Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate
2015 StandoutNobel
Isocitrate Dehydrogenase 1 Codon 132 Mutation Is an Important Prognostic Biomarker in Gliomas
2009
Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process
2016
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
2011
Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH -Mutant Gliomas
2014
Hypoxia induces rapid changes to histone methylation and reprograms chromatin
2019 Science
IDH1 Mutations as Molecular Signature and Predictive Factor of Secondary Glioblastomas
2009
Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951
2012
Long-term Survival in Glioblastoma with Cytomegalovirus pp65-Targeted Vaccination
2017
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
2009 Science
Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo
2012
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas
2010
IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
2010
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
2010
Cancer-Specific High-Throughput Annotation of Somatic Mutations: Computational Prediction of Driver Missense Mutations
2009
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide
2009
2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer
2015 Standout
Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants
2012
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner
2018 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
DeepGene: an advanced cancer type classifier based on deep learning and somatic point mutations
2016
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
2010 Standout
Isocitrate dehydrogenase (IDH) status prediction in histopathology images of gliomas using deep learning
2020
Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma
2012
Emerging insights into the molecular and cellular basis of glioblastoma
2012
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
2012
Clinical Implications of Molecular Neuropathology and Biomarkers for Malignant Glioma
2012
Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial
2012
The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate
2010 Standout
HIF-1: upstream and downstream of cancer metabolism
2009 StandoutNobel
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Cancer-associated IDH mutations: biomarker and therapeutic opportunities
2010
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
2009
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Glioblastoma and Other Malignant Gliomas
2013 Standout
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Predicting the likelihood of an isocitrate dehydrogenase 1 or 2 mutation in diagnoses of infiltrative glioma
2014
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Modulation of oxidative stress as an anticancer strategy
2013 Standout
Otto Warburg's contributions to current concepts of cancer metabolism
2011 Standout
The Molecular Signatures Database Hallmark Gene Set Collection
2015 Standout
IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children’s Oncology Group
2010
The mini-driver model of polygenic cancer evolution
2015 StandoutNobel
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
2011
Established and emerging variants of glioblastoma multiforme: review of morphological and molecular features
2012
Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial
2012
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
2009 StandoutNature
The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary
2016 Standout
Mitochondria: In Sickness and in Health
2012 Standout
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma
2014
Genetic alterations and signaling pathways in the evolution of gliomas
2009
From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Diagnostic Use ofIDH1/2Mutation Analysis in Routine Clinical Testing of Formalin-Fixed, Paraffin-Embedded Glioma Tissues
2009
The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma
2011
Guidelines on management of low‐grade gliomas: report of an EFNS–EANO* Task Force
2010
Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas
2010
The 2016 World Health Organization classification of tumours of the central nervous system
2018
Regulation of cancer cell metabolism
2011 Standout
Deep learning in histopathology: the path to the clinic
2021 Standout
IDH mutation impairs histone demethylation and results in a block to cell differentiation
2012 Nature
IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO
2015
CSF-1R inhibition alters macrophage polarization and blocks glioma progression
2013 Standout
Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy
2013 Standout
Metabolomics: the apogee of the omics trilogy
2012 Standout
IDH1 mutation of gliomas with long-term survival analysis
2012
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
2015
Mutational Heterogeneity in Human Cancers: Origin and Consequences
2009
Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?
2010
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Practical procedures for the integrated diagnosis of astrocytic and oligodendroglial tumors
2019
Understanding the Intersections between Metabolism and Cancer Biology
2017 Standout
Primary brain tumours in adults
2012 Standout
IDH1 and IDH2 Mutations in Gliomas
2013
5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy
2015
Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients
2014
New cancer targets emerging from studies of the Von Hippel‐Lindau tumor suppressor protein
2010 StandoutNobel
Epithelioid GBMs Show a High Percentage of BRAF V600E Mutation
2013
The Warburg Effect: How Does it Benefit Cancer Cells?
2016 Standout
Mitochondrial TCA cycle metabolites control physiology and disease
2020 Standout
DNA Methylation, Isocitrate Dehydrogenase Mutation, and Survival in Glioma
2010
ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma
2014
Mitochondria and cancer
2012 Standout
What do we know about IDH1/2 mutations so far, and how do we use it?
2013
Artificial intelligence in radiology
2018 Standout
Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre
2019
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
2009 StandoutNobel
Gliomatosis cerebri in children shares molecular characteristics with other pediatric gliomas
2016
IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma
2011
IDH1andIDH2Mutations Are Frequent Genetic Alterations in Acute Myeloid Leukemia and Confer Adverse Prognosis in Cytogenetically Normal Acute Myeloid Leukemia WithNPM1Mutation WithoutFLT3Internal Tandem Duplication
2010
Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism
2010
1p/19q testing has no significance in the workup of glioblastomas
2013
Whole exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma
2012
Acute Myeloid Leukemia
2015 Standout
The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
2021 Standout
NCCN Task Force Report: Evaluating the Clinical Utility of Tumor Markers in Oncology
2011
CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010
2013 Standout
Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d -2-Hydroxyglutarate
2014
Determination of Glutamate Dehydrogenase Activity and Its Kinetics in Mouse Tissues using Metabolic Mapping (Quantitative Enzyme Histochemistry)
2014
The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis
2018 Standout
Metabolic reprogramming and cancer progression
2020 StandoutScience
Cancer Genome Landscapes
2013 StandoutScience
Lactate Dehydrogenase C Produces S-2-Hydroxyglutarate in Mouse Testis
2016
Grading of Diffuse Astrocytic Gliomas: A Review of Studies Before and After the Advent of IDH Testing
2018
Glutamate enrichment as new diagnostic opportunity in breast cancer
2014
The Definition of Primary and Secondary Glioblastoma
2012
Epidemiologic and Molecular Prognostic Review of Glioblastoma
2014 Standout
Works of Jörg Balß being referenced
Enzymatic assay for quantitative analysis of (d)-2-hydroxyglutarate
2012
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
2009 Standout
Detection of 2‐Hydroxyglutarate in Formalin‐Fixed Paraffin‐Embedded Glioma Specimens by Gas Chromatography/Mass Spectrometry
2011
Analysis of the IDH1 codon 132 mutation in brain tumors
2008
Monoclonal antibody specific for IDH1 R132H mutation
2009
Characterization of R132H Mutation‐specific IDH1 Antibody Binding in Brain Tumors
2009
Isocitrate dehydrogenase 1 mutant R132H sensitizes glioma cells to BCNU-induced oxidative stress and cell death
2013
PCR‐ and Restriction Endonuclease‐Based Detection of IDH1 Mutations
2009
A Novel, Diffusely Infiltrative Xenograft Model of Human Anaplastic Oligodendroglioma with Mutations in FUBP1, CIC, and IDH1
2013