Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Crystal structure of a GA protein βγdimer at 2.1 Å resolution
1996 Nature
Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors
1993
Evidence that direct binding of Gβγ to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation
1995
Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel
1993 Nature
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Phospholipase C β2 Association with Phospholipid Interfaces Assessed by Fluorescence Resonance Energy Transfer
1996
Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits
1992 Nature
G protein .beta..gamma. subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of .alpha. subunits by pertussis toxin but differential interactions with Gs.alpha.
1989 StandoutNobel
The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein
1989
Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization
2000
The βγ Subunits of G Proteins Gate a K+ Channel by Pivoted Bending of a Transmembrane Segment
2002
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
1994 StandoutNatureNobel
Subunits βγ of heterotrimeric G protein activate β2 isoform of phospholipase C
1992 Nature
Distinct Pathways of Gi- and Gq-mediated Mitogen-activated Protein Kinase Activation
1995 StandoutNobel
G protein interaction with K+ and Ca2+ channels
1997
Stimulation of phospholipase C by guanine‐nucleotide‐binding protein βγ subunits
1992
The G protein-channel connection
1990
Dual control by ATP and acetylcholine of inwardly rectifying K+ channels in bovine atrial cells
1990
Structural Basis of Inward Rectification
2002 StandoutNobel
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+-permeable channel
1992 Nature
Interaction Sites of the G Protein β Subunit with Brain G Protein-coupled Inward Rectifier K+ Channel
2001
Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae
2000
Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+channel
1994 StandoutNatureNobel
Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions
1999
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
A region of the muscarinic-gated atrial K+ channel critical for activation by G protein βγ subunits
1994
The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins
1995 Nature
The importance of G-protein βλ subunits
1993 StandoutNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
1992 StandoutNatureNobel
Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0
2007
Gβγ Binds Directly to the G Protein-gated K+ Channel, IKACh
1995
Heterotrimeric C proteins: Organizers of transmembrane signals
1995
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
1998 StandoutNatureNobel
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
Different β-subunits determine G-protein interaction with transmembrane receptors
1992 Nature
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
2000 StandoutNatureNobel
A Domain on the G Protein β Subunit Interacts with Both Adenylyl Cyclase 2 and the Muscarinic Atrial Potassium Channel
1996
Seven-transmembrane receptors
2002 StandoutNobel
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Voltage-dependent modulation of N-type calcium channels by G-protein β γsubunits
1996 Nature
X-ray structure of the mammalian GIRK2–βγ G-protein complex
2013 NatureNobel
Diversity among the beta subunits of heterotrimeric GTP-binding proteins: Characterization of a novel beta-subunit cDNA
1992
New roles for G-protein (βγ-dimers in transmembrane signalling
1993 Nature
G proteins
1992 StandoutNobel
Identification of the platelet ADP receptor targeted by antithrombotic drugs
2001 StandoutNatureNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria
2001 StandoutNatureNobel
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
1988 StandoutScienceNobel
Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue
1985 Nature
GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists
1979
Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel.
1988
Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization.
1987
Mechanism of Irk1 Channel Block by Intracellular Polyamines
2000
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
1994 StandoutNobel
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
The G protein beta 2 complementary DNA encodes the beta 35 subunit.
1987 StandoutNobel
β-Adrenergic and Somatostatin Receptors Regulate Na-H Exchange Independent of cAMP
1989
An M2 Muscarinic Receptor Subtype Coupled to Both Adenylyl Cyclase and Phosphoinositide Turnover
1987 Science
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide.
1982 StandoutNobel
Rhodopsin and the retinal G-protein distinguish among G-protein beta gamma subunit forms
1991
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
1980 StandoutNatureNobel
G Proteins and Regulation of Adenylyl Cyclase
1989 StandoutNobel
Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues.
1988
Expression of Gsα in Escherichia coli
1989 StandoutNobel
β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family
1989 StandoutScienceNobel
Expression and characterization of calmodulin-activated (type I) adenylylcyclase
1991 StandoutNobel
On the mechanism of G protein beta gamma subunit activation of the muscarinic K+ channel in guinea pig atrial cell membrane. Comparison with the ATP-sensitive K+ channel.
1992
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.
1994 StandoutNobel
Activation by G protein beta gamma subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin.
1992
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Cytoplasmic Signaling Pathways That Regulate Cardiac Hypertrophy
2001
Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist.
1986
G PROTEIN βγ SUBUNITS
1997
Inhibitors of protein synthesis
1974
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Regulation of purified type I and type II adenylylcyclases by G protein beta gamma subunits.
1993 StandoutNobel
Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.
1987
Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.
1993
Structural Diversity in the Cytoplasmic Region of G Protein-Gated Inward Rectifier K+ Channels
2007
The yeast SCG1 gene: A Gα-like protein implicated in the a- and α-factor response pathway
1987
Molecular analysis of spontaneous somatic mutants
1977 StandoutNatureNobel
Atrial G protein-activated K+ channel: expression cloning and molecular properties.
1993
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
1992 StandoutScienceNobel
Inhibition of Adenylyl Cyclase by G iα
1993 StandoutScienceNobel
Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.
1994 StandoutNobel
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
G protein involvement in receptor-effector coupling.
1988 StandoutNobel
Guanine nucleotides modulate muscarinic receptor binding in the heart
1979
Reversion of a Chinese Hamster Cell Auxotrophic Mutant
1974
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
1990 StandoutScienceNobel
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
An Antibody-induced Enhancement of the Transducin-stimulated Cyclic GMP Phosphodiesterase Activity
1989
Expression of functional G protein beta gamma dimers of defined subunit composition using a baculovirus expression system.
1992
Beta gamma-subunit activation of G-protein-regulated phospholipase C.
1992
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Modulation of Serotonin-Controlled Behaviors by G o in Caenorhabditis elegans
1995 Science
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
1991 StandoutScienceNobel
Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning.
1987
Which G protein subunits are the active mediators in signal transduction?
1987
Works of Jonas Galper being referenced
The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart
1987 Nature
Mitochondria
1969
Physiological and Biochemical Evidence for Coordinate Increases in Muscarinic Receptors and G i During Pacing-Induced Heart Failure
1996
The development of physiologic responsiveness to muscarinic agonists in chick embryo heart cell cultures. Role of high affinity receptors and sensitivity to guanine nucleotides.
1984
Agonist and guanine nucleotide modulation of muscarinic cholinergic receptors in cultured heart cells.
1980
The biphasic response of muscarinic cholinergic receptors in cultured heart cells to agonists. Effects on receptor number and affinity in intact cells and homogenates.
1982
Low density lipoproteins induce parasympathetic responsiveness in embryonic chick ventricular myocytes in parallel with a coordinate increase in expression of genes coding for the M2 muscarinic receptor, G alpha i2, and the acetylcholine-sensitive K+ channel.
1994
Properties of muscarinic acetylcholine receptors in heart cell cultures
1978
Muscarinic acetylcholine receptors in developing chick heart
1977
Effects of Low Density Lipoproteins and Mevinolin on Sympathetic Responsiveness in Cultured Chick Atrial Cells
1989
Mitochondrial protein synthesis in HeLa cells
1971
G protein opening of K+ channels
1987 Nature