Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors
1993
S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein
1990
COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes
1998 StandoutNobel
S. cerevisiae α pheromone receptors activate a novel signal transduction pathway for mating partner discrimination
1991 StandoutNobel
Localization and subcellular distribution of cellular ras gene products in rat brain
1989
G protein coupled receptor structure and activation
2006 StandoutNobel
Cloning of bovine GAP and its interaction with oncogenic ras p21
1988 Nature
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle
1989 StandoutNatureNobel
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
The GTPase superfamily: a conserved switch for diverse cell functions
1990 StandoutNature
Adenylyl cyclases
1992 StandoutNobel
Toward the active conformations of rhodopsin and the β2‐adrenergic receptor
2004
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
1994 StandoutNatureNobel
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21
1990
Stimulation of phospholipase C by guanine‐nucleotide‐binding protein βγ subunits
1992
Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands
2007
Courtship in S. cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal
1990 StandoutNobel
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation ofAplysia sensory neurons
1989 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
The C. elegans genome sequencing project: a beginning
1992 StandoutNatureNobel
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
Genetic analysis of mammalian GAP expressed in yeast
1989
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
1992 StandoutNatureNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
The C-terminus of the S. cerevisiae α-pheromone receptor mediates an adaptive response to pheromone
1988 StandoutNobel
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
G protein—coupled receptor kinases
1993 StandoutNobel
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
Purification and characterization of a GTP-binding protein with a molecular weight of 20,000 in bovine brain membranes. Identification as the rho gene product.
1988
Expression of a β-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice
1998 StandoutNobel
A novel yeast mutant defective in the processing of ras proteins: assessment of the effect of the mutation on processing steps.
1987
The long and the short of long–term memory—a molecular framework
1986 StandoutNatureNobel
IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein.
1990
Small GTP-Binding Proteins
2001 Standout
G protein beta gamma subunits. Simplified purification and properties of novel isoforms.
1994 StandoutNobel
Occurrence in Saccharomyces cerevisiae of a gene homologous to the cDNA coding for the alpha subunit of mammalian G proteins.
1987
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
1990
The Action of Oncogenes in the Cytoplasm and Nucleus
1985 Science
Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins
1993 Science
Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21
1986 Nature
Production, processing and partial purification of functional G protein βγ subunits in baculovirus-infected insect cells
1992
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor
1986
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
The posttranslational processing of ras p21 is critical for its stimulation of yeast adenylate cyclase.
1992
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
Possible involvement of RAS-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomyces cerevisiae.
1986
A new cell division operon inEscherichia coli
1986
Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes.
1992 StandoutNobel
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
1994 StandoutNobel
Interaction between G-protein beta and gamma subunit types is selective.
1992
The ras oncogene--an important regulatory element in lower eucaryotic organisms
1989
Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product.
1987
SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.
1992
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Characterization of the cDNA and Genomic Sequence of a G Protein γ Subunit (γ5)
1992
Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae.
1987
Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line
1985 Nature
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma
1992 StandoutNobel
The Cellular Functions of Small GTP-Binding Proteins
1990 Science
Specificity of G protein beta and gamma subunit interactions.
1992
Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase
1987
In vitro synthesis of G protein βγ dimers
1991
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction
1987
G-protein beta gamma dimers. Membrane targeting requires subunit coexpression and intact gamma C-A-A-X domain.
1991
Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.
1992
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method.
1988
MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae.
1989
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
1995 StandoutScienceNobel
Mutations in a gene encoding the alpha subunit of a Saccharomyces cerevisiae G protein indicate a role in mating pheromone signaling.
1988
Complex formation between RAS and RAF and other protein kinases.
1993
Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects.
1986
Retinal rods and cones have distinct G protein beta and gamma subunits.
1992
Phosphorylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae.
1989
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase
1985
IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.
1989
Identification of the subunits of GTP-binding proteins coupled to somatostatin receptors.
1991
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation
1989 StandoutNobel
Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors
1992 StandoutScienceNobel
Inhibition of Adenylyl Cyclase by G iα
1993 StandoutScienceNobel
Control of Yeast Mating Signal Transduction by a Mammalian β 2 -adrenergic Receptor and G s α Subunit
1990 StandoutScienceNobel
CDC25 : a Component of the RAS -Adenylate Cyclase Pathway in Saccharomyces cerevisiae
1987 Science
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Purification and characterization of c-Ki-ras p21 from bovine brain crude membranes.
1988
Characterization, cloning and sequence analysis of the CDC25 gene which controls the cyclic AMP level of Saccharomyces cerevisiae.
1986
A Mutation in the Catalytic Subunit of cAMP-Dependent Protein Kinase That Disrupts Regulation
1988 Science
RAS proteins can induce meiosis in xenopus oocytes
1985
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway
1987
Diversity of G Proteins in Signal Transduction
1991 StandoutScience
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
1991 StandoutScienceNobel
The Effect of Posttranslational Modifications on the Interaction of Ras2 with Adenylyl Cyclase
1993 Science
Phosphorylation of the RAS2 gene product by protein kinase A inhibits the activation of yeast adenylyl cyclase.
1988
Works of John Northup being referenced
Two Amino Acids in the Sixth Transmembrane Segment of the Mouse Gastrin-Releasing Peptide Receptor Are Important for Receptor Activation
2000
Differential activation of yeast adenylate cyclase by wild type and mutant RAS proteins
1985
Evidence for Distinct Cation and Calcimimetic Compound (NPS 568) Recognition Domains in the Transmembrane Regions of the Human Ca2+ Receptor
2002
G protein diversity is increased by associations with a variety of gamma subunits.
1990