Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
2017 Standout
Suppression of Aging in Mice by the Hormone Klotho
2005 StandoutScience
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos
1991
Syndromes Associated with Insulin Resistance and Acanthosis Nigricans
1998
The insulin-like growth factor system and cancer
2003
In vivo and in vitro phosphorylation studies of numatrin, a cell cycle regulated nuclear protein, in insulin-stimulated NIH 3T3 HIR cells
1991
Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg
1992 StandoutNobel
Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor
1991
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
1997 StandoutNature
Rethinking amide bond synthesis
2011 StandoutNature
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 Standout
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
The genetics of ageing
2010 StandoutNature
Cysteine Promoted C‐Terminal Hydrazinolysis of Native Peptides and Proteins
2013 StandoutNobel
The generation of diversity and pattern in animal development
1992 StandoutNobel
Insulin Resistance — Mechanisms, Syndromes, and Implications
1991
Molecular basis of human CD22 function and therapeutic targeting
2017
Sequence requirements for prohormone processing in mouse pituitary AtT‐20 cells
1991
Gβγ Subunits Mediate Mitogen-activated Protein Kinase Activation by the Tyrosine Kinase Insulin-like Growth Factor 1 Receptor
1995 StandoutNobel
Odorant Receptors Govern the Formation of a Precise Topographic Map
1998 StandoutNobel
Polycystic Ovary Syndrome
1995 Standout
Central nervous system control of food intake
2000 StandoutNature
Tracking and Elucidating Alphavirus-Host Protein Interactions
2006 StandoutNobel
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
β2-Adrenergic Receptor Signaling and Desensitization Elucidated by Quantitative Modeling of Real Time cAMP Dynamics
2007 StandoutNobel
Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms
1992
Structure, function, and regulation of adrenergic receptors
1993
Molecular chaperones in cellular protein folding
1996 StandoutNature
ISOLDE: a physically realistic environment for model building into low-resolution electron-density maps
2018
β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor
1998 StandoutNobel
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
An FGF receptor signaling pathway is required for the normal cell migrations of the sex myoblasts in C. elegans hermaphrodites
1995 StandoutNobel
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Cell-signalling dynamics in time and space
2006
The insulin and EGF receptor structures: new insights into ligand-induced receptor activation
2007
Insulin Action and the Insulin Signaling Network*
1995
Intracellular protein trafficking defects in human disease
1992
The alphaviruses: gene expression, replication, and evolution
1994 Standout
The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits
2003
Partial Deletion of Pten in the Hypothalamus Leads to Growth Defects that Cannot be Rescued by Exogenous Growth Hormone
2008 StandoutNobel
Kex2-like endoproteases PC2 and PC3 accurately cleave a model prohormone in mammalian cells: evidence for a common core of neuroendocrine processing enzymes.
1991
Insulin receptor autophosphorylation occurs asymmetrically.
1993
Solid-State NMR Studies of Amyloid Fibril Structure
2011
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
1993 Standout
Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt
1997 StandoutScience
Protein Chemical Synthesis by Ligation of Peptide Hydrazides
2011
A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.
1991
The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies.
1992
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor.
1995 StandoutNobel
A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction.
1990
Synthesis of human GLP-1 (7–36) by chemoselective α-ketoacid–hydroxylamine peptide ligation of unprotected fragments
2011
Alphavirus-based expression vectors: strategies and applications.
1996 StandoutNobel
THE ATP SYNTHASE—A SPLENDID MOLECULAR MACHINE
1997 StandoutNobel
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
A genetically clamped renin transgene for the induction of hypertension
2002 StandoutNobel
Evidence supporting a passive role for the insulin receptor transmembrane domain in insulin-dependent signal transduction
1991
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
2020 StandoutScience
The insulin signaling system.
1994 Standout
Protein Chemical Synthesis by Ligation of Peptide Hydrazides
2011
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.
1990
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
1993 StandoutScience
Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor
1993
Expression and function of IRS-1 in insulin signal transmission.
1992
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Identification of determinants that confer ligand specificity on the insulin receptor.
1992
Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1.
1991 StandoutNobel
Effects of amino acid replacements within the tetrabasic cleavage site on the processing of the human insulin receptor precursor expressed in Chinese hamster ovary cells.
1990
Fusion of a Kinase Gene, ALK , to a Nucleolar Protein Gene, NPM , in Non-Hodgkin's Lymphoma
1994 StandoutScience
Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes.
1991 StandoutNobel
Identification, Quantification, and Localization of mRNA for Three Distinct Alpha1Adrenergic Receptor Subtypes in Human Prostate
1993 StandoutNobel
Insulin as an Effector of Human Ovarian and Adrenal Steroid Metabolism
1991
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Noncytopathic Sindbis virus RNA vectors for heterologous gene expression
1998 StandoutNobel
Extending Healthy Life Span—From Yeast to Humans
2010 StandoutScience
Functionally significant insulin-like growth factor I receptor mutations in centenarians
2008
The R33 G Protein-Coupled Receptor Gene of Rat Cytomegalovirus Plays an Essential Role in the Pathogenesis of Viral Infection
1998
G-protein-coupled Receptor (GPCR) Kinase Phosphorylation and β-Arrestin Recruitment Regulate the Constitutive Signaling Activity of the Human Cytomegalovirus US28 GPCR
2003 StandoutNobel
The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras.
1990
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
1996 StandoutScience
Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins
1997
Works of Jonathan Whittaker being referenced
Human Insulin Receptors Expressed in Insulin-Insensitive Mouse Fibroblasts Couple with Extant Cellular Effector Systems to Confer Insulin Sensitivity and Responsiveness*
1989
Comparison of the Functional Insulin Binding Epitopes of the A and B Isoforms of the Insulin Receptor
2002
Structural biology of insulin and IGF1 receptors: implications for drug design
2002
Identification of Common Ligand Binding Determinants of the Insulin and Insulin-like Growth Factor 1 Receptors
1997
Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected fibroblasts without activating receptor kinase
1989
Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain
2016
An Achilles' Heel in an Amyloidogenic Protein and Its Repair
2010
Characterization of a second ligand binding site of the insulin receptor
2006
Design and Folding of [Glu A4 (O β Thr B30 )]Insulin (“Ester Insulin”): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin
2010
Mapping of an NH--terminal Ligand Binding Site of the Insulin Receptor by Alanine Scanning Mutagenesis
1995
Alanine Scanning Mutagenesis of a Type 1 Insulin-like Growth Factor Receptor Ligand Binding Site
2001
Rescue of ligand binding of a mutant IGF-I receptor by complementation
2005
Comparative Properties of Insulin‐like Growth Factor 1 (IGF‐1) and [Gly7D‐Ala]IGF‐1 Prepared by Total Chemical Synthesis
2007
Molecular cloning and sequencing of a cDNA encoding a human α1A adrenergic receptor
1991
Identification of a Ligand-Binding Region of the Human Insulin Receptor Encoded by the Second Exon of the Gene
1990
Hybrid Insulin Receptors: Molecular Mechanisms of Negative-Dominant Mutations in Receptor-Mediated Insulin Resistance
1990
Insulin-Resistant Diabetes Due to a Point Mutation That Prevents Insulin Proreceptor Processing
1988 Science
Diabetes-Associated Mutations in Insulin: Consecutive Residues in the B Chain Contact Distinct Domains of the Insulin Receptor,
2004
Design and Folding of [GluA4(OβThrB30)]Insulin (“Ester Insulin”): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin
2010
Phorbol ester-induced downregulation of protein kinase C potentiates insulin receptor tyrosine autophosphorylation: evidence for a major constitutive role in insulin receptor regulation
1990