Standout Papers
Citation Impact
Citing Papers
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
2005
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
Phenotypic and functional features of human Th17 cells
2007 Standout
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
A novel subset of CD4+ TH2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
2010
Interleukin-17 is a negative regulator of established allergic asthma
2006
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis
2006
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
2006
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
2006
IL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis
2006
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
IL-25 regulates Th17 function in autoimmune inflammation
2007
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
2008
Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
2003 Standout
Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis
2009
Vaccination against IL‐17 suppresses autoimmune arthritis and encephalomyelitis
2006
T-bet Regulates the Fate of Th1 and Th17 Lymphocytes in Autoimmunity
2007
IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guerin Infection
2007
IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis
2007
Essential Roles of c-Rel in TLR-Induced IL-23 p19 Gene Expression in Dendritic Cells
2007
Major Role of γδ T Cells in the Generation of IL-17+ Uveitogenic T Cells
2009
B Cell Chemoattractant CXCL13 Is Preferentially Expressed by Human Th17 Cell Clones
2008
IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis
2007
Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses
2009
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
2019 StandoutNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
CCR2 defines in vivo development and homing of IL-23-driven GM-CSF-producing Th17 cells
2015
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
2006 Standout
Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
2008
IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice
2008
Innate IL-17-producing cells: the sentinels of the immune system
2010 Standout
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
2006 Standout
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
2006
Interferons as pathogenic effectors in autoimmunity
2005
IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
2007
The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells
2007
Overrepresentation of IL-17A and IL-22 Producing CD8 T Cells in Lesional Skin Suggests Their Involvement in the Pathogenesis of Psoriasis
2010
The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing
2014
Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
2006
Interleukin-17 Family Members and Inflammation
2004 Standout
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation
2010
Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses
2003
Interleukin 18–independent engagement of interleukin 18 receptor-α is required for autoimmune inflammation
2006
IL-23 mediates inflammatory responses to mucoidPseudomonas aeruginosalung infection in mice
2006
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
2006
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
The roles of IL‐17A in inflammatory immune responses and host defense against pathogens
2008
Induction and molecular signature of pathogenic TH17 cells
2012
The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
2007
TH17 cells in development: an updated view of their molecular identity and genetic programming
2008
Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells
2008
The immunological and genetic basis of inflammatory bowel disease
2003
Mixed results with modulation of TH-17 cells in human autoimmune diseases
2009
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
2005 Standout
The IL-12 Family of Heterodimeric Cytokines
2003
IL‐21 and IL‐21R are not required for development of Th17 cells and autoimmunity in vivo
2008
Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4
2010
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
2006
Protective immune mechanisms in helminth infection
2007 Standout
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice
2007
Interleukin‐17 in host defence against bacterial, mycobacterial and fungal pathogens
2008
The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
2011
Autoimmune T cell responses in the central nervous system
2009
Interleukin-22-Producing Natural Killer Cells and Lymphoid Tissue Inducer-like Cells in Mucosal Immunity
2009
IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
2007 Standout
Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction
2008
Development, cytokine profile and function of human interleukin 17–producing helper T cells
2007 Standout
IL-12– and IL-23–induced T helper cell subsets
2005
Current Views on the Roles of Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis
2010
TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1
2007
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
2007 StandoutNature
RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
2011
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
2008
Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
2008
Late Developmental Plasticity in the T Helper 17 Lineage
2009
Induction and effector functions of TH17 cells
2008 Nature
Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells
2006
Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation
2007
Preferential recruitment of interferon‐γ–expressing TH17 cells in multiple sclerosis
2009
Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology
2006
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
2006 StandoutNature
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
2007
Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
2005
IL-17 family member cytokines: Regulation and function in innate immunity
2010
A protective function for interleukin 17A in T cell–mediated intestinal inflammation
2009
Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity
2009 Standout
Interleukin-17 and Type 17 Helper T Cells
2009 Standout
Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis
2005
Th17 Cell Pathway in Human Immunity: Lessons from Genetics and Therapeutic Interventions
2015
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
2006
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo
2009
Expanding the effector CD4 T-cell repertoire: the Th17 lineage
2006
How microorganisms tip the balance between interleukin-12 family members
2007
IL-23 promotes tumour incidence and growth
2006 Nature
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
2011
The phenotype of human Th17 cells and their precursors, the cytokines that mediate their differentiation and the role of Th17 cells in inflammation
2008
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
2006
Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells
2006
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
2007 Standout
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
2005 Standout
Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis
2010
The effects of PDL-Ig on collagen-induced arthritis
2009
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology
2007
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
2008 Standout
A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes
2007
Both IL-12p70 and IL-23 are synthesized during active Crohnʼs disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody
2005
The dichotomous nature of T helper 17 cells
2017
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
2010
Multiple Sclerosis — The Plaque and Its Pathogenesis
2006
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Silencing T-bet Defines a Critical Role in the Differentiation of Autoreactive T Lymphocytes
2004
Functional Specialization of Interleukin-17 Family Members
2011 Standout
RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F
2008
Th17 Cell Differentiation: The Long and Winding Road
2008
Th17: the third member of the effector T cell trilogy
2007
IL‐12 and IL‐23: master regulators of innate and adaptive immunity
2004
A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage
2007
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
2005
Memory CD4+CD127high T cells from patients with multiple sclerosis produce IL-17 in response to myelin antigens
2010
The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation
2006
The IL-23/IL-17 axis in inflammation
2006
Structure and signalling in the IL-17 receptor family
2009 Standout
Cancer-related inflammation
2008 StandoutNature
TH-17 cells in the circle of immunity and autoimmunity
2007
γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism
2010
Chapter 5 Emergence of the Th17 Pathway and Its Role in Host Defense
2008
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
2008 StandoutNature
Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease
2008
Understanding the IL-23–IL-17 immune pathway
2005
A Phase I Study Evaluating the Safety, Pharmacokinetics, and Clinical Response of a Human IL-12 p40 Antibody in Subjects with Plaque Psoriasis
2004
Polarized immune responses differentially regulate cancer development
2008
T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation
2007
Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury
2009
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
2006
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
IL-23 Enhances the Inflammatory Cell Response in Cryptococcus neoformans Infection and Induces a Cytokine Pattern Distinct from IL-12
2006
IL-17–producing human peripheral regulatory T cells retain suppressive function
2009
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Role of IL-12 Receptor β1 in Regulation of T Cell Response by APC in Experimental Autoimmune Encephalomyelitis
2003
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
2005 Standout
CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis
2014
Chronically Inflamed Human Tissues Are Infiltrated by Highly Differentiated Th17 Lymphocytes
2008
Ets-1 is a negative regulator of Th17 differentiation
2007
IL-17 and Th17 Cells
2009 Standout
IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12
2004
IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
2007 Standout
IL-23 Is Increased in Dendritic Cells in Multiple Sclerosis and Down-Regulation of IL-23 by Antisense Oligos Increases Dendritic Cell IL-10 Production
2006
IMMUNOLOGY OF MULTIPLE SCLEROSIS
2005 Standout
Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris
2004
Compromised Humoral and Delayed-Type Hypersensitivity Responses in IL-23-Deficient Mice
2004
Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway
2004
IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease
2007
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Increase in TNF-α and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a)
2005 StandoutNobel
Prostaglandin E2 induces IL‐23 production in bone marrow‐derived dendritic cells
2004
IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
2008
CD4 T cells: fates, functions, and faults
2008
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
PD-1 deficiency reveals various tissue-specific autoimmunity by H-2band dose-dependent requirement of H-2g7for diabetes in NOD mice
2008 StandoutNobel
Conditional stability of T cells
2010 StandoutNatureNobel
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22
2008
Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5− Phenotype
2007
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
IL-17 Promotes Immune Privilege of Corneal Allografts
2010
Functional deficiencies of granulocyte-macrophage colony stimulating factor and interleukin-3 contribute to insulitis and destruction of β cells
2007 StandoutNobel
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
2007
Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability
2007 StandoutNobel
Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases
2015
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
2006
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Cutting Edge: Diabetes-Associated Quantitative Trait Locus, Idd4, Is Responsible for the IL-12p40 Overexpression Defect in Nonobese Diabetic (NOD) Mice
2003
A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
2006
T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis
2007 StandoutNobel
Works of Jonathan Sherlock being referenced
IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells
2012
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature