Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.
1996
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: Assessment of an oral agent that stimulates erythropoietin production
2005 StandoutNobel
Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
1999
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3
2003 Nature
Bcl-2 and Bax mammalian regulators of apoptosis are functional in Drosophila
2000
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast
1998
Processing of the Nedd2 precursor by ICE‐like proteases and granzyme B
1996
Cell-specific Induction of Apoptosis by Microinjection of Cytochrome c
1997
The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
2002
MUF1, A Novel Elongin BC-interacting Leucine-rich Repeat Protein That Can Assemble with Cul5 and Rbx1 to Reconstitute a Ubiquitin Ligase
2001
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
2001 StandoutNobel
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
1999
An Essential Role for the Caspase Dronc in Developmentally Programmed Cell Death in Drosophila
2000
LIN-23-Mediated Degradation of β-Catenin Regulates the Abundance of GLR-1 Glutamate Receptors in the Ventral Nerve Cord of C. elegans
2005
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
Cell cycle: Cull and destroy
1996
A novel protein modification pathway related to the ubiquitin system
1998
Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle
1999
The Drosophila Circadian Network Is a Seasonal Timer
2007 StandoutNobel
Identification of NEDD8-Conjugation Site in Human Cullin-2
1999
Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway
1998
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
1998 StandoutNobel
The conserved nuclear receptor Ftz‐F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans
2000
Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3
1996
Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
1999
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Covalent modification of all members of human cullin family proteins by NEDD8
1999
Roles of ubiquitin-mediated proteolysis in cell cycle control
1997 StandoutNobel
ICE Family Proteases: Mediators of All Apoptotic Cell Death?
1996
Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex
2002 Nature
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Phosphorylation and proteolysis: partners in the regulation of cell division in budding yeast
1997
Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis
1998
Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c
1996 Standout
von Hippel-Lindau Disease
1997 StandoutNobel
F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex
1997
Cell Death
2004 Standout
Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1
2002
Activation of a CrmA-insensitive, p35-sensitive Pathway in Ionizing Radiation-induced Apoptosis
1997
Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα
1999
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells
1996
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions
2003
Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis
1998 Standout
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
Death substrates come alive
1997
BTB/POZ Domain Proteins Are Putative Substrate Adaptors for Cullin 3 Ubiquitin Ligases
2003
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
Molecular Ordering of the Cell Death Pathway
1996
Activation of caspases triggered by cytochrome c in vitro1
1998
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Prediction of the Coding Sequences of Unidentified Human Genes. IX. The Complete Sequences of 100 New cDNA Clones from Brain Which Can Code for Large Proteins in vitro
1998
IAP proteins: blocking the road to death's door
2002
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
A new NEDD8-ligating system for cullin-4A
1998
Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCFCdc4 complex
1998
Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition
2002
Caspases: killer proteases
1997 Standout
Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms
2002
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression
2000 StandoutNobel
Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27Kip1
1997
Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1
2002 StandoutNobel
Processing and Activation of CMH-1 by Granzyme B
1996
Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme
1996
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Ubiquitin-like proteins: new wines in new bottles
2000
Specific Cleavage of α-Fodrin during Fas- and Tumor Necrosis Factor-induced Apoptosis Is Mediated by an Interleukin-1β-converting Enzyme/Ced-3 Protease Distinct from the Poly(ADP-ribose) Polymerase Protease
1996
The cell-death machine
1996
A Subset of Dorsal Neurons Modulates Circadian Behavior and Light Responses in Drosophila
2007
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
1996
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis
1996 Nature
The role of protein stability in the cell cycle and cancer
1998
The Drosophila Caspase Inhibitor DIAP1 Is Essential for Cell Survival and Is Negatively Regulated by HID
1999
Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
1999
Proteolysis and the G1-S transition: the SCF connection
1998
Cdc53 Targets Phosphorylated G1 Cyclins for Degradation by the Ubiquitin Proteolytic Pathway
1996
The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts
2000
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E
1999
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis
1996
Dissecting processing and apoptotic activity of a cysteine protease by mutant analysis.
1996
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
Cdc53p Acts in Concert with Cdc4p and Cdc34p To Control the G1-to-S-Phase Transition and Identifies a Conserved Family of Proteins
1996
Mass Spectrometric Analysis of the Anaphase-Promoting Complex from Yeast: Identification of a Subunit Related to Cullins
1998 Science
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein
1998
BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase
2004
Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.
1996
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Diverse Domains of THREAD/DIAP1 Are Required to Inhibit Apoptosis Induced by REAPER and HID in Drosophila
2000
Different Interleukin-1β Converting Enzyme (ICE) Family Protease Requirements for the Apoptotic Death of T Lymphocytes Triggered by Diverse Stimuli
1996
Activation of CPP32 and Mch3α in wild-type p53-induced apoptosis
1997
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
1997
Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells
1997
Specific requirement for two ADF/cofilin isoforms in distinct actin-dependent processes inCaenorhabditis elegans
2003
SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box
1996
Building and remodelling Cullin–RING E3 ubiquitin ligases
2013
Studying interactions of four proteins in the yeast two-hybrid system: Structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein
1999
The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal
1998
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities.
1997
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Phosphorylation- and Skp1-independent in vitro ubiquitination of E2F1 by multiple ROC-cullin ligases.
2001
How Proteolysis Drives the Cell Cycle
1996 Science
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Inhibition of Ced-3/ICE-related Proteases Does Not Prevent Cell Death Induced by Oncogenes, DNA Damage, or the Bcl-2 Homologue Bak
1997
Caspases: the executioners of apoptosis
1997 Standout
Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.
1996 Nobel
VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubule
1999
Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain
2008 StandoutNobel
Mitochondria and Apoptosis
1998 StandoutScience
Mitochondrial Release of Caspase-2 and -9 during the Apoptotic Process
1999
Developmental regulation of a cyclin-dependent kinase inhibitor controls postembryonic cell cycle progression in Caenorhabditis elegans
1998 StandoutNobel
Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.
1998
Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2
1998 StandoutNobel
Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.
1996
Translocation of C. elegans CED-4 to Nuclear Membranes During Programmed Cell Death
2000 StandoutScienceNobel
Bcl-2 Expression in Neural Cells Blocks Activation of ICE/CED-3 Family Proteases during Apoptosis
1996
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner
1999 Standout
Purification and Characterization of an Interleukin-1β-converting Enzyme Family Protease That Activates Cysteine Protease P32 (CPP32)
1996
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel–Lindau tumor suppressor function
1999
Works of John P. Wing being referenced
cul-1 Is Required for Cell Cycle Exit in C. elegans and Identifies a Novel Gene Family
1996
ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis
1996
Drosophila sickle Is a Novel grim-reaper Cell Death Activator
2002
The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities
2001
Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes
1998
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
2002