Citation Impact
Citing Papers
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Cellular Source and Amount of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor in Tumors Determine Response to Angiogenesis Inhibitors
2009
In Vitro and In Vivo Gene Therapy Vector Evolution via Multispecies Interbreeding and Retargeting of Adeno-Associated Viruses
2008
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Thermal Stability as a Determinant of AAV Serotype Identity
2017
The DNA-damage response in human biology and disease
2009 StandoutNature
Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells
2017
Universal Method for the Purification of Recombinant AAV Vectors of Differing Serotypes
2017
In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy
2016
Evidence for a New Step in Telomere Maintenance
1996
RNA synthetic biology
2006
Selection and evaluation of clinically relevant AAV variants in a xenograft liver model
2013 Nature
Telomeres: No end in sight
1994 StandoutNobel
Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol
2018
Genomic discovery of potent chromatin insulators for human gene therapy
2015
Synthetic biology: applications come of age
2010
AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active Replication
2014
Iron Overload Cardiomyopathy
2010
Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing
2015
Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation
2017
Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents
2011
Ultrasensitive fluorescent proteins for imaging neuronal activity
2013 StandoutNature
Genotoxicity of Retroviral Integration In Hematopoietic Cells
2006
Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
1995 StandoutNobel
Euplotes crassushas genes encoding telomere-binding proteins and telomere-binding protein homologs
1992
Functional Characterization and Developmental Regulation of Mouse Telomerase RNA
1995 StandoutScienceNobel
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
2017 StandoutNature
Analysis of AAV Serotypes 1–9 Mediated Gene Expression and Tropism in Mice After Systemic Injection
2008
Dose-Dependent Prevention of Metabolic and Neurologic Disease in Murine MPS II by ZFN-Mediated In Vivo Genome Editing
2018
Large-scale recombinant adeno-associated virus production
2011
Crystal Structure of the Oxytricha nova Telomere End Binding Protein Complexed with Single Strand DNA
1998
Telomeres Do D-Loop–T-Loop
1999 StandoutNobel
Engineering Allosteric Regulation into Biological Catalysts
2009
The terminal DNA structure of mammalian chromosomes
1997
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Runaway telomere elongation caused by telomerase RNA gene mutations
1995 StandoutNatureNobel
Secondary Structure of Vertebrate Telomerase RNA
2000 StandoutNobel
Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates
1998
A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome
2016
Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
2009
Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators
2012
Protein-DNA interactions in soluble telosomes fromSaccharomyces cerevisiae
1995
Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha
1998 Nobel
Control of telomere growth by interactions of RAP1 with the most distal telomeric repeats
1996 StandoutNatureNobel
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Scalable Downstream Strategies for Purification of Recombinant Adeno- Associated Virus Vectors in Light of the Properties
2015
The β subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA
1993 Nobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Principles and Applications of the Photochemical Control of Cellular Processes
2009
Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges
2011
Adeno-associated virus vector as a platform for gene therapy delivery
2019 Standout
Switching and Signaling at the Telomere
2001 StandoutNobel
Light activation as a method of regulating and studying gene expression
2009
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Manufacturing of recombinant adeno-associated viral vectors for clinical trials
2016
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
Fission yeast Taz1 protein is required for meiotic telomere clustering and recombination
1998 StandoutNatureNobel
Genetics and Molecular Biology of Telomeres
1992
CDC5 and CKII Control Adaptation to the Yeast DNA Damage Checkpoint
1997 StandoutNobel
Inhibition of HIV replication: A powerful antiviral strategy by IFN-β gene delivery in CD4+ cells
2007 StandoutNobel
Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis
2002 StandoutNobel
AAV-ID: A Rapid and Robust Assay for Batch-to-Batch Consistency Evaluation of AAV Preparations
2017
Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector
2015
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Separation of adeno-associated virus type 2 empty particles from genome containing vectors by anion-exchange column chromatography
2006
Emerging Issues in AAV-Mediated In Vivo Gene Therapy
2017
The Human Condition—A Molecular Approach
2014 StandoutNobel
Replication and protection of telomeres
2007 Nature
Bioengineered AAV Capsids with Combined High Human Liver Transduction In Vivo and Unique Humoral Seroreactivity
2017
Unraveling the Complex Story of Immune Responses to AAV Vectors Trial After Trial
2017
Gene Therapy for X-Linked Severe Combined Immunodeficiency: Where Do We Stand?
2016
Hepatic Gene Transfer in Neonatal Mice by Adeno-Associated Virus Serotype 8 Vector
2011
Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors
2010
Adeno-Associated Virus Gene Therapy for Liver Disease
2016
Accurate Identification and Quantification of DNA Species by Next-Generation Sequencing in Adeno-Associated Viral Vectors Produced in Insect Cells
2017
DNA bound by the Oxytricha telomere protein is accessible to telomerase and other DNA polymerases.
1994 StandoutNobel
Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase
1996
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
An Essential Yeast Gene Encoding a TTAGGG Repeat-Binding Protein
1993
Rap1 protein regulates telomere turnover in yeast
1998 StandoutNobel
Multiplexed RNA structure characterization with selective 2′-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq)
2011 StandoutNobel
A conserved sequence motif within the exceptionally diverse telomeric sequences of budding yeasts.
1994 StandoutNobel
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
A class of single-stranded telomeric DNA-binding proteins required for Rap1p localization in yeast nuclei.
1995
Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein
2000
Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
2001 ScienceNobel
The DNA of ciliated protozoa
1994
The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9–dependent innate immune responses in the liver
2011
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
Cdc13p: A Single-Strand Telomeric DNA-Binding Protein with a Dual Role in Yeast Telomere Maintenance
1996 Science
ST-1, a 39-Kilodalton Protein in Trypanosoma brucei, Exhibits a Dual Affinity for the Duplex Form of the 29-Base-Pair Subtelomeric Repeat and Its C-Rich Strand
1995
A Trypanosoma brucei Protein Complex That Binds G-overhangs and Co-purifies with Telomerase Activity
2002 StandoutNobel
The Saccharomyces CDC 13 protein is a single-strand TG 1–3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
1996
Overcoming Preexisting Humoral Immunity to AAV Using Capsid Decoys
2013
In Vivo Potency Assay for Adeno-Associated Virus–Based Gene Therapy Vectors Using AAVrh.10 as an Example
2018
Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits.
1993
Telomere fusions caused by mutating the terminal region of telomeric DNA
2000 StandoutNobel
Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy
2013
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Enhanced T Cell Function in a Mouse Model of Human Glycosylation
2013
Photocrosslinking of 5-Iodouracil-Substituted RNA and DNA to Proteins
1993 ScienceNobel
Improving the Quality of Adeno-Associated Viral Vector Preparations: The Challenge of Product-Related Impurities
2017
Telomerase in Yeast
1995 StandoutScienceNobel
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
2001 StandoutNobel
An essential yeast gene encoding a TTAGGG repeat-binding protein.
1993
Oligonucleotides Complementary to the Oxytricha nova Telomerase RNA Delineate the Template Domain and Uncover a Novel Mode of Primer Utilization
1994
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Telomerase RNAs of different ciliates have a common secondary structure and a permuted template.
1994 Nobel
Mir‐142‐3p target sequences reduce transgene‐directed immunogenicity following intramuscular adeno‐associated virus 1 vector‐mediated gene delivery
2013
Template Boundary in a Yeast Telomerase Specified by RNA Structure
2000 StandoutScienceNobel
Telomeres: Beginning to Understand the End
1995 Science
Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains
1997
Analysis of Particle Content of Recombinant Adeno-Associated Virus Serotype 8 Vectors by Ion-Exchange Chromatography
2012
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry
2016
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
Est1 has the properties of a single-stranded telomere end-binding protein.
1996
A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains
1997 StandoutNobel
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1998 StandoutScience
Works of John T. Gray being referenced
A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells
2010
Correction of Murine Sickle Cell Disease Using γ-Globin Lentiviral Vectors to Mediate High-level Expression of Fetal Hemoglobin
2008
Design and Construction of Functional AAV Vectors
2011
Cloning and expression of genes for the Oxytricha telomere-binding protein: Specific subunit interactions in the telomeric complex
1991 Nobel
Purification of recombinant adeno-associated virus type 8 vectors by ion exchange chromatography generates clinical grade vector stock
2004
Exogenous control of mammalian gene expression through modulation of RNA self-cleavage
2004 Nature
Enhancing transduction of the liver by adeno-associated viral vectors
2008
Comparison of the ability of adeno-associated viral vectors pseudotyped with serotype 2, 5, and 8 capsid proteins to mediate efficient transduction of the liver in murine and nonhuman primate models
2005
Antitumor efficacy of AAV-mediated systemic delivery of interferon-β
2005
A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells
2007
Good Manufacturing Practice Production of Self-Complementary Serotype 8 Adeno-Associated Viral Vector for a Hemophilia B Clinical Trial
2011
Lentiviral Hematopoietic Stem Cell Gene Therapy for Older Patients with X-Linked Severe Combined Immunodeficiency
2015
Soluble receptor-mediated selective inhibition of VEGFR and PDGFRβ signaling during physiologic and tumor angiogenesis
2008
Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus–based lentiviral vector system
2004
547. AAV Preparations Contain Contamination from DNA Sequences in Production Plasmids Directly Outside of the ITRs
2016
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates
2006
Early Clinical Trial Results Following Administration of a Low Dose of a Novel Self Complementary Adeno-Associated Viral Vector Encoding Human Factor IX In Two Subjects with Severe Hemophilia B
2010
An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation
2007
AAV-mediated gene transfer in the perinatal period results in expression of FVII at levels that protect against fatal spontaneous hemorrhage
2011
Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver
2005
Oxytricha telomere-binding protein: separable DNA-binding and dimerization domains of the alpha-subunit.
1993 Nobel
Systemic Errors in Quantitative Polymerase Chain Reaction Titration of Self-Complementary Adeno-Associated Viral Vectors and Improved Alternative Methods
2012