Citation Impact
Citing Papers
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Property‐Driven Development of Passively Permeable Macrocyclic Scaffolds Using Heterocycles**
2022
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
2017
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Structural Alerts, Reactive Metabolites, and Protein Covalent Binding: How Reliable Are These Attributes as Predictors of Drug Toxicity?
2009
Methods for Predicting Human Drug Metabolism
2006
MC4R Agonists: Structural Overview on Antiobesity Therapeutics
2018 StandoutNobel
Peptide therapeutics: Targeting the undruggable space
2015
Cytochrome P450 reaction-phenotyping: an industrial perspective
2007
Arginine Topology Controls Escape of Minimally Cationic Proteins from Early Endosomes to the Cytoplasm
2012
Marine natural products
1990 Standout
Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes
2019 StandoutNobel
Mechanism-Based Inactivation (MBI) of Cytochrome P450 Enzymes: Structure–Activity Relationships and Discovery Strategies To Mitigate Drug–Drug Interaction Risks
2012
Discovery and optimization of peptide macrocycles
2016
Computational Methods in Drug Discovery
2014
DrugBank: a knowledgebase for drugs, drug actions and drug targets
2007 Standout
The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)
2008
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
mRNA display: from basic principles to macrocycle drug discovery
2013 Nobel
Physicochemical drug properties associated within vivotoxicological outcomes: a review
2009
Pharmacological targeting of the HIF hydroxylases – A new field in medicine development
2016 StandoutNobel
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
2021 StandoutNobel
Targeting apoptosis in cancer therapy
2020 Standout
Drug discovery for a new generation of covalent drugs
2012
Organocatalytic Asymmetric Hydrolysis of Epoxides
2014 StandoutNobel
Lipoprotein Signal Peptidase Inhibitors with Antibiotic Properties Identified through Design of a Robust In Vitro HT Platform
2018
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Chemical predictive modelling to improve compound quality
2013
The Future of Peptide‐based Drugs
2012 Standout
The role of drug metabolizing enzymes in clearance
2014
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
2015
Emerging applications of metabolomics in drug discovery and precision medicine
2016
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery
2020 StandoutNobel
Predicting drug metabolism: experiment and/or computation?
2015
Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
2014
2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association
2021 Standout
Orally Absorbed Cyclic Peptides
2017
3d Transition Metals for C–H Activation
2018 Standout
Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
2013 Standout
Total Synthesis of Nominal (11S)- and (11R)-Cyclocinamide A
2012
pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures
2015 Standout
Computer Simulation of Liquids
2017 Standout
Targeted Covalent Inhibitors for Drug Design
2016
Emerging Methods and Design Principles for Cell‐Penetrant Peptides
2018
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
The Current State of Peptide Drug Discovery: Back to the Future?
2017
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors
2015
Design and Development of a Cyclic Decapeptide Scaffold with Suitable Properties for Bioavailability and Oral Exposure
2016
Locally Weighted Learning Methods for Predicting Dose-Dependent Toxicity with Application to the Human Maximum Recommended Daily Dose
2012
MetaboAnalystR: an R package for flexible and reproducible analysis of metabolomics data
2018 Standout
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
2020 Standout
Macrocyclic Peptides as Drug Candidates: Recent Progress and Remaining Challenges
2019
β-Branched Amino Acids Stabilize Specific Conformations of Cyclic Hexapeptides
2019
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
2011 Standout
Accessing Drug Metabolites via Transition‐Metal Catalyzed C−H Oxidation: The Liver as Synthetic Inspiration
2016
Metabolism and bioactivation of famitinib, a novel inhibitor of receptor tyrosine kinase, in cancer patients
2012
Molecular Docking and Structure-Based Drug Design Strategies
2015 Standout
Oxadiazoles in Medicinal Chemistry
2011 Standout
Understanding Cell Penetration of Cyclic Peptides
2019
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Recommendations for Management of Clinically Significant Drug-Drug Interactions With Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association
2016
Picomolar Inhibitors of HIV Reverse Transcriptase Featuring Bicyclic Replacement of a Cyanovinylphenyl Group
2013
Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified
2012
Metabolism-guided drug design
2012
Therapeutic Potential of Conopeptides
2012
Computational design of mixed chirality peptide macrocycles with internal symmetry
2020 StandoutNobel
Molecular Docking: Shifting Paradigms in Drug Discovery
2019 Standout
Finding the sweet spot: the role of nature and nurture in medicinal chemistry
2012
Macrocycles: lessons from the distant past, recent developments, and future directions
2014
Proteome-Wide Reactivity Profiling Identifies Diverse Carbamate Chemotypes Tuned for Serine Hydrolase Inhibition
2013
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
2021 StandoutNobel
Kinetic Models of Cyclosporin A in Polar and Apolar Environments Reveal Multiple Congruent Conformational States
2016
Click-Chemistry-Mediated Synthesis of Selective Melanocortin Receptor 4 Agonists
2017 StandoutNobel
ETCM: an encyclopaedia of traditional Chinese medicine
2018 Standout
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
One‐Step C‐Terminal Deprotection and Activation of Peptides with Peptide Amidase from Stenotrophomonas maltophilia in Neat Organic Solvent
2014 StandoutNobel
Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds
2012
Application of Stable Isotope-Labeled Compounds in Metabolism and in Metabolism-Mediated Toxicity Studies
2008
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Conformational Effects on the Passive Membrane Permeability of Synthetic Macrocycles
2022
Biomedical Importance of Indoles
2013 Standout
Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1
2011
Natural Products as Sources of New Drugs from 1981 to 2014
2016 Standout
Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?
2013
Cyclic peptide oral bioavailability: Lessons from the past
2016
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Applications of Fluorine in Medicinal Chemistry
2015 Standout
Stapled β-Hairpins Featuring 4-Mercaptoproline
2021 StandoutNobel
The Essential Medicinal Chemistry of Curcumin
2017 Standout
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Cyclic Tetrapeptides from Nature and Design: A Review of Synthetic Methodologies, Structure, and Function
2019
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Cytochrome P450 and Chemical Toxicology
2007
Works of Jonathan Bauman being referenced
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
2011
Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists
2009
Atorvastatin Glucuronidation Is Minimally and Nonselectively Inhibited by the Fibrates Gemfibrozil, Fenofibrate, and Fenofibric Acid
2007
Optimized Assays for Human UDP-Glucuronosyltransferase (UGT) Activities: Altered Alamethicin Concentration and Utility to Screen for UGT Inhibitors
2012
Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug
2008
Reaction Phenotyping in Drug Discovery: Moving Forward with Confidence?
2003
UDP-GLUCURONOSYLTRANSFERASE 2B7 IS THE MAJOR ENZYME RESPONSIBLE FOR GEMCABENE GLUCURONIDATION IN HUMAN LIVER MICROSOMES
2005
Biosynthesis of Drug Metabolites and Quantitation Using NMR Spectroscopy for Use in Pharmacologic and Drug Metabolism Studies
2014
Utility of the carboxylesterase inhibitorbis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor
2010
Toxicophores, reactive metabolites and drug safety: when is it a cause for concern?
2008
Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: Retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry
2009
Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists
2010
Determination of Degradation Pathways and Kinetics of Acyl Glucuronides by NMR Spectroscopy
2007
Kinetics of Acetaminophen Glucuronidation by UDP-Glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential Implications in Acetaminophen−Induced Hepatotoxicity
2006
In vitro ADME phenotyping in drug discovery: current challenges and future solutions.
2005
Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
2011