Standout Papers
Citation Impact
Citing Papers
Intermolecular association of the p185 protein and EGF receptor modulates EGF receptor function
1990
erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells
1987 Science
Hallmarks of Cancer: The Next Generation
2011 Standout
Heterodimerization of epidermal growth factor receptorand wild-type or kinase-deficient Neu: a mechanism of interreceptor kinaseactivation and transphosphorylation.
1994
Regulation of phosphorylation of the c-erbB-2/HER2 gene product by a monoclonal antibody and serum growth factor(s) in human mammary carcinoma cells.
1991
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate
1988 Nature
Proteins regulating Ras and its relatives
1993 StandoutNature
Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
1993
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion
1997 Nature
The Ick tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
1989
Specificity in Signal Transduction
2004
A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
1993
Identification of a protein cross-reacting with anti-phosphotyrosine antibodies in yeast insoluble cytoplasmic matrices
1989
Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6
1991
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
1994
Activators and effectors of ras p21 proteins
1994
Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus
1987 Nature
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
1999 StandoutNature
Signal Transduction by the JNK Group of MAP Kinases
2000 Standout
Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways
1992
Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein
1989
PDGF induction of tyrosine phosphorylation of GTPase activating protein
1989 Nature
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 Standout
The molecular heterogeneity of protein kinase C and its implications for cellular regulation
1988 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
1994
Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62
1992
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo
1989 StandoutNatureNobel
Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding
1993
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
1991
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus
1995
cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor
1991
Primary structure of the brain alpha-spectrin [published erratum appears in J Cell Biol 1989 Mar;108(3):following 1175]
1989
Raf meets Ras: completing the framework of a signal transduction pathway
1994
The type III epidermal growth factor receptor mutation
2001
SH2 and SH3 domains
1993
PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
1989
Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts
1988
Signal transduction by receptors with tyrosine kinase activity
1990 Standout
Purified maturation promoting factor phosphorylates pp60c-src at the sites phosphorylated during fibroblast mitosis
1989
Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane
1994 Nature
Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-$gamma;1 complexed with a high affinity binding peptide
1994
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
SH2/SH3 signaling proteins
1994
Regulated portals of entry into the cell
2003 StandoutNature
Platelet-derived Growth Factor Receptor-mediated Signal Transduction from Endosomes
2004
Association between the PDGF receptor and members of the src family of tyrosine kinases
1990
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254
1991
Purification and characterization of a human recombinant T-cell protein-tyrosine-phosphatase from a baculovirus expression system
1991 StandoutNobel
Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc
2002
Phosphatidylinositol-3-OH kinase direct target of Ras
1994 StandoutNature
Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase
1991
Endocytosis and Signaling
2001
PIP2 and PIP3
2000
ERK-dependent threonine phosphorylation of EGF receptor modulates receptor downregulation and signaling
2008
Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein
1998
Oxidative stress and heat shock induce a human gene encoding a protein-tyrosine phosphatase
1992 Nature
The Docking Protein FRS2α Controls a MAP Kinase-Mediated Negative Feedback Mechanism for Signaling by FGF Receptors
2002
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Mitosis-specific phosphorylation of p60c-src by p34cdc2-associated protein kinase
1989 StandoutNobel
Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor
2002
Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment
2009
A transcription factor with SH2 and SH3 domains is directly activated by an interferon α-induced cytoplasmic protein tyrosine kinase(s)
1992
Signaling—2000 and Beyond
2000 Standout
EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling
1989
Heterogeneous expression of four MAP kinase isoforms in human tissues
1992
Direct activation of the serine/threonine kinase activity of raf-1 through tyrosine phosphorylation by the PDGF β-receptor
1989
A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins.
1995 StandoutNobel
Protein modules and signalling networks
1995 StandoutNature
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
1995 Standout
Conservation of mitotic controls in fission and budding yeasts
1989
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2
1996 Nature
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Oncogenes and signal transduction
1991 Standout
Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells
1999
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
1994
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
1994
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
A conserved kinase cascade for MAP kinase activation in yeast
1993
The RIM/NIM Family of Neuronal C2 Domain Proteins
2000 StandoutNobel
The MAP kinase cascade is essential for diverse signal transduction pathways
1993
Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis
1989
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
1995 Nature
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle Priming
2001
The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain
2009
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
1988
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases
1991
Juxtamembrane autoinhibition in receptor tyrosine kinases
2004
Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast
1990 StandoutNatureNobel
Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
1989 StandoutNatureNobel
Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck
1993 Nature
Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
1990 Nature
Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-I cDNA
1988
Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes
1999
Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein
1987
Activation of Protein Kinase Cascades by Osmotic Shock
1995
cDNA cloning of the type 1 neurofibromatosis gene: Complete sequence of the NF1 gene product
1991
Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro
1989
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms
1993
SH3 domains direct cellular localization of signaling molecules
1993
A novel viral oncogene with structural similarity to phospholipase C
1988 Nature
Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB
1988 Nature
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso
1992
A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast
1988
Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters.
1985
SH2 and SH3 Domains: Elements that Control Interactions of Cytoplasmic Signaling Proteins
1991 StandoutScience
Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.
1982
Interactions between SH2 domains and tyrosine-phosphorylated platelet-derived growth factor beta-receptor sequences: analysis of kinetic parameters by a novel biosensor-based approach.
1993
Low Level of Cellular Protein Phosphorylation by Nontransforming Overproduced p60c-src
1985
Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.
1986
DNA sequence encoding the amino-terminal region of the human c-src protein: implications of sequence divergence among src-type kinase oncogenes.
1987
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system
1982 Nature
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
1991 StandoutNobel
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.
1983
Inhibition of the apparent affinity of the epidermal growth factor receptor caused by phorbol diesters correlates with phosphorylation of threonine-654 but not other sites on the receptor
1986
Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes
1991 Science
Growth factors: Mechanism of action and relation to oncogenes
1984
Abelson murine leukemia virus P120: identification and characterization of tyrosine phosphorylation sites
1982
Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21
1988 Science
The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes.
1993
Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain
1987
The pleckstrin homology domain of Bruton tyrosine kinase interacts with protein kinase C.
1994
The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.
1985 StandoutNobel
Nucleotide sequence of rous sarcoma virus
1983 Nobel
Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation.
1989
Cytokinetic failure and asynchronous nuclear division in BHK cells overexpressing a truncated protein-tyrosine-phosphatase.
1992 StandoutNobel
Perspectives on the Role of Protein Kinase C in Stimulus-Response Coupling<xref ref-type="fn" rid="FN4">4</xref>
1986
Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene products.
1985
Transforming potential of the c-fms proto-oncogene (CSF-1 receptor)
1987 Nature
Phosphorylation of receptors for insulin and insulin-like growth factor I. Effects of hormones and phorbol esters.
1986
Protein kinase C phosphorylates human platelet inositol trisphosphate 5′-phosphomonoesterase, increasing the phosphatase activity
1986
Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1
1999
ret transforming gene encodes a fusion protein homologous to tyrosine kinases.
1987
Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.
1993
c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF
1985
EGF receptor affinity is regulated by intracellular calcium and protein kinase C
1985
The nucleotide sequence and the tissue-specific expression of Drosophila c-src
1985 StandoutNobel
Interaction of the IL-2 Receptor with the src -Family Kinase p56 lck : Identification of Novel Intermolecular Association
1991 Science
Tyrosine phosphorylation is a signal for the trafficking of pp85, an 85-kDa phosphorylated polypeptide associated with phosphatidylinositol kinase activity.
1990
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation
1990
The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis
1987 StandoutNobel
Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.
1987 StandoutNobel
Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro.
1985
The biochemistry and physiology of the receptor-kinase for epidermal growth factor
1983
Specific Expression of a Tyrosine Kinase Gene, blk , in B Lymphoid Cells
1990 Science
Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase
1994
Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I
1983 Nature
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.
1992
Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.
1991
The p21 ras C-terminus is required for transformation and membrane association
1984 Nature
The PTB Domain: The Name Doesn't Say It All
1999
Altered phosphorylation and activation of PP60c-src during fibroblast mitosis
1988
The covalent modification of eukaryotic proteins with lipid.
1987
Phorbol esters and beta-adrenergic agonists mediate desensitization of adenylate cyclase in rat glioma C6 cells by distinct mechanisms.
1985
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses
1983
The Role of Protein Kinase C in Transmembrane Signalling
1986
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.
1984
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.
1993
Production of an Epidermal Growth Factor Receptor-Related Protein
1984 Science
Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.
1985
Trends in oncogenes
1985 StandoutNobel
T and B lymphocytes express distinct tyrosine protein kinases.
1984
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
1990
Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
1985 Nature
Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion
1986 Nature
SH2 domains recognize specific phosphopeptide sequences
1993 Standout
The Action of Oncogenes in the Cytoplasm and Nucleus
1985 Science
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences
1986 Nature
Reduction of epidermal growth factor receptor affinity by heterologous ligands: Evidence for a mechanism involving the breakdown of phosphoinositides and the activation of protein kinase C
1984
Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation
1987
Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.
1993
Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor.
1986
Similar action of platelet‐derived growth factor and epidermal growth factor in the prereplicative phase of human fibroblasts suggests a common intracellular pathway
1985
SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.
1993
Enhanced tyrosine phosphorylation in B lymphocytes upon complexing of membrane immunoglobulin
1984
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.
1994
Autophosphorylation sites on the epidermal growth factor receptor
1984 Nature
Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654.
1985
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
1986 Standout
The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins
1981
Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling
1993 Science
Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes
1985 Nature
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.
1990
Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine.
1984
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells.
1989
The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.
1991 Nobel
Characterization of platelet-derived growth factor-stimulated phosphorylation in cell membranes.
1983
Phorbol diesters promote β-adrenergic receptor phosphorylation and adenylate cyclase desensitization in duck erythrocytes
1984
A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.
1991
Activation of the transforming potential of p60c-src by a single amino acid change.
1986
Gap Domains Responsible for Ras P21-Dependent Inhibition of Muscarinic Atrial K + Channel Currents
1992 Science
Myc oncoproteins are phosphorylated by casein kinase II.
1989
Three loci related to the src oncogene and tyrosine-specific protein kinase activity in Drosophila
1983 StandoutNatureNobel
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.
1994
Structural organization and nucleotide sequence of mouse c-myboncogene: activation in ABPL tumors is due to viral integration in an intron which results in the deletion of the 5′ coding sequences
1986
Transcriptional activation encoded by the v-fos gene.
1986
An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins
1985 Nature
Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation.
1994
A carboxyl-terminal cysteine residue is required for palmitic acid binding and biological activity of the ras-related yeast YPT1 protein.
1988
p60c-src is complexed with a cellular protein in subcellular compartments involved in exocytosis.
1988
The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.
1993
Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.
1994
Phosphorylation of the human interleukin-2 receptor and a synthetic peptide identical to its C-terminal, cytoplasmic domain.
1986
Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src
1983 StandoutNobel
Protein kinase C phosphorylation at Thr 654 of the unoccupied EGF receptor and EGF binding regulate functional receptor loss by independent mechanisms
1986
MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING
1997
Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.
1992
Purified human platelet-derived growth factor receptor has ligand-stimulated tyrosine kinase activity.
1986
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis.
1985
Protein-Tyrosine Kinase Activity in Saccharomyces cerevisiae
1986 Science
Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog
1987 StandoutNobel
Protein kinase C: Rapid enzyme purification and substrate-dependence of the diacylglycerol effect
1984
Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.
1987 StandoutNobel
Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor.
1984
Covalently bound myristate in a lymphoma tyrosine protein kinase.
1984
Exogenous sn-1,2-diacylglycerols containing saturated fatty acids function as bioregulators of protein kinase C in human platelets.
1985
A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity.
1985 StandoutNobel
Complementation of the Mitotic Activator, p80 cdc25 , by a Human Protein-tyrosine Phosphatase
1990 StandoutScienceNobel
Elevated expression of pp60c-src alters a selective morphogenetic property of epithelial cells in vitro without a mitogenic effect.
1988
A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions.
1994
Sevenless and Drosophila eye development: a tyrosine kinase controls cell fate
1988
Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.
1988
Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways
1986 Science
Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.
1987
Endocytosis of the transferrin receptor requires the cytoplasmic domain but not its phosphorylation site
1987
Suppression of protein tyrosine kinase activity of the epidermal growth factor receptor by epidermal growth factor.
1986
FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern.
1991
Role of ion flux in the control of c-fos expression
1986 Nature
Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans
1995
Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.
1987
Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.
1988
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.
1987 StandoutNobel
Phosphorylation activates the insulin receptor tyrosine protein kinase.
1983
Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity.
1985
Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors
1990 Science
Phosphorylation of the EGF receptor from A431 epidermoid carcinoma cells by three distinct types of protein kinase C
1987
Interactions of phosphatidylinositol kinase, GTPase-activating protein (GAP), and GAP-associated proteins with the colony-stimulating factor 1 receptor.
1990
Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1.
1994
Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.
1993
Two structurally and functionally different forms of the transforming protein of PRC II avian sarcoma virus.
1982
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
1989
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A
1986 StandoutNature
Tumor-promoting phorbol esters increase the Km of the ATP-binding site of the insulin receptor kinase from rat adipocytes.
1986
Stimulation of Neuronal Acetylcholine Receptors Induces Rapid Gene Transcription
1986 Science
fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.
1988
Stimulation of tyrosine phosphorylation in lectin treated human lymphocytes
1984
Membranes from T and B lymphocytes have different patterns of tyrosine phosphorylation.
1984
After Insulin Binds
1987 Science
Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.
1991 Nobel
The Chronic Myelogenous Leukemia-Specific P210 Protein Is the Product of the bcr / abl Hybrid Gene
1986 ScienceNobel
Product of the cellular oncogene, c-fos, observed in mouse and human tissues using an antibody to a synthetic peptide.
1985
Epidermal growth factor
1986 StandoutNobel
Characterization of insulin-like growth factor I-stimulated tyrosine kinase activity associated with the beta-subunit of type I insulin-like growth factor receptors of rat liver cells.
1985
Self-phosphorylation enhances the protein-tyrosine kinase activity of the epidermal growth factor receptor.
1985
A novel ras-related gene family
1985 StandoutNobel
Viral and cellular fos proteins are complexed with a 39,000-dalton cellular protein.
1985
Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos
1987
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity.
1990
SH2 and PTB Domains in Tyrosine Kinase Signaling
2003
Ionic responses rapidly elicited by porcine platelet-derived growth factor in Swiss 3T3 cells.
1984
yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.
1986
Purification of the major protein-tyrosine-phosphatases of human placenta.
1988 StandoutNobel
Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells.
1984
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Phorbol ester causes desensitization of gonadotropin-responsive adenylate cyclase in a murine Leydig tumor cell line.
1985
Rapid induction of the expression of proto-oncogene fos during human monocytic differentiation
1985
A product of yeast RAS2 gene is a guanine nucleotide binding protein.
1984
A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell.
1987
Transmembrane orientation of glycoproteins encoded by the v-fms oncogene
1985
Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family.
1987
Monoclonal Antibodies Mimic Insulin Activation of Ribosomal Protein S6 Kinase without Activation of Insulin Receptor Tyrosine Kinase
1989
Muscarinic agonists and phorbol esters increase tyrosine phosphorylation of a 40-kilodalton protein in hippocampal slices.
1989
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein.
1991
Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.
1990
Regulation of the epidermal growth factor receptor by phosphorylation
1985
Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.
1988
Phosphorylation of a chromaffin granule-binding protein by protein kinase C.
1985
Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells.
1990
Nonmitogenic Morphoregulatory Action of pp6Ov-src on Multicellular Epithelial Structures
1987
Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region
1987
Identification of lymphocyte integral membrane proteins as substrates for protein kinase C. Phosphorylation of the interleukin-2 receptor, class I HLA antigens, and T200 glycoprotein.
1986
Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21ras GTPase-activating protein.
1991
An 81 kd protein complexed with middle T antigen and pp60c-src: A possible phosphatidylinositol kinase
1987
Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes.
1985
Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.
1984
The Cellular src Gene Product Regulates Junctional Cell-to-Cell Communication
1988 Science
The Drosophila EGF receptor gene homolog: Conservation of both hormone binding and kinase domains
1985
Intracellular Ca2+ and phorbol esters synergistically inhibit internalization of epidermal growth factor in pancreatic acini
1984
Tyrosine residues in bovine phospholipase C-gamma phosphorylated by the epidermal growth factor receptor in vitro.
1990
Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.
1986
A lymphoma protein with an in vitro site of tyrosine phosphorylation homologous to that in pp60src.
1982
Tyrosine kinase activity is essential for the association of phospholipase C-gamma with the epidermal growth factor receptor.
1990
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
1986 Nature
Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells.
1990
Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes.
1982
Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85β protein by using the baculovirus expression system
1992
Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
1994
The purified alpha subunits of Go and Gi from bovine brain require beta gamma for association with phospholipid vesicles.
1986
Binding of Neuroligins to PSD-95
1997 StandoutScienceNobel
The phorbol ester, TPA inhibits glucagon‐stimulated adenylate cyclase activity
1984
Tyrosine phosphorylation of insulin receptor beta subunit activates the receptor tyrosine kinase in intact H-35 hepatoma cells.
1986
Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation
1989
Induction by NGF of Meiotic Maturation of Xenopus Oocytes Expressing the trk Proto-Oncogene Product
1991 Science
Characterization of elk, a brain-specific receptor tyrosine kinase.
1991
Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.
1985
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.
1995
Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186
1985
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen
1984 Nature
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA
1985 StandoutNobel
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase
1987
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
A retrovirus vector expressing the putative mammary oncogene int-1 causes partial transformation of a mammary epithelial cell line
1986
Structure and transforming function of transduced mutant alleles of the chicken c-myc gene
1986
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
1983 Nature
Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells.
1984
Studies and Perspectives of Protein Kinase C
1986 StandoutScience
pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.
1990
Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
1994
Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit
1993
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.
1989
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity
1987
Purification and characterization of phosphoinositide 3-kinase from rat liver.
1990
Diacylglycerol downregulates junctional membrane permeability. TMB-8 blocks this effect
1985
Xenopus M phase MAP kinase: isolation of its cDNA and activation by MPF.
1991
Self-phosphorylation of epidermal growth factor receptor: evidence for a model of intermolecular allosteric activation
1987
Employment of the Epidermal Growth Factor Receptor in Growth Factor–Independent Signaling Pathways
1999
Cloning and expression of multiple protein kinase C cDNAs
1986
Protein kinases in signal transduction
1984
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters
1985 Nature
Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability
1989
Tyrosine protein kinase activity of rat spleen and other tissues.
1983
Increased amount of a 25-kilodalton phosphoprotein after v-mos transfection of CHO cells.
1988
Drosophila melanogaster homologs of the raf oncogene.
1987
The neu oncogene encodes an epidermal growth factor receptor-related protein
1986 Nature
Regulation of casein kinase II activity by epidermal growth factor in human A-431 carcinoma cells
1989
Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes.
1985
THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
1998
Identification of the tyrosine protein kinase from LSTRA cells by use of site-specific antibodies.
1984
Comparative biochemical properties of normal and activated human ras p21 protein
1984 Nature
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.
1988
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Growth Factors and Cancer
1991 StandoutScience
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.
1982
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src
1987
Tumor necrosis factor stimulates multiple serine/threonine protein kinases in Swiss 3T3 and L929 cells. Implication of casein kinase-2 and extracellular signal-regulated kinases in the tumor necrosis factor signal transduction pathway.
1992
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes.
1990 StandoutNobel
Myristic Acid Is Attached to the Transforming Protein of Rous Sarcoma Virus During or Immediately After Synthesis and Is Present in Both Soluble and Membrane-Bound Forms of the Protein
1984
The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity
1984 Nature
Two types of complementary DNAs of rat brain protein kinase C
1986
Steroidogenic properties of phorbol ester and a Ca2+ ionophore in bovine adrenocortical cell suspensions
1984
The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor
1986 Science
Identification of serine 24 as the unique site on the transferrin receptor phosphorylated by protein kinase C.
1986
Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene
1985 StandoutScience
The Src family tyrosine kinases are required for platelet-derived growth factor-mediated signal transduction in NIH 3T3 cells.
1993
Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways
1997 StandoutScience
Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.
1986
Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains
1986
Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.
1992
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src.
1990
Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases.
1987
Molecular cloning and expression of a MAP kinase homologue from pea
1993
Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter
1984
Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro
1985
cAMP-dependent protein kinase stimulates epidermal growth factor-dependent phosphorylation of epidermal growth factor receptors.
1984
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.
1984
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.
1994
Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells.
1987
Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism.
1984
Two G Protein Oncogenes in Human Endocrine Tumors
1990 Science
Protein kinase C catalyzes phosphorylation of guanylate cyclase in vitro.
1985
Induction of expression and phosphorylation of the human interleukin 2 receptor by a phorbol diester.
1984
Nucleotide sequence of Fujinami sarcoma virus: evolutionary relationship of its transforming gene with transforming genes of other sarcoma viruses
1982
Analysis of deletions of the carboxyl terminus of the epidermal growth factor receptor reveals self-phosphorylation at tyrosine 992 and enhanced in vivo tyrosine phosphorylation of cell substrates.
1990
A thousand and one protein kinases
1987
Mechanism of phorbol diester-induced regulation of surface transferrin receptor involves the action of activated protein kinase C and an intact cytoskeleton.
1985
p145, a Protein with Associated Tyrosine Kinase Activity in a Human Gastric Carcinoma Cell Line
1988
Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src.
1986
Cell Surface Expression of v-fms-Coded Glycoproteins Is Required for Transformation
1984
Activation of Raf as a Result of Recruitment to the Plasma Membrane
1994 Science
Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.
1991
Tissue-specific expression of three distinct types of rabbit protein kinase C
1987 Nature
Distinct structural requirements of Ca2+/phospholipid‐dependent protein kinase (protein kinase C) and cAMP‐dependent protein kinase as evidenced by synthetic peptide substrates
1985
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells
1985 Nature
Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation.
1988
Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v-src of Prague Rous sarcoma virus
1986
Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins.
1989
Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.
1994
A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130gag-fps
1986
Chromatin association and DNA binding properties of the c-fosproto-oncogene product
1987
Amino Terminal Myristylation of the Protein Kinase p60 src , a Retroviral Transforming Protein
1985 Science
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates.
1988
A Novel Putative Tyrosine Kinase Receptor Encoded by the eph Gene
1987 Science
Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.
1993
Phosphorylation of synthetic insulin receptor peptides by the insulin receptor kinase and evidence that the preferred sequence containing Tyr-1150 is phosphorylated in vivo.
1986
Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog
1985
Epidermal Growth Factor
1979 StandoutNobel
Activation of Yeast PBS2 MAPKK by MAPKKKs or by Binding of an SH3-Containing Osmosensor
1995 Science
Oncogene v-src transforms and establishes embryonic rodent fibroblasts but not diploid human fibroblasts.
1988 StandoutNobel
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.
1993
Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)
1996 StandoutScience
Platelet-Derived Growth Factor (PDGF)-Dependent Association of Phospholipase C-γ with the PDGF Receptor Signaling Complex
1990
Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose
1986
A Phosphatidylinositol-3 Kinase Binds to Platelet-Derived Growth Factor Receptors through a Specific Receptor Sequence Containing Phosphotyrosine
1991
Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor
1982 Nature
[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
1991
Epidermal growth factor.
1990
A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.
1994 StandoutNobel
Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells.
1984
Tumor promoter phorbol 12-myristate, 13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2+ rise induced by the activation of muscarinic receptors in PC12 cells
1985
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
1995 StandoutNobel
Phosphorylation of the glucose transporter in vitro and in vivo by protein kinase C
1985 Nature
Diacylglycerol modulates binding and phosphorylation of the epidermal growth factor receptor.
1984
A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner
1989
Interleukin-1 represents a new modality for the activation of extracellular signal-regulated kinases/microtubule-associated protein-2 kinases.
1991
Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.
1994
Signal transduction by allosteric receptor oligomerization
1988
Identification of phosphotyrosine in yeast proteins and of a protein tyrosine kinase associated with the plasma membrane.
1985
Cloning of a cDNA for a major human protein-tyrosine-phosphatase.
1990
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus
1983
Only membrane-associated RSV src proteins have amino-terminally bound lipid
1983 Nature
Src homology region 2 domains direct protein-protein interactions in signal transduction.
1990
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
1987
A tumor promoter stimulates phosphorylation on tyrosine
1983
Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.
1986
Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene
1984 StandoutNature
Induction of the proto-oncogene fos by nerve growth factor.
1985
Allosteric regulation of the epidermal growth factor receptor kinase.
1986
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
1994
Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase.
1984
Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.
1990
Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein.
1984
EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.
1988
Antibodies to the autophosphorylation sites of the epidermal growth factor receptor protein-tyrosine kinase as probes of structure and function.
1985
Transformation of Chicken Embryo Fibroblast Cells by Avian Retroviruses Containing the Human Fyn Gene and Its Mutated Genes
1990
Morphf mutants of Rous sarcoma virus: nucleotide sequencing analysis suggests that a class of morphf mutants was generated through splicing of a cryptic intron
1987
Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants
1989
Stable Association of Activated pp60src with Two Tyrosine-Phosphorylated Cellular Proteins
1989
A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps.
1986
RAS proteins can induce meiosis in xenopus oocytes
1985
Phosphorylation of bovine cardiac C-protein by protein kinase C
1985
The Fos Protein Complex Is Associated with DNA in Isolated Nuclei and Binds to DNA Cellulose
1986 Science
The unique insert of cellular and viral fms protein tyrosine kinase domains is dispensable for enzymatic and transforming activities.
1989
Effects of phorbol esters on α1-adrenergic-mediated and glucagon-mediated actions in isolated rat hepatocytes
1985
The Nature and Regulation of the Insulin Receptor: Structure and Function
1985
Highly Purified pp60srcInduces the Actin Transformation in Microinjected Cells and Phosphorylates Selected Cytoskeletal Proteins In Vitro
1983
Microinjection of the oncogene form of the human H-ras (t-24) protein results in rapid proliferation of quiescent cells
1984
Synergism between diacylglycerols and calcium ionophore in the induction of human B cell proliferation mimics the inositol lipid polyphosphate breakdown signals induced by crosslinking surface immunoglobulin
1985
The erbB-2 mitogenic signaling pathway: tyrosine phosphorylation of phospholipase C-gamma and GTPase-activating protein does not correlate with erbB-2 mitogenic potency.
1991
Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins
1990 Science
Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase
1993 Science
Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.
1985
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor.
1984
Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.
1994
Molecular cloning of gene sequences regulated by platelet-derived growth factor
1983
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.
1994
Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.
1988
Signal transduction of the human granulocyte-macrophage colony- stimulating factor and interleukin-3 receptors involves tyrosine phosphorylation of a common set of cytoplasmic proteins
1990
Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.
1992
Antibodies to Xenopus egg S6 kinase II recognize S6 kinase from progesterone- and insulin-stimulated Xenopus oocytes and from proliferating chicken embryo fibroblasts.
1987
Stimulation and inhibition of growth by EGF in different A431 cell clones is accompanied by the rapid induction of c-fos and c-myc proto-oncogenes.
1985
Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.
1985
The mitogen-activated protein kinase signal transduction pathway
1993 Standout
Phosphorylation of the hepatic EGF receptor with cAMP-dependent protein kinase
1984
Feedback regulation of mitogen-activated protein kinase kinase kinase activity of c-Raf-1 by insulin and phorbol ester stimulation.
1994
CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase
1993 Science
Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.
1985
Role of protein kinase C in diacylglycerol-mediated induction of ornithine decarboxylase and reduction of epidermal growth factor binding.
1985
Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells
1984 Science
Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes
1985
Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.
1985
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.
1988
Expression of c- fos Protein in Brain: Metabolic Mapping at the Cellular Level
1988 StandoutScience
GTPase-Activating Protein SH2-SH3 Domains Induce Gene Expression in a Ras-Dependent Fashion
1992
Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor beta subunit and are required for binding of phospholipase C gamma and a 64-kilodalton protein, respectively.
1993
High level of tyrosine protein kinase in a murine lymphoma cell line induced by Moloney leukemia virus.
1982
Works of Jonathan A. Cooper being referenced
MAP Kinase Pathways: Straight and narrow or tortuous and intersecting?
1994
Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice
1997 Nature
Mammalian Ras interacts directly with the serine/threonine kinase raf
1993 Standout
Lipoprotein receptors and a Disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans
2003
Src family kinases are required for integrin but not PDGFR signal transduction
1999
Disabled‐2 Colocalizes with the LDLR in Clathrin‐Coated Pits and Interacts with AP‐2
2001
Myosin VI Binds to and Localises with Dab2, Potentially Linking Receptor‐Mediated Endocytosis and the Actin Cytoskeleton
2002
Protein modification: Docking sites for kinases
1999
Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
1995
Differential Modulation of Mitogen-activated Protein (MAP) Kinase/Extracellular Signal-related Kinase Kinase and MAP Kinase Activities by a Mutant Epidermal Growth Factor Receptor
1995
Neuronal position in the developing brain is regulated by mouse disabled-1
1997 Nature
Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction
1998
Lipoprotein Receptors
1999
In Vivo Binding Properties of SH2 Domains from GTPase-Activating Protein and Phosphatidylinositol 3-Kinase
1993
Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1.
1993
Major Substrate for Growth Factor-Activated Protein-Tyrosine Kinases Is a Low-Abundance Protein
1985
Protein kinase C phosphorylates pp60src at a novel site
1985
Protein kinase C mediates platelet-derived growth factor-induced tyrosine phosphorylation of p42.
1988
Tyrosine protein kinases and their substrates: an overview.
1984
Similarities and differences between the effects of epidermal growth factor and Rous sarcoma virus.
1981
Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases.
1991
Diverse Mitogenic Agents Induce the Phosphorylation of Two Related 42,000-Dalton Proteins on Tyrosine in Quiescent Chick Cells
1984
Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.
1991
Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.
1991
Structural Differences between Repressed and Derepressed Forms of p60c-src
1989
ASAP1, a Phospholipid-Dependent Arf GTPase-Activating Protein That Associates with and Is Phosphorylated by Src
1998
Regulation of Cell Growth and Transformation by Tyrosine-Specific Protein Kinases: The Search for Important Cellular Substrate Proteins
1983
Four Different Classes of Retroviruses Induce Phosphorylation of Tyrosines Present in Similar Cellular Proteins
1981
[42] Detection and quantification of phosphotyrosine in proteins
1983
Dephosphorylation or Antibody Binding to the Carboxy Terminus Stimulates pp60c-src
1986
Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
1993
p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen
1988
Altered Sites of Tyrosine Phosphorylation in pp60c-src Associated with Polyomavirus Middle Tumor Antigen
1986
Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.
1990
Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src.
1985
Changes in Protein Phosphorylation in Rous Sarcoma Virus-Transformed Chicken Embryo Cells
1981
The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids
1999
Structural differences between repressed and derepressed forms of p60c-src.
1989
Two Signaling Molecules Share a Phosphotyrosine-Containing Binding Site in the Platelet-Derived Growth Factor Receptor
1993
Identification and characterization of cellular targets for tyrosine protein kinases.
1983
Tyrosine Phosphorylation and Activation of Homologous Protein Kinases during Oocyte Maturation and Mitogenic Activation of Fibroblasts
1991
Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes
1992 Science
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.
1992
Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.
1986
Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane
1984 Nature
Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.
1981
Protein Phosphorylation and Growth Control
1985
Platelet-derived growth factor (PDGF) stimulates PDGF receptor subunit dimerization and intersubunit trans-phosphorylation
1991
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).
1988
Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.
1982
Ras1-dependent signaling by ectopically-expressed Drosophila src gene product in the embryo and developing eye.
1993
Four different classes of retroviruses induce phosphorylation of tyrosines present in similar cellular proteins.
1981
A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase
1994
Three glycolytic enzymes are phosphorylated at tyrosine in cells transformed by Rous sarcoma virus
1983 Nature
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro.
1984
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.
1992
Role of epidermal growth factor‐stimulated protein kinase in control of proliferation of A431 cells
1982
Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts.
1988
Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells.
1984
Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.
1993
Major substrate for growth factor-activated protein-tyrosine kinases is a low-abundance protein.
1985
Phosphotyrosine-containing proteins and expression of transformation parameters in cells infected with partial transformation mutants of Rous sarcoma virus
1983
Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein
1984 Nature
Role of Tyrosine Phosphorylation in Malignant Transformation by Viruses and in Cellular Growth Control
1983
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor.
1993
Tyr 527 Is Phosphorylated in pp60 c- src : Implications for Regulation
1986 Science
The protein-tyrosine kinase substrate, p81, is homologous to a chicken microvillar core protein.
1986
A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.
1994
Macrophage Colony-Stimulating Factor-Induced Tyrosine Phosphorylation of c-fms Proteins Expressed in FDC-P1 and BALB/c 3T3 Cells
1990
GTPase-Activating Protein and Phosphatidylinositol 3-Kinase Bind to Distinct Regions of the Platelet-Derived Growth Factor Receptor β Subunit
1992
Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK.
1993
Csk suppression of Src involves movement of Csk to sites of Src activity.
1994
Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen.
1986
C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor-stimulated tyrosine protein kinase activity.
1984
Epidermal growth factor receptor metabolism and protein kinase activity in human A431 cells infected with Snyder-Theilen feline sarcoma virus or harvey or Kirsten murine sarcoma virus
1983
Similar effects of platelet-derived growth factor and epidermal growth factor on the phosphorylation of tyrosine in cellular proteins
1982
The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid
1982
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
1989
In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase.
1993
Effects of protein kinase C activation after epidermal growth factor binding on epidermal growth factor receptor phosphorylation.
1986
Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells
1981
PROTEIN-TYROSINE KINASES
1985 Standout
The Carboxy-Terminal Sequence of p56lck Can Regulate p60c-src
1988
Binding of GAP to Activated PDGF Receptors
1990 Science
Related Proteins Are Phosphorylated at Tyrosine in Response to Mitogenic Stimuli and at Meiosis
1989
Restriction of the In Vitro and In Vivo Tyrosine Protein Kinase Activities of pp60c-src Relative to pp60v-src
1985
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo.
1992
Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation.
1988
Neoplastic Transformation Induced by an Activated Lymphocyte-Specific Protein Tyrosine Kinase (pp56lck)
1988 StandoutNobel