Jonathan C. Chen

Four-component protein nanocages designed by programmed symmetry breaking

Screening Libraries to Discover Molecular Design Principles for the Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers Derived from Plant Phenolic Acids

Saturation variant interpretation using CRISPR prime editing

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity

Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae

Extraordinary Acceleration of Cogwheel Helical Self-Organization of Dendronized Perylene Bisimides by the Dendron Sequence Encoding Their Tertiary Structure

Sequence-Defined Dendrons Dictate Supramolecular Cogwheel Assembly of Dendronized Perylene Bisimides

Accurate proteome-wide missense variant effect prediction with AlphaMissense

Engineered pegRNAs improve prime editing efficiency

Evolution of sequence-defined highly functionalized nucleic acid polymers

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

Characterizing the in vivo role of trehalose inSaccharomyces cerevisiaeusing theAGT1transporter