015
HMGB1 and RAGE in Inflammation and Cancer
2010
IgG Fc Receptors
2001
gC1q Receptor Ligation Selectively Down-Regulates Human IL-12 Production through Activation of the Phosphoinositide 3-Kinase Pathway
2005
Microbial Hijacking of Complement–Toll-Like Receptor Crosstalk
2010
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Rheumatoid arthritis and the complement system
2007
Generation of C5a in the absence of C3: a new complement activation pathway
2006
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Cyclic AMP plays a critical role in C3a-receptor–mediated regulation of dendritic cells in antigen uptake and T-cell stimulation
2008
The Inflammatory Response to Cell Death
2008
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Legionella PneumophilaPathogenesis: A Fateful Journey from Amoebae to Macrophages
2000
Regulation of Toll-like receptor–mediated inflammatory response by complement in vivo
2007
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Dendritic Cell Function in Allostimulation Is Modulated by C5aR Signaling
2009
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Impaired T cell receptor signaling and development of T cell–mediated autoimmune arthritis
2020 StandoutNobel
Sepsis: Multiple Abnormalities, Heterogeneous Responses, and Evolving Understanding
2013
Functions of the complement components C3 and C5 during sepsis
2008
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature
2009
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
C5a stimulates production of plasminogen activator inhibitor-1 in human mast cells and basophils
2002
Works of Jörg Köhl being referenced
CD4 + CD25 + T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
2005
Complement drives Th17 cell differentiation and triggers autoimmune arthritis
2010 StandoutNobel
Cutting Edge: Fc Receptor Type I for IgG on Macrophages and Complement Mediate the Inflammatory Response in Immune Complex Peritonitis
1999
A Protective Role for C5a in the Development of Allergic Asthma Associated with Altered Levels of B7-H1 and B7-DC on Plasmacytoid Dendritic Cells
2009
C5a receptor‐deficient dendritic cells promote induction of Treg and Th17 cells
2009
The C terminus of the human C5a receptor (CD88) is required for normal ligand‐dependent receptor internalization
1997
Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans
2005
Complement regulates inhalation tolerance at the dendritic cell/T cell interface
2006
Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U‐937 cells
1996
A complex role for complement in allergic asthma
2010
C5a Negatively Regulates Toll-like Receptor 4-Induced Immune Responses
2005
Site‐Directed Mutagenesis of Conserved Charged Residues in the Helical Region of the Human C5a Receptor
1996
Circulating complement proteins in multiple trauma patients-Correlation with injury severity, development of sepsis, and outcome
1997
Epitope mapping of a C5a neutralizing mAb using a combined approach of phage display, synthetic peptides and site-directed mutagenesis
1996
Gc-globulin concentrations and C5 haplotype-tagging polymorphisms contribute to variations in serum activity of complement factor C5
2007
Functional roles for C5a receptors in sepsis
2008
Anaphylatoxins and infectious and non-infectious inflammatory diseases
2001
Chronic myelogenous leukemia‐derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a
1993
Complement and Toll-like receptors: Key regulators of adaptive immune responses
2005
Chimeric Receptors of the Human C3a Receptor and C5a Receptor (CD88)
1999
Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6
2000
Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma
2000
C5a Mutants Are Potent Antagonists of the C5a Receptor (CD88) and of C5L2
2003
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma
2006
The Role of Complement in Danger Sensing and Transmission
2006
The role of the anaphylatoxins in health and disease
2009
Self, Non-Self, and Danger: A Complementary View
2007
Complement Factors C3a and C5a Are Increased in Bronchoalveolar Lavage Fluid after Segmental Allergen Provocation in Subjects with Asthma
2001
Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a
1999
Distinct Tissue Site-Specific Requirements of Mast Cells and Complement Components C3/C5a Receptor in IgG Immune Complex-Induced Injury of Skin and Lung
2001
C5a Initiates the Inflammatory Cascade in Immune Complex Peritonitis
2004
C3a and C5a Stimulate Chemotaxis of Human Mast Cells
1997
Molecular epitope identification by limited proteolysis of an immobilized antigen-antibody complex and mass spectrometric peptide mapping.
1990
Macrophages Induce the Inflammatory Response in the Pulmonary Arthus Reaction through Gαi2 Activation That Controls C5aR and Fc Receptor Cooperation
2005
Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome
1996
Essential role of the C5a receptor in E coli-induced oxidative burst and phagocytosis revealed by a novel lepirudin-based human whole blood model of inflammation.
2002
Drug evaluation: the C5a receptor antagonist PMX-53.
2006
Phase-variable Expression of Lipopolysaccharide Contributes to the Virulence of Legionella pneumophila
1998
Human anaphylatoxin C4a is a potent agonist of the guinea pig but not the human C3a receptor.
1998
IFN-γ up-regulates the human C5a receptor (CD88) in myeloblastic U937 cells and related cell lines
1995
IL-4 Down-Regulates Anaphylatoxin Receptors in Monocytes and Dendritic Cells and Impairs Anaphylatoxin-Induced Migration In Vivo
2003
C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
2013
Cutting Edge: Human Anaphylatoxin C4a Is a Potent Agonist of the Guinea Pig But Not the Human C3a Receptor,
1998
On the role of complement and Fc γ-receptors in the Arthus reaction
1999
Pathogen-driven CCR5/C5aR heterodimerization initiates a JNK2/JIP1-dependent signaling pathway that protects from Toxoplasma gondii infection
2008
Dextran sulfate activates contact system and mediates arterial hypotension via B2 kinin receptors
1994
Opposing Regulatory Roles of Complement Factor 5 in the Development of Bleomycin-Induced Pulmonary Fibrosis
2005
The Human C3a Receptor Is Expressed on Neutrophils and Monocytes, but Not on B or T Lymphocytes
1997
A Codominant Role of FcγRI/III and C5aR in the Reverse Arthus Reaction
2000
Cutting Edge: Guinea Pigs with a Natural C3a-Receptor Defect Exhibit Decreased Bronchoconstriction in Allergic Airway Disease: Evidence for an Involvement of the C3a Anaphylatoxin in the Pathogenesis of Asthma
2000
Staphylococcal complement evasion by various convertase-blocking molecules
2007
Acylation-stimulating protein (ASP): structure–function determinants of cell surface binding and triacylglycerol synthetic activity
1999
Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE
2014
Complement Factor C5a Mediates Renal Ischemia-Reperfusion Injury Independent from Neutrophils
2003
Selection of a C5a Receptor Antagonist from Phage Libraries Attenuating the Inflammatory Response in Immune Complex Disease and Ischemia/Reperfusion Injury
1999