Standout Papers
- Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1 (2006)
- Titration of Syntaxin1 in Mammalian Synapses Reveals Multiple Roles in Vesicle Docking, Priming, and Release Probability (2013)
- Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion (2008)
- Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1 (2005)
Citation Impact
Citing Papers
Alternative Zippering as an On-Off Switch for SNARE-Mediated Fusion
2009 StandoutScienceNobel
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
2013 StandoutNobel
How Synaptotagmin Promotes Membrane Fusion
2007 Science
In vitro system capable of differentiating fast Ca 2+ -triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release
2011 Nobel
Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion
2009 StandoutScienceNobel
Synaptotagmin-1 Utilizes Membrane Bending and SNARE Binding to Drive Fusion Pore Expansion
2008
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
2012 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation
2010
A Clamping Mechanism Involved in SNARE-Dependent Exocytosis
2006 Science
A fast, single-vesicle fusion assay mimics physiological SNARE requirements
2010 StandoutNobel
Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE–Sec1/Munc18 membrane fusion complex
2010
Munc18-1 binds directly to the neuronal SNARE complex
2007 StandoutNobel
Phosphatidylinositol 4,5-Bisphosphate Increases Ca2+ Affinity of Synaptotagmin-1 by 40-fold
2012
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
The Longin SNARE VAMP7/TI-VAMP Adopts a Closed Conformation
2010
Phosphatidylinositol 4,5-bisphosphate clusters act as molecular beacons for vesicle recruitment
2013 StandoutNobel
Structural and Mutational Analysis of Functional Differentiation between Synaptotagmins-1 and -7
2010 StandoutNobel
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis
2010 StandoutNobel
Close membrane-membrane proximity induced by Ca2+-dependent multivalent binding of synaptotagmin-1 to phospholipids
2006 StandoutNobel
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
The PIP2 binding mode of the C2 domains of rabphilin‐3A
2008
The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function
2008
Cell biology of Ca2+-triggered exocytosis
2010 StandoutNobel
Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release
2006
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
2003
SNARE Force Synchronizes Synaptic Vesicle Fusion and Controls the Kinetics of Quantal Synaptic Transmission
2010
The Ca2+ Affinity of Synaptotagmin 1 Is Markedly Increased by a Specific Interaction of Its C2B Domain with Phosphatidylinositol 4,5-Bisphosphate
2009
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses
2009 StandoutNobel
The Presynaptic Active Zone
2012 StandoutNobel
The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors
2011
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity
2010
Store-Operated Calcium Channels
2005 Standout
Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes
2009
Synaptic vesicle fusion
2008
Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release
2013 StandoutNobel
Syntaxin‐1 N‐peptide and Habc‐domain perform distinct essential functions in synaptic vesicle fusion
2012 StandoutNobel
Molecular machines governing exocytosis of synaptic vesicles
2012 Nature
Differential Regulation of Synaptic Vesicle Tethering and Docking by UNC-18 and TOM-1
2010
Synaptotagmin Increases the Dynamic Range of Synapses by Driving Ca2+-Evoked Release and by Clamping a Near-Linear Remaining Ca2+ Sensor
2011
Mechanisms of membrane fusion: disparate players and common principles
2008
A Quaternary SNARE–Synaptotagmin–Ca2+–Phospholipid Complex in Neurotransmitter Release
2007
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex
2011
Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation
2011
Cross-linking of Phospholipid Membranes is a Conserved Property of Calcium-sensitive Synaptotagmins
2008
Subtle Interplay between Synaptotagmin and Complexin Binding to the SNARE Complex
2013
Synaptic Vesicle Exocytosis
2011
Activity-Dependent IGF-1 Exocytosis Is Controlled by the Ca2+-Sensor Synaptotagmin-10
2011 StandoutNobel
Complexin and Ca2+ stimulate SNARE-mediated membrane fusion
2008
Munc13-1 C1 Domain Activation Lowers the Energy Barrier for Synaptic Vesicle Fusion
2007
A Gain-of-Function Mutation in Synaptotagmin-1 Reveals a Critical Role of Ca 2+ -Dependent Soluble N -Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Complex Binding in Synaptic Exocytosis
2006 StandoutNobel
A role of complexin–lipid interactions in membrane fusion
2009
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity
2009 Standout
Synaptic AMPA receptor composition in development, plasticity and disease
2016
Membrane Bridging and Hemifusion by Denaturated Munc18
2011
At the junction of SNARE and SM protein function
2010
Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex
2010 Nobel
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
2007 StandoutNobel
A Complexin/Synaptotagmin 1 Switch Controls Fast Synaptic Vesicle Exocytosis
2006 StandoutNobel
Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins
2013
Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis
2008 StandoutNobel
Ultrastructural organization of presynaptic terminals
2011
Post-Translational Modifications and Lipid Binding Profile of Insect Cell-Expressed Full-Length Mammalian Synaptotagmin 1
2011 Nobel
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
Differential but convergent functions of Ca 2+ binding to synaptotagmin-1 C 2 domains mediate neurotransmitter release
2009 StandoutNobel
SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion
2010 StandoutNobel
Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans
2008
Push-and-pull regulation of the fusion pore by synaptotagmin-7
2010 StandoutNobel
Synaptotagmin-1 and -7 are functionally overlapping Ca 2+ sensors for exocytosis in adrenal chromaffin cells
2008 StandoutNobel
RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
2011 StandoutScienceNobel
Calcium-sensing beyond neurotransmitters: functions of synaptotagmins in neuroendocrine and endocrine secretion
2009
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
2009 StandoutNobel
Synaptobrevin N-terminally bound to syntaxin–SNAP-25 defines the primed vesicle state in regulated exocytosis
2010
How Does Synaptotagmin Trigger Neurotransmitter Release?
2008
β-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or β-amyloid deposits
2006
Crystal Structure of the RIM1α C2B Domain at 1.7 Å Resolution,
2007 StandoutNobel
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
2012 StandoutNobel
E-Syts, a family of membranous Ca 2+ -sensor proteins with multiple C 2 domains
2007 StandoutNobel
RIM genes differentially contribute to organizing presynaptic release sites
2012 StandoutNobel
Two distinct secretory vesicle–priming steps in adrenal chromaffin cells
2010
Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle
2010
Principles of Allosteric Interactions in Cell Signaling
2014
Conflicting Views on the Membrane Fusion Machinery and the Fusion Pore
2009
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
2013 StandoutNobel
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
2010 StandoutNobel
Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography
2010
The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?
2012 StandoutNobel
Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells
2007
Deconstructing complexin function in activating and clamping Ca 2+ -triggered exocytosis by comparing knockout and knockdown phenotypes
2013 StandoutNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex
2011
Works of Jong‐Cheol Rah being referenced
Augmenting neurotransmitter release by enhancing the apparent Ca 2+ affinity of synaptotagmin 1
2005 StandoutNobel
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
Phosphatidylinositol Phosphates as Co-activators of Ca2+ Binding to C2 Domains of Synaptotagmin 1
2006 StandoutNobel
An Essential Role for PICK1 in NMDA Receptor-Dependent Bidirectional Synaptic Plasticity
2008
Carboxyl-terminal Peptide of β-Amyloid Precursor Protein Blocks Inositol 1,4,5-Trisphosphate-sensitive Ca2+ Release in Xenopus laevis Oocytes
2002
Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity
2000