Jonathan Appleby

Structure of the human TRPM4 ion channel in a lipid nanodisc

Pathophysiology of Migraine: A Disorder of Sensory Processing

Single particle electron cryo-microscopy of a mammalian ion channel

Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks

Structure of the TRPA1 ion channel suggests regulatory mechanisms

Zinc activates damage-sensing TRPA1 ion channels

TRPV1: a therapeutic target for novel analgesic drugs?

Molecular Understanding and Modern Application of Traditional Medicines: Triumphs and Trials

Natural products: An evolving role in future drug discovery

Targeting TRP channels for pain relief

Transient receptor potential channels: targeting pain at the source

The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept

Natural products to drugs: natural product-derived compounds in clinical trials

Transient receptor potential channels as therapeutic targets

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain

The nervous system of airways and its remodeling in inflammatory lung diseases

The TRPV1 receptor and nociception

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial

Translating nociceptive processing into human pain models

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

Nociceptors: the sensors of the pain pathway

TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin

TRPV1 and TRPA1 Mediate Peripheral Nitric Oxide-Induced Nociception in Mice

7-tert-Butyl-6-(4-Chloro-Phenyl)-2-Thioxo-2,3-Dihydro-1H-Pyrido[2,3-d]Pyrimidin-4-One, a Classic Polymodal Inhibitor of Transient Receptor Potential Vanilloid Type 1 with a Reduced Liability for Hyperthermia, Is Analgesic and Ameliorates Visceral Hypersensitivity

Recent advances in the study on capsaicinoids and capsinoids

Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

Discovery, Optimization, and Biological Evaluation of 5-(2-(Trifluoromethyl)phenyl)indazoles as a Novel Class of Transient Receptor Potential A1 (TRPA1) Antagonists

Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?

TRP Channels and Pain

DAMP-sensing receptors in sterile inflammation and inflammatory diseases

Transient Receptor Potential Channels - Emerging Novel Drug Targets for the Treatment of Pain

TRP Channels in Skin Biology and Pathophysiology

Chemical activation of the mechanotransduction channel Piezo1

Targeting TRPV1 for pain relief: limits, losers and laurels

The effects of the TRPV1 receptor antagonist SB-705498 on trigeminovascular sensitisation and neurotransmission

The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans

702 A RANDOMISED, TWO‐PERIOD CROSS‐OVER STUDY TO INVESTIGATE THE EFFICACY OF THE TRPV1 ANTAGONIST SB‐705498 IN ACUTE MIGRAINE

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