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1985 Nature
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1978
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2002
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2001 Nobel
Cachectin alters anterior pituitary hormone release by a direct action in vitro.
1989 StandoutNobel
Influence of delayed immune reactions on human epidermal keratinocytes.
1986 StandoutNobel
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2000 Nobel
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2005
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2012
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2008
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2002
Cachectin: More Than a Tumor Necrosis Factor
1987 StandoutNobel
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1999
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2013
Spectroscopic Analysis of the Trinuclear Cluster in the Fet3 Protein from Yeast, a Multinuclear Copper Oxidase
2000
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1998
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2002 Science
Bioinorganic Chemistry of Alzheimer’s Disease
2012
Structural Basis of the Ferrous Iron Specificity of the Yeast Ferroxidase, Fet3p
2006
Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts
1977 StandoutNobel
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2002
The Steap proteins are metalloreductases
2006
Recombinant Gamma Interferon Induces HLA-DR Expression on Cultured Human Keratinocytes
1984
Protein transport: A selective membrane mechanism
1976
Chimeric tumor necrosis factor receptors with constitutive signaling activity.
1995 StandoutNobel
Cellular copper management—a draft user's guide
2009
A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts
1977 StandoutNatureNobel
Function, Structure, and Mechanism of Intracellular Copper Trafficking Proteins
2001
Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy
2005
Maintenance of in Vivo Tolerance by Persistence of Antigen
1992 StandoutScienceNobel
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2005
Cell-mediated immunity and the CNS a key role for γ interferon
1985 StandoutNobel
Imaging the glycome
2008 StandoutNobel
Human interferon-? induces expression of HLA-DR on keratinocytes and melanocytes
1985
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2013
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2003 StandoutNobel
Programmed cell death in amyotrophic lateral sclerosis
2003
Copper Coordination in the Full-Length, Recombinant Prion Protein
2003 Nobel
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2000
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2005
Advances in Copper Complexes as Anticancer Agents
2013 Standout
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2009
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2009
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2005
Photochemical Tools for Studying Metal Ion Signaling and Homeostasis
2012
Paradoxical roles for lysyl oxidases in cancer—A prospect
2007
Coupled prediction of protein secondary and tertiary structure
2003 StandoutNobel
Perspectives in Inorganic Structural Genomics: A Trafficking Route for Copper
2004
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
1984 StandoutNatureNobel
Copper-related diseases: From chemistry to molecular pathology
2009
Immune mechanisms in atherosclerosis.
1989
Solution Structure of the Apo and Copper(I)-Loaded Human Metallochaperone HAH1
2004
The Basis for the Immunoregulatory Role of Macrophages and Other Accessory Cells
1987 Science
Immune Mechanisms in Atherosclerosis
2001
COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS
2003
Review article: Fcγ receptors in the human placenta
1981
Treatment of metastatic cancer with tetrathiomolybdate, an anticopper, antiangiogenic agent: Phase I study.
2000
Endotoxin and tumor necrosis factor induce interleukin-1 gene expression in adult human vascular endothelial cells.
1986
Ferrous Binding to the Multicopper OxidasesSaccharomyces cerevisiaeFet3p and Human Ceruloplasmin: Contributions to Ferroxidase Activity
2004
Chelators at the Cancer Coalface: Desferrioxamine to Triapine and Beyond
2006
The Octarepeat Domain of the Prion Protein Binds Cu(II) with Three Distinct Coordination Modes at pH 7.4
2005
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
The crystal structure of yeast copper thionein: The solution of a long-lasting enigma
2004
Oxidation versus aggregation — how do SOD1 mutants cause ALS?
2000
Chemical Glycoproteomics
2016 StandoutNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Evidence for Iron Channeling in the Fet3p−Ftr1p High-Affinity Iron Uptake Complex in the Yeast Plasma Membrane
2006
Oxidative stress in neurodegeneration: cause or consequence?
2004 Standout
Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease.
1984
Dynamic Copper(I) Imaging in Mammalian Cells with a Genetically Encoded Fluorescent Copper(I) Sensor
2010
Works of Jonathan D. Gitlin being referenced
Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis
2006
Mechanisms of Copper Incorporation into Human Ceruloplasmin
2002
The Copper Chaperone for Superoxide Dismutase
1997
Use of desferrioxamine in the treatment of aceruloplasminemia
1997
Increased plasma lipid peroxidation in patients with aceruloplasminemia
1996
Wilson's Disease
2000
Role of Copper in the Proteosome-mediated Degradation of the Multicopper Oxidase Hephaestin
2004
Copper deficiency
2007
The Neuronal Adaptor Protein X11α Interacts with the Copper Chaperone for SOD1 and Regulates SOD1 Activity
2001
Copper Homeostasis in the CNS: A Novel Link Between the NMDA Receptor and Copper Homeostasis in the Hippocampus
2006
Disease-associated Mutations at Copper Ligand Histidine Residues of Superoxide Dismutase 1 Diminish the Binding of Copper and Compromise Dimer Stability
2006
The Role of Copper in Neurodegenerative Disease
1999
Zebrafish Mutants calamity and catastrophe Define Critical Pathways of Gene–Nutrient Interactions in Developmental Copper Metabolism
2008
HAH1 Is a Copper-binding Protein with Distinct Amino Acid Residues Mediating Copper Homeostasis and Antioxidant Defense
1998
Brain Copper Content and Cuproenzyme Activity Do Not Vary with Prion Protein Expression Level
2000
Distinct Wilson’s Disease Mutations in ATP7B Are Associated With Enhanced Binding to COMMD1 and Reduced Stability of ATP7B
2007
Mechanisms of the Copper-dependent Turnover of the Copper Chaperone for Superoxide Dismutase
2006
NMDA Receptor Activation Mediates Copper Homeostasis in Hippocampal Neurons
2005
Essential role for the alpha 1 chain of type VIII collagen in Zebrafish notochord formation
2008
Biochemical Analysis of a Missense Mutation in Aceruloplasminemia
2002
Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae
1997
Atp7a determines a hierarchy of copper metabolism essential for notochord development
2006
Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading
2002
The copper-iron connection: Hereditary aceruloplasminemia
2002
Aceruloplasminemia
1998
Intracellular Pathways of Copper Trafficking in Yeast and Humans
1999
Identification and Functional Expression of HAH1, a Novel Human Gene Involved in Copper Homeostasis
1997
GLUT1 Deficiency Links Nutrient Availability and Apoptosis during Embryonic Development
2006
Functional Expression of the Menkes Disease Protein Reveals Common Biochemical Mechanisms Among the Copper-transporting P-type ATPases
1998
Assembling the pieces
2008
Mechanisms of Biosynthesis of Mammalian Copper/Zinc Superoxide Dismutase
2003
Copper Chaperones for Cytochrome c Oxidase and Human Disease
2002
The Copper Toxicosis Gene Product Murr1 Directly Interacts with the Wilson Disease Protein
2003
CERULOPLASMIN METABOLISM AND FUNCTION
2002
Regulation of the Copper Chaperone CCS by XIAP-Mediated Ubiquitination
2010
A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia
2004
Hepatocyte-specific localization and copper-dependent trafficking of the Wilson’s disease protein in the liver
1999
Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
1999
The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis
2001
Essential role for Atox1 in the copper-mediated intracellular trafficking of the Menkes ATPase
2003
Role of the Menkes copper-transporting ATPase in NMDA receptor-mediated neuronal toxicity
2006
Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation
1998
Copper and Iron Disorders of the Brain
2007
Wilson disease
2003
Protein Binding by Specific Receptors on Human Placenta, Murine Placenta, and Suckling Murine Intestine in Relation to Protein Transport across These Tissues
1974
Biochemical characterization and intracellular localization of the Menkes disease protein
1996
THE SELECTIVE TRANSPORT OF MATERNAL PLASMA. PROTEINS ACROSS THE MAMMARY GLAND
1974
Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis
1999
Combined zebrafish-yeast chemical-genetic screens reveal gene–copper-nutrition interactions that modulate melanocyte pigmentation
2010
A Novel Pineal Night-Specific ATPase Encoded by the Wilson Disease Gene
1999
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon
1983 Nature
IV. Wilson’s disease and Menkes disease
1999
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase
2000
Localization of C‐reactive protein in synovium of patients with rheumatoid arthritis
1977
The Copper Chaperone CCS Directly Interacts with Copper/Zinc Superoxide Dismutase
1998