Citation Impact
Citing Papers
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
Crystal structure of a core spliceosomal protein interface
2006
Structural inference of native and partially folded RNA by high-throughput contact mapping
2008 StandoutNobel
Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome
2008 StandoutScienceNobel
Automated de novo prediction of native-like RNA tertiary structures
2007 StandoutNobel
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing
2004
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Structure and function of an RNase H domain at the heart of the spliceosome
2008
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome
2000 Nature
Characterization of Sm-like proteins in yeast and their association with U6 snRNA
1999
Demonstration by NMR of folding domains in lysozyme
1991 StandoutNatureNobel
The box C/D and H/ACA snoRNPs: key players in the modification, processing and the dynamic folding of ribosomal RNA
2011
Protein Diversity from Alternative Splicing
2000
Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly
2001 Nature
RNA Helicase A Interacts with RISC in Human Cells and Functions in RISC Loading
2007
The group II intron ribonucleoprotein precursor is a large, loosely packed structure
2010 StandoutNobel
Multisite RNA Binding and Release of Polypyrimidine Tract Binding Protein during the Regulation of c-src Neural-Specific Splicing
2000
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome
2008
Yeast Pre-mRNA splicing: Methods, mechanisms, and machinery
2002
Large-Scale Proteomic Analysis of the Human Spliceosome
2002
Discriminatory RNP remodeling by the DEAD-box protein DED1
2006
Identification and characterization of yUAP/Sub2p, a yeast homolog of the essential human pre-mRNA splicing factor hUAP56
2001
An RNA helicase, RHIV -1, induced by porcine reproductive and respiratory syndrome virus (PRRSV) is mapped on porcine chromosome 10q13
2000
Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae
1999
The 5′ End of U2 snRNA Is in Close Proximity to U1 and Functional Sites of the Pre-mRNA in Early Spliceosomal Complexes
2007
Visualizing the splicing of single pre-mRNA molecules in whole cell extract
2007
Splicing double: insights from the second spliceosome
2003
Comprehensive proteomic analysis of the human spliceosome
2002 Nature
A Common Core RNP Structure Shared between the Small Nucleoar Box C/D RNPs and the Spliceosomal U4 snRNP
2000 StandoutNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Determinants of the inherent strength of human 5′ splice sites
2005
The Spliceosome: Design Principles of a Dynamic RNP Machine
2009 Standout
Suppression of Multiple Substrate Mutations by Spliceosomal prp8 Alleles Suggests Functional Correlations with Ribosomal Ambiguity Mutants
2004
Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p
2006
Crystal structure of the C‐terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants
2007
Defining a 5??? splice site by functional selection in the presence and absence of U1 snRNA 5??? end
2002
The spliceosome: a flexible, reversible macromolecular machine
2012
The Long Unwinding Road of RNA Helicases
2007
Structure of a self-splicing group II intron catalytic effector domain 5: Parallels with spliceosomal U6 RNA
2006
The Active Site of the Ribosome Is Composed of Two Layers of Conserved Nucleotides with Distinct Roles in Peptide Bond Formation and Peptide Release
2004
Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase
2004 Nature
Antagonism between RSF1 and SR proteins for both splice-site recognition in vitro and Drosophila development
1999
Alternative RNA splicing in the nervous system
2001
Is the spliceosome a ribonucleoprotein enzyme?
2008
Crystal structure of a model branchpoint–U2 snRNA duplex containing bulged adenosines
2001 StandoutNobel
Multiple roles for the yeast SUB2/yUAP56 gene in splicing
2001
Telomere states and cell fates
2000 StandoutNatureNobel
Composition and Functional Characterization of the Yeast Spliceosomal Penta-snRNP
2002
DExD/H Box RNA Helicases
2001
A Yeast Intronic Splicing Enhancer and Nam8p Are Required for Mer1p-Activated Splicing
2000
Yeast U1 snRNP–pre-mRNA complex formation without U1snRNA–pre-mRNA base pairing
2001 StandoutNobel
What recent ribosome structures have revealed about the mechanism of translation
2009 StandoutNatureNobel
Human RNase III Is a 160-kDa Protein Involved in Preribosomal RNA Processing
2000
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
The question remains: is the spliceosome a ribozyme?
2000
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components
2007
Building specificity with nonspecific RNA-binding proteins
2005
U2–U6 RNA folding reveals a group II intron-like domain and a four-helix junction
2004
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation
2008
The Cell as a Collection of Protein Machines: Preparing the Next Generation of Molecular Biologists
1998
Remodeling of ribonucleoprotein complexes with DExH/D RNA helicases
2006
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Functional interaction of a novel 15.5kD [U4/U6middle dotU5] tri-snRNP protein with the 5' stem-loop of U4 snRNA
1999
Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center
1999
The 100-kDa U5 snRNP protein (hPrp28p) contacts the 5′ splice site through its ATPase site
2001
Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome
2008
Structure and Function of the Pre-mRNA Splicing Machine
2008
Mechanism of maturase-promoted group II intron splicing
2001
Isolation of an active step I spliceosome and composition of its RNP core
2008 Nature
Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution
2009 Nature
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
Spliceosomal UsnRNP biogenesis, structure and function
2001
Modulation of msl-2 5′ splice site recognition by Sex-lethal
2001
Insights into the mechanisms of splicing: more lessons from the ribosome: Figure 1.
2005
PP1/PP2A Phosphatases Are Required for the Second Step of Pre-mRNA Splicing and Target Specific snRNP Proteins
2006
Protein complexes in nucleotide excision repair
1999
Functional and physical interactions between components of the Prp19p-associated complex
2002
The DExH protein NPH-II is a processive and directional motor for unwinding RNA
2000 Nature
Spliceosome disassembly catalyzed by Prp43 and its associated components Ntr1 and Ntr2
2005
Formation of an Intricate Helical Bundle Dictates the Assembly of the 26S Proteasome Lid
2013
Splicing factor SF3b as a target of the antitumor natural product pladienolide
2007
Repositioning of the Reaction Intermediate within the Catalytic Center of the Spliceosome
2006
RNA helicases — one fold for many functions
2007
Cotranscriptional Spliceosome Assembly Occurs in a Stepwise Fashion and Requires the Cap Binding Complex
2005
Hypermethylation of the Cap Structure of Both Yeast snRNAs and snoRNAs Requires a Conserved Methyltransferase that Is Localized to the Nucleolus
2002
Cardiotonic steroids on the road to anti-cancer therapy
2007
Cotranscriptional Spliceosome Assembly Dynamics and the Role of U1 snRNA:5′ss Base Pairing in Yeast
2005 StandoutNobel
The dsRNA Binding Protein RDE-4 Interacts with RDE-1, DCR-1, and a DExH-Box Helicase to Direct RNAi in C. elegans
2002 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Three-Dimensional Structure of the Native Spliceosome by Cryo-Electron Microscopy
2004
Protein folding: local structures, domains, subunits, and assemblies
1991
Functional Recognition of the 5′ Splice Site by U4/U6.U5 tri-snRNP Defines a Novel ATP-Dependent Step in Early Spliceosome Assembly
2000
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation
2010 Nature
Proximity of conserved U6 and U2 snRNA elements to the 5′ splice site region in activated spliceosomes
2006
Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon
2005 StandoutNobel
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
2014 Standout
Characterization of U4 and U6 interactions with the 5′ splice site using a S. cerevisiae in vitro trans-splicing system
2001
Structural elucidation of a PRP8 core domain from the heart of the spliceosome
2008
“Nought May Endure but Mutability”: Spliceosome Dynamics and the Regulation of Splicing
2008
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6middle dotU5] tri-snRNP
1999
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
2005 StandoutNatureNobel
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
A Conformational Rearrangement in the Spliceosome Sets the Stage for Prp22-Dependent mRNA Release
2008
Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis
2002
Prp8 protein: At the heart of the spliceosome
2005
DEAD-Box Proteins Unwind Duplexes by Local Strand Separation
2007
Specific telomerase RNA residues distant from the template are essential for telomerase function
1998 StandoutNobel
Hepatitis C Virus Core Protein Interacts with a Human DEAD Box Protein DDX3
1999
Functional Association of U2 snRNP with the ATP-Independent Spliceosomal Complex E
2000
Three-dimensional structure of a pre-catalytic human spliceosomal complex B
2004
ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8
2008
Generation of Alternative Ultrabithorax Isoforms and Stepwise Removal of a Large Intron by Resplicing at Exon–Exon Junctions
1998
Pre-mRNA Splicing
2003
Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry
2000
The folding of an enzyme
1992
The network of protein–protein interactions within the human U4/U6.U5 tri-snRNP
2006
Protein folding dynamics: The diffusion‐collision model and experimental data
1994
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Competition between the ATPase Prp5 and Branch Region-U2 snRNA Pairing Modulates the Fidelity of Spliceosome Assembly
2007
Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
2013 StandoutNobel
Early organization of pre-mRNA during spliceosome assembly
2002
RNA helicases at work: binding and rearranging
2010
Extended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognition
2005
Dead-box proteins: a family affair—active and passive players in RNP-remodeling
2006
A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro
1999
Spliceosomal Small Nuclear Ribonucleoprotein Particles Repeatedly Cycle through Cajal Bodies
2008
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Protein-free small nuclear RNAs catalyze a two-step splicing reaction
2009
Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing
1999
An Intronic Downstream Enhancer Promotes 3′ Splice Site Usage of a Neural Cell-specific Exon
2000
The Prp19p-Associated Complex in Spliceosome Activation
2003 Science
Structural Characterization of a Partly Folded Apomyoglobin Intermediate
1990 Science
Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)
2011 StandoutNobel
Consensus-derived structural determinants of the ankyrin repeat motif
2002
Binding of the Human Prp31 Nop Domain to a Composite RNA-Protein Platform in U4 snRNP
2007 Science
Quality Control by DNA Repair
1999 StandoutScienceNobel
Protein folding
1990
Cotranscriptional Recruitment of the U1 snRNP to Intron-Containing Genes in Yeast
2003
Prediction of protein-folding mechanisms from free-energy landscapes derived from native structures
1999 StandoutNobel
Recognition of RNA Branch Point Sequences by the KH Domain of Splicing Factor 1 (Mammalian Branch Point Binding Protein) in a Splicing Factor Complex
2001 StandoutNobel
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
The U1 snRNP Base Pairs with the 5′ Splice Site within a Penta-snRNP Complex
2003
The Human U5-220kD Protein (hPrp8) Forms a Stable RNA-Free Complex with Several U5-Specific Proteins, Including an RNA Unwindase, a Homologue of Ribosomal Elongation Factor EF-2, and a Novel WD-40 Protein
1998
The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosome
2002
NMR Determination of Residual Structure in a Urea-Denatured Protein, the 434-Repressor
1992 StandoutScienceNobel
Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
2010 StandoutNobel
On the importance of being co-transcriptional
2002
Molecular Matchmakers
1993 StandoutScienceNobel
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
2001 StandoutNobel
Structure of a Multipartite Protein-Protein Interaction Domain in Splicing Factor Prp8 and Its Link to Retinitis Pigmentosa
2007
Crystal structure of the β-finger domain of Prp8 reveals analogy to ribosomal proteins
2008
In vitro reconstitution of the human RISC-loading complex
2008 StandoutNobel
Regulation of Alternative Splicing by the ATP-Dependent DEAD-Box RNA Helicase p72
2002
ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation
1998
A cyclophilin functions in pre-mRNA splicing
2002
Purification of the yeast U4/U6⋅U5 small nuclear ribonucleoprotein particle and identification of its proteins
1999
A Targeted Bypass Screen Identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for Stable U1 snRNP/Pre-mRNA Interaction
2009 StandoutNobel
Cellular cofactors affecting hepatitis C virus infection and replication
2007 StandoutNobel
A Mutate-and-Map Strategy for Inferring Base Pairs in Structured Nucleic Acids: Proof of Concept on a DNA/RNA Helix
2010
Translocation and Unwinding Mechanisms of RNA and DNA Helicases
2008
Both Catalytic Steps of Nuclear Pre-mRNA Splicing Are Reversible
2008 Science
CRYO-ELECTRON MICROSCOPY OF SPLICEOSOMAL COMPONENTS
2006
TAPping into mRNA Export
2001 StandoutScienceNobel
Allosteric Cascade of Spliceosome Activation
2002
The Ubiquitin Code
2012 Standout
The yeast U2A′/U2B″ complex is required for pre-spliceosome formation
1998
Structural basis for the function of DEAH helicases
2010
Template Boundary in a Yeast Telomerase Specified by RNA Structure
2000 StandoutScienceNobel
hnRNP H Is a Component of a Splicing Enhancer Complex That Activates a c-srcAlternative Exon in Neuronal Cells
1999
Conservation of the Protein Composition and Electron Microscopy Structure of Drosophila melanogaster and Human Spliceosomal Complexes
2008
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Mechanisms of Alternative Pre-Messenger RNA Splicing
2003 Standout
Protein Displacement by DExH/D "RNA Helicases" Without Duplex Unwinding
2004 Science
Effects of the U1C L13 mutation and temperature regulation of yeast commitment complex formation
2004 StandoutNobel
Proteomics Analysis Reveals Stable Multiprotein Complexes in Both Fission and Budding Yeasts Containing Myb-Related Cdc5p/Cef1p, Novel Pre-mRNA Splicing Factors, and snRNAs
2002
Phosphorylation Regulates In Vivo Interaction and Molecular Targeting of Serine/Arginine-rich Pre-mRNA Splicing Factors
1999
Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays
2002 Science
Structural Insights into Group II Intron Catalysis and Branch-Site Selection
2002 StandoutScienceNobel
p68 RNA Helicase Is an Essential Human Splicing Factor That Acts at the U1 snRNA-5′ Splice Site Duplex
2002
Characterization of protein folding intermediates
1991
Works of Jonathan P. Staley being referenced
Mechanical Devices of the Spliceosome: Motors, Clocks, Springs, and Things
1998
Multiple functions for the invariant AGC triad of U6 snRNA
2004
U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicing
2007
RNA catalyses nuclear pre-mRNA splicing
2013 Nature
The DEAH Box ATPases Prp16 and Prp43 Cooperate to Proofread 5′ Splice Site Cleavage during Pre-mRNA Splicing
2010
An RNA Switch at the 5′ Splice Site Requires ATP and the DEAD Box Protein Prp28p
1999
Exon ligation is proofread by the DExD/H-box ATPase Prp22p
2006
The EF-G-like GTPase Snu114p Regulates Spliceosome Dynamics Mediated by Brr2p, a DExD/H Box ATPase
2006
Formation of a native‐like subdomain in a partially folded intermediate of bovine pancreatic trypsin inhibitor
1994
Role of a subdomain in the folding of bovine pancreatic trypsin inhibitor
1990 Nature
Specific Alterations of U1-C Protein or U1 Small Nuclear RNA Can Eliminate the Requirement of Prp28p, an Essential DEAD Box Splicing Factor
2001
A role for ubiquitin in the spliceosome assembly pathway
2008
Assembly of ribosomes and spliceosomes: complex ribonucleoprotein machines
2009
Spliceosome discards intermediates via the DEAH box ATPase Prp43p
2010
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation
2013
The Splicing Factor Prp43p, a DEAH Box ATPase, Functions in Ribosome Biogenesis
2005
Complete folding of bovine pancreatic trypsin inhibitor with only a single disulfide bond.
1992