Citation Impact
Citing Papers
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
2010 StandoutScience
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Quantitative assessment of brown adipose tissue metabolic activity and volume using 18F-FDG PET/CT and β3-adrenergic receptor activation
2011
Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors
1999 StandoutNobel
Asymmetric Counteranion‐Directed Catalysis: Concept, Definition, and Applications
2012 StandoutNobel
Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo
2013 StandoutNobel
Identification and Importance of Brown Adipose Tissue in Adult Humans
2009 Standout
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
2015 StandoutNature
Catalytic Asymmetric Benzidine Rearrangement
2013 StandoutNobel
Targeted Disruption of the β2 Adrenergic Receptor Gene
1999 StandoutNobel
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
2001 StandoutNature
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
1993 Nature
1,4‐Pentenyne as a Five‐Carbon Synthon for Efficient and Selective Syntheses of Natural Products Containing 2,4‐Dimethyl‐1‐penten‐1,5‐ylidene and Related Moieties by Means of Zr‐Catalyzed Carboalumination of Alkynes and Alkenes
2007 StandoutNobel
Nutrient sensing and inflammation in metabolic diseases
2008
The metabolic syndrome
2010 Standout
Hypertrophy of brown adipocytes in brown and white adipose tissues and reversal of diet-induced obesity in rats treated with a β3-adrenoceptor agonist
1997
Function and regulation of the β3-adrenoceptor
1996
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
1999 Standout
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis
2011
Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3
2000
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis
1998 Standout
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Role of the Microbiota in Immunity and Inflammation
2014 Standout
PRDM16 controls a brown fat/skeletal muscle switch
2008 StandoutNature
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)
2013 StandoutNobel
Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation
2000 StandoutNobel
Pharmacologic Manipulation of ob Expression in a Dietary Model of Obesity
1996
The metabolic syndrome
2005 Standout
Role of the β3-Adrenergic Receptor and/or a Putative β4-Adrenergic Receptor on the Expression of Uncoupling Proteins and Peroxisome Proliferator-Activated Receptor-γ Coactivator-1
1999
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor
2000 StandoutNobel
Fatty acid metabolism and insulin secretion in pancreatic beta cells
2003
Antimicrobial activity and spectrum of the new glycylcycline, GAR-936 tested against 1,203 recent clinical bacterial isolates
2000
Membrane Fusion
2003 StandoutNobel
The Impact of the Gut Microbiota on Human Health: An Integrative View
2012 Standout
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
2012 Standout
The Negative Inotropic Effect of β3-Adrenoceptor Stimulation in the Beating Guinea Pig Heart
2000
Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936
1999
Synthesis of Oxacyclic Scaffolds via Dual Ruthenium Hydride/Brønsted Acid‐Catalyzed Isomerization/Cyclization of Allylic Ethers
2014
The β3-Adrenergic Receptor Activates Mitogen-activated Protein Kinase in Adipocytes through a Gi-dependent Mechanism
1999
What We Talk About When We Talk About Fat
2014 Standout
Functional beta3-adrenoceptor in the human heart.
1996
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Obesity and the Regulation of Energy Balance
2001 Standout
Crystal structure of the tet repressor in complex with a novel tetracycline, 9-( N , N -dimethylglycylamido)-6-demethyl-6-deoxy-tetracycline 1 1Edited by R. Huber
1999
Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents
1991
The Organocatalytic Asymmetric Prins Cyclization
2015 StandoutNobel
A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
2007 Standout
Targeted Disruption of the β3-Adrenergic Receptor Gene
1995
Unusually Broad Substrate Profile of Self‐Sufficient Cytochrome P450 Monooxygenase CYP116B4 from Labrenzia aggregata
2014
Further evidence for differences between cardiac atypical β‐adrenoceptors and brown adipose tissue β3‐adrenoceptors in the pithed rat
1997
Linkage of β1-adrenergic stimulation to apoptotic heart cell death through protein kinase A–independent activation of Ca2+/calmodulin kinase II
2003 StandoutNobel
BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY
1997
Glycylcyclines bind to the high-affinity tetracycline ribosomal binding site and evade Tet(M)- and Tet(O)-mediated ribosomal protection
1996
Synthesis of Oxacycles Employing the Oxa‐Pictet–Spengler Reaction: Recent Developments and New Prospects
2011
Anti-Obesity Effects of Selective Agonists to the .BETA.3-Adrenergic Receptor in Dogs. II. Recruitment of Thermogenic Brown Adipocytes and Reduction of Adiposity after Chronic Treatment with a .BETA.3-Adrenergic Agonist.
1998
In Vitro and In Vivo Antibacterial Activities of a Novel Glycylcycline, the 9- t -Butylglycylamido Derivative of Minocycline (GAR-936)
1999
βAR Signaling Required for Diet-Induced Thermogenesis and Obesity Resistance
2002 StandoutScienceNobel
Directed Evolution: Bringing New Chemistry to Life
2017 StandoutNobel
pH-Dependent Changes in Photoaffinity Labeling Patterns of the H1 Influenza Virus Hemagglutinin by Using an Inhibitor of Viral Fusion
1999
In vitro activities of two new glycylcyclines, N,N-dimethylglycylamido derivatives of minocycline and 6-demethyl-6-deoxytetracycline, against 339 strains of anaerobic bacteria
1994
The first catalytic enantioselective Diels–Alder reactions of 1,2-dihydropyridine: efficient syntheses of optically active 2-azabicyclo[2.2.2]octanes with chiral BINAM derived Cr(III) salen complexes
2002
Mapping epitopes and antigenicity by site-directed masking
2006 StandoutNobel
Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites
2005 StandoutNobel
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Sampling the Antibiotic Resistome
2006 StandoutScience
Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump
1994
N,N-dimethylglycyl-amido derivative of minocycline and 6-demethyl-6-desoxytetracycline, two new glycylcyclines highly effective against tetracycline-resistant gram-positive cocci
1994
Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin
2000 Standout
Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance
2001 Standout
Inflammatory Mechanisms in Obesity
2011 Standout
Micromanaging insulin secretion
2004 StandoutNobel
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
Augmentation of Cardiac Contractility Mediated by the Human β 3 -Adrenergic Receptor Overexpressed in the Hearts of Transgenic Mice
2001 StandoutNobel
A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter
1995
Strategies for the Diversity-Oriented Synthesis of Macrocycles
2019
STRUCTURE AND FUNCTION OF THE β3-ADRENERGIC RECEPTOR
1997
Nitrated Confined Imidodiphosphates Enable a Catalytic Asymmetric Oxa-Pictet–Spengler Reaction
2016 StandoutNobel
Improved Glucose and Lipid Metabolism in Genetically Obese Mice Lacking aP2
2000
Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides
2010
In vitro and in vivo antibacterial activities of the glycylcyclines, a new class of semisynthetic tetracyclines
1993
Biocatalytic Synthesis of Chiral Alcohols and Amino Acids for Development of Pharmaceuticals
2013
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
Works of Jonathan D. Bloom being referenced
Beta-3 adrenoceptor selectivity of the dioxolane dicarboxylate phenethanolamines.
1994
Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity
2011
Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent .beta.-adrenergic agonist virtually specific for .beta.3 receptors. A promising antidiabetic and antiobesity agent
1992
Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines
1994
Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model
2011
Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model
2011
Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity
2011
Discovery of Pyrano[3,4-b]indoles as Potent and Selective HCV NS5B Polymerase Inhibitors
2004
Total synthesis of milbemycin .beta.3
1982
Inhibition of Influenza A Virus Replication by Compounds Interfering with the Fusogenic Function of the Viral Hemagglutinin
1999
Diels-Alder adducts of 1-benzenesulfonylindole-2-acrylates and 1-(alkoxycarbonyl)-1,2-dihydropyridines. Intermediates for synthesis of iboga alkaloid analogs
1981
Potential antiatherosclerotic agents. 5. An acyl-coenzyme A:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity
1986
Glucose intolerance in pulmonary tuberculosis.
1969
Borohydride and cyanoborohydride reduction of thioimonium salts. A convenient route for transformation of amides to amines
1981
ChemInform Abstract: Glycylcyclines. Part 1. A New Generation of Potent Antibacterial Agents Through Modification of 9‐Aminotetracyclines.
1994
Milbemycin-avermectin studies. 5. Total synthesis of milbemycin .beta.3 and its C(12) epimer
1986