Citation Impact
Citing Papers
Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8
2009
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis
2010 Standout
Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens
2008
TLR7-dependent and FcγR-independent production of type I interferon in experimental mouse lupus
2008
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Evidence for Genes in Addition to Tlr7 in the Yaa Translocation Linked with Acceleration of Systemic Lupus Erythematosus
2008
TLR9 Blockade Inhibits Activation of Diabetogenic CD8+ T Cells and Delays Autoimmune Diabetes
2010
Recognition of Borrelia burgdorferi , the Lyme Disease Spirochete, by TLR7 and TLR9 Induces a Type I IFN Response by Human Immune Cells
2009
Potent Induction of IFN-α and Chemokines by Autoantibodies in the Cerebrospinal Fluid of Patients with Neuropsychiatric Lupus
2009
Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair
2012 StandoutNobel
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Transmembrane Mutations in Toll-like Receptor 9 Bypass the Requirement for Ectodomain Proteolysis and Induce Fatal Inflammation
2011
Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
2013 Standout
Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation
2007
Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity
2008
The Forward Genetic Dissection of Afferent Innate Immunity
2008 StandoutNobel
Necroptosis and its role in inflammation
2015 StandoutNature
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
2010 Standout
Development of TLR inhibitors for the treatment of autoimmune diseases
2008
Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes
2017 StandoutNobel
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Human Genetics Shape the Gut Microbiome
2014 Standout
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
2007 StandoutNobel
Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation
2014 StandoutNobel
The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases
2011
UNC93B1 Is Essential for TLR11 Activation and IL-12-dependent Host Resistance to Toxoplasma gondii
2010
Atopic dermatitis
2015 Standout
Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9
2007
Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice
2011
Type I Interferon in Systemic Lupus Erythematosus
2007
Pattern Recognition Receptors and Inflammation
2010 Standout
Melioidosis
2012 Standout
Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
2010 StandoutNobel
Severe Sepsis and Septic Shock
2013 Standout
Toll-like receptors in systemic autoimmune disease
2006
Immune Regulatory Function of B Cells
2012
Intracellular Toll-like Receptors
2010 StandoutNobel
Female Bias in Systemic Lupus Erythematosus is Associated with the Differential Expression of X-Linked Toll-Like Receptor 8
2015
Sensors of the innate immune system: their link to rheumatic diseases
2010 StandoutNobel
The Impact of the Gut Microbiota on Human Health: An Integrative View
2012 Standout
A cell biological view of Toll-like receptor function: regulation through compartmentalization
2009
Systemic Lupus Erythematosus
2011 Standout
Immune Sensing of DNA
2013
Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease
2012
Yaa autoimmune phenotypes are conferred by overexpression of TLR7
2008
Efficacy and safety of rituximab in moderately‐to‐severely active systemic lupus erythematosus: The randomized, double‐blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial
2009
Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 Mice
2009
CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype
2014
Mechanisms and Functions of Inflammasomes
2014 Standout
Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors
2007
T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells
2008
Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases
2008 StandoutNobel
Recognition of Endogenous Nucleic Acids by the Innate Immune System
2016
Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking
2011
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
2009 StandoutNature
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
2008 StandoutNature
2′-O-methyl-modified RNAs Act as TLR7 Antagonists
2007
The Toll of Too Much TLR7
2007
Connections between antiviral defense and autoimmunity
2009
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
B Cell TLR7 Expression Drives Anti-RNA Autoantibody Production and Exacerbates Disease in Systemic Lupus Erythematosus–Prone Mice
2012
UNC93B1 mediates differential trafficking of endosomal TLRs
2013 StandoutNobel
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
2009 StandoutNobel
Expression of an anti‐RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN ‐I expression
2013
Immunologically Active Autoantigens: The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease
2007
Toll-like Receptor 2 Senses β-Cell Death and Contributes to the Initiation of Autoimmune Diabetes
2007
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development.
2007 StandoutNobel
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
2011 StandoutNobel
Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
2011 StandoutNobel
TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity
2008
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
2019 Standout
Nucleic Acid Recognition by the Innate Immune System
2011
Cytokine Storm
2020 Standout
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Metagenomics of the Human Body
2010
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Regulation of Adaptive Immunity by the Innate Immune System
2010 StandoutScience
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells
2013
Dosage of X‐linked Toll‐like receptor 8 determines gender differences in the development of systemic lupus erythematosus
2014
A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding
2011 StandoutNobel
Works of Jonathan Shupe being referenced
Depletion of B Cells in Murine Lupus: Efficacy and Resistance
2007
TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus
2010
Activation of Human Monocytes by Live Borrelia burgdorferi Generates TLR2-Dependent and -Independent Responses Which Include Induction of IFN-β
2009
Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
2006
A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation
2010