Standout Papers
Citation Impact
Citing Papers
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
The Anatomy and Taxonomy of Protein Structure
1981 Standout
Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons
2004
Evolutionary divergence plots of homologous proteins
1992
A route to high surface area, porosity and inclusion of large molecules in crystals
2004 StandoutNatureNobel
Recent applications of protein crystallography and structure-guided drug design
2005
Maintenance of functional equivalence during paralogous Hox gene evolution
2000 StandoutNatureNobel
Crystal and molecular structure of the bovine α-chymotrypsin-eglin c complex at 2.0 Å resolution
1992
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
High-throughput crystallography for lead discovery in drug design
2002
Structure of the 30S ribosomal subunit
2000 StandoutNatureNobel
The housekeeping gene xanthine oxidoreductase is necessary for milk fat droplet enveloping and secretion: gene sharing in the lactating mammary gland
2002 StandoutNobel
Glucocorticoid Ligands Specify Different Interactions with NF-κB by Allosteric Effects on the Glucocorticoid Receptor DNA Binding Domain
2004
MUSCLE: multiple sequence alignment with high accuracy and high throughput
2004 Standout
Peptidomimetics derived from natural products
1993
Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels
2008 StandoutNobel
Role of the N-terminal Catalytic Domain of Angiotensin-converting Enzyme Investigated by Targeted Inactivation in Mice
2004 StandoutNobel
Structural biology in fragment-based drug design
2010
Modeling of loops in protein structures
2000 Standout
An algorithm for determining the conformation of polypeptide segments in proteins by systematic search
1986
The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships
1992
Gene Switching and the Stability of Odorant Receptor Gene Choice
2004 StandoutNobel
Conformation of β-hairpins in protein structures
1989
Developments in theCCP4 molecular-graphics project
2004
Analysis of side-chain orientations in homologous proteins
1987
Dynamic template-assisted strategies in fragment-based drug discovery
2009
[10] Electron-density map interpretation
1997
Large-scale comparison of protein sequence alignment algorithms with structure alignments
2000
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
2004 Standout
Conformations of immunoglobulin hypervariable regions
1989 StandoutNatureNobel
Recent Developments in Fragment-Based Drug Discovery
2008
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
Amino acid substitutions in structurally related proteins a pattern recognition approach
1988
A new method for building protein conformations from sequence alignments with homologues of known structure
1991
Transforming fragments into candidates: small becomes big in medicinal chemistry
2009
Identification of the haemoglobin scavenger receptor
2001 StandoutNature
Prediction of protein secondary structure and active sites using the alignment of homologous sequences
1987
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools
1997 Standout
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
1994 Standout
Fragment-based QSAR strategies in drug design
2010
Features and development of Coot
2010 Standout
The rise of fragment-based drug discovery
2009
Recent progress in fragment-based lead discovery
2009
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Calculating three‐dimensional changes in protein structure due to amino‐acid substitutions: The variable region of immunoglobulins
1986
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Novel trends in high-throughput screening
2009
Cysteine proteases of positive strand RNA viruses and chymotrypsin‐like serine proteases
1989
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents
2006 StandoutNobel
Rose: generating sequence families.
1998
A workbench for multiple alignment construction and analysis
1991
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
A player of many parts: The spotlight falls on thrombin's structure
1993
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Structural patterns in globular proteins
1976 StandoutNatureNobel
Knowledge-based prediction of protein structures and the design of novel molecules
1987 Nature
Fluorine in medicinal chemistry
2007 Standout
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Modelling of the combining sites of three anti-lysozyme monoclonal antibodies and of the complex between one of the antibodies and its epitope.
1986
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Gene duplications in the structural evolution of chymotrypsin
1979
GEPOL: An improved description of molecular surfaces. III. A new algorithm for the computation of a solvent‐excluding surface
1994
The membrane glycoprotein encoded by the retroviral oncogene v-erb-B is structurally related to tyrosine-specific protein kinases.
1984 StandoutNobel
Axonal Ephrin-As and Odorant Receptors
2003 StandoutNobel
X-ray crystal structure of the complex of human leukocyte elastase (PMN elastase) and the third domain of the turkey ovomucoid inhibitor.
1986 StandoutNobel
Splice Junctions: Association with Variation in Protein Structure
1983 Science
The molecular surface package
1993
Interactive computer surface graphics approach to study of the active site of bovine trypsin
1978
Lectins: Cell-Agglutinating and Sugar-Specific Proteins
1972 StandoutScience
The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related
1983 StandoutNatureNobel
Design and NMR-Based Screening of LEF, a Library of Chemical Fragments with Different Local Environment of Fluorine
2009
The Kinetics of the Alkaline Bohr Effect of Human Hemoglobin
1970
Crystal Structure of the Aequorea victoria Green Fluorescent Protein
1996 StandoutScienceNobel
Toward simpler and faster genome-wide mutagenesis in mice
2007 StandoutNobel
Reverse Turns in Peptides and Protein
1980
Estimation of globular protein secondary structure from circular dichroism
1981 Standout
Identification of protein sequence homology by consensus template alignment
1986
Inhibition of Bohr Effect after Removal of C-Terminal Histidines from Haemoglobin β-Chains
1970 Nature
Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
1983 Standout
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Solvent-Accessible Surfaces of Proteins and Nucleic Acids
1983 StandoutScience
X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain
2008
An analysis of incorrectly folded protein models
1984
Reduced surface: An efficient way to compute molecular surfaces
1996 Standout
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
Characterization of multiple bends in proteins
1980
Comparative Protein Structure Modeling of Genes and Genomes
2000 Standout
Specific recognition in the tertiary structure of β-sheets of proteins
1980
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
Using known substructures in protein model building and crystallography.
1986
Structure and function of haemoglobin
1976
Structure of concanavalin A at 2.4-Ang resolution
1972
Three Dimensional Fourier Synthesis of Horse Deoxyhaemoglobin at 2.8 Å Resolution
1970 Nature
Stereochemistry of Cooperative Effects in Haemoglobin: Haem–Haem Interaction and the Problem of Allostery
1970 StandoutNature
Determination of the secondary structure of proteins from the amide I band of the laser Raman spectrum
1981
A tool for multiple sequence alignment.
1989
Structure-Based Design of Novel, Urea-Containing FKBP12 Inhibitors
1996
Quantum Mechanical Continuum Solvation Models
2005 Standout
Reactions of Haemoglobin Dimers after Ligand Dissociation
1970 Nature
Refined 2 Å X-ray crystal structure of porcine pancreatic kallikrein A, a specific trypsin-like serine proteinase
1983
New scoring matrix for amino acid residue exchanges based on residue characteristic physical parameters
1987
Amino acid substitution matrices from protein blocks.
1992 Standout
Structure of Concanavalin A at 4 Å Resolution
1971 StandoutNobel
Secondary, tertiary, and quaternary structure of T-cell-specific immunoglobulin-like polypeptide chains.
1986 StandoutNobel
Unusual Fragments in the Subunit Structure of Concanavalin A
1971 StandoutNobel
The relation between the divergence of sequence and structure in proteins.
1986 Standout
Real-Time Color Graphics in Studies of Molecular Interactions
1981 Science
Minimum message length inference of secondary structure from protein coordinate data
2012
Polypeptide secondary structure determination by nuclear magnetic resonance observation of short proton-proton distances
1984 StandoutNobel
Works of Jonathan Greer being referenced
Comparative Modeling of Proteins in the Design of Novel Renin Inhibitors
1991
Application of the Three-Dimensional Structures of Protein Target Molecules in Structure-Based Drug Design
1994
Targeting genes for self-excision in the germ line
1999 StandoutNobel
Discovering novel ligands for macromolecules using X-ray crystallographic screening
2000
Comparative modeling methods: Application to the family of the mammalian serine proteases
1990
The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain
2003
A decade of fragment-based drug design: strategic advances and lessons learned
2007
Three-dimensional Fourier Synthesis of Human Deoxyhaemoglobin at 3.5 Å Resolution
1970 Nature
Three-dimensional structure of abnormal human haemoglobins Chesapeake and J Capetown
1971
Model for haptoglobin heavy chain based upon structural homology.
1980
Three-dimensional pattern recognition: An approach to automated interpretation of electron density maps of proteins
1974
Three-dimensional structure of abnormal human haemoglobins Kansas and Richmond
1971
Automatic identification of secondary structure in globular proteins
1977 StandoutNobel
Three Dimensional Structure of Haemoglobin Rainier
1971
Automated Crystal Mounting and Data Collection for Protein Crystallography
2000
Structure and assembly of haptoglobin polymers by electron microscopy
1984
Three-dimensional structure of abnormal human haemoglobins M Hyde Park and M Iwate
1971
An X-ray crystallographic study of concanavalin A
1970
Computer skeletonization and automatic electron density map analysis
1985
Application of the automated interpretation of electron density maps to Bence-Jones protein Rhe
1976
Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series
2003
Macromolecular shape and surface maps by solvent exclusion.
1978
Identification of Residues responsible for the Alkaline Bohr Effect in Haemoglobin
1969 Nature
Model Structure for the Inflammatory Protein C5a
1985 Science
Comparative model-building of the mammalian serine proteases
1981
Model of a specific interaction
1981
Protein Structure and Function by Comparative Model Building
1985