Standout Papers
- Discrimination as a consequence of genetic testing. (1992)
Citation Impact
Citing Papers
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation
2001 StandoutNobel
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Structure of the signal recognition particle interacting with the elongation-arrested ribosome
2004 StandoutNatureNobel
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
Crystallization of Escherichia coli catabolite gene activator protein with its DNA binding site
1990 StandoutNobel
SecB functions as a cytosolic signal recognition factor for protein export in E. coli
1989 StandoutNobel
Membrane protein structure prediction
1992
Intracellular traffic of newly synthesized proteins. Current understanding and future prospects.
1989
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
A predictor of transmembrane ?-helix domains of proteins based on neural networks
1996
SecA protein is required for secretory protein translocation into E. coli membrane vesicles
1988
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding
1993 StandoutNatureNobel
Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen
2001 Standout
The signal recognition particle in S. cerevisiae
1991
Principles governing amino acid composition of integral membrane proteins: application to topology prediction 1 1Edited by J. Thornton
1998
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
Export of Protein: A Biochemical View
1987
Structural basis for initiation of transcription from an RNA polymerase–promoter complex
1999 StandoutNatureNobel
The Engagement of Sec61p in the ER Dislocation Process
1999 StandoutNobel
Redox sensing by prokaryotic transcription factors
2000
A Model Recognition Approach to the Prediction of All-Helical Membrane Protein Structure and Topology
1994
Evolutionary conservation of components of the protein translocation complex
1994 Nature
Topology prediction for helical transmembrane proteins at 86% accuracy–Topology prediction at 86% accuracy
1996
Position and orientation of the globular domain of linker histone H5 on the nucleosome
1998 StandoutNatureNobel
Structural studies of protein–nucleic acid interaction: the sources of sequence-specific binding
1990 StandoutNobel
Structure of the protein subunits in the photosynthetic reaction centre of Rhodopseudomonas viridis at 3Å resolution
1985 StandoutNatureNobel
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex
1991 StandoutNatureNobel
SNAP receptors implicated in vesicle targeting and fusion
1993 StandoutNatureNobel
Chemical remodelling of cell surfaces in living animals
2004 StandoutNatureNobel
Crystal structure of trp represser/operator complex at atomic resolution
1988 Nature
Structure of the E. coli protein-conducting channel bound to a translating ribosome
2005 StandoutNatureNobel
Transmembrane helices predicted at 95% accuracy
1995
Regulation of protein function by S‐glutathiolation in response to oxidative and nitrosative stress
2000
DNA sequence determinants of CAP-induced bending and protein binding affinity
1988 Nature
The structure and function of the homeodomain
1989 Standout
Free radicals and antioxidants in normal physiological functions and human disease
2006 Standout
SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion
1994
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons
1992 StandoutNatureNobel
Emergence of vancomycin tolerance in Streptococcus pneumoniae
1999 StandoutNatureNobel
A protein-folding reaction under kinetic control
1992 StandoutNatureNobel
Topological ?frustration? in multispanning E. coli inner membrane proteins
1994
SEC21 is a gene required for ER to Golgi protein transport that encodes a subunit of a yeast coatomer
1992 StandoutNatureNobel
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
70K heat shock related proteins stimulate protein translocation into microsomes
1988 StandoutNatureNobel
Stringent spacing requirements for transcription activation by CRP
1990
Protein Translocation: Tunnel Vision
1998
Signal recognition particle-depencent protein targeting, universal to all kingdoms of life
2002
Escherichia coli cAMP receptor protein: evidence for three protein conformational states with different promoter binding affinities
1989
Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein
2001
Investigating Mitochondrial Redox Potential with Redox-sensitive Green Fluorescent Protein Indicators
2004 StandoutNobel
What determines the specificity of action of Drosophila homeodomain proteins?
1990
The FAD- and O2-Dependent Reaction Cycle of Ero1-Mediated Oxidative Protein Folding in the Endoplasmic Reticulum
2002
Translocation gets a push
1994 StandoutNobel
Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein
1990 StandoutNatureNobel
Lysine 188 of the catabolite gene activator protein (CAP) plays no role in specificity at base pair 7 of the DNA half site
1990
SecY, SecE, and band 1 form the membrane-embedded domain of Escherichia coli preprotein translocase.
1992
In Vivo Imaging of Membrane-Associated Glycans in Developing Zebrafish
2008 StandoutScienceNobel
Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase as Reporter
1998 StandoutScienceNobel
Mechanisms of protein localization
1983
A defined mutation in the protein export gene within the spc ribosomal protein operon of Escherichia coli: isolation and characterization of a new temperature-sensitive secY mutant.
1984
In vitro translocation of bacterial proteins across the plasma membrane of Escherichia coli.
1984 StandoutNobel
Determination of the Transmembrane Topology of Yeast Sec61p, an Essential Component of the Endoplasmic Reticulum Translocation Complex
1996
Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery.
1990 StandoutNobel
A bacterial secretory protein requires signal recognition particle for translocation across mammalian endoplasmic reticulum.
1982 StandoutNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
[1] Genetic analysis of protein export in Escherichia coli
1983
New suppressors of signal-sequence mutations, prlG, are linked tightly to the secE gene of Escherichia coli.
1989
Purification of the Escherichia coli secB gene product and demonstration of its activity in an in vitro protein translocation system
1989
Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.
1992 StandoutNobel
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
A hidden Markov model for predicting transmembrane helices in protein sequences.
1998 Standout
Determination of the orientation of a DNA binding motif in a protein-DNA complex by photocrosslinking.
1992
Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity
1989
A novel membrane protein involved in protein translocation across the cytoplasmic membrane of Escherichia coli.
1993
Topology analysis of the SecY protein, an integral membrane protein involved in protein export in Escherichia coli.
1987
Mechanisms for Redox Control of Gene Expression
1999
The mature portion of Escherichia coli maltose-binding protein (MBP) determines the dependence of MBP on SecB for export
1989
Probing the sequence-specific interaction of the cyclic AMP receptor protein with DNA by site-directed mutagenesis
1987
TnphoA: a transposon probe for protein export signals.
1985 Standout
SecA protein autogenously represses its own translation during normal protein secretion in Escherichia coli
1989
Distinct mutation sites in prlA suppressor mutant strains of Escherichia coli respond either to suppression of signal peptide mutations or to blockage of staphylokinase processing
1988
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Regulation of the Escherichia coli secA gene by protein secretion defects: analysis of secA, secB, secD, and secY mutants
1988
Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA
1981 StandoutNatureNobel
Site-Specific Protein Modification Using a Ketone Handle
1996
Multiple Mechanisms of Protein Insertion into and Across Membranes
1985 Science
The use of extragenic suppressors to define genes involved in protein export in Escherichia coli
1984
Energy-requiring translocation of the OmpA protein and alkaline phosphatase of Escherichia coli into inner membrane vesicles
1984
Identification of a contact between arginine-180 of the catabolite gene activator protein (CAP) and base pair 5 of the DNA site in the CAP-DNA complex.
1990
The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids.
1993
The binding of the cyclic AMP receptor protein to synthetic DNA sites containing permutations in the consensus sequence TGTGA
1987
Protein phosphorylation and regulation of adaptive responses in bacteria
1989
Escherichia coli cyclic AMP receptor protein mutants provide evidence for ligand contacts important in activation
1992
Sequence homology between the tetracycline-resistance determinants of Tn10 and pBR322
1983
Mutations in a new gene, secB, cause defective protein localization in Escherichia coli
1983
The secE gene encodes an integral membrane protein required for protein export in Escherichia coli.
1989
Uses of lac fusions for the study of biological problems
1985
Sec-independent translocation of a 100-residue periplasmic N-terminal tail in the E. coli inner membrane protein proW.
1994
Mutations that alter the signal sequence of alkaline phosphatase in Escherichia coli
1983
The role of the beta-lactamase signal sequence in the secretion of proteins by Escherichia coli.
1984
Synthetic peptides as nuclear localization signals
1986 StandoutNatureNobel
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Regulation of a membrane component required for protein secretion in escherichia coli
1982
Biochemical evidence for the secY24 defect in Escherichia coli protein translocation and its suppression by soluble cytoplasmic factors.
1987
SecA suppresses the temperature-sensitive SecY24 defect in protein translocation in Escherichia coli membrane vesicles.
1988
Mutants of the catabolite activator protein of Escherichia coli that are specifically deficient in the gene-activation function.
1987
Isolation and characterization of PEP3, a gene required for vacuolar biogenesis in Saccharomyces cerevisiae.
1991
GENETIC ANALYSIS OF PROTEIN EXPORT IN ESCHERICHIA COLI K12
1985
Activation of the OxyR Transcription Factor by Reversible Disulfide Bond Formation
1998 Science
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
Escherichia coli Preprotein Translocase
1996
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Xenopus oocytes can secrete bacterial β-lactamase
1984 Nature
Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA
1993 StandoutScienceNobel
Lac DNA, RNA Polymerase and Cyclic AMP Receptor Protein, Cyclic AMP, Lac Repressor and Inducer are the Essential Elements for Controlled Lac Transcription
1971
SecD and SecF are required for the proton electrochemical gradient stimulation of preprotein translocation.
1994
Band 1 subunit of Escherichia coli preportein translocase and integral membrane export factor P12 are the same protein.
1994
Protein oxidation in response to increased transcriptional or translational errors
2000
The structure of a CAP–DNA complex having two cAMP molecules bound to each monomer
1997 StandoutNobel
Primary structure of the L subunit of the reaction center from Rhodopseudomonas sphaeroides.
1984
SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state
1994
The ATPase activity of secA is regulated by acidic phospholipids, secY, and the leader and mature domains of precursor proteins
1990
Secretion and processing of an immunoglobulin light chain in Escherichia coli
1984
SecD and SecF facilitate protein export in Escherichia coli.
1994
Protein export in Escherichia coli requires a soluble activity.
1984 StandoutNobel
Expression of the Rous Sarcoma Virus pol Gene by Ribosomal Frameshifting
1985 StandoutScienceNobel
Fusions of secreted proteins to alkaline phosphatase: an approach for studying protein secretion.
1985
Trigger factor: a soluble protein that folds pro-OmpA into a membrane-assembly-competent form.
1987
Reconstitution of protein translocation from detergent-solubilized Escherichia coli inverted vesicles: PrlA protein-deficient vesicles efficiently translocate precursor proteins.
1990 StandoutNobel
Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA Gln and ATP at 2.8 Å Resolution
1989 StandoutScienceNobel
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
Structural and functional dissection of a membrane glycoprotein required for vesicle budding from the endoplasmic reticulum.
1991 StandoutNobel
Role of the mature protein sequence of maltose-binding protein in its secretion across the E. coli cytoplasmic membrane
1981
Role of glutamic acid-181 in DNA-sequence recognition by the catabolite gene activator protein (CAP) of Escherichia coli: altered DNA-sequence-recognition properties of [Val181]CAP and [Leu181]CAP.
1987
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Construction of defined polytopic integral transmembrane proteins. The role of signal and stop transfer sequence permutations.
1988
Structural and Functional Dissection of a Membrane Glycoprotein Required for Vesicle Budding from the Endoplasmic Reticulum
1991 StandoutNobel
A temperature-sensitive mutant of E. coli exhibiting slow processing of exported proteins
1983
Synthetic curved DNA sequences can act as transcriptional activators in Escherichia coli.
1989
One of three transmembrane stretches is sufficient for the functioning of the SecE protein, a membrane component of the E. coli secretion machinery.
1991
The polypeptide fold of the globular domain of histone H5 in solution. A study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics.
1987
Analysis of protein localization by use of gene fusions with complementary properties
1990
Works of Jon Beckwith being referenced
The role of charged amino acids in the localization of secreted and membrane proteins
1990
A mutation affecting the regulation of a secA-lacZ fusion defines a new sec gene.
1988
The topological analysis of integral cytoplasmic membrane proteins
1993
The Role of the Thioredoxin and Glutaredoxin Pathways in Reducing Protein Disulfide Bonds in the Escherichia coliCytoplasm
1997
Molecular basis of DNA sequence recognition by the catabolite gene activator protein: detailed inferences from three mutations that alter DNA sequence specificity.
1984
Escherichia coli K-12 mutants that allow transport of maltose via the beta-galactoside transport system
1979
Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm
1999
Characterization of cold-sensitive secY mutants of Escherichia coli
1990
Escherichia coli alkaline phosphatase fails to acquire disulfide bonds when retained in the cytoplasm
1991
secD, a new gene involved in protein export in Escherichia coli
1987
Roles of Thiol-Redox Pathways in Bacteria
2001
Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol—disulfide status
1999
A Genetic Approach to Analyzing Membrane Protein Topology
1986 Science
In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli
1983
In vitro Transcription of the lac Operon Genes
1970
The Implications of Sociobiology
1976 Science
Blue ghosts: a new method for isolating amber mutants defective in essential genes of Escherichia coli
1981
An Escherichia coli mutation preventing degradation of abnormal periplasmic proteins.
1988
GENETIC ANALYSIS OF PROTEIN EXPORT IN ESCHERICHIA COLI
1990
Mechanism of Incorporation of Cell Envelope Proteins in Escherichia Coli
1982
Determinants of membrane protein topology.
1987
Mutations that alter the DNA sequence specificity of the catabolite gene activator protein of E. coli
1984 Nature