Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity
2015
Removing T-cell epitopes with computational protein design
2014 StandoutNobel
Generation of knock-in primary human T cells using Cas9 ribonucleoproteins
2015 StandoutNobel
Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy
2012 StandoutScienceNobel
The Basic Principles of Chimeric Antigen Receptor Design
2013
The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature
2012
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Role of viruses in etiology and pathogenesis of multiple sclerosis
2001
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis
1992
Is autoimmunity the Achilles' heel of cancer immunotherapy?
2017
Increased mRNA Expression of IL‐10 in Mononuclear Cells in Multiple Sclerosis and Optic Neuritis
1995
Fv1. the mouse retrovirus resistance gene
1998
FOXP3+ regulatory T cells: control of FOXP3 expression by pharmacological agents
2011 StandoutNobel
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
Multi-input chemical control of protein dimerization for programming graded cellular responses
2019 StandoutNobel
In vitro study of mediators of inflammation in multiple sclerosis
1989
A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis
2003
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature
Regulatory T Cells
2010
Nitric oxide induces necrotic but not apoptotic cell death in oligodendrocytes
1995 StandoutNobel
Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology
2013
CD4+ T-cell subsets in autoimmunity
1997
Regulatory T Cells
2000 StandoutNobel
Immunotherapy of Hematologic Malignancy
2003
Exacerbation of Viral and Autoimmune Animal Models for Multiple Sclerosis by Bacterial DNA
1999
Cancer Statistics, 2006
2006 Standout
Identification of the transforming EML4–ALK fusion gene in non-small-cell lung cancer
2007 StandoutNature
The Principles of Engineering Immune Cells to Treat Cancer
2017
Controlling mRNA stability and translation with the CRISPR endoribonuclease Csy4
2015
Complex immunomodulatory effects of interferon‐β in multiple sclerosis include the upregulation of T helper 1‐associated marker genes
2001
Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic
2015
Adoptive immunotherapy for cancer: harnessing the T cell response
2012
TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes
2003
A Rapamycin-Activated Caspase 9-Based Suicide Gene
2018
Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses
2018
Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?
1988
Mac-1+ myelopoiesis induced by CFA: a clue to the paradoxical effects of IFN-γ in autoimmune disease models
2001
Decreases in Interleukin-4 Secretion by Invariant CD4−CD8−Vα24JαQ T Cells in Peripheral Blood of Patients with Relapsing–Remitting Multiple Sclerosis
2001
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors
2013
Human antibody-based chemically induced dimerizers for cell therapeutic applications
2017
Interferon γ, interleukin 4 and transforming growth factor β in experimental autoimmune encephalomyelitis in lewis rats: Dynamics of cellular mrna expression in the central nervous system and lymphoid cells
1995
Can graft-versus-leukemia reactivity be dissociated from graft-versus-host disease?
2007
Identification and expansion of human colon-cancer-initiating cells
2006 StandoutNature
IL-18 is linked to raised IFN-γ in multiple sclerosis and is induced by activated CD4+ T cells via CD40–CD40 ligand interactions
2002
Heat shock proteins and experimental autoimmune encephalomyelitis (EAE): I. Immunization with a peptide of the myelin protein 2?,3? cyclic nucleotide 3? phosphodiesterase that is cross-reactive with a heat shock protein alters the course of EAE
1996
Genetic models for CNS inflammation
2001
Cancer immunotherapy comes of age
2011 StandoutNature
Engineered Cell-Based Therapeutics: Synthetic Biology Meets Immunology
2019
Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice
2003
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Ligand-targeted therapeutics in anticancer therapy
2002
Single amino-acid changes in HIV envelope affect viral tropism and receptor binding
1989 StandoutNatureNobel
Increased transforming growth factor‐β, interleukin‐4, and interferon‐γ in multiple sclerosis
1994
Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.
1990
Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes
2016 StandoutNobel
Flow Cytometric Analysis of In Vitro Proinflammatory Cytokine Secretion in Peripheral Blood from Multiple Sclerosis Patients
1999
Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo
2014
Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities
2003
Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System
1996
Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+CD25−LAP+ T cells
2006
Adoptive Immunotherapy for Cancer or Viruses
2014
Remote control of therapeutic T cells through a small molecule–gated chimeric receptor
2015 Science
The biosynthesis of oncovirus proteins
1978
SPAS-1 (stimulator of prostatic adenocarcinoma-specific T cells)/SH3GLB2: A prostate tumor antigen identified by CTLA-4 blockade
2008 StandoutNobel
Dendritic cells with TGF-β1 differentiate naïve CD4+CD25−T cells into islet-protective Foxp3+regulatory T cells
2007 StandoutNobel
PD-1– and CTLA-4–Based Inhibitory Chimeric Antigen Receptors (iCARs) Divert Off-Target Immunotherapy Responses
2013
ISOLATION OF HUMAN T-LYMPHOTROPIC RETROVIRUS (LAV) FROM ZAIRIAN MARRIED COUPLE, ONE WITH AIDS, ONE WITH PRODROMES
1984 StandoutNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Adoptive immunotherapy with genetically modified lymphocytes in allogeneic stem cell transplantation
2013
Genome organization and transactivation of the human immunodeficiency virus type 2
1987 StandoutNatureNobel
Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides.
1994
Adoptive cell transfer as personalized immunotherapy for human cancer
2015 StandoutScience
Adoptive cellular therapy: A race to the finish line
2015
Decrease of the okt8 positive t cell subset in polymyalgia rheumatica
1983
Correct integration of retroviral DNA in vitro
1987 StandoutNobel
A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.
1984 StandoutNobel
Molecular biology: Reverse transcriptase rides again
1985 StandoutNatureNobel
Increased numbers of CCR5+ interferon-?- and tumor necrosis factor-?-secreting T lymphocytes in multiple sclerosis patients
2000
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product
1980 StandoutNatureNobel
Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P
2009
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
1986 Standout
IMMUNOLOGY OF MULTIPLE SCLEROSIS
2005 Standout
A phase I trial of the single-chain immunotoxin SGN-10 (BR96 sFv-PE40) in patients with advanced solid tumors.
2002
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
CRISPR-enhanced engineering of therapy-sensitive cancer cells for self-targeting of primary and metastatic tumors
2018
Treatment of Hematologic Malignancies with Immunotoxins and Antibody-Drug Conjugates
2011
Drug Delivery Systems: Entering the Mainstream
2004 StandoutScience
Chemical synthesis of a polypeptide predicted from nucleotide sequence allows detection of a new retroviral gene product
1980 Nature
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis
2001
Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage
1998 StandoutNobel
Going viral: chimeric antigen receptor T‐cell therapy for hematological malignancies
2014
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.
1993 StandoutNobel
Interleukin‐12 and Perforin mRNA Expression is Augmented in Blood Mononuclear Cells in Multiple Sclerosis
1998
Construction and analysis of deletion mutations in the pol gene of moloney murine leukemia virus: A new viral function required for productive infection
1984
De novo design of protein homodimers containing tunable symmetric protein pockets
2022 StandoutNobel
Chemically induced proximity in biology and medicine
2018 Science
Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells
1992 StandoutScienceNobel
Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease
2007
CAR T cell immunotherapy for human cancer
2018 StandoutScience
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
A cell nanoinjector based on carbon nanotubes
2007 StandoutNobel
Multivalent Ligand: Design Principle for Targeted Therapeutic Delivery Approach
2012
De novo design of protein logic gates
2020 StandoutScienceNobel
T-cell subsets in autoimmunity
1993
Mutations affecting segment number and polarity in Drosophila
1980 StandoutNatureNobel
COMBINES-CID: An Efficient Method for De Novo Engineering of Highly Specific Chemically Induced Protein Dimerization Systems
2019
Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
2014 StandoutNobel
The Fv-1 Gene of the Mouse and its Control of Murine Leukemia Virus Replication
1979
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
1996 StandoutScience
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of John Schindler being referenced
Donor T lymphocyte infusion following ex vivo depletion of donor anti-host reactivity by a specific anti–interleukin-2 receptor P55 chain immunotoxin
2002
Add-back of allodepleted donor T cells to improve immune reconstitution after haplo-identical stem cell transplantation
2005
Immune reconstitution without graft-versus-host disease after haemopoietic stem-cell transplantation: a phase 1/2 study
2002
Partial Reduction of Human FOXP3+ CD4 T Cells In Vivo After CD25-directed Recombinant Immunotoxin Administration
2008
A phase I study of a combination of anti‐CD19 and anti‐CD22 immunotoxins (Combotox) in adult patients with refractory B‐lineage acute lymphoblastic leukaemia
2011
Optimized clinical-scale culture conditions for ex vivo selective depletion of host-reactive donor lymphocytes: a strategy for GvHD prophylaxis in allogeneic PBSC transplantation
2002
Treatment of refractory Hodgkin's lymphoma patients with an anti-CD25 ricin A-chain immunotoxin
2000
Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
2011
A Phase 1 Study of Combotox in Pediatric Patients With Refractory B-lineage Acute Lymphoblastic Leukemia
2009
Six-NB-tropic murine leukemia viruses derived from a B-tropic virus of BALB/c have altered p30
1977
Evidence for recombination between N- and B-tropic murine leukemia viruses
1977
Structural markers on core protein p30 of murine leukemia virus: functional correlation with Fv-1 tropism.
1978
Evaluation of T cell subsets with monoclonal antibodies in patients with rheumatoid arthritis.
1982
A phase I study of bolus versus continuous infusion of the anti-CD19 immunotoxin, IgG-HD37-dgA, in patients with B-cell lymphoma
1996
A Phase I study with an anti-CD30 ricin A-chain immunotoxin (Ki-4.dgA) in patients with refractory CD30+ Hodgkin's and non-Hodgkin's lymphoma.
2002
A Phase-I Study of an Anti-CD25 Ricin A-Chain Immunotoxin (RFT5-SMPT-dgA) in Patients With Refractory Hodgkin's Lymphoma
1997
The toxicity of deglycosylated ricin A chain-containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: a retrospective analysis of patients in five clinical trials.
2001
Treatment of multiple sclerosis with gamma interferon
1987
Human in vivo antigenic modulation induced by the anti‐T cell OKT3 monoclonal antibody
1982
Evidence for recombination between N- and B-tropic murine leukemia viruses: analysis of three virion proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis
1977
Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation
2005
A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma.
2000
Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system
2011