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Citing Papers
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Ceramide 1-Phosphate Is Required for the Translocation of Group IVA Cytosolic Phospholipase A2 and Prostaglandin Synthesis
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2000
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
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Pharmacology of LY315920/S-5920, [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1 H-indol-4-yl]oxy]acetate, a Potent and Selective Secretory Phospholipase A2Inhibitor: A New Class of Anti-Inflammatory Drugs, SPI
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The Genomic Organization, Complete mRNA Sequence, Cloning, and Expression of a Novel Human Intracellular Membrane-associated Calcium-independent Phospholipase A2
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Resistance of cultured human fibroblasts and other cells to purine and pyrimidine analogues in relation to mutagenesis detection
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1998
Human Pancreatic Islets Express mRNA Species Encoding Two Distinct Catalytically Active Isoforms of Group VI Phospholipase A2 (iPLA2) That Arise from an Exon-skipping Mechanism of Alternative Splicing of the Transcript from the iPLA2 Gene on Chromosome 22q13.1
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Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory
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Plasma Platelet-activating Factor Acetylhydrolase Is a Secreted Phospholipase A2 with a Catalytic Triad
1995
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Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
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Maintenance of functional equivalence during paralogous Hox gene evolution
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Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2
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Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2
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Group IV Phospholipase A2α Controls the Formation of Inter-Cisternal Continuities Involved in Intra-Golgi Transport
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Biaryl diacid inhibitors of human s-PLA2 with anti-inflammatory activity
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Phospholipase A2 expression in tumours: a target for therapeutic intervention?
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Purification and Characterization of 1-O-Acylceramide Synthase, a Novel Phospholipase A2 with Transacylase Activity
1998
Physiology of Cell Volume Regulation in Vertebrates
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The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2α blocks arachidonic acid release in a variety of mammalian cells
2001
Group VIA Calcium-independent Phospholipase A2 Mediates Endothelial Cell S Phase Progression
2006
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2
2004
Selective Induction of Prostaglandin G/H Synthase I by Stem Cell Factor and Dexamethasone in Mast Cells
1995
Ceramide 1-Phosphate Acts as a Positive Allosteric Activator of Group IVA Cytosolic Phospholipase A2α and Enhances the Interaction of the Enzyme with Phosphatidylcholine
2005
Mechanism of Inhibition of Human Nonpancreatic Secreted Phospholipase A2 by the Anti-inflammatory Agent BMS-181162*
1995
The ABC's of Group IV cytosolic phospholipase A2
2004
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
1987 Standout
Mechanism of Regulation of Group IVA Phospholipase A2 Activity by Ser727 Phosphorylation
2007
Inhibition of secretory phospholipase A. 1-Design, synthesis and structure–activity relationship studies starting from 4-tetradecyloxybenzamidine to obtain specific inhibitors of group II sPLAs
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Kinetic analysis of a high molecular weight phospholipase A2 from rat kidney: divalent metal-dependent trapping of enzyme on product-containing vesicles
1992
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
Identification of Novel Cytosolic Phospholipase A2s, Murine cPLA2δ, ϵ, and ζ, Which Form a Gene Cluster with cPLA2β
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The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
2003
A Novel Cytosolic Calcium-independent Phospholipase A2 Contains Eight Ankyrin Motifs
1997
Functional Interaction of Calcium-/Calmodulin-dependent Protein Kinase II and Cytosolic Phospholipase A2
2001
The emerging role of group VI calcium-independent phospholipase A2 in releasing docosahexaenoic acid from brain phospholipids
2008
JmjC-domain-containing proteins and histone demethylation
2006
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
Roles for cytosolic phospholipase A2α as revealed by gene-targeted mice
2002
Crystal Structure of Human Group X Secreted Phospholipase A2
2002
Crystal Structure of Human Cytosolic Phospholipase A2 Reveals a Novel Topology and Catalytic Mechanism
1999
Transgenic Expression of Group V, but Not Group X, Secreted Phospholipase A2 in Mice Leads to Neonatal Lethality because of Lung Dysfunction
2006
Structures of two novel crystal forms of Naja naja naja phospholipase A 2 lacking Ca 2+ reveal trimeric packing 1 1Edited by I. A. Wilson
1998
A Novel Calcium-independent Phospholipase A2, cPLA2-γ, That Is Prenylated and Contains Homology to cPLA2
1998
Characterization of an ATP-stimulatable calcium2+ independent phospholipase A2 from clonal insulin-secreting HIT cells and rat pancreatic islets: a possible molecular component of the .beta.-cell fuel sensor
1994
Complexins Regulate a Late Step in Ca2+-Dependent Neurotransmitter Release
2001 StandoutNobel
Phospholipase A2 Biochemistry
2008
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
2011
Biochemical properties and pathophysiological roles of cytosolic phospholipase A2s
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Involvement of the Ca2+-dependent Phosphatase Calcineurin in Gene Transcription That Is Stimulated by cAMP through cAMP Response Elements
1995
Metal ion and salt effects on the phospholipase A2, lysophospholipase, and transacylase activities of human cytosolic phospholipase A2
1993
The Crystal Structure of Prokaryotic Phospholipase A2
2002
Secretory phospholipase A2 of group IIA: Is it an offensive or a defensive player during atherosclerosis and other inflammatory diseases?
2005
The phospholipase A2 superfamily and its group numbering system
2006 Standout
Essential Ca2+-independent Role of the Group IVA Cytosolic Phospholipase A2 C2 Domain for Interfacial Activity
2003
Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2
1995
Thielocin B3, a novel antiinflammatory human group II phospholipase A2 specific inhibitor from ascomycetes.
1994
Roles of Trp31 in High Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase A2
1999
Anionic lipids activate group IVA cytosolic phospholipase A2 via distinct and separate mechanisms
2007
Crystal Structure of a Calcium-Phospholipid Binding Domain from Cytosolic Phospholipase A2
1998
Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox geneHox-#150;1.6
1992 StandoutNatureNobel
Ceramide-1-phosphate Binds Group IVA Cytosolic Phospholipase a2 via a Novel Site in the C2 Domain
2007
Design of new secreted phospholipase A2 inhibitors based on docking calculations by modifying the pharmacophore segments of the FPL67047XX inhibitor
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Properties of the Group IV phospholipase A2 family
2006
Calcium Binding Rigidifies the C2 Domain and the Intradomain Interaction of GIVA Phospholipase A2 as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
2008
Calcium-independent phospholipase A2: structure and function
2000
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Expression, Purification, and Kinetic Characterization of a Recombinant 80-kDa Intracellular Calcium-independent Phospholipase A2
1996
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
Wnt-independent activation of β-catenin mediated by a Dkk1-Fz5 fusion protein
2005
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2
1997 Nature
Purified Group X Secretory Phospholipase A2 Induced Prominent Release of Arachidonic Acid from Human Myeloid Leukemia Cells
1999
Cloning of a Gene for a Novel Epithelium-specific Cytosolic Phospholipase A2, cPLA2δ, Induced in Psoriatic Skin
2004
Modulation of phospholipase A2 activity in primary cultures of rat cortical neurons
2005
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
The Highly Selective Production of 2-Arachidonoyl Lysophosphatidylcholine Catalyzed by Purified Calcium-independent Phospholipase A2γ
2005
Fas-induced Arachidonic Acid Release Is Mediated by Ca2+-independent Phospholipase A2 but Not Cytosolic Phospholipase A2, Which Undergoes Proteolytic Inactivation
1998
Irreversible inhibition of Ca2+-independent phospholipase A2 by methyl arachidonyl fluorophosphonate
1996
Group IV Cytosolic Phospholipase A2 Binds with High Affinity and Specificity to Phosphatidylinositol 4,5-Bisphosphate Resulting in Dramatic Increases in Activity
1998
Spinal phospholipase A2 in inflammatory hyperalgesia: role of Group IVA cPLA2
2005
The growing phospholipase A2 superfamily of signal transduction enzymes
1997
Regulation of Lysophospholipase Activity of the 85-kDa Phospholipase A2 and Activation in Mouse Peritoneal Macrophages
1995
A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis
2002
The expanding superfamily of phospholipase A2 enzymes: classification and characterization
2000 Standout
Molecular Characterization of Cytosolic Phospholipase A2-β
1999
Insulin Secretory Responses and Phospholipid Composition of Pancreatic Islets from Mice That Do Not Express Group VIA Phospholipase A2 and Effects of Metabolic Stress on Glucose Homeostasis
2006
Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β)
2006
Interfacial Kinetic and Binding Properties of Mammalian Group IVB Phospholipase A2 (cPLA2β) and Comparison with the Other cPLA2 Isoforms
2010
Phospholipase A2inhibitors as potential therapeutic agents for the treatment of inflammatory diseases
2009
Activation, Inhibition, and Regiospecificity of the Lysophospholipase Activity of the 85-kDa Group IV Cytosolic Phospholipase A2
1997
Function and Inhibition of Intracellular Calcium-independent Phospholipase A2
1997
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Swaying is a mutant allele of the proto-oncogene Wnt-1
1991 StandoutNobel
Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels
2006
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
1988 StandoutNatureNobel
Mice deficient in cytosolic phospholipase A2 are less susceptible to cerebral ischemia/reperfusion injury
2003
Localization and function of cytosolic phospholipase A2α at the Golgi
2010
JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2β
2001
Synthesis and activity of 2-oxoamides containing long chain β-amino acids
2004
Phospholipase A2 enzymes
2002
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
2008
LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength
2016 StandoutNobel
Characterization and Function in Vivo of Two Novel Phospholipases B/Lysophospholipases fromSaccharomyces cerevisiae
1999
Cytosolic phospholipase A2 gene in human and rat: chromosomal localization and polymorphic markers
1995
Role of cytosolic phospholipase A2 in allergic response and parturition
1997 Nature
cPLA2 is phosphorylated and activated by MAP kinase
1993 Standout
Identification of Phosphorylation Sites of Human 85-kDa Cytosolic Phospholipase A2 Expressed in Insect Cells and Present in Human Monocytes
1996
Macrophage arachidonate-mobilizing phospholipase A2: Role of Ca2+ for membrane binding but not for catalytic activity
1992
Phospholipase A 2 in Eicosanoid Generation
2000
BMS-229724 Is a Tight-Binding Inhibitor of Cytosolic Phospholipase A2 That Acts at the Lipid/Water Interface and Possesses Anti-Inflammatory Activity in Skin Inflammation Models
2001
Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector.
1984
Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells.
1993
Design and Synthesis of a Novel and Potent Series of Inhibitors of Cytosolic Phospholipase A2 Based on a 1,3-Disubstituted Propan-2-one Skeleton
2002
Differential Regulation of Chromogranin B and Synapsin I Gene Promoter Activity by cAMP and cAMP‐Dependent Protein Kinase
1994
Cytosolic Phospholipase A2-α Mediates Endothelial Cell Proliferation and Is Inactivated by Association with the Golgi Apparatus
2005
Altering Genotype and Phenotype by DNA-Mediated Gene Transfer
1980 StandoutScienceNobel
Inhibition of Group IVA Cytosolic Phospholipase A2by Novel 2-Oxoamides in Vitro, in Cells, and in Vivo
2004
Transformation of mammalian cells with genes from procaryotes and eucaryotes
1979 StandoutNobel
Macrophage colony stimulating factor activates phosphatidylcholine hydrolysis by cytoplasmic phospholipase A2.
1992
Activated Ketones as Inhibitors of Intracellular Ca2+-Dependent and Ca2+-Independent Phospholipase A2
1996
Altering the Genome by Homologous Recombination
1989 StandoutScienceNobel
Cytoplasmic Phospholipase A2 Deletion Enhances Colon Tumorigenesis
2005
Structures of Free and Inhibited Human Secretory Phospholipase A 2 from Inflammatory Exudate
1991 Science
Role of Conserved Active Site Residues in Catalysis by Phospholipase B1 from Cryptococcus neoformans
2007
Calcium-independent Phospholipases in the Heart: Mediators of Cellular Signaling, Bioenergetics, and Ischemia-induced Electrophysiologic Dysfunction
2009
Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association.
1993
Novel 2-Oxoamide Inhibitors of Human Group IVA Phospholipase A2
2002
A structure for amplified DNA
1983 StandoutNobel
Cell type-specific enhancer element associated with a mouse MHC gene, Eβ
1984 StandoutNatureNobel
Stimulus-response coupling in insulin-secreting HIT cells. Effects of secretagogues on cytosolic Ca2+, diacylglycerol, and protein kinase C activity.
1990
Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C
1992 StandoutScience
Variants of Mouse Myeloma Cells That Produce Short Immunoglobulin Heavy Chains
1974
A Bromoenol Lactone Suicide Substrate Inactivates Group VIA Phospholipase A2 by Generating a Diffiusible Bromomethyl Keto Acid That Alkylates Cysteine Thiols
2005
Characterization of a novel inhibitor of cytosolic phospholipase A2α, pyrrophenone
2002
Effects of Biological Oxidants on the Catalytic Activity and Structure of Group VIA Phospholipase A2
2006
In Vivo Protective Role of Human Group IIA Phospholipase A2 against Experimental Anthrax
2005
Dicarboxylic acid inhibitors of phospholipase A2
1997
Identification of amber and ochre mutants of the human virus Ad2+ND1.
1977
Substrate specificity of phospholipase B from guinea pig intestine. A glycerol ester lipase with broad specificity.
1992
Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes
1983 Nature
Bipartite Ca 2+ -Binding Motif in C 2 Domains of Synaptotagmin and Protein Kinase C
1996 StandoutScienceNobel
Calcium-independent phospholipases in the heart: mediators of cellular signaling, bioenergetics, and ischemia-induced electrophysiologic dysfunction.
2009
Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus.
1986
Location of Inhibitors Bound to Group IVA Phospholipase A2 Determined by Molecular Dynamics and Deuterium Exchange Mass Spectrometry
2009
Mutant alleles for hypoxanthine phosphoribosyltransferase: Codominant expression, complementation, and segregation in hybrid Chinese hamster cells
1976
Differential Inhibition of Group IVA and Group VIA Phospholipases A2by 2-Oxoamides
2006
Selective Degradation of Abnormal Proteins in Mammalian Tissue Culture Cells
1974 StandoutNobel
Purification of Recombinant Human cPLA2γ and Identification of C-Terminal Farnesylation, Proteolytic Processing, and Carboxymethylation by MALDI-TOF-TOF Analysis
2003
Cloned cDNA sequences of the hypoxanthine/guanine phosphoribosyltransferase gene from a mouse neuroblastoma cell line found to have amplified genomic sequences.
1982
Expression of a Bacterial Gene in Mammalian Cells
1980 StandoutScienceNobel
Regulation of phospholipase A2 activation by phosphorylation in mouse peritoneal macrophages.
1993
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells
1980 StandoutNobel
Interleukin-1 alpha induces the accumulation of cytosolic phospholipase A2 and the release of prostaglandin E2 in human fibroblasts.
1992
Cloning and expression of a membrane receptor for secretory phospholipases A2.
1994
Mammalian non-pancreatic phospholipases A2
1993
Diversity of group types, regulation, and function of phospholipase A2.
1994 Standout
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes
1982 StandoutNobel
Purification and characterization of mouse hypoxanthine-guanine phosphoribosyltransferase.
1975 StandoutNobel
Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells
1976
A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice
1987 StandoutNatureNobel
Molecular Docking and 3D-QSAR CoMFA Studies on Indole Inhibitors of GIIA Secreted Phospholipase A2
2010
The role of cytosolic free Ca2+ and protein kinase C in acetylcholine-induced insulin release in the clonal β-cell line, HIT-T15
1990
Phospholipase A2 inhibitors in inflammation
2001
Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1.
1991 StandoutNobel
Renal concentrating defect in mice lacking group IV cytosolic phospholipase A2
2001
Inhibition of Cytosolic Phospholipase A2α: Hit to Lead Optimization
2005
Molecular analysis of spontaneous somatic mutants
1977 StandoutNatureNobel
Interfacial Catalysis by Human 85 kDa Cytosolic Phospholipase A2 on Anionic Vesicles in the Scooting Mode
1997
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments
1979 StandoutNatureNobel
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Structure-activity relationship studies on (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: Variation of the alkanoic acid substituent, the acyl chain and the position of the pyrrole nitrogen
1997
Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C.
1993
Thrombin-induced phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in human platelets.
1993
Structure−Activity Relationship of 2-Oxoamide Inhibition of Group IVA Cytosolic Phospholipase A2and Group V Secreted Phospholipase A2
2007
REGULATION AND INHIBITION OF PHOSPHOLIPASE A2
1999
Plant and Animal Sensors of Conserved Microbial Signatures
2010 StandoutScienceNobel
Immunological characterization of hypoxanthine‐guanine phosphoribosyl transferase mutants of mouse L cells: Evidence for mutations at different loci in the HGPRT gene
1975 StandoutNobel
Unusual genes at the aminoterminus of human immunoglobulin variants
1978 StandoutNatureNobel
An immunoglobulin deletion mutant with implications for the heavy-chain switch and RNA splicing
1980 StandoutNatureNobel
Hypoxanthine-guanine phosphoribosyltransferase genes of mouse and Chinese hamster: construction and sequence analysis of cDNA recombinants
1982
Insulin secretory responses of a clonal cell line of simian virus 40-transformed B cells
1986
Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA
1990 StandoutScienceNobel
Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.
1995
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Response : Nitric Oxide and Arginine-Evoked Insulin Secretion
1992 StandoutScienceNobel
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor
1978 StandoutNobel
Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.
1994
Transformation of the gene for hypoxanthine phosphoribosyltransferase
1979
Works of John Sharp being referenced
Molecular Cloning of Two New Human Paralogs of 85-kDa Cytosolic Phospholipase A2
1999
Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 Å resolution
1991 Nature
Identification of Essential Residues for the Catalytic Function of 85-kDa Cytosolic Phospholipase A2
1996
Calcium-sensitive cytosolic phospholipase A2 (cPLA2) is expressed in human brain astrocytes
1994
Cytosolic phospholipase A2 (cPLA2) distribution in murine brain and functional studies indicate that cPLA2 does not participate in muscarinic receptor-mediated signaling in neurons
1998
Structure, function and regulation of Ca2+‐sensitive cytosolic phospholipase A2 (cPLA2)
1997
Recent Insights into the Structure, Function and Biology of cPLA2
1995
Functional and structural diversity of the human Dickkopf gene family
1999
Interleukin 1-induced pathophysiology: Induction of cytokines, development of histopathologic changes, and immunopharmacologic intervention
1989
Characterization by Electrospray Mass Spectrometry of Human Ca2+–sensitive Cytosolic Phospholipase A2 Produced in Baculovirus–infected Insect Cells
1994
Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration
1999
Transgenic model for the discovery of novel human secretory non-pancreatic phospholipase A2 inhibitors
1996
Altered Enzymes in Drug-Resistant Variants of Mammalian Tissue Culture Cells
1973 StandoutNobel
Serine 228 is essential for catalytic activities of 85-kDa cytosolic phospholipase A2.
1994
Molecular cloning and expression of human Ca(2+)-sensitive cytosolic phospholipase A2
1991
Reactive Glia Express Cytosolic Phospholipase A2 After Transient Global Forebrain Ischemia in the Rat
1996
Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells.
1981
Cytosolic PLA2: mRNA levels and potential for transcriptional regulation.
1993