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Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation
2002 StandoutNobel
Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping.
1995
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
1996
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.
1996
The peroxisome proliferator activated receptor regulates malic enzyme gene expression.
1994
Adaptive Myogenesis under Hypoxia
2005
Induction of the Acyl-Coenzyme A Synthetase Gene by Fibrates and Fatty Acids Is Mediated by a Peroxisome Proliferator Response Element in the C Promoter
1995
Caenorhabditis elegans HCF-1 Functions in Longevity Maintenance as a DAF-16 Regulator
2008
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
1998 StandoutNature
Identification of a Functional Peroxisome Proliferator-responsive Element in the Murine Fatty Acid Transport Protein Gene
1999
Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor
1997
Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry
2012 StandoutNobel
The Human Peroxisome Proliferator-activated Receptor (PPAR) Subtype NUC1 Represses the Activation of hPPARα and Thyroid Hormone Receptors
1995
cDNA cloning and characterization of the transcriptional activities of the hamster peroxisome proliferator-activated receptor haPPARγ
1995
Ligand-induced Peroxisome Proliferator-activated Receptor α Conformational Change
1997
Expression of the Peroxisome Proliferator-activated Receptor α Gene Is Stimulated by Stress and Follows a Diurnal Rhythm
1996
Xenopus peroxisome proliferator activated receptors: Genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids
1993
Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids
1995
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Identification, Characterization, and Tissue Distribution of Human Peroxisome Proliferator-activated Receptor (PPAR) Isoforms PPARγ2 versus PPARγ1 and Activation with Retinoid X Receptor Agonists and Antagonists
1997
Peroxisome Proliferator-activated Receptor α Activation Modulates Cellular Redox Status, Represses Nuclear Factor-κB Signaling, and Reduces Inflammatory Cytokine Production in Aging
1998
Phytanic Acid Activates the Peroxisome Proliferator-activated Receptor α (PPARα) in Sterol Carrier Protein 2-/ Sterol Carrier Protein x-deficient Mice
1999
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Polarity and Specific Sequence Requirements of Peroxisome Proliferator-activated Receptor (PPAR)/Retinoid X Receptor Heterodimer Binding to DNA
1997
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
PPAR Tissue Distribution and Interactions with Other Hormone‐Signaling Pathwaysa
1996
Nuclear receptor coactivators
1997
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
Gene Expression and Physiologic Responses of the Heart to the Initiation and Withdrawal of Caloric Restriction
2006
Structure and function of transcriptional activation domains
1995
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
1998 StandoutNature
Peroxisome proliferator-activated receptor alpha: role in rodent liver cancer and species differences
1999
Positive regulation of the peroxisomal β‐oxidation pathway by fatty acids through activation of peroxisome proliferator‐activated receptors (PPAR)
1993
Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm
1999 Standout
Transcriptional activation by viral regulatory proteins
1991
PPAR-γ agonists inhibit production of monocyte inflammatory cytokines
1998 StandoutNature
Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.
1995
Transcriptional Suppression of the Transferrin Gene by Hypolipidemic Peroxisome Proliferators
1996
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
A Carboxyl-terminal Extension of the Zinc Finger Domain Contributes to the Specificity and Polarity of Peroxisome Proliferator-activated Receptor DNA Binding
1998
Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements.
1995
A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice.
1998
Evidence for Transcriptional Induction of the Liver Fatty-Acid-Binding-Protein Gene by Bezafibrate in the Small Intestine
1995
Cooperative Formation of Higher Order Peroxisome Proliferator-activated Receptor and Retinoid X Receptor Complexes on the Peroxisome Proliferator Responsive Element of the Rat Hydratase-Dehydrogenase Gene
1995
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
DNA Binding Properties of Peroxisome Proliferator-activated Receptor Subtypes on Various Natural Peroxisome Proliferator Response Elements
1997
Identification of an extended half‐site motif required for the function of peroxisome proliferator‐activated receptor α
1997
Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements
1998
Fatty Acid Flip-Flop in Phospholipid Bilayers Is Extremely Fast
1995
Eukaryotic release factor 1 (eRF1) abolishes readthrough and competes with suppressor tRNAs at all three termination codons in messenger RNA
1997
Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs
1997
RNA interference
2002 StandoutNature
The hormone resistin links obesity to diabetes
2001 StandoutNature
Differential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*
1994
Novel Sequence Determinants in Peroxisome Proliferator Signaling
1995
The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein
1993
Peroxisome Proliferator-Activated Receptor-alpha and the Pleiotropic Responses to Peroxisome Proliferators
1998
Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors
1997
Control of the Functional Activity of an Antisense RNA by a Tetracycline-Responsive Derivative of the Human U6 snRNA Promoter
2000
Bifidobacteria can protect from enteropathogenic infection through production of acetate
2011 StandoutNature
Electron Crystal Structure of an RNA Polymerase II Transcription Elongation Complex
1999 StandoutNobel
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Fibrates Increase Human REV-ERBα Expression in Liver via a Novel Peroxisome Proliferator-Activated Receptor Response Element
1999
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Fatty Acid Binding: A New Kind of Posttranslational Modification of Membrane Proteins
1983
Gene Silencing by Chicken Ovalbumin Upstream Promoter-Transcription Factor I (COUP-TFI) Is Mediated by Transcriptional Corepressors, Nuclear Receptor-Corepressor (N-CoR) and Silencing Mediator for Retinoic Acid Receptor and Thyroid Hormone Receptor (SMRT)
1997
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Import of amber and ochre suppressor tRNAs into mammalian cells: A general approach to site-specific insertion of amino acid analogues into proteins
2001
Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver.
1993
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
1985 StandoutScienceNobel
Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations.
1992
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
Altering the Genome by Homologous Recombination
1989 StandoutScienceNobel
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator.
1993
Protein-DNA Interactions at a Drug-responsive Element of the Human Apolipoprotein A-I Gene
1996
Release of fatty acids from virus glycoproteins by hydroxylamine
1984
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles
2004 StandoutNobel
Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription
1995
Fat and Beyond: The Diverse Biology of PPARγ
2008 Standout
PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology
1996
Association of the Herpes Simplex Virus Type 1 Us11 Gene Product with the Cellular Kinesin Light-Chain-Related Protein PAT1 Results in the Redistribution of Both Polypeptides
2003
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
1993 StandoutNobel
Possible role for fatty acyl-coenzyme A in intracellular protein transport
1987 StandoutNatureNobel
BASIC MECHANISMS OF TRANSCRIPT ELONGATION AND ITS REGULATION
1997
Synaptic Activity and the Construction of Cortical Circuits
1996 StandoutScience
The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats.
1994
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Thyroid hormone (T3) inhibits ciprofibrate-induced transcription of genes encoding beta-oxidation enzymes: cross talk between peroxisome proliferator and T3 signaling pathways.
1995
Identification of palmitoylated mitochondrial proteins using a bio‐orthogonal azido‐palmitate analogue
2007 StandoutNobel
A dominant positive and negative selectable gene for use in mammalian cells.
1991 StandoutNobel
Evidence for Transcriptional Induction of the Liver Fatty‐Acid‐Binding‐Protein Gene by Bezafibrate in the Small Intestine
1995
The PPARs: From Orphan Receptors to Drug Discovery
2000 Standout
Replication Strategies of the Single Stranded RNA Viruses of Eukaryotes
1983
Liver Regeneration
1997 StandoutScience
Cross-talk between Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) and Peroxisome Proliferator-activated Receptor-α (PPARα) Signaling Pathways
1999
Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity.
1994
Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression.
1996
Evidence that a downstream pseudoknot is required for translational read-through of the Moloney murine leukemia virus gag stop codon.
1991
Myostatin Inhibits Myoblast Differentiation by Down-regulating MyoD Expression
2002 Standout
The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression.
1994
Intrinsic Disorder and Protein Function
2002
Cryo-EM structure of the mammalian eukaryotic release factor eRF1–eRF3-associated termination complex
2012 StandoutNobel
INTRACELLULAR LIPID-BINDING PROTEINS AND THEIR GENES
1997
Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function.
1995
Do Peroxisome Proliferating Compounds Pose a Hepatocarcinogenic Hazard to Humans?
1998
Human S mu binding protein-2 binds to the drug response element and transactivates the human apoA-I promoter: role of gemfibrozil
1998 StandoutNobel
Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis
1999
Mediator protein mutations that selectively abolish activated transcription
1999 StandoutNobel
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
1999 Standout
Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids.
1994
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells
2003
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
1995
Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
1994
Calreticulin: one protein, one gene, many functions
1999
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids.
1994
Critical Structural Elements of the VP16 Transcriptional Activation Domain
1991 Science
Structural Basis for Misaminoacylation by Mutant E. coli Glutaminyl-tRNA Synthetase Enzymes
1989 StandoutScienceNobel
Model Substrates for an RNA Enzyme
1987 StandoutScienceNobel
RXR Agonists Activate PPARα-Inducible Genes, Lower Triglycerides, and Raise HDL Levels In Vivo
1998
Transactivation of the peroxisome proliferator-activated receptor is differentially modulated by hepatocyte nuclear factor-4.
1994
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
Identification of a Nuclear Receptor for Bile Acids
1999 StandoutScience
Interaction of the peroxisome proliferator-activated receptor alpha with the retinoid X receptor alpha unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter.
1994
NMR structure of the calreticulin P-domain
2001 StandoutNobel
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator
2002
Role of Important Hydrophobic Amino Acids in the Interaction between the Glucocorticoid Receptor τ1-Core Activation Domain and Target Factors
1998
Construction of two Escherichia coli amber suppressor genes: tRNAPheCUA and tRNACysCUA.
1986
Positive genetic selection for gene disruption in mammalian cells by homologous recombination.
1989
Works of John P. Capone being referenced
Host Cell Factor-1 Interacts with and Antagonizes Transactivation by the Cell Cycle Regulatory Factor Miz-1
2002
Oxysterol Activators of Liver X Receptor and 9-cis-Retinoic Acid Promote Sequential Steps in the Synthesis and Secretion of Tumor Necrosis Factor-α from Human Monocytes
2002
Calreticulin modulates the in vitro DNA binding but not the in vivo transcriptional activation by peroxisome proliferator-activated receptor/retinoid X receptor heterodimers
1995
Regulated expression of plant tRNA genes by the prokaryotic tet and lac repressors
1997
Peroxisome Proliferator-activated Receptor γ Ligands Differentially Modulate Muscle Cell Differentiation and MyoD Gene Expression via Peroxisome Proliferator-activated Receptor γ-dependent and -independent Pathways
2001
Mutational analysis of the herpes simplex virus trans-inducing factor Vmw65
1989
The Orphan Nuclear Hormone Receptor LXRα Interacts with the Peroxisome Proliferator-activated Receptor and Inhibits Peroxisome Proliferator Signaling
1996
A PPARγ mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus
2000
A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARα
1998
Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor α and liver-X-receptor α
1998
Identification of COUP-TFII as a peroxisome proliferator response element binding factor using genetic selection in yeast: COUP-TFII activates transcription in yeast but anatagonizes PPAR signaling in mammalian cells
1996
Orphan Nuclear Hormone Receptor RevErbα Modulates Expression from the Promoter of the Hydratase-dehydrogenase Gene by Inhibiting Peroxisome Proliferator-activated Receptor α-Dependent Transactivation
1999
RNA Chain Elongation and Termination by Mammalian RNA Polymerase III
1994
A p56 Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor
1996
An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65.
1993
Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function.
1996
Chicken ovalbumin upstream promoter transcription factor (COUP-TF) binds to a peroxisome proliferator-responsive element and antagonizes peroxisome proliferator-mediated signaling.
1993
Regulated Expression of a Mammalian Nonsense Suppressor tRNA Gene In Vivo and In Vitro Using the lac Operator/Repressor System
1992
Amber, ochre and opal suppressor tRNA genes derived from a human serine tRNA gene.
1985
A cellular factor binds to the herpes simplex virus type 1 transactivator Vmw65 and is required for Vmw65-dependent protein-DNA complex assembly with Oct-1.
1990
Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression.
1993
Identification of a peroxisome proliferator-responsive element upstream of the gene encoding rat peroxisomal enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase.
1992
Introduction of UAG, UAA, and UGA Nonsense Mutations at a Specific Site in the Escherichia coli Chloramphenicol Acetyltransferase Gene: Use in Measurement of Amber, Ochre, and Opal Suppression in Mammalian Cells
1986
Characterization of protein-DNA interactions within the peroxisome proliferator-responsive element of the rat hydratase-dehydrogenase gene
1993
Purification and characterization of the carboxyl-terminal transactivation domain of Vmw65 from herpes simplex virus type 1.
1992
Synthesis and assembly of membrane glycoproteins. Membrane anchoring COOH-terminal domain of vesicular stomatitis virus envelope glycoprotein G contains fatty acids.
1982
An inducible mammalian amber suppressor: Propagation of a poliovirus mutant
1987
A Cellular Factor Binds to the Herpes Simplex Virus Type 1 Transactivator Vmw65 and Is Required for Vmw65-Dependent Protein-DNA Complex Assembly with Oct-1
1990
An upstream region of the enoyl-coenzyme A hydratase/3-hydroxyacyl-coenzyme A dehydrogenase gene directs luciferase expression in liver in response to peroxisome proliferators in transgenic mice.
1994
The p56 -interacting Protein p62 Stimulates Transcription via the SV40 Enhancer
1999
Identification of a domain of the herpes simplex virus trans-activator Vmw65 required for protein-DNA complex formation through the use of protein A fusion proteins
1989